• The Korean Journal of Pharmacology
• /
• v.24 no.1
• /
• pp.43-52
• /
• 1988

To elucidate the mechanism of action of local anesthetics, the effects of local anethetics on the microenvironment of the lipid bilayers of synaptosomal plasma membrane vesicles (SPMV) isolated from bovine brain and dimyristoylphosphatidylcholine (DMPC) multilamellar liposomes were investigated employing the intermolecular excimer fluorescence technique and differential scanning calorimetry (DSC). The relative intensities of excimer and monomer fluorescence of pyrene are a simple linear function of the viscosity of a homologous series of solvents. The microviscosity(${\eta}$)of the hydrocarbon region of SPMV was measured by this method and the value was $57.3{\pm}5.3\;cP$ at $37^{\circ}C$. In the presence of lidocaine-HCl and procaine-HCl, the values decreased to $46.5{\pm}5.1\;cP$ and $54.7{\pm}4.8\;cP$, respectvely. The differential scanning thermograms of DMPC multilamellar liposomes showed that local anesthetics significantly lowered the phase transition temperature, broadened the thermogram peaks, and reduced the size of the cooperative unit. These results indicate that local anesthetics have significant fluidizing effects on biomembranes and perturbation of membrane lipids may produce some, but not all, of their pharmacological actions.

• Archives of Pharmacal Research
• /
• v.20 no.1
• /
• pp.1-6
• /
• 1997

We determined the microviscosity of synaptosomal plasma membrane vesicles (SPMV) isolated from bovine cerebral cortex and liposomes of total lipids (SPMTL) and phospholipids (SPMPL) extracted from SPMV. Changes in the microviscosity induced by the range and rate of lateral diffusion were measured by the intramolecular excimerization of 1, 3-di(1-pyrenyl)propane (Py-3-Py). The microviscosity values of the direct probe environment in SPMV, SPMTL and SPMPL were 38.17, 31.11 and 27.64 cP, respectively, at$37^{\circ}C$and the activation energies $(E_a)$ of the excimer formation of Py-3-Py in SPMV, SPMTL and SPMPL were 8.236, 7.448 amd 7.025 kcal/mol, respectively. Probe location was measured by polarity and polarizability parameters of the probe Py-3-Py and probe analogues, pyrene, 1-pyrenenonanol and 1-pyrenemethyl-3${\beta}$-hydroxy-22, 23-bisnor-5-cholenate (PMC), incorporated into membranes or solubilized in reference solvents. There existed a good linear relationship between the first absorption peak of the $^1_a$ band and the polarizability parameter $(n^{2}-1)/(2n^{2}+1)$.The calculated refractive index values for SPMV, SPMTL and SPMPL were close to 1.50, which is higher than that of liquid paraffin (n=l.475). The probe location was also determined by using a polarity parameter $(f-1/2f^{I})$. Here f=$({\varepsilon}-1)/(2{\varepsilon}+1)$ is the dielectric constant function and $f^I=(n^2-1)/(2n^2+1)$ is the refractive index function. A correlation existed between the monomer fluorescence intensity ratio and the solvent polarity parameter. The probes incorporated in SPMV, SPMTL, and SPMPL report a polarity value close to that of 1-hexanol $({\varepsilon}=13.29)$. In conclusion, Py-3-Py is located completely inside the membrane, not in the very hydrophobic core, but displaced toward the polar head groups of phospholipid molecules, e.g., central methylene region of aliphatic chains of phospholipid molecules.

• Maxillofacial Plastic and Reconstructive Surgery
• /
• v.41
• /
• pp.4.1-4.10
• /
• 2019

Background: The mandibular third molar (M3) is typically the last permanent tooth to erupt because of insufficient space and thick soft tissues covering its surface. Problems such as alveolar bone loss, development of a periodontal pocket, exposure of cementum, gingival recession, and dental caries can be found in the adjacent second molars (M2) following M3 extraction. The specific aims of the study were to assess the amount and rate of bone regeneration on the distal surface of M2 and to evaluate the aspects of bone regeneration in terms of varying degree of impaction. Methods: Four series of panoramic radiographic images were obtained from the selected cases, including images from the first visit, immediately after extraction, 6 weeks, and 6 months after extraction. ImageJ software^® (NIH, USA) was used to measure linear distance from the region of interest to the distal root of the adjacent M2. Radiographic infrabony defect (RID) values were calculated from the measured radiographic bone height and cementoenamel junction with distortion compensation. Repeated measures of analysis of variance and one-way analysis of variance were conducted to analyze the statistical significant difference between RID and time, and a Spearman correlation test was conducted to assess the relationship between Pederson's difficulty index (DI) and RID. Results: A large RID (> 6 mm) can be reduced gradually and consistently over time. More than half of the samples recovered nearly to their normal healthy condition (RID ≤ 3 mm) by the 6-month follow-up. DI affected the first 6 weeks of post-extraction period and only showed a significant positive correlation with respect to the difference between baseline and final RID. Conclusions: Additional treatments on M2 for a minimum of 6 months after an M3 extraction could be recommended. Although DI may affect bone regeneration during the early healing period, further study is required to elucidate any possible factors associated with the healing process. The DI does not cause any long-term adverse effects on bone regeneration after surgical extraction.

• Proceedings of the Korean Geotechical Society Conference
• /
• 2006.03a
• /
• pp.86-95
• /
• 2006

Brillouin backscatter is a type of reflection that occurs when light is shone into an optical fibre. Brillouin reflections are very sensitive to changes in the fibre arising from external effects, such as temperature, strain and pressure. We report here several case studies on the measurement of strain using Brillouin reflections. A mechanical bending test of an I beam, deployed with both fiber optic sensors and conventional strain gauge rosettes, was performed with the aim of evaluating: (1) the capability and technical limit of the DTSS technology for strain profile sensing; (2) the reliability of strain measurement using fiber optic sensor. The average values of strains obtained from both DTSS and strain gauges (corresponding to the deflection of I beam) showed a linear relationship and an excellent one-to-one match. A practical application of DTSS technology as an early warning system for land sliding or subsidence was examined through a field test at a hillside. Extremely strong, lightweight, rugged, survivable tight-buffered cables, designed for optimal strain transfer to the fibre, were used and clamped on the subsurface at a depth of about 50cm. It was proved that DTSS measurements could detect the exact position and the progress of strain changes induced by land sliding and subsidence. We also carried out the first ever distributed dynamic strain measurement (10Hz) on the Korean Train eXpress(KTX) railway track in Daejeon, Korea. The aim was to analyse the integrity of a section of track that had recently been repaired. The Sensornet DTSS was used to monitor this 85m section of track while a KTX train passed over. In the repaired section the strain increases to levels of 90 microstrain, whereas in the section of regular track the strain is in the region of 30-50 microstrain. The results were excellent since they demonstrate that the DTSS is able to measure small, dynamic changes in strain in rails during normal operating conditions. The current 10km range of the DTSS creates a potential to monitor the integrity of large lengths of track, and especially higher risk sections such as bridges, repaired track and areas at risk of subsidence.

• Journal of the Korean Data and Information Science Society
• /
• v.27 no.3
• /
• pp.677-687
• /
• 2016

Among lots of sabermetric statistics for baseball batters' ability, the wins above replacement (WAR) is the most popular statistic in MLB. However, there exists a difficulty applying WAR to KBO, since KBO data do not have position adjustment, league adjustment and park factor which are essential in calculating WAR. In this paper, using five statistics for both KBO and MLB qualified batters, we propose hitting ability index (HAI), an alternative sabermetric indices to represent batters' ability. Comparing HAI with WAR of MLB batters, we evaluate the validity of HAI and then applied HAI to 2015 KBO data in which HAI is analyzed statistically with respect to different teams, ages, and positions. Moreover, the linear relationship between KBO batter's HAI and their annual salary is discussed. Grouping 46 KBO batters based on confidence region of the regression model for annual salary, we also statistically investigate batter's annual salary in these groups with respect to several factors.

• The Bulletin of The Korean Astronomical Society
• /
• v.42 no.2
• /
• pp.59.5-60
• /
• 2017

We present the relationship between vector magnetic field parameters and solar major flare occurrence rate. Based on this, we are developing a forecast model of major flare (M and X-class) occurrence rate within a day using hourly vector magnetic field data of Space-weather HMI Active Region Patch (SHARP) from May 2010 to April 2017. In order to reduce the projection effect, we use SHARP data whose longitudes are within ${\pm}60$ degrees. We consider six SHARP magnetic parameters (the total unsigned current helicity, the total photospheric magnetic free energy density, the total unsigned vertical current, the absolute value of the net current helicity, the sum of the net current emanating from each polarity, and the total unsigned magnetic flux) with high F-scores as useful predictors of flaring activity from Bobra and Couvidat (2015). We have considered two cases. In case 1, we have divided the data into two sets separated in chronological order. 75% of the data before a given day are used for setting up a flare model and 25% of the data after that day are used for test. In case 2, the data are divided into two sets every year in order to reduce the solar cycle (SC) phase effect. All magnetic parameters are divided into 100 groups to estimate the corresponding flare occurrence rates. The flare identification is determined by using LMSAL flare locations, giving more numbers of flares than the NGDC flare list. Major results are as follows. First, major flare occurrence rates are well correlated with six magnetic parameters. Second, the occurrence rate ranges from 0.001 to 1 for M and X-class flares. Third, the logarithmic values of flaring rates are well approximated by two linear equations with different slopes: steeper one at lower values and lower one at higher values. Fourth, the sum of the net current emanating from each polarity gives the minimum RMS error between observed flare rates and predicted ones. Fifth, the RMS error for case 2, which is taken to reduce SC phase effect, are smaller than those for case 1.

• Journal of the Korean Chemical Society
• /
• v.31 no.5
• /
• pp.389-394
• /
• 1987

The electrical conductivity of CeO$_2$ has been measured in the temperature range of 300 to 1000${\circ}$C under the oxygen pressures of 10$^{-5}$ to 10$^{-1}$ atm. Plots of log ${\sigma}$ vs. 1/T at constant PO$_2$ are found to be linear with an inflection, and the activation energy obtained from the slopes appears to be 2.16 eV for the intrinsic region. The conductivity dependences on PO$_2$ at the above temperature range are closely approximated by ${\sigma}$ ${\alpha}$PO$_2^{-1/4}$ for the intrinsic and ${\sigma}$ ${\alpha}$PO$_2^{-1/6.2}$ for the extrinsic, respectively. The dominant defects in this sample are believed to be Ce$^{3{\cdot}}$ interstitial for the intrinsic and the (Vo-2e') for the extrinsic range. The interpretations of conductivity dependences on temperature and $PO_2$ are presented, and conduction mechanisms are proposed to explain the data.

• Proceedings of the Korean Nuclear Society Conference
• /
• 1996.05b
• /
• pp.233-240
• /
• 1996

Analyses of the viscous and end effects on electromagnetic (EM) pumps of annular linear induction type for the sodium coolant circulation in Liquid Metal Fast Breeder Reactors have been carried out based on the MHD laminar flow analysis and the electromagnetic field theory. A one-dimensional MHD analysis for the liquid metal flowing through an annular channel has been performed on the basis of a simplified model of equivalent current sheets instead of three-phase currents in the discrete primary windings. The calculations show that the developed pressure difference resulted from electromagnetic and viscous forces in the liquid metal is expressed in terms of the slip, and that the viscous loss effects are negligible compared with electromagnetic driving forces except in the low-slip region where the pumps operate with very high flow velocities comparable with the synchronous velocity of the electromagnetic fields, which is not applicable to the practical EM pumps. A two-dimensional electromagnetic field analysis based on an equivalent current sheet model has found the vector potentials in closed form by means of the Fourier transform method. The resultant magnetic fields and driving forces exerted on the liquid metal reveal that the end effects due to finiteness of the pump length are formidable. In addition, a two-dimensional numerical analysis for vector potentials has been performed by the SOR iterative method on a realistic EM pump model with discretely-distributed currents in the primary windings. The numerical computations for the distributions of magnetic fields and developed pressure differences along the pump axial length also show considerable end effects at both inlet and outlet ends, especially at high flow velocities. Calculations of each magnetic force contribution indicate that the end effects are originated from the magnetic force caused by the induced current ( u x B ) generated by the liquid metal movement across the magnetic field rather than the one (E) produced by externally applied magnetic fields by three-phase winding currents. It is concluded that since the influences of the end effects in addition to viscous losses are extensive particularly in high-velocity operations of the EM pumps, it is necessary to find ways to suppress them, such as proper selection of the pump parameters and compensation of the end effects.

• Applied Chemistry for Engineering
• /
• v.10 no.4
• /
• pp.537-542
• /
• 1999

Removal of sulfur compounds in the petroleum products is essential for the prevention of sulfur oxides. However, conventional methods involving catalytic reactions are found to have some limitations in complete removal of harmful sulfur compounds and to require relatively high cost. Recently, desulfurization process using microorganisms is known to be promising in terms of excellent sulfur removal efficiency and reasonably low treatment cost. For the biodesulfurization process to be effective, the solubilization of sulfur compounds into aqueous solution is a prerequisite. In this study, polyoxyethylene nonionic surfactants were used in order to enhance the solubilization of sulfur spectrophotometer. The solubilization of sulfur compounds was found to increase with temperature and to bo abruptly increased at above 1 wt % surfactant solutions. It was also observed that the longer the hydrophobic chain of the surfactant molecule, the higher solubilizing power of a nonionic surfactant. It was found that the Tergitol series surfactants showed higher solubilizing capacity than Neodol series presumably due to the disruption of the regular packing in the hydrocarbon region of the surfactant aggregates.

• Journal of the Korean Society for Nondestructive Testing
• /
• v.22 no.5
• /
• pp.465-473
• /
• 2002

Images are easily corrupted by noise during the data transmission, data capture and data processing. A technical method of noise analyzing and adaptive filtering for reducing of quantum noise in radiography is presented. By adjusting the characteristics of the filter according to local statistics around each pixel of the image as moving windowing, it is possible to suppress noise sufficiently while preserve edge and other significant information required in reading. We have proposed adaptive weighted median(AWM) filters based on local statistics. We show two ways of realizing the AWM filters. One is a simple type of AWM filter, whose weights are given by a simple non-linear function of three local characteristics. The other is the AWM filter which is constructed by homogeneous factor(HF). Homogeneous factor(HF) from the quantum noise models that enables the filter to recognize the local structures of the image is introduced, and an algorithm for determining the HF fitted to the detection systems with various inner statistical properties is proposed. We show by the experimented that the performances of proposed method is superior to these of other filters and models in preserving small details and suppressing the noise at homogeneous region. The proposed algorithms were implemented by visual C++ language on a IBM-PC Pentium 550 for testing purposes, the effects and results of the noise filtering were proposed by comparing with images of the other existing filtering methods.