• Korean Journal of Animal Reproduction
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• v.20 no.4
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• pp.453-458
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• 1997

It is known that the incorporation of genes into transgenic mice is generally stable and is p passed on to succeeding generations in a Mendelian fashion. In this report, transgenic mice were set as a model to evaluate whether the transgenes are transmitted in a Mendelian principle in a successive generations and how they are tran s smitted into their offspring. A 3.0 kb linear DNA fragment, containing the MMTV LTR, bovine aSI casein cDNA and SV 40 splicing and polyadenylation site; was microinjected into fertilized mouse embryos. The tail DNAs of the resulting pups were subjected to dot and Southern hybridizations to screen transgenic founders. The DNAs of their offspring were anlyzed by PCR to confirm the transmission of the transgene from F0. Out of 72 live pups four pups (5.6%), 3 males and 1 female, were positive for the transgene. The rates of transmission from F0 into F1 were 33.3, 7.7, 0, and 62.5%. Those from F1 into F2 were 63.6, 5.9, and 68.8% and those from F2 into F3 were 85.7, and 88.2%. In this report, the transmission pattern of transgenes in transgenic mice into their offspring was demonstrated. It either follows or does not follow in a Mendelian fashion. Deletion or loss of the transgenes from F0 in some lines became apparant to the succeeding generations.

• Imaging Science in Dentistry
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• v.31 no.3
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• pp.135-143
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• 2001

Purpose : To evaluate the effect of all-trans-retinoic acid on radiosensitivity and radiation-induced apoptosis in NHOK, HEp-2 and FaDu cell lines. Material and Methods: We measured the changes in survival fraction at 2 Gy (SF2), α and β after treatment of retinoic acid (1μM) prior to irradiation with doses of 2, 4, 6 and 10 Gy and correlated the radiosensitizing effect of retinoic acid with them. Also, apoptosis induction was assayed with the flow cytometry on days 1,2, 3, 4 and 5 after irradiation (2, 10 and 20 Gy) combined with retinoic acid. Results and Conclusion: SF2 values for NHOK, HEp-2 and FaDu cell lines were 0.54, 0.64 and 0.41, respectively and the cell line of FaDu was the most radiosensitive. For cell lines of NHOK and HEp-2, pretreatment of cells with retinoic acid resulted in a significant decrease of the SF2 values. The α/β ratios of x-ray survival curve were 8.714 (NHOK), 4.098 (HEp-2) and 11.79 (FaDu). The α/β ratio for NHOK decreased on pretreatment with retinoic acid, whereas those for HEp-2 and FaDu increased. Radiation induced apoptosis in all cell lines but, retinoic acid did not affect the apoptosis.

• Korean Journal of Food Science and Technology
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• v.50 no.4
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• pp.451-456
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• 2018

The current study was conducted to confirm the anti-cancer effect of Sarijang, which is a mixture of extracts from purple bamboo salt, Rhynchosia nulubilis, garlic, and Ulmi cortex. Nude mice were injected with a human-derived colorectal cancer cell (HCT116 cell line) and subsequently administered Sarijang for 4 weeks, following which the body weight, organ weight, and tumor size were measured. To evaluate the anti-cancer mechanism of Sarijang, the levels of p16 and extracellular signal-regulated kinase (ERK), cell cycle regulators in colorectal cancer, were measured. To evaluate the toxicity of Sarijang on liver and kidney, aspartate transaminase, alanine transaminase, blood urea nitrogen, and creatinine were analyzed. Sarijang not only reduced the tumor size by enhancing p16 and suppressing ERK, but also showed no side-effect in the liver and kidneys. Taken together, Sarijang has the potential to inhibit tumor growth without side effects, and may be used as a useful functional food.

• Journal of Embryo Transfer
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• v.22 no.3
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• pp.143-147
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• 2007

Records on 546 Korea native pigs for average daily gain (ADG), age at 70 kg (D70 kg) and backfat thickness (BF) made between 2001 and 2006 in herds on National Institutes of Animal Science in Korea were used to estimate genetic parameters. The data was analyzed by the DF-REML (Derivative-Free Restricted Maximum Likelihood) program of Boldman using a single-trait animal model. Heritabilities were 0.26, 0.09, and 0.29 for ADG, D70 kg and BF, respectively. The phenotypic correlations of ADG with D70 kg and BF were -0.71 and 0.30. The phenotypic correlation of D70 kg with BF was -0.15. The genetic correlations of ADG with D70 kg and BF were -0.11, 0.41, respectively. The genetic correlation of D70 kg with BF was -0.16. The data of weights and measurements on body length, body height and chest width after age at 11 months (days to 330) were shown scarcely less differences compare to data of age at 11 months.

• Research in Plant Disease
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• v.23 no.3
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• pp.249-255
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• 2017

The rice blast fungus is a representative model phytopathogenic fungus in which Gene-for-Gene interaction with host rice is applicable. After 1980, eight differential varieties have been constructed and classified to analyze the race of rice blast isolates in Korea. However, since there is limited information about the genetic background of rice blast resistance genes within the Korean differentials, scientific analysis on the emergence of new race or resistance break down was difficult. Recently, a differential system has been developed using monogenic resistance lines to understand the interactions of pathogen race and rice resistance genes. In this study, a total of 50 isolates were selected from four different races isolated in Korea, and they were inoculated into monogenic lines. As a result, the isolates in the same race classified by the Korean differential system reacted differently in single monogenic lines. This suggests that the isolates categorized as the same race group contains different avirulence genes and furthermore, it is presumed that the Korean differential system is difficult to provide useful information for breeding program. For this reason, introduction of differential system using monogenic resistance lines is required in addition to the current system.

• Journal of Korean Society of Steel Construction
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• v.21 no.5
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• pp.451-459
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• 2009

The purpose of this study was to evaluate the in-plane bending moment for T-joints made of cold-formed square hollow steel sections. In the previous studies, the T-joint was shown not to have an obvious peak load, and the failure mode was the main chord flange failure at the branch-width-to-chord-width ratio ($\beta$) of below 0.71. Based on the experimental results, including the tests conducted by Zhao, the deformation limit of 1% B was proposed for ${16.7{\leq}2{\gamma}(=B/T){\leq}33}$ and ${0.34{\leq}{\beta}(=b_{1}/B){\leq}0.71}$. Then, the ultimate in-plane bending strength was shown to be Mu=1.5${\cdot}$M1% B. The existing strength formulae for the original T-joint were investigated and were determined to be the main chord flange failure for the branch-squared T-joint. The bending strength formulae of CIDECT and other researchers were compared with the test results. Finally, a reasonably good agreement with Zhao's formula was found. Therefore, the design guidelines were presented based on Zhao's strength formula for T-joints.

• Journal of Aquaculture
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• v.19 no.4
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• pp.225-230
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• 2006

A long-term (26 weeks) feeding experiment was conducted to examine the essentiality and requirement of inositol in diets for olive flounder because no information is available in the species. Five casein-gelatin based semi-purified diets were formulated to contain four different levels of myo-inositol (0, 0+antibiotic, 400, 800, and 1600 mg/kg, designated as M0, M0+, M400, M800, and M1600, respectively). One (M0+) of the control diets contained tetracycline hydrochloride (0.4%, wt/wt) as an antibiotic to inhibit biosynthesis of inositol by micro-organism in intestine of fish. Olive flounder at the early juvenile stage (initial body weight 1.22 g) were randomly distributed into fifteen 35 L tanks (48 fish/tank) and fed with one of the experimental diets (3 replicates per diet). At the end of the feeding trial, the weight gain, feed intake, specific growth rate, and protein efficiency ratio of fish fed diets containing higher levels of myo-inositol (M800 & M1600) were significantly higher than those of fish fed the other diets (P<0.05). Feed conversion ratio, survival, hematocrits, and hemoglobin of fish fed experimental diets were not significantly different among all the fish groups. Whole body compositions of fish were not different except for lipid content. The lipid content was significantly different between M0 and M400 diet groups. These results indicate that juvenile olive flounder requires dietary supplementation of myo-inositol in diets for normal growth and its optimum level seems to be approximately 800 mg myo-inositol/kg diet.

• Journal of KIISE:Software and Applications
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• v.26 no.12
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• pp.1445-1454
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• 1999

광역 조건식의 계산은 분산 프로그램의 수행을 테스트 또는 디버깅하기 위한 방법으로 활 발히 연구되고 있다. 이제까지 주로 연구된 광역조건식은 AND 또는 OR 광역 조건식 등이 있는데, 특히 AND 광역 조건식은 분산 프로그램의 동시적 조건을 표현하는데 유용하여 효율적인 검색 알고리즘이 활발히 연구되었다. 분산프로그램의 수행오류로서 공유자원의 배타적 접근조건은 가장 중요하고 일반적인 경우라 할 수 있다. 본 논문에서는 XOR 연산을 이용하여 공유자원 프로그램의 오류 검색을 위한 광역조건식을 기술하는 방식에 대해 제안하였다. XOR 연산을 이용한 광역 조건식은 연산자 중 많아야 하나의 지역조건식만이 참일 때 전체 조건식이 참이 되는데 이러한 성질은 여러 프로세스 중 한번에 하나만이 공유자원에 배타적으로 접근할 수 있는 조건을 표현하는데 매우 유용하다. n 개의 프로세스로 이루어진 분산프로그램에서 한개의 공유자원에 대한 배타적 접근 조건을 기술하기 위해서 AND로 연결된 광역조건식을 이용하면 O(n2)개의 광역 조건식이 필요한데 반해 XOR 연산으로는 하나의 조건식으로 나타낼 수 있다. 더구나 XOR 연산을 이용한 광역조건식은 최근 소개된 겹치는 구간의 개념을 활용하면 매우 간단하게 검색할 수 있다. 본 논문에서는 겹치는 구간을 찾는 검색 알고리즘을 소개하고 증명하였다.Abstract Detecting global predicates is an useful tool for debugging and testing a distributed program. Past research has considered several restricted forms of predicates, including conjunctive or disjunctive form of predicates. Especially, conjunctive predicates have attracted main attention not only because they are useful to describe simultaneous conditions in a distributed program, but also because it is possible to find algorithms to evaluate them within reasonable time bound. Detecting errors in accessing shared resources are the most popular and important constraints of distributed programs. In this paper, we introduced an exclusive OR predicates as a model of global predicates to describe shared resource conditions in distributed programs. An exclusive OR predicate holds only when at most one operand is true, which is useful to describe mutual exclusion conditions of distributed programs where only one process should be allowed to access the shared resource at a time. One exclusive OR predicate is enough to describe mutual exclusion condition of n processes with one shared resource, while it takes O(n2) conjunctive predicates. Moreover, exclusive OR condition is easily detectable using the concept of overlapping intervals introduced by Venkatesan and Dathan. An off-line algorithm for evaluating exclusive OR global predicates is presented with a correctness proof.

• Journal of Korean Society of Transportation
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• v.36 no.3
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• pp.216-228
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• 2018

In this study analyzed the ponding changing of plastic deformation section follwed time development to apply weather, geometry and traffic data in additon to time development to improve road management service and safety of roads during or after rain. After We selected an 8.3km section of old national highway the Seongnam-Janghowon section and created a three-demensional surface of terrain through the numerical transformantion of design drawing data, with reflection the linear data of the same coordinate system in order to describe more realistic roads, we design additional structures with shading above roads. The altitude and azimuth of the sun were calculated and set based on the longitude and latitude data of the survey line for the analysis of the sun rate, and the daylight impact zone was visualized by setting the shaded time to an interval of 1 hour and the shade rate of the corresponding section. In addition, the evaporation volume calculated from weather data such as temperature, humidity, radiant energy, and road temperature analyzes together, it will use the way of a safer and more efficient road management as grasping the ponding changing more efficent in time development.

• Magazine of the Korean Society of Agricultural Engineers
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• v.18 no.2
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• pp.4089-4095
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• 1976

The safety of shore structure including the sea dipe is largely affected by typhoon. Accordingly it is desirable to analize the typhoon and determine the wind direction and velocity for use in planning and design of the structure. This method was adopted for the design of the Yong San Gang Estuary Dam. A comparative study of the results of typhoon analysis with the meteorological data obtained through actual observation is summarized as follows; (1) 62% of the typhoons occur during May to June in a year, and 62% of the typhoons which have an influence on the Korean peninsula, especially the proposed estuary dam fsite, proceed eastward through the zone in lat. 36$^{\circ}$-37$^{\circ}$N. Such typhoons occur two to three times a year on the average. (2) Data on typhoon "SARL" were used as a model case in designing the estuary dam, where it was proved that a southwesterly wind had a maximum velocity of 30m/sec in case r=150km, ${\alpha}$=120$^{\circ}$. Within the range of 22$^{\circ}$30'on the right and left side of the fetch line of the estuary dam, the wind direction varied SSW\longrightarrowSW\longrightarrowWSW, and the wind velocity varied 29m/sec\longrightarrow30m/sec\longrightarrow125m/sec. Such phenomemum lasted for five hours. (3) An analysis of data obtained during 44 years at Mok Po Meteorological Station shows that a wind with a velocity of some 25m/sec occurred twelve times in the S-direction and two times in the SW-direction, while that with a velocity of 30m/sec occurred three times in the S-direction, three times in the SSW-direction and one time in the SW-direction. The wind which had an influence on the estuary dam had a direction of SSW\longrightarrowSW\longrightarrowWSW and a velocity of min. 30m/sec. Actually, a wind with a max. velocity of 31.3m/sec occurred in the SSW-direction on March 15 and 16, 1956 where the mean velocity during two hours was 28m/sec and that during four hours was 24.6m/sec. (4) The data obtained through actual observation show that when the velocity is low, the wind with a fixed direction lasts long, and when the velocity is high, it is short-lived. It is difficult to determine the velocity of a wind which blows in a fixed direction for consecutive two or four hours. Therefore, the values obtained through typhoon analysis are larger that those obtained through actual observation, and hence, it is resonable to use the analyzed valuse for design of the estuary dam and shore structures. (5) The greatest effect was had on the estuary dam when typhoon was proceeding at a velocity of 29.71m/sec in the direction of ${\alpha}$=120$^{\circ}$(SW) at a point of R=150km from the center of the typhoon.