• Molecules and Cells
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• 제45권12호
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• pp.923-934
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• 2022

Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) have great potential in applications such as regenerative medicine, cardiac disease modeling, and in vitro drug evaluation. However, hPSC-CMs are immature, which limits their applications. During development, the maturation of CMs is accompanied by a decline in their proliferative capacity. This phenomenon suggests that regulating the cell cycle may facilitate the maturation of hPSC-CMs. Aurora kinases are essential kinases that regulate the cell cycle, the role of which is not well studied in hPSC-CM maturation. Here, we demonstrate that CYC116, an inhibitor of Aurora kinases, significantly promotes the maturation of CMs derived from both human embryonic stem cells (H1 and H9) and iPSCs (induced PSCs) (UC013), resulting in increased expression of genes related to cardiomyocyte function, better organization of the sarcomere, increased sarcomere length, increased number of mitochondria, and enhanced physiological function of the cells. In addition, a number of other Aurora kinase inhibitors have also been found to promote the maturation of hPSC-CMs. Our data suggest that blocking aurora kinase activity and regulating cell cycle progression may promote the maturation of hPSC-CMs.

• 방사성폐기물학회지
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• 제14권1호
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• pp.79-90
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• 2016

The second-stage near surface disposal facility for low and very low level radioactive waste's permanent disposal is to be built. During the institutional control period, the inadvertent intrusion of the general public is limited. But after the institutional control period, the access to the general public is not restricted. Therefore human who has purpose of residence and resource exploration can intrude the disposal facility. In this case, radioactive effects to the intruder should be limited within regulatory dose limits. This study conducted the safety assessment of human intrusion on the second-stage surface disposal facility through drilling and post drilling scenario. Results of drilling and post drilling scenario were satisfied with regulatory dose limits. The result showed that post-drilling scenario was more significant than drilling scenario. According to the human intrusion time and behavior after the closure of the facility, dominant radionuclide contributing to the intruder was different. Sensitivity analyses on the parameters about the human behavior were also satisfied with regulatory dose limits. Especially, manual redistribution factor was the most sensitive parameter on exposure dose. A loading plan of spent filter waste and dry active waste was more effective than a loading plan of spent filter waste and other wastes for the radiological point of view. These results can be expected to provide both robustness and defense in depth for the development of safety case further.

• International Journal of Automotive Technology
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• 제1권1호
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• pp.17-25
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• 2000

The electromechanical valve train (EMV) technology allows for a reduction in fuel consumption while operating under a stoichiometric air-fuel-ratio and preserves the ability to use conventional exhaust gas aftertreatment technology with a 3-way-catalyst. Compared with an engine with a camshaft-driven valve train, the variable valve timing concept makes possible an additional optimization of cold start, warm-up and transient operation. In contrast with the conventionally throttled engine, optimized control of load and in-cylinder gas movement can be used for each individual cylinder and engine cycle. A load control strategy using a "Late Intake Valve Open" (LIO) provides a reduction in start-up HC emissions of approximately 60%. Due to reduced wall-wetting, the LIO control strategy improves the transition from start to idle. "Late Exhaust Valve Open" (LEO) timing during the exhaust stroke leads to exhaust gas afterburning and, thereby, results in high exhaust gas temperatures and low HC emissions. Vehicle investigations have demonstrated an improved accuracy of the air-fuel-ratio during transient operation. Results in the New European Driving Cycle have confirmed a reduction in fuel consumption of more than 15％ while meeting EURO IV emission limits.

• 품질경영학회지
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• 제28권3호
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• pp.18-30
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• 2000

Recent studies have shown that the $\bar{X}$ chart with variable sampling intervals(VSI) and the $\bar{X}$ chart with variable sample size(VSS) are much quicker than Shewhart $\bar{X}$ chart in detecting shiks in the process. Shewhart $\bar{X}$ chart has been beneficial to detect large shifts but it is hard to apply Shewhart $\bar{X}$ chart in detecting moderate shifts in the process mean. In this article the $\bar{X}$ chart using variable sample size(VSS) and variable sampling Intervals(VSI) has been proposed to supplement the weak point mentioned above. So the purpose of this paper is to consider finding the design parameters which minimize expected loss costs for unit process time and measure the performance of VSSI(variable sample size and sampling interval) $\bar{X}$ chart. It is important that assignable causes be detected to maintain the process controlled. This paper has been studied under the assumption that one cycle is from starting of the process to eliminating the assignable causes in the process. The other purpose of this article is to represent the expected loss costs in one cycle with three process parameters(sample size, sampling interval and control limits) function and find the three parameters.

• 전기학회논문지
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• 제67권2호
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• pp.179-185
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• 2018

A considerable cost gap between three major power generation technologies, namely nuclear, coal, and combined cycle gas turbine (CCGT), has been a well-established fact in the Korean electricity market. Alternatively, this paper analyzes the levelized costs of electricity (LCOE) of the three technologies reflecting overall social costs of electricity generation including accident risk, $CO_2$ emission, and air pollution damage. The paper unveils to what extent current discriminative subsidies on fuels regarding the social costs, mostly through tax exemptions, affect economic competitiveness of the technologies. In particular, it finds relative positions of coal and CCGT could be altered depending on appreciation level of the social costs. It has limits in analyzing fixed costs of the technologies, however, due to limited data availability of nuclear power, and suggests further studies on the issue.

• 한국공간구조학회논문집
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• 제6권3호
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• pp.51-57
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• 2006

본 연구의 목적은 한국건축프로젝트의 경영적 특성을 파악하는데 있다. 본문은 건축프로젝트의 주요 세 요소인 디자인, 건설, 유지관리의 프로세스 질 관리에 영향을 미치는 요소들을 조사한다. 설문조사는 건축관련 대학원생 및 교수, 설계자, 시공자들의 건축프로젝트에 있어서 프로세스 질 관리에 대한 상이한 시각을 보여주고 있다. 이러한 요소들을 분석함으로써 현재 국내의 질 관리 시스템과 프로그램 내용을 교정하고 개선하는데 도움이 될 것이다. 프로세스 질 관리에 있어서 여러 요소 중 설계자와의 협조가 가장 주요 요소로써 부각되었다.

• Journal of Advanced Marine Engineering and Technology
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• 제27권3호
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• pp.412-420
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• 2003

This study describes the merits of PWM control of hydraulic system using high speed on-off valves. Generally, Electro-hydraulic valves can be classified into two classification: valves which are controlled by analog signal and which are controlled by digital. The former includes hydraulic servo valves and proportional valves which require A/D converters as interface to digital computer and too costly and sensitive to oil contamination because of complexity in structures. The latter includes high speed on-off valves which do not require A/D converters because they are normally operated in a pulse width modulation(PWM) method, and are low in price and robust to oil contamination because of their simple structures. The objectives of this study is to analyze the limit cycle which regularly appear in the position control system using 2/2way high speed on-off valves and to give a criterion for the stability of this system. The nonlinear characteristics of PWM and cylinder friction of this system are described by harmonic linearization and the effects of parameter variations to the system stability are simulated.

• Nuclear Engineering and Technology
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• 제48권2호
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• pp.318-329
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• 2016

Reducing critical boron concentration in a commercial pressurized water reactor core offers many advantages in view of safety and economics. This paper presents a preliminary investigation of a reduced-boron pressurized water reactor core to achieve a clearly negative moderator temperature coefficient at hot zero power using the newly-proposed "Burnable absorber-Integrated Guide Thimble" (BigT) absorbers. The reference core is based on a commercial OPR1000 equilibrium configuration. The reduced-boron ORP1000 configuration was determined by simply replacing commercial gadolinia-based burnable absorbers with the optimized BigT-loaded design. The equilibrium cores in this study were directly searched via repetitive Monte Carlo depletion calculations until convergence. The results demonstrate that, with the same fuel management scheme as in the reference core, application of the BigT absorbers can effectively reduce the critical boron concentration at the beginning of cycle by about 65 ppm. More crucially, the analyses indicate promising potential of the reduced-boron OPR1000 core with the BigT absorbers, as its moderator temperature coefficient at the beginning of cycle is clearly more negative and all other vital neutronic parameters are within practical safety limits. All simulations were completed using the Monte Carlo Serpent code with the ENDF/B-VII.0 library.

• 한국경제지리학회지
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• 제20권2호
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• pp.189-213
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• 2017

본 연구는 클러스터 진화의 분석에 있어서 클러스터 적응주기 모델의 의의와 한계점을 비판적으로 검토하고, 이를 토대로 향후 클러스터 진화 분석을 위한 연구 과제를 제시하고자 하였다. 1980년대 이전까지 클러스터를 비롯한 산업집적지 연구는 특정 시점에서 경제 공간의 양상에 주목하는 '정태적 관점'을 기초로 이루어졌지만, 최근에는 '복잡적 응계'의 '진화'에 주목하는 '동태적 연구'로 패러다임이 전환되었다. 이에 역동적 지속적으로 진화하는 클러스터에 적절한 분석도구로 적응주기 모델이 주목받게 되었으나, 클러스터 및 그 진화의 속성에 맞게 수정 및 보완되어 클러스터 적응주기 모델이 등장하게 되었다. 클러스터 적응주기 모델은 자원축적, 상호의존성 그리고 회복력의 측면에서 클러스터 진화의 특성을 규명하고, 클러스터 진화 경로를 6가지로 구분하여 살펴 볼 수 있는 포괄적인 분석틀이지만, 모델의 확대 및 심화를 위해서 이론적 경험적 연구 측면에서 더욱 활발한 논의와 보완이 요구된다. 따라서 향후 클러스터 진화 분석에 있어서의 연구 과제로는 클러스터 진화 모델의 구체화 및 정교화, 회복력 개념의 강조 그리고 경험적 연구를 통한 모델의 적용가능성과 유용성의 검증을 제시하고자 한다.

• 인터넷정보학회논문지
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• 제9권4호
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• pp.61-68
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• 2008

EPON(Ethernet Passive Optical Network: 이더넷 수동 광 네트워크)은 대용량 LAN과 백본망 사이의 트래픽 병목현상을 완화시킬 수 있는 하나의 방법으로 저렴한 비용으로 광대역의 서비스를 제공할 수 있어 많은 연구가 진행되고 있다. 대용량 LAN과 백본망 사이의 병목현상은 트래픽이 갑자기 증가는 트래픽 특성으로 인해 더욱 심각해진다. 본 논문은 트래픽의 특성을 고려하여 ONU(Optical Network Unit: 광 네트워크 가입자 단말)에게 적절한 대역폭을 할당함으로써 네트워크의 성능을 개선한다. 또한 본 논문은 지원하는 ONU의 수에 상관없이 고정된 시간 이내에 해당 ONU가 다시 서비스 받을 수 있도록 제안 방식을 설계함으로써 지연에 민감한 트래픽을 효율적으로 지원할 수 있다. 컴퓨터 시뮬레이션 결과에 따르면, 본 논문에서 제안하는 방식은 최대 사이클 시간을 기준 사이클 시간의 두 배로 제한하면서 기존 방식보다 중위 트래픽에서 패킷 지연 및 ONU 큐 크기를 각각 최대 77%와 82%만큼 감소시킨다.