• Molecules and Cells
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• 제27권1호
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• pp.5-14
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• 2009

The availability of effective vaccines has had the most profound positive effect on improving the quality of public health by preventing infectious diseases. Despite many successful vaccines, there are still old and new emerging pathogens against which there is no vaccine available. A better understanding of how vaccines work for providing protection will help to improve current vaccines as well as to develop effective vaccines against pathogens for which we do not have a proper means to control. Recent studies have focused on innate immunity as the first line of host defense and its role in inducing adaptive immunity; such studies have been an intense area of research, which will reveal the immunological mechanisms how vaccines work for protection. Toll-like receptors (TLRs), a family of receptors for pathogen-associated molecular patterns on cells of the innate immune system, play a critical role in detecting and responding to microbial infections. Importantly, the innate immune system modulates the quantity and quality of long-term T and B cell memory and protective immune responses to pathogens. Limited studies suggest that vaccines which mimic natural infection and/or the structure of pathogens seem to be effective in inducing long-term protective immunity. A better understanding of the similarities and differences of the molecular and cellular events in host responses to vaccination and pathogen infection would enable the rationale for design of novel preventive measures against many challenging pathogens.

• 한국컴퓨터그래픽스학회논문지
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• 제14권1호
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• pp.27-33
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• 2008

모바일 시스템은 메모리, CPU 등의 자원이 기존 데스크탑 시스템 보다 상대적으로 많이 부족하고 정수형 연산처리만을 사용해야 하는 제약이 있다. 본 논문에서는 모바일 시스템의 특성에 적합한 새로운 모바일 3D 연결데이터 압축 기법을 소개 하고자 한다. 연결 데이터 압축 시 옥트리 구조와 메쉬 삼각화 특성을 활용하여 연결되는 점간의 거리에 기초한 새로운 압축 방법을 개발하였다. 또한, 압축 및 해제 시에 정수형 연산만을 사용하고 동적 메모리 할당을 최소화하였다. 실제 핸드폰에서 실시간 압축 해제된 3D 메쉬 테스트 자료도 소개하여 본 알고리즘의 실용성을 높이고자 한다.

• 대한간호
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• 제35권4호
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• pp.64-74
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• 1996

In general. social cognition for a disabled person seemed that he was limited aspects of emotion and psychology. Thus he was rejected. avoided. worthless and not accepted. People who have been raised in an ethnic collectivity often acquire from that experience not only basic conceps and attitudes toward health and illness but also fundamental styles of interpersonal behavior and concerns about the world. The effects of this enculuration carryover into health- care situation and also become an important influence on personal activities devoted to health maintenance and disease prevention. Our Korean culture is a state of tradition Confucianism. respects his honor and external feature. Therefore recognition of a disabled person is more specipic. This study uses Walker and Avant's process of concept analysis. The concep of recognition of disabilty can be defined as follows : Recognition of disability is a person's conscious process of sensation. perception. memory and thought and is constructed from value. attitude. emotion and expierince which is dynamics. and in everyday life is feeling that basic activity is not free and occurs interaction of envionment. Attributes of disability recognition are defined as 1) It is feeling that basic activity of his daily life is not free in everyday life. 2) It is a person's conscious process of sensation. perception. memory and thought. 3) It occurs interaction of enviornment. 4) It is constructed from value. attitude. emotion and experience. 5) it is dynamics ( changing but not stasis). Nurse is always suppoted and pushed him. She plans institutional and situational surroundings.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제6권11호
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• pp.2849-2865
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• 2012

In order to block mobile junk messages automatically, many studies on spam filters have applied machine learning algorithms. Most previous research focused only on the accuracy rate of spam filters from the view point of the algorithm used, not on individual user's preferences. In terms of individual taste, the spam filters implemented on a mobile device have the advantage over spam filters on a network node, because it deals with only incoming messages on the users' phone and generates no additional traffic during the filtering process. However, a spam filter on a mobile phone has to consider the consumption of resources, because energy, memory and computing ability are limited. Moreover, as time passes an increasing number of feature words are likely to exhaust mobile resources. In this paper we propose a spam filter model distributed between a users' computer and smart phone. We expect the model to follow personal decision boundaries and use the uniform resources of smart phones. An authorized user's computer takes on the more complex and time consuming jobs, such as feature selection and training, while the smart phone performs only the minimum amount of work for filtering and utilizes the results of the information calculated on the desktop. Our experiments show that the accuracy of our method is more than 95% with Na$\ddot{i}$ve Bayes and Support Vector Machine, and our model that uses uniform memory does not affect other applications that run on the smart phone.

• 사상체질의학회지
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• 제23권3호
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• pp.402-411
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• 2011

1. Objectives: This study is about three vascular dementia patients with disorientation, memory impairment and cognitive disorder. In this study, we evaluated the effects of Sasang constitutional treatment and suggested using the Mini Mental Status Examination - Korea (MMSE-K), Global Deterioration Scale (GDS). 2. Methods: These three patients were treated by Sasang constitutional herbal medications based on "Donguisusebowon". Acupuncture and west medications were limited as much as possible. We evaluated the symptoms through the Mini Mental Status Examination - Korea (MMSE-K), GDS (Global Deterioration Scale). 3. Results and Conclusions: Disorientation, memory impairment and cognitive disorder that were these three patients chief complaints were improved. This case study shows that Sasang constitutional herbal medications are an effective treatment for vascular dementia patients.

• 한국지능시스템학회논문지
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• 제11권7호
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• pp.680-688
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• 2001

In this paper, we propose a reliable method for searching the optimally performing generalized brain-state-in-a-box (GBSB) neural associative memory using an evolution program (EP) given a set of prototype patterns to be stored as stable equilibrium points. First, we exploit some qualitative guidelines necessary to synthesize the GBSB model. Next, we parameterize the solution space utilizing the limited number of parameters to represent the solution space. Then, we recast the synthesis of GBSB neural associative memories as two constrained optimization problems, which are equivalent to finding a solution to the original synthesis problem. Finally, we employ an evolution program (EP), which enables us to find an optimal set of parameters related to the size of domains of attraction (DOA) for prototype patterns. The validity of this approach is illustrated by a design example and computer simulations.

• 한국전자통신학회논문지
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• 제10권7호
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• pp.769-774
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• 2015

사물인터넷의 하부 구조로 센서네트워크는 네트워크의 신뢰성이 중요한 이슈이다. 센서네트워크의 각 노드는 제한된 메모리와 파워로 인해 데이터의 신뢰성을 향상시켜야 한다. 본 연구에서는 센서 노드가 생성한 데이터를 이웃 노드에 복제하는 기법을 제안한다. 네트워크의 신뢰성을 향상시키기 위해서 주변 노드의 메모리 및 파워 잔량이 높은 노드에 사본을 저장하는데 1 홉 이상의 노드들에도 저장하여 공간적인 재해에도 대비한다. 실험을 통해 적절한 사본을 유지하는 것은 네트워크의 수명에 부정적인 영향을 미치지 않으면서도 사물인터넷의 신뢰성을 향상시킴을 확인하였다.

• 생약학회지
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• 제48권4호
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• pp.304-313
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• 2017

These days, as the average span of population's life increases, the number patients of dementia also increases. But Research on Korean medicine is stilled limited. The research evaluates the effect of the extract from Cornus officinalis S.et Z on cognitive impairment induced by scopolamine in mice. The mice were randomly divided into five groups of ten mice. The normal group was treated with only 0.9% saline. The control group was treated with scopolamine (5 mg/kg, i.p.). The positive control group was treated with tacrin. The C100, 200 group was treated with C. officinalis extracts 100, 200 mg/kg. Memory-related behaviors were evaluated using a morris water maze and a passive avoidance test. Protein levels of BDNF, p-CREB (ser133), immunohistochemistry staining, and cholinergic activities were measured in brain tissue. The effects of C. officinalis extract significantly increased acetylcholine concentration and decreased acetylcholinesterase activity. The C. officinalis extract affected memory formation. Also, to confirm expression of protein BDNF, p-CREB (ser133) in the hippocampus, the researchers observed that immunohistochemistry and western blot increased in C. officinalis extract. These results suggest that C. officinalis provides a significant neuroprotective effect against scopolamine-induced cholinergic system and cognitive impairment.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제10권11호
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• pp.5271-5289
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• 2016

On large-scale data analysis platforms deployed on cloud infrastructures over the Internet, the instability of the data transfer time and the dynamics of the processing rate require a more sophisticated data distribution scheme which maximizes parallel efficiency by achieving the balanced load among participated computing elements and by eliminating the idle time of each computing element. In particular, under the constraints that have the real-time and limited data buffer (in-memory storage) are given, it needs more controllable mechanism to prevent both the overflow and the underflow of the finite buffer. In this paper, we propose an auto regulated data provisioning model based on receiver-driven data pull model. On this model, we provide a synchronized data replenishment mechanism that implicitly avoids the data buffer overflow as well as explicitly regulates the data buffer underflow by adequately adjusting the buffer resilience. To estimate the optimal size of buffer resilience, we exploits an adaptive buffer resilience control scheme that minimizes both data buffer space and idle time of the processing elements based on directly measured sample path analysis. The simulation results show that the proposed scheme provides allowable approximation compared to the numerical results. Also, it is suitably efficient to apply for such a dynamic environment that cannot postulate the stochastic characteristic for the data transfer time, the data processing rate, or even an environment where the fluctuation of the both is presented.

• 한국전기전자재료학회논문지
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• 제29권3호
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• pp.135-140
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• 2016

In this study, we developed the solution-processed PMMA-$HfO_x$ hybrid ReRAM devices to overcome the respective drawbacks of organic and inorganic materials. The performances of PMMA-$HfO_x$ hybrid ReRAM were compared to those of PMMA- and $HfO_x$-based ReRAMs. Bipolar resistive switching behavior was observed from these ReRAMs. The PMMA-$HfO_x$ hybrid ReRAMs showed a larger operation voltage margin and memory window than PMMA-based and $HfO_x$-based ReRAMs. The reliability and electrical instability of ReRAMs were remarkably improved by blending the $HfO_x$ into PMMA. An Ohmic conduction path was commonly generated in the LRS (low resistance state). In HRS (high resistance state), the PMMA-based ReRAM showed SCLC (space charge limited conduction). the PMMA-$HfO_x$ hybrid ReRAM and $HfO_x$-based ReRAM revealed the Pool-Frenkel conduction. As a result of flexibility test, serious defects were generated in $HfO_x$ film deposited on PI (polyimide) substrate. On the other hand, the PMMA and PMMA-$HfO_x$ films showed an excellent flexibility without defect generation.