• 대한물리의학회지
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• 제9권2호
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• pp.133-140
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• 2014

PURPOSE: The purpose of this study was to compare the effect of current density on penetration depth, tissue concentration and transdermal transport of methylene blue(MB) by iontophoretic transdermal delivery. METHODS: Twenty-four male Sprague-Dawley rats were randomly divided into 1 mA($0.11mA/cm^2$), 2 mA($0.22mA/cm^2$), 4 mA($0.44mA/cm^2$), and 8 mA($0.89mA/cm^2$) groups. These rats were exposed to anodic iontophoresis of 1% MB using a direct current for 15 minutes. The penetration depth were measured using light microscopy from cryosections of skin tissue. The tissue concentration and transdermal transport were measured using biochemical analysis from target skin tissues. The data were analyzed with one-way analysis of variance. RESULTS: The significant differences in the penetration depth, tissue concentration and transdermal transport were detected among the groups(p<.001). Post hoc comparisons of the penetration depth, tissue concentration and transdermal transport of he 2 mA, 4 mA, and 8 mA iontophoresis groups were greater than in the 1 mA iontophoresis group(p<.05). There was no significant difference, however, among 2 mA, 4 mA, and 8 mA iontophoresis group. CONCLUSION: There was no difference in the efficiency of iontophoresis from 2 mA($0.22mA/cm^2$) to 8 mA($0.89mA/cm^2$). Higher current density can cause skin injury and discomfort sensation. In general, $0.5mA/cm^2$ is proposed to be the maximum iontophoretic current which should be used on human. The appropriate current amplitude should be selected by considering the safety current density and the depth of the target tissue.

• 공업화학
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• 제32권5호
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• pp.509-515
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• 2021

본 연구는 생체적합성 및 생분해성의 특성을 갖는 PLGA (poly lactic-co-glycolic acid)를 이용하여 이중(w/o/w) emlusion과 유화 용매-증발 기법을 통해 PLGA 나노입자(PNP)를 제조하였고, 이에 키토산을 전하 상호작용을 통해 키토산이 코팅된 PLGA 나노입자(CPNP)를 제조하여 입자의 안정성과 생체이용률을 극대화할 수 있는 경구 투여용 약물 전달체로 사용 가능성을 입증하고자 하였다. CPNP의 화학적 구조는 ¹H-NMR 및 FT-IR을 통해 분석하였으며, 모든 특성 피크가 나타남으로써 성공적으로 제조되었음을 확인하였다. 또한, CPNP의 입자 크기, 제타 전위 및 형태학적 이미지는 DLS와 TEM을 이용하여 각각 분석하였으며, TGA를 통해 CPNP의 열적 분해 거동을 관찰하였다. 또한, CPNP의 세포 독성은 HEK293 및 L929 세포에서 MTT assay를 수행하여 확인하였고, 모든 농도에서 70% 이상의 세포 생존율을 확인함으로써 독성이 없음을 입증하였다. 이러한 결과를 통해 본 연구에서 개발된 CPNP가 경구용 약물 전달체로써 사용 가능성이 있음을 제안한다.

• 한국산학기술학회논문지
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• 제19권10호
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• pp.401-409
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• 2018

본 연구는 패스(Path) 제어방법을 적용하여 소형전술차량에 적용된 NSD의 소음을 저감하기 위한 것이다. 소형전술차량은 고기동성 확보를 위해 후차축에 차동제한장치 중 하나인 NSD를 적용하였다. NSD는 높은 제한율을 가져 기동성을 향상 시켜주지만 기계적 구조에 의해 특정 조건에서 소음이 발생되는 단점이 있다. 이 소음은 NSD가 차동장치로써 원활한 역할 수행을 위해 기어간 유격에 의해 치간 접촉에 따라 발생되는 소음이다. 이러한 소음이 지속적으로 사용자에게 전달됨에 따라 운용자가 지속적인 문제 제기 및 개선 요구를 하고 있다. 물론, NSD의 소음으로 인해 제품의 성능 또는 내구성에 미치는 영향은 없으며, 국방규격에서 규정하는 소음 조건 역시 만족한다. 하지만, 사용자의 지속적인 개선요구에 따라 소음저감을 위한 방안에 대해 연구를 수행하였다. 따라서, 본 연구에서는 소음원의 제거가 현실적으로 제한되는 전술차량의 NSD 소음을 감소하기 위해 NSD의 소음이 전달되는 경로를 제어하는 패스제어방법을 적용하였다. 이를 통해 구조 전달계를 개선 보완하고 이에 대한 개선효과를 검증하고자 한다.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2008년도 International Meeting on Information Display
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• pp.1261-1262
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• 2008

Laser-based crystallization techniques are ideally-suited for forming high-quality crystalline Si films on active-matrix display backplanes, because the highly-localized energy deposition allows for transformation of the as-deposited a-Si without damaging high-temperature-intolerant glass and plastic substrates. However, certain significant and non-trivial attributes must be satisfied for a particular method and implementation to be considered manufacturing-worthy. The crystallization process step must yield a Si microstructure that permits fabrication of thin-film transistors with sufficient uniformity and performance for the intended application and, the realization and implementation of the method must meet specific requirements of viability, robustness and economy in order to be accepted in mass production environments. In recent years, Low Temperature Polycrystalline Silicon (LTPS) has demonstrated its advantages through successful implementation in the application spaces that include highly-integrated active-matrix liquid-crystal displays (AMLCDs), cost competitive AMLCDs, and most recently, active-matrix organic light-emitting diode displays (AMOLEDs). In the mobile display market segment, LTPS continues to gain market share, as consumers demand mobile devices with higher display performance, longer battery life and reduced form factor. LTPS-based mobile displays have clearly demonstrated significant advantages in this regard. While the benefits of LTPS for mobile phones are well recognized, other mobile electronic applications such as portable multimedia players, tablet computers, ultra-mobile personal computers and notebook computers also stand to benefit from the performance and potential cost advantages offered by LTPS. Recently, significant efforts have been made to enable robust and cost-effective LTPS backplane manufacturing for AMOLED displays. The majority of the technical focus has been placed on ensuring the formation of extremely uniform poly-Si films. Although current commercially available AMOLED displays are aimed primarily at mobile applications, it is expected that continued development of the technology will soon lead to larger display sizes. Since LTPS backplanes are essentially required for AMOLED displays, LTPS manufacturing technology must be ready to scale the high degree of uniformity beyond the small and medium displays sizes. It is imperative for the manufacturers of LTPS crystallization equipment to ensure that the widespread adoption of the technology is not hindered by limitations of performance, uniformity or display size. In our presentation, we plan to present the state of the art in light sources and beam delivery systems used in high-volume manufacturing laser crystallization equipment. We will show that excimer-laser-based crystallization technologies are currently meeting the stringent requirements of AMOLED display fabrication, and are well positioned to meet the future demands for manufacturing these displays as well.

• 한국펄프종이공학회:학술대회논문집
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• 한국펄프종이공학회 2008년도 제33회 펄프종이기술 국제세미나
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• pp.47-70
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• 2008

Cost efficiency is today the primary requirement in the paper and board industry. This has led therefore, to a greater preponderance of products with specifically designed functionality to take account of current industry needs. Continually increasing machine coating speeds together with these new coating colour components have put more emphasis on the importance of the correct rheology and water retention of the coating colours to achieve good runnability and end product quality. In the coating process, some penetration of the aqueous phase, to the base paper or board must occur to anchor the pre-coating to the base or the topcoat to the pre-coat. The aqueous phase acts as a vehicle not only for the binder, but also for the other components. If this water or material penetration is not controlled, there will be excessive material shift from the coating colour to the base, before immobilization of the coating colour will stop this migration. This can result in poor machine runnability, unstable system and uneven coating layer, impacting print quality. The performance of rheology modifiers or thickeners on the coating color have tended to be evaluated by the term, "water retention". This simple term is not sufficient to explain their performance changes during coating. In this paper we are introducing a new concept of "material retention", which takes note of the total composition of the coating colour material and therefore goes beyond the concept of only water retention. Controlled material retention leads to a more uniform z-directional distribution of coating colour components. The changes that can be made to z-directional uniformity will have positive effects on print quality as measured by surface strength, ink setting properties, print gloss, mottling tendency. Optical properties, such as light scattering, whiteness and light fastness delivery should also be improved. Additionally, controlled material retention minimizes changes to the coating colour with time in re-circulation giving less fluctuation in quality in the machine direction since it more closely resembles fresh coating for longer periods. Use of the material retention concept enables paper and board producers to have more stable runnability (i.e. lower process costs), improved end product quality (i.e. better performance of used chemicals) and/or optimized use of coating colour components (i.e. lower total formulation cost)

• 재활복지
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• 제22권3호
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• pp.225-257
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• 2018

본 연구의 목적은 청각장애인이 경험하는 위험상황과 청각 대체기술로 사용하는 보조기기 사용실태를 조사하여 청각증강 기술 개발의 적용점을 모색하는 데 있다. 이를 위해 청각장애 등급을 판정받은 청각장애인을 대상으로 설문조사하여 총 355명의 자료를 분석에 사용하였다. 연구결과 첫째, 소리 및 진동을 인지한 경험이 없는 상황으로 교통수단, 사물, 자연 영역 순으로 높게 나타났다. 이 중 교통수단의 소리와 진동을 인지하지 못한 비율이 높아 일상생활에서 청각장애인이 경험하는 위험 가능성이 높은 것으로 조사되었다. 둘째, 청각장애인이 경험한 위험상황은 교통사고, 보행사고, 가정에서의 일상생활 순으로 높게 조사되었다. 셋째, 위험상황 인식과 알림을 위한 보조기기로 2G폰/스마트폰, 진동디지털알람시계, 경광등, 진동손목시계의 인지도가 높았으며, 2G폰/스마트폰의 만족도가 가장 높았다. 넷째, 의사소통을 위한 보조기기로 보청기, 스마트폰, 영상전화기, 인공와우, 2G폰 순으로 인지도가 높았으며, 스마트폰을 사용하였을 경우 만족도와 의사소통 개선정도가 가장 높게 조사되었다. 마지막으로 청각증강 기술 개발을 위해 고려할 점으로 휴대/착용 편의성, 가격, 동작 정확도 순으로 선호하였으며, 알림 전달 방식은 시각(문자와 빛)을 활용한 알림방식을 선호하였다. 연구결과에 근거하여 위험상황에서 청각장애인의 청각증강 기술 개발을 위한 정책적, 실천적 방안을 제시하였다.

• 대한치과교정학회지
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• 제22권2호
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• pp.373-388
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• 1992

The purpose of this study was to clarify the histologic changes in the expansion of midpalatal suture by the tensile forces. 39 Sprague-Dawley rats were divided into a control group (3 rats) and three experimental groups (36 rats) -group 1, pressured with a light force(50-75 g), group 2, with a heavy force(250-300 g) and group 3, with a heavy force (250-300 g) plus laser irradiation. Autoradiographic and histopathologic observations were performed in 12, 24, 48 and 96 hours after force delivery. The results were as follows; 1. The anterior portion of midpalatal suture was more separated than the posterior portion in all experimental groups. Group 2 showed more separation than group 1 and no difference to group 3 2. Ligament tearing appeared intensively in 24 hours, but the sutural matrices increased with times. ; Group 2 showed more tearing than group 1, and active regeneration of sutural matrices was observed in group 3. 3. Vascular dilatation appeared intensively in 24 hours and decreased with times. ; The anterior portion of midpalatal suture showed more dilatation than the posterior portion, ; The changes was the greatest in group 3, group 2, group 1, in that order. 4. New bone formation and the new capillary prolieferation began to appear in 12 hours and increased with times, : Group 2 showed more changes than group 1 and no difference to group 3. 5. Infiltration of inflammatory cells was little observed and was the greatest in group 2, group 1, group 3, in that order 6. Positive reaction of cells to $[^3H]$ thymidine was the greatest in 24 hours, and decreased with times ; The reaction was the greatest in group 3, group 2, group 1, in that order.

• Journal of Pharmaceutical Investigation
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• 제35권1호
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• pp.17-23
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• 2005

Polyethylenimine (PEI) has been used as cationic polymers for efficient gene transfer without the need for endosomolytic agents. Various kinds of PEIs with different molecular weight were tested in order to investigate the effects of the molecular weight of PEI on the transfection efficiency and cell cytotoxicity. The ${\beta}-galactosidase$ expression $(pCMV-{\beta}-gal)$ plasmid was used as a model DNA. Complex formation between PEI and pDNA was assessed by 1% agarose gel electrophoresis method. Particle size and zeta-potential of complexes were determined by electrophoretic light scattering spectrometer. In vitro transfection efficiency was assayed by measuring ${\beta}-galactosidase$ activity. Cell cytotoxicity was determined by MTT assay. Particle sizes of the complexes became smaller on increasing molecular weights of PEI and N/P ratios. Surface potential of complexes was increased as the molecular weight of PEI increased. Transfection efficiency of $pCMV-{\beta}-ga1$ on the HEK 293 cells was greatest with PEI 25 K system but having the lowest cell viability. PEI with high molecular weight showed higher transfection efficiency and cell viability than PEI with low molecular weight.

• Journal of Pharmaceutical Investigation
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• 제34권5호
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• pp.401-406
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• 2004

To develop an intravenous delivery system of all-trans retinoic acid (ATRA) for the cancer therapy, poly(L-lactic acid) nanoparticles were prepared and characterized. Emulsification-solvent evaporation method was chosen to prepare submicron sized nanoparticles. Spherical nanoparticles less than 200 nm in diameter with narrow size distribution were prepared, and the entrapment efficiency of drug was more than 95%. The endothermic peak at $183^{\circ}C$ and X-ray crystallographic peak of ATRA appeared in the nanoparticle system, suggesting the inhibition of crystallization of ATRA by polymer adsorption during the precipitation process. ATRA was released at $37^{\circ}C$ for 60 days and the release rate was dependent on the concentration of drug incorporated in the nanoparticles. While ATRA was unstable in the light, it was very stable at $4^{\circ}C$. These results suggest the usefulness of PLA nanoparticles as a sustained and prolonged release carrier for ATRA.

• 한국콘텐츠학회논문지
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• 제18권9호
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• pp.81-90
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• 2018

SBS <그것이 알고 싶다>는 시사 고발 프로그램들이 위축되는 2010년대에 공론 장을 지키는 역할을 수행했다. 이러한 성취에는 <그것이 알고 싶다>의 수사학적 특성이 자리하고 있을 것이라는 가정을 바탕으로 분석을 실시했다. 수사학이라는 특성을 바탕으로 <그것이 알고 싶다>를 일반적인 시사고발 프로그램으로 보기보다는 '미스터리성 고발 다큐멘터리'로 인식할 때 프로그램의 본질에 더 다가갈 수 있다고 보았다. 프로그램의 수사학적 성격과 제목, 부제목, 대본에 나타난 수사학적 특성을 분석한 결과 프로그램의 제목에는 철저하게 시청자가 보고 싶어 하는 욕망을 충족시키려는 관점이 반영되어 있었으며, 부제목들에는 미스터리라는 단어의 활용, 지명의 빈번한 사용, 의문문 형식의 문장 등의 특성을 발견할 수 있었다. 또한 대본에서는 반전의 수사학, 심층의 수사학, 감탄의 수사학을 사용하고 있다는 것을 발견했으며, 이와 같은 수사학적 특성으로 인해 시청자의 관심을 끌어 모으며 시청자와 왕성한 상호작용을 수행할 수 있다고 결론내릴 수 있다.