• Journal of Pharmacopuncture
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• v.27 no.1
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• pp.1-13
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• 2024

Background: Diabetic nephropathy (DN) is one of the major complications of chronic hyperglycaemia affecting normal kidney functioning. The ayurvedic medicine curcumin (CUR) is pharmaceutically accepted for its vast biological effects. Objectives: The Curcuma-derived diferuloylmethane compound CUR, loaded on Poly (lactide-co-glycolic) acid (PLGA) nanoparticles was utilized to combat DN-induced renal apoptosis by selectively targeting and modulating Bcl2. Methods: Upon in silico molecular docking and screening study CUR was selected as the core phytocompound for nanoparticle formulation. PLGA-nano-encapsulated-curcumin (NCUR) were synthesized following standard solvent displacement method. The NCUR were characterized for shape, size and other physico-chemical properties by Atomic Force Microscopy (AFM), Dynamic Light Scattering (DLS) and Fourier-Transform Infrared (FTIR) Spectroscopy studies. For in vivo validation of nephro-protective effects, Mus musculus were pre-treated with CUR at a dose of 50 mg/kg b.w. and NCUR at a dose of 25 mg/kg b.w. (dose 1), 12.5 mg/kg b.w (dose 2) followed by alloxan administration (100 mg/kg b.w) and serum glucose levels, histopathology and immunofluorescence study were conducted. Results: The in silico study revealed a strong affinity of CUR towards Bcl2 (dock score -10.94 Kcal/mol). The synthesized NCUR were of even shape, devoid of cracks and holes with mean size of ~80 nm having -7.53 mV zeta potential. Dose 1 efficiently improved serum glucose levels, tissue-specific expression of Bcl2 and reduced glomerular space and glomerular sclerosis in comparison to hyperglycaemic group. Conclusion: This study essentially validates the potential of NCUR to inhibit DN by reducing blood glucose level and mitigating glomerular apoptosis by selectively promoting Bcl2 protein expression in kidney tissue.

• Korean Journal of Plant Resources
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• v.9 no.1
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• pp.11-21
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• 1996

This study has observed the development, structure and distribution of oil canals in mitsuba, seri, ashitaba and hamabohu, that are condiment herbs belonging to the Umbelliferae family, using a light microscope. Oil canals were found in the petioles, leaf blades, stems, roots, hypocotyls and cotyledons. Oil classified into distribution due to ring vascular bundles, as in mitsuba and seri, and distribution due to diffuse vascular bundles, as in ashitaba and hamabohu. Oil canal development in the cortex due to petiole thickening was followed by the development of collenchyma and vascular bundles. However, no vascular bundles were formed in some cases. Many oil canals were found in the periphery of the petioles. Oil canals in leaf blades were found on the adaxial and abaxial sides on the veins. Those around the main veins were larger. Steam oil canals were found in the cortex and pith in mitsuba and seri, and in the cortex and fundamental tissues around the xylem, in ashitaba and hamabohu, while those in the roots were found in the pericycle in mitsuba and seri, and in the collenchyma-like tissues and phloem in ashitaba and hamabohu. The transverse sections of oil canals were round or elliptical. The secretory cells in the cortex and pith were smaller than the neighboring parenchyma cells, while they were larger than the neighboring parenchyma cells in the phloem.

• Journal of Korean Society of Water and Wastewater
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• v.37 no.5
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• pp.261-269
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• 2023

In light of recent social concerns related to issues such as water supply pipe deterioration leading to problems like leaks and degraded water quality, the significance of maintenance efforts to enhance water source quality and ensure a stable water supply has grown substantially. In this study, scan statistic was applied to analyze water quality complaints and water leakage accidents from 2015 to 2021 to present a reasonable method to identify areas requiring improvement in water management. SaTScan, a spatio-temporal statistical analysis program, and ArcGIS were used for spatial information analysis, and clusters with high relative risk (RR) were determined using the maximum log-likelihood ratio, relative risk, and Monte Carlo hypothesis test for I city, the target area. Specifically, in the case of water quality complaints, the analysis results were compared by distinguishing cases occurring before and after the onset of "red water." The period between 2015 and 2019 revealed that preceding the occurrence of red water, the leak cluster at location L2 posed a significantly higher risk (RR: 2.45) than other regions. As for water quality complaints, cluster C2 exhibited a notably elevated RR (RR: 2.21) and appeared concentrated in areas D and S, respectively. On the other hand, post-red water incidents of water quality complaints were predominantly concentrated in area S. The analysis found that the locations of complaint clusters were similar to those of red water incidents. Of these, cluster C7 exhibited a substantial RR of 4.58, signifying more than a twofold increase compared to pre-incident levels. A kernel density map analysis was performed using GIS to identify priority areas for waterworks management based on the central location of clusters and complaint cluster RR data.

• Korean Journal of Environment and Ecology
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• v.27 no.3
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• pp.396-404
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• 2013

The purpose of this study is to propose the method to improve management aspect and facilities plan to enhance spatial cognition of visitors through visitors' analysis of spatial cognition regarding tourism destination facilities. The research model was established by factors affecting spatial cognition such as facilities characteristics and visitor characteristics as well as spatial cognition of visitors' facilities to achieve objectives of research, and actual proof analysis was made to visitors to Nami Island tourism destination based of this. As a result of analysis, it was proved that visitor characteristics including their gender and age, and tour map use as well as facilities characteristics of facilities type, location, etc showed a statistically significant difference in visitors' spatial cognition. In addition, it is deemed as a result of analysis that Nami Island requires re-organization of symbolic features and attractiveness of food and beverage facility, while needing additional installment and rearrangement of information facilities and related facilities. The result of this research suggests that close analysis and application of factors affect spatial cognition such as facilities and visitors' characteristics to plan and manage the tourism destination facilities effectively. Moreover, visitors' spatial cognition is related to spatial characteristics of tourism destination, therefore it is analyzed that the uniqueness of facilities played an important role in improving female's spatial cognition. In particular, the result of this study is meaningful in that in light of plan and management for tourism destination facilities, the function to provide tourism destination plays a major role in improving visitors' spatial cognition regardless of complexity of spatial structure of tourism destination.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.13 no.6
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• pp.39-48
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• 2010

The purpose of this study was to analyze air temperature decreasing effects by shading and ventilation at micro-scale experiment plots, especially focused on the Wet Bulb Globe Temperature (WBGT) in outdoor spaces. To monitor the time-serial changes of Dry-bulb Temperature (DT), Globe Temperature (GT) and Relative Humidity (RH) in the wind blocking and shading conditions, Two hexahedral steel frames were established on the open grass field, the dimension of each frame was 1.5m(W)${\times}$1.5m(L)${\times}$1.5m(H). Four vertical side of one frame was covered by transparent polyethylene film to prevent wind passing through (Wind break plot; WP). The top side of the other frame was covered with shading curtain which intercept 95% of solar light and energy (Shading plot; SP). And, Another vertical steel frame without any treatment preventing ventilation and sunlight was set up, which represents natural conditions (Control plot; CP). The major findings were as follows; 1. The average globe temperature (GT) was highest at WP showing $50.94^{\circ}C$ and lowest at SP showing $34.58^{\circ}C$. The GT of natural condition (SP) was $42.31^{\circ}C$ locating the midst between WP and SP. The difference of GT of each plot was about $8-16^{\circ}C$, which means the ventilation and shading has significant effect on decreasing the temperature. 2. WP showed the highest average dry-bulb temperature (DT) of $38.41^{\circ}C$ which apparently differ from SP and CP showing $31.94^{\circ}C$ and $33.15^{\circ}C$ respectively. The DT of SP and CP were nearly the same. 3. The average relative humidity (RH) was lowest at WP showing 15.21%, but SP and CP had similar RH 28.79%, 28.02% respectively. 4. The average of calculated WBGT were the highest at the WP ($27.61^{\circ}C$) and the lowest at the SP ($23.64^{\circ}C$). The CP ($25.49^{\circ}C$) was in the middle of the others. As summery, compared with natural condition (CP), the wind blocking increased about $2.11^{\circ}C$ WBGT, but the shading decreased about $1.84^{\circ}C$ WBGT. So It can be apparently said that the open space with much shading trees, sheltering furnitures and well-delivered wind corridor can reduce useless and even harmful energy for human outdoor activity considerably in outdoor spaces.

• Archives of design research
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• v.12 no.4
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• pp.317-326
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• 1999

The Korean traditional color passed down over countless generations has surpassed both surpassed both time and space and continue today to breathe life into its people's everyday. In order to clarify the characteristics of Korean traditional color blue and red, we investigate the names of them and measured the color tones of textile remains in Chosun era. The characteristics of Korean traditional color blue and red have been surveyed by means of the examination of color names in many famous literatures in Chosun era. Korean terms for color tones were characterized by enormous variety of epithes crowned on them. The color names mentioned contain many unaccountable epithes which were characterized also deep colors and light colors were dominant in it. As a means of enhancing possibilities within limited colors, the commoners increased the names for varying tones of blue color group(32kinds) and red color group(40kinds). These "blue(indigo dyeing)' and 'red(safflower dyeing)' in Chosun era were shown very high frequency in use and the costume colors in Royal Court. With combination of these various blue and red colors they represented a thought of color based on Yinyang Theory and created a polished aesthetic taste. The color samples of textile remains in museum were measured and designated by Munsell color system and the ISCC-NBS color designation system. THe appeared rates were derived on Chosun era and features of colors using on the period were discussed. We aim to present specific recipes in indigo dyeing and safflower dyeing for using our apparel product and folk art.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.26 no.1
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• pp.47-59
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• 2023

Due to climate change and urbanization, abnormally high temperatures and heat waves are expected to increase in urban and deteriorate thermal comfort. Planting of street trees and changing the albedo of urban surfaces are the strategies for mitigating the thermal environment of urban, and both of these strategies affect the exposure and blocking of radiative fluxes to pedestrians. After measuring the shortwave and longwave radiation according to the ground surface with different albedo and the presence of street trees using the CNR4 net radiometer, this study analyzed the relationship between this two strategies in terms of thermal environment mitigation by calculating the MRT(Mean Radiant Temperature) of each environment. As a result of comparing the difference between the downward shortwave radiation measured under the right tree and at the control, the shortwave radiation blocking effect of the tree increased as the downward shortwave radiation increased. During daytime hours (from 11 am to 3 pm), the MRT difference caused by the albedo difference(The albedo of the surfaces are 0.479 and 0.131, respectively.) on surfaces with no tree is approximately 3.58℃. When tree is present, the MRT difference caused by the albedo difference is approximately 0.49℃. In addition, in the case of the light-colored ground surface with high albedo, the surface temperature was low and the range of temperature change was lower than the surrounding surface with low albedo. This result shows that the urban thermal environment can be midigate through the planting of street trees, and that the ground surface with high albedo can be considered for short pedestrians. These results can be utilized in planning street and open space in urban by choosing surfaces with high albedo along with the shading effect of vegetation, considering the use by various users.

• Korean Journal of Plant Tissue Culture
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• v.25 no.6
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• pp.453-475
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• 1998

During the 100 years since the initial discovery of meiotic phenomenon many brilliant aspects have been elucidated, but further researches based on light microscopy alone as an experimental tool have been found to have some limits and shortcomings. By the use of electron microscopy and armed with the advanced knowledges on modern genetics and biochemistry it has been possible to applu molecular technology in gaining information on the detailed aspects of meiosis. As synapsis takes place, a three-layered proteinous structure called the synatonemal complex starts to form in the space between the homologous chromosomes. To be more precise, it begins to form along the paired chromosomes early in the prophase I of meiotic division. The mechanism that leads to precise point-by-point pairing between homologous chromocomes division. The mechamism that leads to precise point-by-point pairing between homologous chromosomes remains to be ascertained. Several items of information, however, suggest that chromsome alignment leading to synapsis may be mediated somehow by the nuclear membrane. Pachytene bivalents in eukaryotes are firmly attached to the inner niclear membrane at both termini. This attached begins with unpaired leptotene chromosomes that already have developed a lateral element. Once attached, the loptotene chromosomes begin to synapse. A number of different models have been proposed to account for genetic recombination via exchange between DNA strands following their breakage and subsequent reunion in new arrangement. One of the models accounting for molecular recombination leading to chromatid exchange and chiasma formation was first proposed in 1964 by Holliday, and 30 years later still a modified version of his model is favored. Nicks are made by endomuclease at corresponding sites on one strant of each DNA duplex in nonsister chromatid of a bivalent during prophase 1 of meiosis. The nicked strands loop-out and two strands reassociate into an exchanged arrangement, which is sealed by ligase. The remaining intact strand of each duplex is nicked at a site opposite the cross-over, and the exposed ends are digested by exonuclease action. Considerable progress has been made in recent years in the effort to define the molecular and organization features of the centromere region in the yeast chromosome. Centromere core region of the DNA duplex is flanked by 15 densely packed nucleosomes on ons side and by 3 packed nucleosomes on the other side, that is, 2000 bp on one side and 400 400 bp in the other side. All the telomeres of a given species share a common DNA sequence. Two ends of each chromosome are virtually identical. At the end of each chromosome there exist two kinds of DNA sequence" simple telpmeric sequences and telpmere-associated sequencies. Various studies of telomere replication, function, and behabior are now in progress, all greatly aided by molecular methods. During nuclear division in mitosis as well as in meiosis, the nucleili disappear by the time of metaphase and reappear during nuclear reorganizations in telophase. When telophase begins, small nucleoli form at the NOR of each nucleolar-organizing chromosome, enlarge, and fuse to form one or more large nucleoli. Nucleolus is a special structure attached top a specific nucleolar-organizing region located at a specific site of a particular chromosome. The nucleolus is a vertical factory for the synthesis of rRNAs and the assenbly of ribosome subunit precursors.sors.

• Fire Science and Engineering
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• v.34 no.2
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• pp.14-21
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• 2020

This paper presents the study of a fire risk to the backside of two miniatures of ISO 9705 2/5 using a lightweight partition for indoor space division and reproduction of the ISO 9705 test. An SGP partition, stud partition, glass wool panel, urethane foam panel, sandwich panel, and glass partition were selected as the test specimens, which are frequently used in construction. According to the ISO 9705 test standard, stabilization was achieved using a measuring device that recorded data before the ignition of a burner and continued recording for 120 s thereafter. After ignition was achieved, the power was increased to 300 kW for 600 s and then reduced to 100 kW for 600 s. The specimens were subsequently observed for 180 s, and the fire risk to the backside and the fire pattern of the wall unit were analyzed. Owing to the amount of heat generated by the ignition source, the maximum temperature of the backside was observed to be 67.7 ℃ for the SGP partition, 55.1 ℃ for the stud partition, 52.4 ℃ for the glass wool panel, 727.4 ℃ for the sandwich panel, 561 ℃ for the urethane foam panel, and 630.5 ℃ for the glass partition. In the cases of the sandwich and urethane foam panels, the explosion of flammable gas occurred by virtue of fusion of the interior materials. The reinforced glass was fractured owing to the temperature difference between the heat- and nonheat-responsive parts. Ultimately, the fire risk to the nearby section room was deemed to be high.

• Korean Journal of Environment and Ecology
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• v.30 no.4
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• pp.793-799
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• 2016

This study examined Platanus orientalis and Ulmus davidiana planted in downtown parks to identify the correlations among microclimatic factors such as temperature in the crown, air flow, and wind speed. For the field survey, measurements were taken at 1 hour intervals from 09:00 am to 06:00 pm in August. For the measurement of microclimatic factors, data on temperature, light intensity, air flow, and wind speed were collected using a quantum sensor (PAR Quantum Sensor SKP215), a precision thermometer (Pt1000-Sensor), and a combination anemometer (1467 G4 & HG4). The results of the analysis demonstrated that both Platanus orientalis and Ulmus davidiana, showed a greater cooling effect inside the crown as compared with the outside temperature. The cooling effect inside the crown was more evident with air flow and wind speed factors. With relation to wind, the inner temperature of the crown of Platanus orientalis decreased due to air flow while that of Ulmus davidiana decreased due to wind speed. With no wind, the average variation in temperature inside the crown was $-0.9^{\circ}C$ for Ulmus davidiana and $-0.958^{\circ}C$ for Platanus orientalis, indicating that Platanus orientalis was relatively more effective in lowering the temperature of the planting space than Ulmus davidiana. This study is significant because it shows that different tree species have different effects on the microclimate and that factors affecting the formation of the microclimate of trees may vary with species. Further studies on species other than broad leaf trees, such as evergreen trees and shrubs, are required in order to plan the distribution of landscaping trees that are effective in regulating the microclimate within urban green spaces.