• 대한예방한의학회지
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• 제8권2호
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• pp.141-156
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• 2004

Objectives : JianTeng-Yuan(交藤圓) is said to be a prescription for preservation of health in ${\ulcorner}$HuaTuo ZhongZangJing(華陀 中藏經)${\lrcorner}$. It is known to have the effect of Bu-Shen(補腎: strengthening kidney) and Yi-Shou(益壽: prolonging the span of one's life). This study investigates whether JTY is effective on inhibition of oxidation stress. Methods : Sprague-Dawley Rats(12-week-old, weight $300{\pm}20g$) were divided into 3 groups. Normal group(n=8) was injected PBS(1ml/body, s.c) at the back neck's skin. Control group(n=8) was injected D-galactose(50mg/kg, 1ml PBS/body, s.c) to induce pathological animals. JTY group was injected the same treatment for the Control group, and fed containing JTY(10%). The whole groups were treated 1 time per day for 6 weeks. After rats were sacrificed and anti-oxidant enzyme(SOD, CAT, G-px) activity, GSH quantity of RBC and tissue(heart, liver and kidney), plasma Vit-C quantity were examined. Besides, the MDA levels of liver and kidney, lipofuscin of heart and endurance of erythrocyte membrane were measured. Results : In the JTY group, RBC's SOD activity decline was halted by 21% of the normal level, compared to the control group ; G-px activity(unit/g of Hb) increased significantly, compared to the normal group ; and the level of Vit-C in plasma increased by 16%. Heart's SOD activity was kept at the same level as that of the normal group ; and CAT activity decline was halted by 26%. Kidney's CAT and G-px activities were kept at the same level as that shown in the normal group, implying the existence of halting effect. Liver also showed a slight halting effect against the decline of anti-oxidant ability, but the effect was not significant(a=0.05). A comparison between the levels of peroxide in SD rats showed that the level of TBARS in plasma increased significantly in the control group and that it was normal in the JTY group. The livers in the JTY group, compared to those in the control group, showed 36% halting effect of the normal level while their kidney's indicated the level significantly lower than the normal level. Heart's lipofuscin increased significantly in the control group, but was alike in both the JTY and the normal groups. Endurance of erythrocyte membrane(%) decreased significantly in the control group while it was kept at the similar level in both the JTY and the normal groups, indicating the halting effect. Conclusions : This study suggests that JTY is effective to defend oxidation stress caused by D-galactose in the animals. It showed that the anti-oxidant ability was maintained and strengthened. On the other hand, it reduced the level of peroxide in animals. In sum, JTY appeared to have the equilibrium normal physiological function in SD rat.

• 한국식품영양과학회지
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• 제38권6호
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• pp.683-693
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• 2009

본 연구에서는 건강한 성인 남자를 대상으로 민들레즙이 알코올 섭취 후 산화적 스트레스 및 숙취에 미치는 효과를 확인하여 알코올 섭취로 인한 간 기능 보호와 숙취해소 효과를 가진 소재 개발을 위한 기초자료를 제공하고자 실시하였다. 대상자는 평균 주량이 소주 1병 이상으로 술을 즐겨 마시는 건강한 20대 식품전공 남자 대학생 9명을 선정하여 개인차를 없애기 위해 실험 시작 전 1주일 간 금주를 시켰으며 시험에 앞서 임상대상자들에게 본 연구에 대해 충분히 숙지시킨 후 안정된 분위기에서 시험을 cross over design으로 진행하였다. 대상자들에게 매일 민들레즙 220 mL씩 1주일간 보충시킨 후 각각 20% 에탄올을 함유한 소주 360 mL씩 (에탄올 함량 72 g)을 섭취시켰다. 술은 자유로운 분위기에서 1시간 내에 다 마시게 하였으며 두 번의 실험 사이에는 2주간의 wash-out period를 가졌다. 민들레즙을 보충한 군에서 알코올 섭취 후 혈중 HDL-C 농도가 유의적으로 (p<0.01) 증가하였으며 LDL-C 농도는 현저하게 감소하였고 ADH와 ALDH 활성을 향상시켜 에탄올과 아세트알데히드 농도를 다소 저하시키는 것으로 나타났다. 총 항산화능과 지질과산화 정도는 민들레즙 보충에 따른 군 간의 유의적인 차이를 보이지 않았으나 민들레즙을 보충한 군에서는 알코올 섭취 후 다소 지질과산화가 감소되는 경향을 보였다. 적혈구의 항산화 효소계 활성은 GSH-red와 catalase 활성이 민들레즙을 보충한 군에서 유의적으로(p<0.05) 증가되는 것을 알 수 있었으며 알코올 섭취로 인한 임파구의 DNA 손상정도는 민들레즙의 보충에 따른 유의적인 차이는 보이지 않았지만 민들레즙을 보충한 군에서 알코올에 의한 임파구DNA 손상을 다소 억제시키는 경향이 있는 것으로 나타났다. 음주 동안과 술 마신 다음날에 나타나는 숙취증상에 대한 설문조사에서는 각 문항에서 민들레즙 보충에 따른 유의적인 차이는 보이지 않았다. 이상의 결과들로 미루어 볼 때 민들레즙 보충이 알코올 섭취 후 HDL-C 농도를 증가시켰고 ALDH 활성을 향상시켜 혈중 아세트알데히드 농도를 감소시키며 GSH-red와 catalase 활성을 증가시켜 체내에서 알코올에 의한 산화과정이나 지질과산화 생성을 다소 억제하는 것으로 보인다. 이러한 결과는 민들레에 포함되어 있는 유효 물질이 숙취해소와 간 기능 보호 및 항산화 효과를 나타내는 것으로 사료되며, 따라서 민들레즙이 알코올에 의한 간 기능 보호, 숙취해소 및 항산화 효과를 가진 기능성 물질로서의 가능성을 보여준다고 할 수 있겠다.

• 한국초지조사료학회지
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• 제43권4호
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• pp.206-215
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• 2023

본 연구는 고온 스트레스에 노출된 홀스타인종 젖소와 이후 회복 기간을 가진 홀스타인종 젖소의 혈액을 분석하여 면역세포의 분포와 기능을 확인하여 고온 스트레스에 대한 시간에 따른 면역변화를 규명하고자 하였다. 실험은 HTP(THI: 76 ± 1.2)와 CTP(THI: 66 ± 1.3)의 국립축산과학원 낙농과에서 사육중인 홀스타인종 젖소를 그룹당 5마리를 사용하여 수행되었다. EDTA tube를 사용하여 혈액을 샘플링하여 CBC 분석과 PBMC를 분리되었다. 분리된 PBMC는 유세포 분석을 실시하였다. CBC 결과는 그룹 간 면역세포 수에 변화가 없었다. PBMC의 Flow Cytometry를 사용한 분석에서는 그룹 간 B cell, Helper T cell, cytotoxic T cell, γδ T cell 간에 유의한 차이가 관찰되지 않았다. 그러나 IL-17a를 생산하는 Th17 cell의 증가가 있었던 반면, CTP 중 Th1 cell은 감소하였다. CTP에서 IL-10의 발현 증가와 HSP70과 HSP90의 발현 감소가 관찰되었다. 결론적으로, IL-10의 발현 증가와 HSP 발현의 감소는 고온 스트레스로부터 약한 회복의 가능성을 시사한다. 그러나 B cell, T cell 및 기타 면역세포의 관찰된 변화가 없다는 것은 CTP 중 고온 스트레스로부터 불완전하게 회복되었음을 나타낸다. 본 연구에서는 적온기 정상수준의 젖소 면역세포 분포에 대한 결과가 부재하여 적온기, 고온기, 회복기의 연결성 있는 비교분석이 부족하다는 한계가 있으며 젖소의 생리대사와 유생산량, 고온 스트레스 바이오마커 등에 대한 분석이 함께 이루어진다면 좀 더 명확한 회복기 대사 및 면역반응에 대한 결과 도출이 가능할 것으로 생각된다.

• 동의생리병리학회지
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• 제16권1호
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• pp.150-153
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• 2002

To elucidate the toxic effect of oxygen free radicals on cultured mouse spinal motor neurons damaged by hydrogen peroxide(H₂O₂)-induced neurotoxicity, we examined the neurotoxicity induced by oxygen radicals by NR assay when cultured spinal motor neurons were grown in the medium containing various concentrations of H₂O₂ for 6 hours. In addition, neuroprotective effects of herb extracts such Rhizoma Gastrodiae(RG), on H₂O₂-induced neurotoxicity in cultured spinal motor neurons were evaluated after cultured spinal motor neurons were preincubated with various concentrations of herb extract, RG for 2 hours before 50uM H₂O₂ for 6 hours. H₂O₂ decreased remarkably cell viability in dose-and time-dependent manner in these cultures, and also herb extract, RG increased cell viability of spinal motor neurons damaged by H₂O₂ in these cultures. From the above results, it is suggested that H₂O₂ was toxic in cultured spinal motor neurons derived from mouse, and RG was effective in blocking the neurotoxicity induced by oxidative stress in these cultures.

• 한국산학기술학회논문지
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• 제15권1호
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• pp.306-315
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• 2014

이 연구의 목적은 만19세 이상의 성인을 대상으로 만성질환에 대한 관리적 특성인 질환진단, 치료, 교육, 신체활동, 일상생활활동이 정신건강(스트레스인지, 우울증상경험, 자살생각경험여부)과의 관련성과 영향을 주는 요인을 분석한다. 연구대상은 국민건강영양조사 2010년도 제5기 1차년도 19세 이상 6,227명의 원시데이터를 활용하였다. 일반적 특성에 따른 정신건강과의 관련성을 분석한 결과 연구대상자들 6,227명중 스트레스를 느낌 84.8%, 우울증상경험 있음 13.2%, 자살생각경험 있음 15.1% 이었다. 스트레스인지는 연령이 낮을수록, 배우자가 있는 경우, 교육수준이 높을수록, 주관적 건강상태가 나쁠수록, 우울증상경험은 성별은 남자보다 여자가, 연령은 19-54세, 교육수준이 낮을수록, 주관적 건강상태가 나쁠수록, 당뇨병에 관한 교육을 받지 않은 경우, 신체활동을 4일 이상 하는 경우. 자살생각경험여부는 성별은 여자가, 배우자가 없는 경우, 교육수준이 낮을수록, 주관적 건강상태가 나쁠수록, 신체활동을 전혀 하지 않는 경우 영향을 주었다. 만성질환자들에게 의학적인 치료를 제공하는 방안에 대해서만 관심을 가질 것이 아니라 정신건강에도 깊은 관심을 가지고 심리적인 치료를 병행할 수 있는 정책적인 지원이 제공된다면 이들이 보다 건강한 삶을 영위하는데 기여할 수 있을 것이다.

• 대한간호학회지
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• 제23권2호
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• pp.255-268
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• 1993

This descriptive correlational research was conducted to compare the relationship between self-esteem performance of antenatal care and health pro-motion lifestyles for unmarried and married pregnant women. The sample consisted of 94 married women attending one general hospital and residing in Seoul and 82 unmarried women from two social institutes for unmarried women. The tool used for this study was a structured questionnaire which was developed and revised by the researcher. The tool consisted of 12 items related to demographic characteristics, 10 items on self-esteem measurement, 20 items on performance of antenatal care and 37 items on health promotion lifestyle profile. The data collected from the interviews were analyzing using the SPSS, yielding frequencies, percentiles, means, standard deviations, t-test, ANOVA, Pearson’s Product Moment Correlation. The results of this study are as follows : 1) The demographic variables for the two groups were heterogenous except for religion. 2) The results of the comparison between the two groups were significantly different for self-esteem, married women(mean 20.41, standard deviation 3. 94) had higher scores on self-esteem than unmarried women(mean 24.02, standard deviation 4.11), (t=-5.91, p .001) 3) There was a stastically significant difference between the two groups on the health promotion lifestyle profile. The married women had higher scores on the health promotion lifestyle profile (t=7.22, p〈.001) 4) The score for married women on performance of antenatal care has higher than the score for unmarried women(t=8.83, p〈.001) 5) With regard to the relationship between health promotion lifestyle and performance of antenatal care and self-esteem, the correlation coefficient between self-esteem and health Promotion lifestyle for married women was .45, between per formance of antenatal care and health promotion lifestyle, .54, between self-esteem and performance of antenatal care, .32. For the unmarried women, between self-esteem and health promotion lifestyle, .39, between performance of antenatal care and health promotion lifestyle, .67, between self-esteem and performance of antenatal care, .30. 6) There was a statistically significant different between the two groups on all subconcepts of the health promotion lifestyle profile (p〈.001). 7) Comparison of the order of the scores between the two groups for the married women showed that the highest score was for nutrition, then self-actualization, interpersonal support, health responsibility, stress management and exercise in that order. For the unmarried women the highest score was for self-actualization followed by nutrition, interpersonal support, stress management, health responsibility, and exercise in that order. The score in the exercise domain was lowest in both groups. In conclusion, on the basis of the results of this study, resources and protection facilities for unmarried pregnant women could be improved through government policies and health care policies that would allow unmarried women to utilize significant social support resources and actualize health pro-motion lifestyles. Nursing should offer interventions to increase psychosocial adjustment and support tp improve the quality of life for unmarried pregnant women and further to promote improved growth and development of the infants.

• Environmental Analysis Health and Toxicology
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• 제31권
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• pp.22.1-22.7
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• 2016

Objectives This study analyzed the associations between mobile phone call frequency and duration with non-specific symptoms. Methods This study was conducted with a population group including 532 non-patient adults established by the Korean Genome and Epidemiology Study. The pattern of phone call using a mobile phone was investigated through face-to-face interview. Structured methods applied to quantitatively assess health effects are Headache Impact Test-6 (HIT-6), Psychosocial Well-being Index-Short Form, Beck Depression Inventory, Korean-Instrumental Activities of Daily Living, Perceived Stress Scale (PSS), Pittsburgh Sleep Quality Index, and 12-item Short Form Health Survey where a higher score represents a higher greater health effect. Results The average daily phone call frequency showed a significant correlation with the PSS score in female subjects. Increases in the average duration of one phone call were significantly correlated with increases in the severity of headaches in both sexes. The mean (standard deviation) HIT-6 score in the subgroup of subjects whose average duration of one phone call was five minutes or longer was 45.98 (8.15), as compared with 42.48 (7.20) in those whose average duration of one phone call was <5 minutes. The severity of headaches was divided into three levels according to the HIT-6 score (little or no impact/moderate impact/substantial or severe impact), and a logistic regression analysis was performed to investigate the association between an increased phone call duration and the headache severity. When the average duration of one phone call was five minutes or longer, the odds ratio (ORs) and the 95% confidence intervals (CIs) for the moderate impact group were 2.22 and 1.18 to 4.19, respectively. The OR and 95% CI for the substantial or severe impact group were 4.44 and 2.11 to 8.90, respectively. Conclusions Mobile phone call duration was not significantly associated with stress, sleep, cognitive function, or depression, but was associated with the severity of headaches.

• 한국콘텐츠학회논문지
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• 제16권8호
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• pp.580-591
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• 2016

본 문헌분석 연구는 국내에서 최근 11년간 발표된 대학신입생의 학교적응 관련 문헌을 분석한 연구로, 대학신입생의 학교적응 요인을 파악하고 이에 대한 학교적응 방안과 대학 교육 프로그램 개선의 방향을 제공하고자 시도되었다. 본 문헌분석은 3개의 데이터베이스 국회도서관 자료실, 학술연구정보서비스(RISS), 한국학술정보(KISS)를 통하여 문헌 탐색기준에 의해 선택하였으며, 최종 24개의 연구가 선택되었다. 이 중 20편은 상관관계연구, 4편은 실험연구이었다. 대학신입생 학교적응 연구는 2009년부터 매년 1편씩 연구되다가 2012년부터 매년 5-6편으로 증가되어 대학 신입생의 적응에 대해 관심이 증가함을 볼 수 있다. 이 24개 문헌들에서 이용한 학교적응 조사도구는 Baker와 Siryk(1984)가 만든 도구를 23편에서 이용되었다. 분석된 상관관계 연구에서의 대학신입생 학교적응 평균은 3.25점으로 나타났다. 대학신입생의 학교적응과 관련된 변수는 20개 정도로 조사되었으며, 그 중 자기존중감, 자기효능감, 스트레스는 학교적응에 중요한 변수로 나타났다. 또한 대학신입생의 학교적응과 관련된 일반적 특성 중 외향적 성격, 가족과 사는 경우, 나이가 많은 경우, 학과에 만족한 경우, 학교생활에 만족한 경우 학교적응이 높게 나타났다. 이에 대학에서는 신입생 적응 프로그램을 계획할 때 자기효능감 증진방안, 스트레스 관리, 대학신입생을 위한 멘토-멘티 프로그램, 신입생 적응 프로그램 등을 학교와 학과에 맞게 지속적으로 진행할 것을 제언한다.

• 대한간호학회지
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• 제25권1호
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• pp.45-60
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• 1995

This study investigated the effects of education program conducted through individual home visit by CHPs, which was developed ,by the operational re-search technique for families of dementia patients. (Yeo Shin Hong et at,1994) The study was conducted in the form of a primary experimental design with 43 people as subjects, including dementia patients and family member in several Myon areas of Chungcheong Namdo between June 10 and August 20, 1994. The data was collected by questionnaires through the home visit by the CHPs. The results of study are as follows. 1. There is no difference in the quality of life between before and after the education program. 2. Role stress 'before the education program' was significantly different than 'after the education program'. 3. There was no difference in the feeling of burden between before and after the education program. 4. There was a significant difference in the abnormal behaviors of patients between before and after the education program. 5. The knowledge of dementia by the patient's family increased significantly after the education program, compared to that of 'before the education program'. 6. There was a significant difference in the attitude of family members toward the education program on dementia between before and after the education program. 7. The results of analysis on the coefficient relationship of various variables showed that the age of patients and family members have a significant correlation with role stress(p=.01). 8. In the subjective evaluation of family members on changes in actual nursing actions and the improvement of knowledge and technique in terms of daily living, (including abnormal behavior of patients, adjustment of environment for patients, activity programs for patients, communication technique with patients, ensuring the safety of patients, clothing, meals and elimination, 60-65% of family members responded that their knowledge had increased. As for improvement in techniques for each item, the technique for communication with patients showed the greatest improvement while the action program method for patients showed the least change. As for the nursing service provided to patients, most respondents showed a positive change. The specific items for which more than 80% respondents answered positively were as follows : recognizing the demand of patients, getting patients to do simple house works, talking softly and gently, removing dangerous things, preparing comfortable clothes that are easy to put on and take off, and limiting water consumption at night. As a result of study, the following suggestions can be made. The purpose of the study was to examine the effect of an education program developed and applied for dementia patients and family members in the community. This needs to be compared with a similar study conducted in the urban setting. In addition, a community service program (ex : nursing hem and shelter) including the application of the education program should be developed and the study done to investigate its effect.

• 콘크리트학회논문집
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• 제16권5호
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• pp.581-589
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• 2004

본 논문에서는 일정진폭 휨인장 및 쪼갬인장 반복하중을 받는 콘크리트의 피로신뢰성과 모델제안을 위하여 도로포장에 사용되는 콘크리트를 대상으로 연구하였다. 실험데이터는 2-모수 Weibull 확률분포함수를 사용하여 신뢰성 해석을 수행하였고, 적합도 검정을 통하여 이를 기반으로 한 모델을 제시하였다. 피로실험은 $150 mm{\times}75 mm$ 시험체의 쪼갬인장피로 실험방법과 $150 mm{\times}150 mm{\times}550 mm$ 시험체의 휨인장피로 실험방법을 적용였으며 일정 진폭 피로하중에 대하여 수행하였다. 두 가지의 실험방법에 대하여 응력 수준 90, 80, $70\%$로 변화하여 실험하고 이때 적용한 응력비는 0.1, 하중재하속도 20Hz, 정현파(sine)를 적용하였다. 연구결과 콘크리트 피로데이터의 분산성으로 인하여 보다 정확한 해석을 위해 두 가지의 해석 기준을 설정하여 제시하였으며, 그래픽방법, 모멘트방법 및 최우도법에 의해 2-모수 Weibull의 매개변수 $\alpha$와 u를 계산하고 이를 이용하여 확률밀도함수(P.D.F)와 누적분포함수(C.D.F)를 도시하였다. 또한, Weibull의 확률분포함수를 이용한 신뢰성 해석은 Kolmogorov-Smirnov의 방법을 사용하여 $5\%$의 유의수준에서 적합도 검정을 수행한 결과 채택되는 것으로 나타났다. 이러한 해석에 기초하여 쪼갬인장피로실험과 휨인장피로 실험에 대한 피로모델을 제시하고 응력수준에 따른 피로수명과 200만회 및 1,000만회에서의 피로강도를 산정하여 제시하였으며 국외의 주요 피로모델과 비교하였다.