• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 1999년도 봄 학술발표회 논문집
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• pp.305-312
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• 1999

This study is intended to propose a systematic and practical life cycle cost(LCC) model for the development of the reliability-based seismic safety and cost-effective performance criteria for design and upgrading of long-span PC bridges. The LCC models consist of five cost functions such as initial cost, repair/replacement cost, human losses, road user cost, and indirect losses of regional economy. The proposed model Is successfully expressed in temrs of Park-Ang damage indices and life cycle damage probability obtained from SMART-DRAIN-2DX which is an existing algorithm for nonlinear time history analysis. The proposed LCC model is successfully applied to a viaduct constructed by PSM, in Seoul. Based on the observations, the proposed systematic procedure for the formulation of LCC model may be useful for the development of the reliability-based seismic safety and cost-effective performance criteria for design and upgrading of long-span PC bridges.

• 한국산업정보학회논문지
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• 제12권3호
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• pp.1-9
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• 2007

본 논문에서는 주화나 메달의 제조 공정에서 극인의 수명을 향상시키는 제조 조건에 대하여 연구하였다. 먼저, 경계요소법을 이용하여 응력의 주요 집중부를 찾아내어 실제 압인 실험에서 극인의 최초 균열 위치가 일치하는지를 검증하여 이를 금형의 수명을 측정하는 기준으로 사용하였다. 주화생산 조건의 요소 중, 완제품인 주화의 정해진 규격과 문양의 심도를 만족하는 범위 내에서 압인 공정의 주요 변수인 압인력과 칼라 및 소전의 크기 변화에 따른 금형의 수명을 비교하였다. 그 결과, 칼라와 소전의 직경을 조절하고 이 조건에 적합한 압인력을 사용하면 실험 대상 주화에서 극인의 수명이 최대 60% 증가하는 효과를 볼 수 있음을 보였다.

• Journal of Ginseng Research
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• 제42권3호
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• pp.343-351
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• 2018

Background: Red ginseng is a popularly used traditional medicine with antiaging effects in Asian countries. The present study aimed to explore the changes in protein expression underlying the mechanisms of life span extension and antiaging caused by red ginseng extract (RGE) in Drosophila melanogaster. Methods: A proteomic approach of two-dimensional polyacrylamide gel electrophoresis (2-DE) was used to identify the differential abundance of possible target proteins of RGE in D. melanogaster. The reliability of the 2-DE results was confirmed via Western blotting to measure the expression levels of selected proteins. Proteins altered at the expression level after RGE treatment (1 mg/mL) were identified by matrix-assisted laser desorption/ionization-time of flight tandem mass spectrometry and by searching against the National Center for Biotechnology nonredundant and Uniprot protein databases. The differentially expressed proteins were analyzed using bioinformatics methods. Results: The average survival life span of D. melanogaster was significantly extended by 12.60% with RGE treatment (1 mg/mL) compared to untreated flies. This followed increased superoxide dismutase level and decreased methane dicarboxylic aldehyde content. Based on the searching strategy, 23 differentially expressed proteins were identified (16 up-regulated and 7 down-regulated) in the RGE-treated D. melanogaster. Transduction pathways were identified using the Kyoto Encyclopedia of Genes and Genomes database, and included the hippo and oxidative phosphorylation pathways that play important roles in life span extension and antiaging process of D. melanogaster. Conclusion: Treatment with RGE in D. melanogaster demonstrated that mechanisms of life span extension and antiaging are regulated by multiple factors and complicated signal pathways.

• 생약학회지
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• 제39권4호
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• pp.310-315
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• 2008

Viscum album coloratum (Korean mistletoe; KM) is a semi-parasitic plant growing on various trees. This plant hasbeen shown to possess a variety of biological functions such as immunomodulation, apoptosis-induction and antitumor activity. However, there is no information about how the extract of KM affects life span of the host. In this study, in order to examine the effect of KM on the longevity of the host, we investigated whether a Korean mistletoe extract (KME) was able to extend the life length in an experimental model using the spring silkworm moth of Bombyx mori (Lepidoptera bombycidae). We established a model test for survival in which all of the male and female moths died within 18 days after the beginning of the experiment. Mean survival time of female moths was longer than that of male moths. Both male and female moths fed with KME containing diet (200 or 400 ${\mu}g$/head/day) showed significantly higher mean survival times than those of the control moths. Studying the effect of KME on prolongation of mean survival time showed that male moths were more susceptible than female moths. The moths fed with KME-containing diet showed a slight decrease in body weight. Interestingly, however, no difference in food intake was observed between moths fed with KME-containing diet and those with control diet. In analysis for mRNA increase in the SIRT2 gene, a member of the Sir2 gene family playing important roles in regulation of cell death and prolongation of life span, moths fed with KME-containing diet showed a significant increase in SIRT2 gene expression. These results suggest that KME has a potential to extend the life span in Bombyx mori, and its effect is partly associated with increase in SIRT2 gene expression.

• 약학회지
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• 제45권6호
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• pp.641-649
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• 2001

In this study, the antitumor activities were investigated using $\beta$-lmmunan, a proteoglycan obtained from cultured mycelia of the IY009 strain of Ganoderma lucidum belonging to basidiomycetes. The result showed the significant effect of cytotoxicity test against murine sarcoma 180 and murine lymphocytic leukemia L1210 using immunized macrophage cultures by $\beta$-lmmunan. When intraperitoneally injected at 40 mg/kg/day daily for 10 days, $\beta$-lmmunan inhibited the growth of sarcoma 180 solid tumor in ICR mice by 88.8% (p<0.05). It was also observed that $\beta$-lmmunan increased life span by 85.2% (p<0.01) after treatment of 100 mg/kg/day in BDF1 mice bearing lymphocytic leukemia L1210. And combination therapy with cisplatin (dosage: 4 mg/kg) increased life span by 140.4% (p<0.05) after treatment of 100 mg/kg/day daily in BDF1 mice bearing lymphocytic leukemia L1210.

• 한국가정과교육학회지
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• 제24권3호
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• pp.123-142
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• 2012

본 연구에서는 가정교과에서 진로교육은 어떻게 자리매김 되어 왔으며, "진로와 직업" 과목과의 공통점과 상이점의 검토를 통해, 가정교과에서 진로교육의 정체성을 밝히고, 이러한 특성을 살릴 수 있는 대안적 진로교육 교수 학습 전략을 탐색하였다. 이를 위해 2007 및 2009 개정 실과(기술 가정) 교육과정, 2007 개정 교육과정에 기초해 집필된 중학교 1-3학년 가정과 교과서 각각 7권씩 21권과 진로와 직업 교과서 1권을 분석했다. 연구결과는 다음과 같다. 첫째, 가정과 교육과정과 가정과 관련 학회지를 분석한 결과, 가정과에서의 진로교육은 가정교과의 중요한 한 영역으로서 자리매김 되고 있었다. 둘째, 가정교과와 "진로와 직업" 과목에서 다루는 진로교육의 내용은 자신의 이해, 진로탐색, 진로의사결정, 진로계획 수립 및 진로라는 내용을 다루고 있는 점에서는 공통점을 가지고 있으나, 교육내용을 다루는 관점과 구체적 내용에서는 차이를 보이고 있었다. 즉, "진로와 직업" 과목에서는 '직업과 연계된' 진로(vacational career) 개념의 진로교육에 초점을 맞추고 있는 반면, 가정교과에서는 가정생활, 직업생활, 지역생활을 고려하면서, 직업에 한정하지 않고 '생활과 연계된' 진로(life career) 개념의 진로교육에 초점을 맞추고 있었다. 셋째, 파악된 가정교과에서의 진로교육의 정체성을 살린 대안적 교수 학습 전략을 제안했다.

• 한국산학기술학회논문지
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• 제9권2호
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• pp.281-285
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• 2008

냉간단조금형(Cold Forging Die)의 다이블록(Dieblock)을 제작하는 방법 중의 하나로, 다이블록 제작용 재료를 면가공 하여 다이블록 상면(上面)을 마스터펀치(Master Punch)인 호브(Hob)로 압입(Indentation) 시켜 절삭가공((Cutting Work)이 아닌 다이호빙(Die Hobbing) 방법으로 임프레션(Impression)을 성형하여 제작하고 있다. 이 방법에 의하여 다이블록의 재료를 합금공구강(Alloy Tool Steel)인 SKD11을 사용하여 제작하고, 스테인리스판(Stainless Sheet Metal)을 제품 재료로 하여 냉간단조가공(Cold Forging Work)을 수행하였더니 6,000 스트로크(Stroke)에서 금형수명(Die Life)을 다 하고 파손되었다. 본 논문에서는 다이블록 재료를 고속도공구강(High Speed Tool Steel)인 SKH51로 교체 제작하고, 탄소강(Carbon Steel)인 S45C를 제품 재료로 하여 냉간단조가공을 수행하였더니 21,000 스트로크에서 금형수명을 다하고 파손되어 종래의 방법과 비교 검토하였을 때 350%의 금형수명 연장 효과를 얻게 되었다.

• Molecules and Cells
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• 제37권1호
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• pp.51-57
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• 2014

NOG1 is a nucleolar GTPase that is critical for 60S ribosome biogenesis. Recently, NOG1 was identified as one of the downstream regulators of target of rapamycin (TOR) in yeast. It is reported that TOR is involved in regulating lifespan and fat storage in Caenorhabditis elegans. Here, we show that the nog1 ortholog (T07A9.9: nog-1) in C. elegans regulates growth, development, lifespan, and fat metabolism. A green fluorescence protein (GFP) promoter assay revealed ubiquitous expression of C. elegans nog-1 from the early embryonic to the adult stage. Furthermore, the GFP-tagged NOG-1 protein is localized to the nucleus, whereas the aberrant NOG-1 protein is concentrated in the nucleolus. Functional studies of NOG-1 in C. elegans further revealed that nog-1 knockdown resulted in smaller broodsize, slower growth, increased life span, and more fat storage. Moreover, nog-1 over-expression resulted in decreased life span. Taken together, our data suggest that nog-1 in C. elegans may be an important player in regulating life span and fat storage via the insulin/IGF pathway.

• 한국신뢰성학회지:신뢰성응용연구
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• 제10권4호
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• pp.213-235
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• 2010

In this paper, we carried out an accelerated degradation test that is commonly used to predict characteristics life of rubber gaskets for a pole transformer. The potential failure mode applied for the test is rubber elongation and the corresponding failure mechanism is heat. From the result, we found that Weibull distribution is the fatigue life distribution in NBR and H-NBR. After estimating characteristics life in commonly used temperature, the average life span of $B_{50}$ in NBR is 7.7 years under $50^{\circ}C$ and the life span in H-NBR is 28 years.

• Structural Engineering and Mechanics
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• 제85권4호
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• pp.461-468
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• 2023

Edible coatings are one of the most innovative methods to preserve the quality and increase the shelf life of fresh fruits and vegetables. A successful edible coating should have a barrier against gases, especially oxygen and water vapor, and have good surface characteristics. Today, chitosan coating is widely used due to its properties, such as non-toxic, biodegradable, and biocompatibility. Is. Coating the surface of fruits and vegetables with chitosan increases shelf life due to reducing weight loss and reducing respiration rate and also reduces decay due to its antimicrobial and anti-fungal effect. This work discusses the effect of using chitosan coating containing chamomile extract to increase fresh vegetables'shelf life. In addition to increasing the shelf life of vegetables, this method can be used as a solution for the economic management of human resources. The results of this method confirm the successful synthesis of these nanoparticles, and the results of applying this food coating on vegetables have been successful. They have increased the shelf life of vegetables such as basil and spinach.