• Structural Engineering and Mechanics
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• v.74 no.2
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• pp.157-173
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• 2020

In the finite element modelling of long-span cable-stayed bridges, there are a lot of uncertainties brought about by the complex structural configuration, material behaviour, boundary conditions, structural connections, etc. In order to reduce the discrepancies between the theoretical finite element model and the actual static and dynamic behaviour, updating is indispensable after establishment of the finite element model to provide a reliable baseline version for further analysis. Traditional sensitivity-based updating methods cannot support updating based on static and dynamic measurement data at the same time. The finite element model is required in every optimization iteration which limits the efficiency greatly. A convenient but accurate Kriging surrogate model for updating of the finite element model of cable-stayed bridge is proposed. First, a simple cable-stayed bridge is used to verify the method and the updating results of Kriging model are compared with those using the response surface model. Results show that Kriging model has higher accuracy than the response surface model. Then the method is utilized to update the model of a long-span cable-stayed bridge in Hong Kong. The natural frequencies are extracted using various methods from the ambient data collected by the Wind and Structural Health Monitoring System installed on the bridge. The maximum deflection records at two specific locations in the load test form the updating objective function. Finally, the fatigue lives of the structure at two cross sections are calculated with the finite element models before and after updating considering the mean stress effect. Results are compared with those calculated from the strain gauge data for verification.

• Journal of the Korean housing association
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• v.26 no.6
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• pp.139-146
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• 2015

In this study, the plane type of main building relics of unified Silla period house site which excavated in Gyeongju city after 1990s was classified and the architectural characteristic of them was investigated. The chronology of building relics in Silla capital city site was mostly known as 8-9th century, and by standard of column arrangement, the plane types of them could be classified as grid type, front veranda-grid type, outer column type. The outstanding characteristic of plane is wide span and open front veranda. In most relics the span were over 4 meters, and inner foundations for small post and strip foundation were found between columns. The front veranda added type buildings were composited of enclosed main room and open front veranda, and column arrangement of them dose not fall into line in most case. Thus it thought that the structures of enclosed main room and open front veranda were independent. The interior space of enclosed main room were divided two rooms by partition wall in some case. In this case, one room is enclosed by wall, and the other room has open front side. This plane is considered for the pleasant life in cold winter and hot summer.

• Journal of KSNVE
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• v.5 no.1
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• pp.95-106
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• 1995

Flow-induced vibration in heat exchanger (or fuel rod) in nuclar power plant can cause dynamic interactions between tubes and tube supports resulting in fretting-wear. To increase the reliability and design life of heat exchanger components, design criteria that establish acceptable limits of vibration and minimize fretting wear are necessary. The fretting-wear rate is dependent upon material combination, contact configuration, environmental conditions and tube-to tube support dynamic interaction. It is demostrated that the fretting -wear rate correlates well with tube-to-support contact force or work rate. The tube-to-support dynamic interaction, which consists of dynamic contact forces and tube motion, is used to relate single-span wear data to real heat exchanger configurations consisting of multi-span tube bundles. This paper describes the test facility to measure tube-to-support dynamic impact force and reports its dynamic characteristics through the four impact tests - a force transduces independent and external impact tests, central ring inside impact test and additional cylinder impact test. Through the tests the impact parameter change dependent upon the material difference of impacting ball is studied, and the impact parameters of Force Transducer Assembly components are measured. And also the dynamic behavior of Force Transducer Assembly is analyzed. The force measurement technique herein is shown to provide a reasonable measure of dynamic contact forces.

• Structural Engineering and Mechanics
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• v.53 no.6
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• pp.1105-1126
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• 2015

Many vibrating mechanical systems from the real life are modeled as combined dynamical systems consisting of beams to which spring-mass secondary systems are attached. In most of the publications on this topic, masses of the helical springs are neglected. In a paper (Cha et al. 2008) published recently, the eigencharacteristics of an arbitrary supported Bernoulli-Euler beam with multiple in-span helical spring-mass systems were determined via the solution of the established eigenvalue problem, where the springs were modeled as axially vibrating rods. In the present article, the authors used the assumed modes method in the usual sense and obtained the equations of motion from Lagrange Equations and arrived at a generalized eigenvalue problem after applying a Galerkin procedure. The aim of the present paper is simply to show that one can arrive at the corresponding generalized eigenvalue problem by following a quite different way, namely, by using the so-called "characteristic force" method. Further, parametric investigations are carried out for two representative types of supporting conditions of the bending beam.

• Advances in Traditional Medicine
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• v.5 no.4
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• pp.322-330
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• 2005

The plant Bryonia laciniosa (Family: Cucurbitaceae) has been indicated for the treatment of various diseases one among which is cancer. The purpose of this study was investigating experimentally the possible anti-tumor effect and antioxidant role of Bryonia laciniosa leaves in animal model. The methanol extract of Bryonia laciniosa (MEBL) administered at the doses of 62.5, 125 and 250 mg/kg in mice for 14 days after 24 h of tumor inoculation. The effect of MEBL on the growth of transplantable murine tumor, life span of EAC bearing mice, hematological profile and liver biochemical parameters (lipid peroxidation, antioxidant enzymes) were estimated. Treatment with MEBL decreased the tumor volume and viable cell count thereby increasing the life span of EAC bearing mice and brought back the hematological parameter more or less normal level. The effect of MEBL also decreases the levels of lipid peroxidation and increased the levels of glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT). The present work indicates that the methanol extract of Bryonia laciniosa exhibited significant antitumor and antioxidant activity in vivo.

• Journal of Nutrition and Health
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• v.36 no.4
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• pp.368-375
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• 2003

Cancer cachexia, characterized by weight loss and progressive tissue wasting, has been postulated to be mediated by cytokines. This study was conducted to evaluate the effect of Korean Traditional Medicine (KTM ; mokhyang, jisil, osooyu) mixture on food intake, blood cytokines level and blood nutrients status of the cachexia induced-mice. Thirty male Balb/c mice aged 6-8 weets were blocked into 3 groups that were Normal (no colon26 cells) Control (colon 26 cells) and KTM (colon26 cells + KTM extract mixture) group. In Control and KTM groups, murine adenocarcinoma colon 26 cells were injected subcutaneously to induce cachexia. KTM mice were given 200 ul KTM extract mixture (7%) per day. Half of each groups were sacrificed at the 14 th day to see serum cytokines & nutrients and the others were fed until almost of control group died to see life span. food intake and body weight were decreased significantly in cachexia induced groups. Tumor weight of KTM group was significantly lower than control group. Serum cytokines (IL-1$\beta$ and TNF-$\alpha$) level of cachexia induced groups were increased than those of normal group, and those of KTM group were significantly lower than the level of control group. Total serum protein and serum albumin were higher in KTM group than other groups. TG and fatty acid were lower in cachexia induced groups than normal group. HDL-cholesterol in serum was increased in KTM group. Effect of oral administration of KTM extract mixture on survival time of colon26 bearing mice showed extension of the life span. Overall, this study showed that KTM (mokhyang, jisil, osooyu) extract mixture inhibited the growth of cancer cell, changed the secretion of cytokines induced by colon26 adenocarcinoma in mice, and changed nutrition metabolism.

• The Korean Journal of Pharmacology
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• v.26 no.1
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• pp.91-100
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• 1990

The benzylacycoluridines (BAU and BBAU) are potent and specific inhibitors of uridine phosphorylase (UrdPase). In contrast to the report that benzylacyclouridines potentiated 5-fluoro-2'-deoxyuridine (FdUrd) cytotoxicity against human solid tumor cells (Cancer Res., 44:1852, 1984), continuous exposure of mouse lymphoma L5178Y cells, to FdURd, 5-fluorouridine (FUrd), 5'-deoxy-5-fluorouridine (5'-dFUrd), or 5-fluorouracil (FUra) showed no potentiation of cytotoxicity by benzylacyclouridines. In fact, under the conditions employed, benzylacycoluridines protected the cells from the cytotoxicity of FdUrd, FUrd, or 5'-dFUrd, but not FUra in a dose dependent manner. Intraperitoneal coadministration of BAU or BBAU and a 5-fluorinated pyrimidine (i.e., FdUrd, FUrd, or FUra), to mice bearing L5178Y cells also did not significantly increase the life span compared to those treated with the antimetabolites alone. Anabolism of these nucleosides through the sequential action of UrdPase and orotate phosphoribosyltransferase (OPRTase), inhibition of nucleoside transport by benzylacyclouridines, or both could be responsible for the ineffectiveness of UrdPase inhibitors to potentiate the antineoplastic activity of fluoropvrimidines in L5178Y cells.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.6
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• pp.2292-2299
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• 2010

The wear and abrasion mechanism of conventional PET/Cotton fabric which is used as a lining layer for thermotherapy massager was elaborately investigated in order to increase the life-span of the fabrics for Thermotherapy Massager. Based on the destruction mechanism, the feasible PET fabrics were prepared and its anti-wearing performance was evaluated. It is revealed that the wearing destruction is mainly caused by the repeat abrasion on a specific part of folded fabric as well as abrasion itself. Therefore, it is necessary that the prevention of fabric folding while massager is running is essential and the recovery from the crease on a fabric is also necessary to solve this problem. Covered elastic yarn, high twisted yarn, change of fabric structure or different fiber were utilized to prepare the possible alternatives. As a result, the anti-wearing performance of the fabrics are greatly improved to have about 2 times and 1.5 times longer life-span for the fabric with covered elastic yarn and high twisted yarn, respectively.

• YAKHAK HOEJI
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• v.38 no.2
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• pp.166-173
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• 1994

Sex hormones not only regulate external sexual characteristics but several internal biochemical processes. It is well accepted that life-span of female is longer than that of male. Life-span is closely related with aging process in which free radicals are known to be involved. We investigated the effect of testosterone on free radical generating systems and lipid peroxidation based on the sexual difference. Lipid peroxide levels of male and female mouse were increased proportionately with age, especially in male mouse. Increase in enzyme activity of aldehyde oxidase with age was observed in male mouse, while no siginificant change in enzyme activity was found in female mouse. Enzyme activity of xanthine oxidase also showed similar results. It, however, was not significant statistically. Lipid peroxide level and xanthine oxidase type conversion ratio of male and female mouse liver homogenate incubated at $37^{\circ}C$, increased remarkably in proportion to incubation time, especially in male mouse. Lipid peroxide level and aldehyde oxidase activity were measured in normal male mouse, castrated mouse and testosterone treated-castrated mouse. Castrated mouse group showed decrease in lipid peroxide level and aldehyde oxidase activity compared with normal group. Treatment of castrated mouse with testosterone, however turned the level of lipid peroxide and aldehyde oxidase activity back to normal. From the above results, it might be concluded that testosteron could increase the activities of free radical generating enzymes which would result in the formation of lipid peroxide, consequently leading to aging.

• YAKHAK HOEJI
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• v.38 no.3
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• pp.311-321
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• 1994

Anticancer effects of Aloe on sarcoma 180 in ICR mouse or human cancer cells were determined. Sarcoma 180 cells were inoculated subcutaneously into male ICR mouse to determine effect of Aloe on tumor gowth, or inoculated intraperitoneally into male ICR mouse to determine effect of Aloe on life span prolongation, followed by oral administration of Aloe vera(10 mg/kg/day, 50 mg/kg/day) or Aloe arborescens(10 mg/kg/day, 100 mg/kg/day) once a day for 14 days. The administration of Aloe vera or Aloe arborescens did not suppress tumor growh. However the life span of ICR mouse was prolonged to 19%(p<0.05), 22%(p<0.05) and 32%(p<0.05) by administration of Aloe vera 10 mg/kg/day, Aloe vera 50 mg/kg/day, and Aloe arborescens 100 mg/kg/day, respectively. To determine anticancer effect of Aloe in vitro, Aloe extract was added to the culture of human gastric cancer cells(SNU-1) and colorectal cancer cells(SNU-C2A), and concentration of Aloe to inhibit cancer cell growth was determined using MTT(3-[ 4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) cytotoxicity assay. High $ID_{50}$ values of Aloe vera and Aloe arborescens against gastric cancer cell line(SNU-1) and colorectal cancer cell line(SNU-C2A) suggest that Aloe gel does not have anticancer effect on these specific human cancer cells although high concentration of Aloe inhibited growth of human cancer cells significantly.