• Journal of Families and Better Life
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• v.26 no.6
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• pp.51-69
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• 2008

The purpose of this study was to identify the level of awareness, uses, and satisfaction on home automation systems by the digital home residents, to reveal the existing problems using home automation systems, and to clarify residents' positive or negative life changes after using home automation systems. Two apartment complexes, which were relatively well equipped with home automation systems compared to other recently built apartments, were selected to perform the survey by digital home residents who were housewives and have lived in current home more than 6 months. The researcher developed a survey questionnaire for each apartment complex and collected data from 501 residents from May to June, 2008. The results of the study found low awareness and low uses of remote control systems of electric appliances through a cellular phone or PC from outside. Also, the significant variables which showed group differences in level of uses and satisfation were age, annual income, duration of residence, and level of considering home automation system before decision to move in. The results of the study also revealed that frequent breakdown was the most critical problem using home automation systems. Generally, using home automation systems affected to residents' life changes positively. More findings and suggestions for development of more user-friendly digital home services were discussed.

• Korean Journal of Human Ecology
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• v.14 no.5
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• pp.859-869
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• 2005

The purpose of this study was to research university students' awareness of gender equality and practice of clothing and textiles education contents(classifying them into four units; choice and dressing of clothes, textile and management of clothes, design and sewing of clothes, and knitting and embroidery) in their real life. This is the investigation of 344 university students living in Choongchungnam bukdo, Junrabukdo, and Daejeon. In this statistical analysis, SPSS 10.0 for Windows Program was utilized to calculate percentage, mean and standard deviation. Also, these data were verified by t-test, One-way Anova, Duncan's multiple range, Pearson's correlation coefficient. The results of this research were as follows: The more university students have awareness of gender equality, the more they have practice of clothing and textiles education content in their real life. There was a significant difference in practical awareness of contents of clothing and textiles education according to demographic variables and correlation of variables differed significantly. As a conclusion, university students' awareness of gender equality plays an important role in practice of clothing and textiles education contents in their real life. These results would provide fundamental information for improving students' critical practice.

• The Journal of Korean Academic Society of Nursing Education
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• v.24 no.1
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• pp.50-60
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• 2018

Purpose: This study aims to determine the bioethical subjectivity of nursing students with experience volunteering in elderly care facilities, and the characteristics that comprise the types thereof. Methods: Q methodology, which analyzes the subjectivity of each type, was used. The 37 selected Q statements from 32 participants were classified into the shape of a normal distribution using a 9-point scale. The collected data were analyzed using the PC-QUANL program. Results: The survey revealed that the bioethical subjectivity of nursing students with experience volunteering in elderly care facilities can be divided into three types: a rational dignity emphasis, an autonomous right to life belief, and conflict avoidance. All three attitudes regard human beings as possessing dignity, and life and death as elements to be experienced as aspects of human life. Bioethical values are critical to treatment and care; however, it is sometimes also held that humans have the right to commit suicide. Conclusion: This study enhanced our awareness of nursing students' bioethics. The findings can be used as a basis for the design of differentiated bioethics education according to each type of bioethical subjectivity. This calls for diverse research on bioethics and the implementation of effective bioethics education.

• Korean Journal of Health Education and Promotion
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• v.32 no.3
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• pp.97-107
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• 2015

Objectives: The current study aims to examine whether the influence of National Long-term Care Insurance(NLCI) on the quality of life(QoL) trajectory of older adults with disabilities is more positive than its influence on those without disabilities. Methods: Sample consisted of 5,362 elderly aged 65 and over who participated in the Korean Welfare Panel Study from Wave1 to Wave7. Data were analyzed using latent growth curve modeling. Results: Major findings are as follows. (1) Before the NLCI, the trajectories of QoL between older adults with disabilities and those without were same. (2) After the NLCI, elders with disabilities showed lower levels of QoL at the beginning, but the gaps gradually decreased with time. These results indicate that the implementation of NLCI more positively affected elders with disabilities than those without disabilities. Conclusions: These results suggest that the NLCI functions properly as one of social security nets to cope with the needs of older adults with disabilities. In conclusion, it is critical to develop a sustainable NLCI system to enhance the QoL of older adults with disabilities.

• BMB Reports
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• v.48 no.7
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• pp.367-368
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• 2015

It has long been thought that glucocorticoid receptor (GR) functions as a DNA-binding transcription factor in response to its ligand (a glucocorticoid) and thus regulates various cellular and physiological processes. It is also known that GR can bind not only to DNA but also to mRNA; this observation points to the possible role of GR in mRNA metabolism. Recent data revealed a molecular mechanism by which binding of GR to target mRNA elicits rapid mRNA degradation. GR binds to specific RNA sequences regardless of the presence of a ligand. In the presence of a ligand, however, the mRNA-associated GR can recruit PNRC2 and UPF1, both of which are specific factors involved in nonsense-mediated mRNA decay (NMD). PNRC2 then recruits the decapping complex, consequently promoting mRNA degradation. This mode of mRNA decay is termed "GR-mediated mRNA decay" (GMD). Further research demonstrated that GMD plays a critical role in chemotaxis of immune cells by targeting CCL2 mRNA. All these observations provide molecular insights into a previously unappreciated function of GR in posttranscriptional regulation of gene expression. [BMB Reports 2015; 48(7): 367-368]

• Child Health Nursing Research
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• v.25 no.1
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• pp.38-47
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• 2019

Purpose: The purpose of this study was to investigate the influence of perceptions of death, end-of-life (EOL) care stress, and emotional intelligence on attitudes toward EOL care among nurses in the neonatal intensive care unit (NICU). Methods: The participants were 111 nurses working in a NICU who had experienced EOL care at least once. Data were analyzed using the t-test, Pearson correlation coefficient, and stepwise multiple regression analysis in SPSS for Windows. Results: The mean score for perceptions of death was 3.16 out of 5, the mean score for EOL care stress was 3.61 out of 5, the mean emotional intelligence score was 4.66 out of 7, and the average score for EOL care attitudes was 2.77 out of 4. The factors affecting attitudes towards EOL care were academic degree, anxiety regarding death, negativity towards death, experiences of patient death, and emotional intelligence. The explanatory power of these variables for attitudes towards EOL care was 24.7%. Conclusion: The results of this study are expected to serve as a basic reference for the development of nursing education programs and EOL care protocols to improve attitudes toward EOL care among NICU nurses.

• Genomics & Informatics
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• v.21 no.3
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• pp.41.1-41.11
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• 2023

The Dengue virus M protein is a 75 amino acid polypeptide with two helical transmembranes (TM). The TM domain oligomerizes to form an ion channel, facilitating viral release from the host cells. The M protein has a critical role in the virus entry and life cycle, making it a potent drug target. The oligomerization of the monomeric protein was studied using ab initio modeling and molecular dynamics simulation in an implicit membrane environment. The representative structures obtained showed pentamer as the most stable oligomeric state, resembling an ion channel. Glutamic acid, threonine, serine, tryptophan, alanine, isoleucine form the pore-lining residues of the pentameric channel, conferring an overall negative charge to the channel with approximate length of 51.9 Å. Residue interaction analysis for M protein shows that Ala94, Leu95, Ser112, Glu124, and Phe155 are the central hub residues representing the physicochemical interactions between domains. The virtual screening with 165 different ion channel inhibitors from the ion channel library shows monovalent ion channel blockers, namely lumacaftor, glipizide, gliquidone, glisoxepide, and azelnidipine to be the inhibitors with high docking scores. Understanding the three-dimensional structure of M protein will help design therapeutics and vaccines for Dengue infection.

• Journal of Wind Energy
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• v.14 no.3
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• pp.34-42
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• 2023

The reduction of operation and maintenance (O&M) costs is a critical factor in determining the competitiveness of wind energy. Predictive maintenance based on the estimation of remaining useful life (RUL) is a key technology to reduce logistic costs and increase the availability of wind turbines. Although a mechanical component usually has sudden changes during operation, most RUL estimation methods use the trend of a state index over the whole operation period. Therefore, overestimation of RUL causes confusion in O&M plans and reduces the effect of predictive maintenance. In this paper, two RUL estimation methods (load based and data driven) are proposed for the bearings of a wind turbine with the results of trend classification, which differentiates constant and increasing states of the state index. The proposed estimation method is applied to a bearing degradation test, which shows a conservative estimation of RUL.

• BMB Reports
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• v.57 no.3
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• pp.161-166
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• 2024

Aberrant DNA methylation plays a critical role in the development and progression of colorectal cancer (CRC), which has high incidence and mortality rates in Korea. Various CRC-associated methylation markers for cancer diagnosis and prognosis have been developed; however, they have not been validated for Korean patients owing to the lack of comprehensive clinical and methylome data. Here, we obtained reliable methylation profiles for 228 tumor, 103 adjacent normal, and two unmatched normal colon tissues from Korean patients with CRC using an Illumina Infinium EPIC array; the data were corrected for biological and experiment biases. A comparative methylome analysis confirmed the previous findings that hypermethylated positions in the tumor were highly enriched in CpG island and promoter, 5' untranslated, and first exon regions. However, hypomethylated positions were enriched in the open-sea regions considerably distant from CpG islands. After applying a CpG island methylator phenotype (CIMP) to the methylome data of tumor samples to stratify the CRC patients, we consolidated the previously established clinicopathological findings that the tumors with high CIMP signatures were significantly enriched in the right colon. The results showed a higher prevalence of microsatellite instability status and MLH1 methylation in tumors with high CMP signatures than in those with low or non-CIMP signatures. Therefore, our methylome analysis and dataset provide insights into applying CRC-associated methylation markers for Korean patients regarding cancer diagnosis and prognosis.

• BMB Reports
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• v.51 no.7
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• pp.350-355
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• 2018

HnRNPK is a multifunctional protein that participates in chromatin remodeling, transcription, RNA splicing, mRNA stability and translation. Here, we uncovered the function of hnRNPK in regulating the proliferation and differentiation of myoblasts. hnRNPK was mutated in the C2C12 myoblast cell line using the CRISPR/Cas9 system. A decreased proliferation rate was observed in hnRNPK-mutated cells, suggesting an impaired proliferation phenotype. Furthermore, increased G2/M phase, decreased S phase and increased sub-G1 phase cells were detected in the hnRNPK-mutated cell lines. The expression analysis of key cell cycle regulators indicated mRNA of Cyclin A2 was significantly increased in the mutant myoblasts compared to the control cells, while Cyclin B1, Cdc25b and Cdc25c were decreased sharply. In addition to the myoblast proliferation defect, the mutant cells exhibited defect in myotube formation. The myotube formation marker, myosin heavy chain (MHC), was decreased sharply in hnRNPK-mutated cells compared to control myoblasts during differentiation. The deficiency in hnRNPK also resulted in the repression of Myog expression, a key myogenic regulator during differentiation. Together, our data demonstrate that hnRNPK is required for myoblast proliferation and differentiation and may be an essential regulator of myoblast function.