• Journal of Welding and Joining
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• v.13 no.2
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• pp.12-24
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• 1995

Recently, more researches have been actively performed for the assessment of material degradation and residual-life of elevated temperature plant components, as some of domestic fossil power plants become older than 30 years. In this paper, results of on_site residual life assessment are reported for main steam pipes of Youngwol power station #2 which have operated since 1965. For critical weld locations such as butt welds branch welds, Y_sections and a T-section, replication technique and hardness measurement technique were employed for life_assessment. When cracks were detected by conventional NDT tests, crack growth life was calculated using a computer code. On the other hand, for matrix of pipes, residual life was quantitatively estimated by an analytic method and material degradation was estimated qualitatively using diameter measurement data and grain-boundary etching method. Also, direction in further improvement of on-site life assessment techniques are proposed.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.10
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• pp.5663-5669
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• 2013

The histone methyltransferase EZH2 (enhancer of zeste homolog 2) plays critical roles in prostate cancer (PCa) development and is a potential target for PCa treatment. Triptolide possesses anti-tumor activity, but it is unknown whether its therapeutic effect relates with EZH2 in PCa. Here we described EZH2 as a target for Triptolide in PCa cells. Our data showed that Triptolide suppressed PCa cell growth and reduced the expression of EZH2. Overexpression of EZH2 attenuated the Triptolide induced cell growth inhibition. Moreover, Triptolide treatment of PC-3 cells resulted in elevated mRNA levels of target genes (ADRB2, CDH1, CDKN2A and DAB2IP) negatively regulated by EZH2 as well as reduced mRNA levelsan of EZH2 positively regulated gene (cyclin D1). Our findings suggest the PCa cell growth inhibition mediated by Triptolide might be associated with downregulation of EZH2 expression and the subsequent modulation of target genes.

• Mycobiology
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• v.50 no.5
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• pp.366-373
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• 2022

Regulation of proper gene expression is important for cellular and organismal survival, maintenance, and growth. Abnormal gene expression, even for a single critical gene, can thwart cellular integrity and normal physiology to cause diseases, aging, and death. Therefore, gene expression profiling serves as a powerful tool to understand the pathology of diseases and to cure them. In this study, the difference in gene expression in Flammulina velutipes was compared between the wild type (WT) mushroom and the mutant one with clogging phenomenon. Differentially expressed transcripts were screened to identify the candidate genes responsible for the mutant phenotype using the DNA microarray analysis. A total of 88 genes including 60 upregulated and 28 downregulated genes were validated using the real-time quantitative PCR analysis. In addition, proteomic differences between the WT and mutant mushroom were analyzed using two-dimensional gel electrophoresis and matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF). Interestingly, the genes identified by these genomic and proteomic analyses were involved in stress response, translation, and energy/sugar metabolism, including HSP70, elongation factor 2, and pyruvate kinase. Together, our data suggest that the aberrant expression of these genes attributes to the mutant clogging phenotype. We propose that these genes can be targeted to foster normal growth in F. velutipes.

• Journal of the Korean Society for Railway
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• v.16 no.3
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• pp.163-168
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• 2013

The maintenance of an urban transit vehicle accounts for 60-70% of total costs over its entire life cycle, so it is critical to reduce maintenance costs and extend the life times of urban transit EMUs (electric multiple units) through research. For these researches, the reliability and availability data management system was constructed through the case study of several industries in the domestic and international in the field of reliability centered maintenance system. And we created a system to manage reliability and availability data for use in urban-EMU maintenance. In this work, we identified the major functions needed to successfully develop the system. Here we report the successful development of a reliability and availability data management system for maintenance of urban transit vehicles.

• Korean Journal of Computational Design and Engineering
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• v.13 no.5
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• pp.352-361
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• 2008

Architectural design work depends on information made from earlier phases such as feasibility study, planning, and conceptual design. This design guideline information includes design objectives, requirements, and constraints made by decision-making, and has great influence on various works of latter phases of design process. Despite of this cognition, however, the lack of design guideline information management still remains as one among the critical issues in design area. Design tools with design guideline information do not also address the issue of interoperability throughout the life-cycle of buildings. The purpose of this research is to propose a method for design guideline information management by using the IFC technology and IFC Property set (Pset) extension mechanism. The method comprises defining and mapping the practically used design guideline items and extensible IFC data model, and includes the management of relationships that exist between design guideline information and design model in the IFC data model.

• International Journal of Reliability and Applications
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• v.13 no.2
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• pp.57-69
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• 2012

Our goal in this paper is to establish inequalities for the moments of new better than used in the moment generating function class ($NBU_{mgf}$). Using these inequalities we propose a new test for exponentiality versus $NBU_{mgf}$ class. Pitman's asymptotic relative efficiency, power and critical values of this test are calculated to assess the performance of the test. We proposed also a new test for exponentiality versus $NBU_{mgf}$ in the right censored data. Sets of real data are used as an example to elucidate the use of the proposed test for practical problems.

• The Journal of Information Technology and Database
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• v.7 no.1
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• pp.1-15
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• 2000

A repository has been conceived as a critical weapon for managing organizational information resources. The system can help control the heterogeneous data in a variety of CASE (Computer-Aided Software Engineering) tools. However, current repository systems have limitation in creating a synergetic effect by integrating information resources. Therefore, it is important to develop an integrative repository system, called Enterprise Repository System (ERS). This paper (i) defines ERS on the basis of a framework for repository systems, and (ii) suggests an ERS architecture and its detailed components. Finally, a real-life case of developing ERP repository system is illustrated according to the proposed architecture and components. This illustration may demonstrate the usefulness of this research for help developing an advanced repository system.

• Development and Reproduction
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• v.27 no.1
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• pp.9-24
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• 2023

The advancement in high-throughput sequencing (HTS) technology has revolutionized the field of biology, including genomics, epigenomics, transcriptomics, and metagenomics. This technology has become a crucial tool in many areas of research, allowing scientists to generate vast amounts of genetic data at a much faster pace than traditional methods. With this increased speed and scale of data generation, researchers can now address critical questions and gain new insights into the inner workings of living organisms, as well as the underlying causes of various diseases. Although the first HTS technology have been introduced about two decades ago, it can still be challenging for those new to the field to understand and use effectively. This review aims to provide a comprehensive overview of commonly used HTS technologies these days and their applications in terms of genome sequencing, transcriptome, DNA methylation, DNA-protein interaction, chromatin accessibility, three-dimensional genome organization, and microbiome.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.14 no.4
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• pp.227-232
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• 2014

Recent development and generalization of Internet technology contributes to the large scale of commerce and capital followed by appearance and growth of large portal sites. As a result, the personal data on the Internet not deleted for a long period of time is a new risk factor, for example, the invasion of people's privacy. In particular, exposing personal data like witch-hunts is a critical issue so that the person concerned cannot carry on with normal life. This study suggests the necessity of the right to request personal data deletion related to a person concerned on Internet sites, a method of introducing the right in Korea, and a method of improving the application.

• Journal of Families and Better Life
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• v.26 no.6
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• pp.51-69
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• 2008

The purpose of this study was to identify the level of awareness, uses, and satisfaction on home automation systems by the digital home residents, to reveal the existing problems using home automation systems, and to clarify residents' positive or negative life changes after using home automation systems. Two apartment complexes, which were relatively well equipped with home automation systems compared to other recently built apartments, were selected to perform the survey by digital home residents who were housewives and have lived in current home more than 6 months. The researcher developed a survey questionnaire for each apartment complex and collected data from 501 residents from May to June, 2008. The results of the study found low awareness and low uses of remote control systems of electric appliances through a cellular phone or PC from outside. Also, the significant variables which showed group differences in level of uses and satisfation were age, annual income, duration of residence, and level of considering home automation system before decision to move in. The results of the study also revealed that frequent breakdown was the most critical problem using home automation systems. Generally, using home automation systems affected to residents' life changes positively. More findings and suggestions for development of more user-friendly digital home services were discussed.