• Molecules and Cells
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• v.43 no.9
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• pp.793-803
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• 2020

Myeloid-derived suppressor cells (MDSCs) promote tumour progression by contributing to angiogenesis, immunosuppression, and immunotherapy resistance. Although recent studies have shown that microRNAs (miRNAs) can promote the expansion of MDSCs in the tumour environment, the mechanisms involved in this process are largely unknown. Here, we report that microRNA 449c (miR-449c) expression was upregulated in myeloid progenitor cells upon activation of C-X-C motif chemokine receptor 2 (CXCR2) under tumour conditions. MiR-449c upregulation increased the generation of monocytic MDSCs (mo-MDSCs). The increased expression of miR-449c could target STAT6 mRNA in myeloid progenitor cells to shift the differentiation balance of myeloid progenitor cells and lead to an enhancement of the mo-MDSCs population in the tumour environment. Thus, our results demonstrate that the miR-449c/STAT6 axis is involved in the expansion of mo-MDSCs from myeloid progenitor cells upon activation of CXCR2, and thus, inhibition of miR-449c/STAT6 signalling may help to attenuate tumour progression.

• Proceedings of the KSR Conference
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• 2011.05a
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• pp.1248-1253
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• 2011

It is increasing construction of long span railway bridge with concrete track system for speed up of railway and efficient maintenance of track. As the sleeper of the concrete track system layed on a bridge is fixed on deck of the bridge, the displacement of the sleeper and deck is same. Therefore, the spacing between two sleeper installed at the end of the adjacent deck near the expansion joint of bridge becomes vary according to the longitudinal expansion of a deck by temperature change. By the way, if the spacing of sleepers become increase excessively, it causes large bending stress of in a rail, and it can leads failure or reduction of fatigue life of the rail. Further more, the excessive displacement of the rail may induce decrease ride comfort as well as corrugation of rail surface. Therefore, it is required to determine the allowable maximum sleeper spacing to prevent such problems. For the purpose, investigation on the influence factor on sleeper spacing for straight track was carried out. Variation of bending moment in a rail, wheel force, and the ratio of primary and secondary deflection of the rail according to sleeper spacing was investigated, and, as a result, the maximum allowable sleeper spacing at the bridge expansion joint was suggested.

• Journal of the Korean Society for Precision Engineering
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• v.26 no.5
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• pp.135-141
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• 2009

The bearing clearance is influenced by shrink fit and thermal expansion during operation. The designer must take into account the reduction of clearance after installation to the interference fits, and thermal expansion must be considered. The purpose of this study is to grasp the internal clearance variation and behavior of a bearing which is a deep connected with fatigue life of bearing and performance of spindle through FEM(Finite Element Method). Finite element analysis is performed by using commercial code ANSYS according to variation of thermal condition and rotational speeds. This paper presents correct negative internal clearance according to temperature during operation. Furthermore, interrelation between thermal expansion and contraction are presented to maintain adequate contact force for three type of spindle system (HSK-A60, HSK-40E, HSK-32E). The influence of the centrifugal force and Internal clearance variation of bearing is studied to operating rotational speed.

• Animal cells and systems
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• v.10 no.1
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• pp.27-40
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• 2006

Tree of heaven (Ailanthus altissima Swingle) as an invasive alien plant, appeared usually in the disturbed locations such as road-side, incised slope, and trampling path-side. They appeared abundantly in the trampling pathside but they did not appear or were rare in the interior of forest. Density and importance value of tree of heaven were proportionate to the relative light intensity measured according to distance from the trampling path toward forest interior and closely related to the breadth of trampling path as well. They were associated with annual, other exotic species or ruderal plants well. Distributional pattern of mature trees of them in the study area and its surrounding environments implied that they were introduced intentionally. Size class distribution of them showed that they are in expansion and artificial interferences such as, installing physical training space and developing hiking course functioned as trigger factors in their invasion and expansion. The results support the facts known generally in relation to invasion and expansion of the invasive alien plants. In this viewpoint, we suggest a management plan that applies ecological restoration principles to address ecosystems infected with tree of heaven by restoring the integral feature of the degraded nature and conserving the remained nature more thoroughly.

• Journal of Life Science
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• v.29 no.4
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• pp.447-454
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• 2019

Fat accumulation in adipocytes occurs through the process of adipogenesis in which preadipocytes differentiate into adipocytes. Obesity is a metabolic disorder caused by excessive accumulation of fat in the body, which increases the incidence of cardiovascular diseases, hypertension, type 2 diabetes, hyperlipidemia, and various cancers. Recently, inhibition of adipocyte differentiation was shown to be a potential antiobesity strategy. In this study, the inhibitory effect of dichloromethane fractions from Illicium verum Hooker fil. water extract on the differentiation of 3T3-L1 preadipocytes to adipocytes was investigated. Dichloromethane fractions from I. verum Hooker fil. significantly inhibited adipocyte differentiation when applied during the adipocyte differentiation process, as assessed by measuring fat accumulation using Oil-red O staining. In addition, dichloromethane fractions from I. verum Hooker fil. reduced important adipogenic transcription factors, such as CCAAT/enhancer binding protein ${\alpha}$ ($C/EBP{\alpha}$), $C/EBP{\beta}$, and peroxisome proliferator activated receptor ${\gamma}$ ($PPAR{\gamma}$). The expression of FAS and LPL, which are terminal differentiation markers of mature adipocytes, was also reduced in the 3T3-L1 adipocytes treated with dichloromethane fractions from I. verum Hooker fil. In addition, the treatment significantly inhibited mitotic clonal expansion, which is essential for adipocyte differentiation, by arresting the G1 phase of the cell cycle. Taken together, these results suggest that dichloromethane fractions from I. verum Hooker fil. may be a natural material with antiobesity effects.

• Journal of Korean Clinical Health Science
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• v.3 no.2
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• pp.320-327
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• 2015

Purpose. This study was conducted to provide basic data for decrease campus life stress investigated survey on the socio-demographic characteristic and campus life stress of the dental hygiene students. Methods. The research subjects are the total 220 and it was analyzed with structured questionnaires. The collected data was analyzed by IBM SPSS ver. 20.0, a statistical program (IBM Co., Armonk, NY, USA) for the frequency and percentage, ANOVA, Regression. The result is as following Results. The campus life stress was statistically significant differences by in case of poor family reason (${\beta}$=0.287), the fourth grader(${\beta}$=0.151), pocket money a month(${\beta}$=-0.136). Conclusions. As the results of the reasearch, it is necessary support and expansion plan with systemized cooperation between the government and school to state scholarship, living expenses and worker's scholarship for decrease the campus life stress.

• Journal of the Korea institute for structural maintenance and inspection
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• v.28 no.2
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• pp.1-8
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• 2024

The expansion joint is installed to offset the expansion of the superstructure and must ensure sufficient gap during its service life. In detailed guideline of safety inspection and precise safety diagnosis for bridge, damage due to lack or excessive gap is specified, but there are insufficient standards for determining the abnormal behavior of superstructures. In this study, a data-based maintenance was proposed by continuously monitoring the expansion-gap data of the same expansion joint. A total of 2,756 data were collected from 689 expansion joint, taking into account the effects of season. We have developed a method to evaluate changes in the expansion joint-gap that can analyze the thermal movement through four or more data at the same location, and classified the factors that affect the superstructure behavior and analyze the influence of each factor through deep learning and explainable artificial intelligence(AI). Abnormal behavior of the superstructure was classified into narrowing and functional failure through the expansion joint-gap evaluation graph. The influence factor analysis using deep learning and explainable AI is considered to be reliable because the results can be explained by the existing expansion gap calculation formula and bridge design.

• Proceedings of the Safety Management and Science Conference
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• 2001.05a
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• pp.211-215
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• 2001

In the last year, the number of registered vehicles in Korea surpassed the 12 million mark, and increase in number continuously Nowdays, this tendency has raised some problems inevitably in the view of expansion of ELV(end of life vehicle) and earth environment pollution resulted from it. For the proper scope with this environment pollution, recycling of parts and materials, minimization of wastes are desirable. And application of disassembly technology is required for it necessarily. Therefore it is essential to study systematically about disassembly technology of ELV with high efficiency for improvement recycling ratio and diminution shredder dust amount also in Korea.

• Proceedings of the Safety Management and Science Conference
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• 2005.11a
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• pp.411-417
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• 2005

In the last year, the number of registered vehicles in Korea surpassed the 15 million mark, and increase in number continuously. Nowdays, this tendency has raised some problems inevitably in the view of expansion of ELV(End of Life Vehicles) and earth environment pollution resulted from it. A foreign country is strengthening law about a car recycling for to solve this problem. Car recycling technology in Japan was introduced in this paper.

• International Journal of Advanced Culture Technology
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• v.9 no.1
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• pp.79-88
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• 2021

This study was a cross-sectional descriptive investigative study to analyze the effects of sub-factors of cognitive emotional control on life goals. The subjects of the study were 184 people in their 20s, and they were collected online from December 2020 to January 5, 2021 using structured cognitive control capabilities and life goal questionnaires. The collected data were performed using SPSS 18.0 for Frequency, Independent Sample t-test, Pearson correction analysis, Simple regression analysis, and Multiple regression analysis. According to the study, men had both life-oriented and achievement-oriented life goals higher than women. Among the sub-factors of cognitive emotional control (positive focus change, positive reassessment, expansion of view, re-accept plan, acceptance, rumination, self-criticism, others criticism, and destruction) were male and female were higher in self-criticism. Factors affecting life-oriented life goals have been shown to be expanding views, re-accepting plans, and criticizing others, while positive re-evaluation negatively affects achievement-oriented life goals. Based on these results, life-oriented life-goals tend to exhibit adaptive responses to expand views and revise plans and maladaptive responses to blame others, while achievement-oriented life-goals have the ability to positively reassess situations, modify plans and accept negative reactions.