• Journal of Plant Biotechnology
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• v.36 no.1
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• pp.53-58
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• 2009

Calcium signals can be transduced by binding calmodulin (CaM), a $Ca^{2+}$ sensor in eukaryotes, is known to be involved in the regulation of diverse cellular functions. We isolated a CaM-binding protein 63 kD (AtCBP63) from the pathogen-treated Arabidopsis cDNA expression library. Recently, AtCBP63 was identified as a CaM bining protein. The CaM binding domain of AtCBP63 was reported to be located in its N-terminal region, In this study, however, we showed that ACaM2 could specifically bind to second CaM-binding domain (CaMBD) of AtCBP63 at the C-terminal region. The specific binding of CaM to CaM binding domain was confirmed by a gel mobility shift assay, a split ubiquitin assay, site-directed mutagenesis, and a competition assay using a $Ca^{2+}$/CaM-dependent enzyme. The gene expression of AtCBP63 was induced by pathogens and pathogens related second messengers. This result suggests that a CaM binding protein, AtCBP63, may play role in pathogen defense signaling pathway.

• Health Policy and Management
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• v.8 no.2
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• pp.110-124
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• 1998

Determining of Strategic Business Units in the organization is a major critical process for improving the organizational performance. On increasing the demands for extension in function of health center, many health centers are trying to provide the various services. But most health center determined the kind and level of service without scientific considerations. The purposes of this study are to develope the model for determination of strategic business units in health center and to test the availability of implementation for it. Our model is rooted from the McKinsey matrix analysis of Product Portfolio Analysis which used widely in marketing field. We modified the evaluation criteria of the McKinsey matrix analysis for health care field appropriately. Our evaluation criteria are categorized into two concepts; contribution of service, availability of service. At first, in terms of contribution of service, market size, market growth rate, needs and demands of regional people, existences of alternative services in that region, correspondence with health policy. The other component, availability of service are included the availability of manpower, financial availability, the level of knowhow on service, acceptance of health care manpower. In the result of analysis, we could conclude that antismoking and antialcoholics education programs, health screening program are important strategically in that aspects of contributions and availability of services. Also, vaccination program is important in that aspect of service availability and diet and exercise program, health library are meaningful in the aspect of service contribution. Therefore, we think that efforts to investigate the evaluation criteria for priority setting or determination of service area in health center are useful challenges.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.33 no.9
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• pp.104-112
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• 2005

This paper presents the technique to develop an operational flight program(OFP) of avionic system computer(ASC) which integrates the avionics control, navigation and fire control and provides informations for flight, navigation and weapon aiming missions. For the development of the OFP of ASC, two i960KB chips are used as central processing units board and standard computer interface library(SCIL) which is built in house is used. The Irvine compiler corporation(ICC) integrated development environment(IDE) and the programming language Ada95 are used for the OFP development. We designed the OFP to a computer software configuration item(CSCI) which consists of to three parts for independency of software modules. The OFP has been verified through a series of flight tests. The relevant tests also have been rigorously conducted on the OFP such as software integrated test, and ground functional test.

• Journal of the Korean Society of Propulsion Engineers
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• v.10 no.3
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• pp.18-25
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• 2006

In order to perform system requirements quickly and accurately, an automatic design program of solid rocket motors(SRM) structure designated as the 'ProDes software' has been developed and verified. from given system design criteria and constraints, it has the capabilities to design, analysis, simulation and drawing process to greatly reduce the over 'design cycle time' and manpower of a project. The conception of the program is modular, and calculations are performed step by step allowing parametric design studies and providing final selected design goal. Each configurations of SRM components and joint types composed of various master models is obtained from the data base module of the library. Between the design results of the ProDes software and those of the previous detail design of the established motor showed good agreements.

• The Transactions of the Korean Institute of Electrical Engineers A
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• v.54 no.4
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• pp.185-192
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• 2005

This paper proposes a DRMS(Distribution Remote Management System) which can enhance highly the economics of automatic metering system and the power quality supplied to the electric customer improving the efficiency of the meter reading, voltage management and load management work by realizing the remote meter reading, the remote voltage management and the remote load management based on the ADWHM(Advanced Digital Watt Hour Meter). The DRMS is designed so that the voltage management and load management work in remote site can be processed by collecting the voltage pattern and current pattern as well as watt hour data from all ADWHMs one time every month regularly or from special ADWHMS several time irregularly, A new on-line voltage and load management strategy based on the ADWHM is designed by analyzing the existing voltage management and load management process. Also, DRMS is designed so that watt-hour data, voltage pattern data, load pattern data and power factor data can be collected selectively according to the selection of user to assist effectively the methodology. Remote management program and database of the DRMS are implemented based on Visual C++, MFC and database library of MS. Also, DRMS is designed so as to communicate with the ADWHM using RS232C-TCP/IP converter and ADSL. The effectiveness of the remote metering function is proven by collecting and analyzing the data after ADWHMs installed in any site. The developed strategy and program also is verified through the simulation of voltage management and load management.

• The KIPS Transactions:PartD
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• v.16D no.1
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• pp.83-92
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• 2009

Complicated business logic makes program complexity more complicated. It's inevitable that the program must undergo reengineering processes all the way of in its lifetime. Hot spot analysis that has diverse purposes is getting an important question more and more. As a rule, reengineering process is done by UML model-based approach to analyze the legacy system. The smallest fragment of targets to be analysed is unit, that is function or class. Today's software development is to deal with huge change of software product and huge class including heavy quantity of LOC(Lines Of Code). However, analysis of unit is not precise approach process for reliable reengineering consequence. In this paper, we propose very precise hot spot analysis approach using Aspect-Oriented Programming languages, such as AspectJ. Typically the consistency between UML and source is needed code to redefine the modified library or framework boundaries. But reengineering approach using AOP doesn't need to analyze UML and source code. This approach makes dynamic event log data that contains detailed program interaction information. This dynamic event log data makes it possible to analyze hot spot.

• Journal of Convergence for Information Technology
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• v.9 no.2
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• pp.148-154
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• 2019

The study was performed to prepare basic data for the development of entrepreneur education programs for nursing students through literature review and text network of relevant studies on entrepreneurship education for college students. The research was found in the database of the Korea Education and Research Information Service, the Korean Academic Information Service System, DBpia and the National Assembly Library with keywords such as 'entrepreneur', 'student', 'education', 'program' and 'training. The final selected paper was 35 studies in Korea from 2000 to September 2016. The largest number of studies have been conducted since 2011 with 85.71%, and the largest proportion of survey(88.57 %). The major independent variables were entrepreneur self-efficacy and entrepreneurship and the dependent variables were entrepreneur intention and entreprenuer self-efficacy. Based on this result, entrepreneur education programs will be developed suitable for the target, and it can promote the entrepreneur education for nursing students.

• Journal of dental hygiene science
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• v.21 no.4
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• pp.199-212
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• 2021

Background: Various oral health management programs in Korea affect the oral health improvement in the elderly Several studies have been conducted to date; however, those studies have not shown uniform results due to the differences in research methods or designs. Hence, this study aimed to review the overall research trends of the reported oral health care programs for the elderly in Korea, verify their effects, and clarify them based on the systematic literature review. Methods: The literature search selected intervention studies that applied the oral health care program for the elderly in Korea from 2001 to 2020. Following the COre, Standard, and Ideal (COSI) models presented by the US National Library of Medicine, we selected databases including Korean studies Information Service System (KISS), ScienceOn, Research Information Sharing Service (RISS), DBpia, PubMed, and Google Scholar. Of the 1,335 studies searched using keywords, titles, and abstracts, 21 were finally selected based on primary and secondary exclusion criteria. Results: The most frequent intervention period was 4 weeks, and the number of interventions varied between 2 and 90 times. As for the type of intervention, 14 studies that conducted both theory and practice were the most frequent. Significant differences in the clinical indicators, such as calculus, halitosis, salivation rate, swallowing function, and dry mouth, were found in most oral health care programs. Conclusion: Based on the results of this study, the intervention program needs further verification using multiple indicators in future studies. In addition, a study extending the intervention period and the number of samples is considered necessary for verifying continuous effectiveness of the intervention program.

• Journal of Dental Anesthesia and Pain Medicine
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• v.21 no.6
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• pp.479-506
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• 2021

Background: Chronic neuropathic pain (NP) presents therapeutic challenges. Interest in the use of cannabis-based medications has outpaced the knowledge of its efficacy and safety in treating NP. The objective of this review was to evaluate the effectiveness of cannabis-based medications in individuals with chronic NP. Methods: Randomized placebo-controlled trials using tetrahydrocannabinol (THC), cannabidiol (CBD), cannabidivarin (CBDV), or synthetic cannabinoids for NP treatment were included. The MEDLINE, Cochrane Library, EMBASE, and Web of Science databases were examined. The primary outcome was the NP intensity. The risk of bias analysis was based on the Cochrane handbook. Results: The search of databases up to 2/1/2021 yielded 379 records with 17 RCTs included (861 patients with NP). Meta-analysis showed that there was a significant reduction in pain intensity for THC/CBD by -6.624 units (P < .001), THC by -8.681 units (P < .001), and dronabinol by -6.0 units (P = .008) compared to placebo on a 0-100 scale. CBD, CBDV, and CT-3 showed no significant differences. Patients taking THC/CBD were 1.756 times more likely to achieve a 30% reduction in pain (P = .008) and 1.422 times more likely to achieve a 50% reduction (P = .37) than placebo. Patients receiving THC had a 21% higher improvement in pain intensity (P = .005) and were 1.855 times more likely to achieve a 30% reduction in pain than placebo (P < .001). Conclusion: Although THC and THC/CBD interventions provided a significant improvement in pain intensity and were more likely to provide a 30% reduction in pain, the evidence was of moderate-to-low quality. Further research is needed for CBD, dronabinol, CT-3, and CBDV.

• Journal of Preventive Medicine and Public Health
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• v.55 no.1
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• pp.37-48
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• 2022

Objectives: Depression is a frequent complication of type 2 diabetes mellitus. This study aimed to investigate the relationship between low social support and risk for depression in people with type 2 diabetes through a meta-analysis. Methods: PubMed, ProQuest, SpringerLink, ScienceDirect, Scopus, the Cochrane Library, Embase, and Google Scholar were searched for English-language articles published up to 2021. Pooled adjusted odds ratios (aORs) were calculated using a random-effect model with 95% confidence intervals (CIs). Heterogeneity was evaluated by using the Cochrane Q test and I² statistics. The risk of publication bias was estimated using a funnel plot, the Egger test, and the Begg test. The Joanna Briggs Institute Critical Appraisal Tools were used to assess the quality of evidence and the risk of bias. Results: Eleven studies were included in this meta-analysis, containing a total of 3151 people with type 2 diabetes mellitus. The pooled analysis showed that people with type 2 diabetes mellitus who had low social support had twice as high a risk of depression as those with high social support (aOR, 2.02; 95% CI, 1.51 to 2.70; p<0.001). A random-effect model was used because the heterogeneity was high (I² = 87%). Conclusions: Low social support was found to increase the risk of depression among people with type 2 diabetes mellitus. Further investigation into factors that may moderate this relationship is required.