• Asian Pacific Journal of Cancer Prevention
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• 제14권8호
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• pp.4907-4911
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• 2013

The key signaling networks regulating glioma cell proliferation remain poorly defined. The leucine-rich repeat containing G-protein coupled receptor 4 (Lgr4) has been implicated in intestinal, gastric, and epidermal cell functions. We investigated whether Lgr4 functions in glioma cells and found that Lgr4 expression was significantly increased in glioma tissues. In addition, Lgr4 overexpression promoted while its knockdown using small interfering RNA oligos inhibited glioma cell proliferation. In addition, Wnt/${\beta}$-catenin signaling was activated in cells overexpressing Lgr4. Therefore, our results revealed that Lgr4 activates Wnt/${\beta}$-catenin signaling to regulate glioma cell proliferation.

• Journal of Gastric Cancer
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• 제8권4호
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• pp.225-231
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• 2008

목적: 위 점막하 종양(gastric submucosal tumor, gastric SMT)은 최근 건강검진의 보편화로 증가하는 추세에 있다. 이에 반해 악성도에 따라 예후가 달라지고, 방사선 검사나 내시경 조직검사로 다른 종양과의 감별이 어려워 아직도 치료 방침을 결정하는데 어려움이 있다. 이에 저자들은 위 점막하 종양 환자에서 임상병리학적 특성을 분석하고, 이에 따른 복강경 수술과 개복술의 결과를 각각 비교 분석하였다. 위 점막하종양의 복강경 절제술의 학습곡선 의미를 도출하여, 위 점막하종양의 적절한 치료방법을 제시하고자 한다. 대상 및 방법: 2003년 4월부터 2008년 8월까지 본원에서 위점막하종양으로 개복 위절제술을 받은 25명과 복강경 위절제술을 시행 받은 78명의 환자들을 대상으로 하였으며, 수술 후 임상경과 및 병리학적 특징에 대하여 전향적인 자료 수집 후 후향적으로 결과를 비교 분석하였다. 결과: 환자의 평균 연령은 53.7세(22~80세)였으며 남녀비는 각각 44명, 59명으로 1 : 1.34였다. 대부분 무증상으로 내원하였으며, 주로 쐐기형 위절제술을 시행 받았다. 종양의 평균 장경은 4.33 cm (1.2~17.0 cm)였고, 주로 위상부에 위치하였으며, 평균 수술 시간은 117.3분(35~255분)이었다. 평균 출혈량은 113.9 ml (0~1,000 ml), 평균 수술 후 재원기간은 8.0일(1~69일)이었다. 술 전 내시경적 절제술이 실패하여 수술이 의뢰된 환자가 5명 있었다. 수술 후 합병증은 13명(12.6%)에서 발생하였고, 수술과 관련된 사망은 없었다. 위 점막하종양의 대부분은 간질유래성증양으로 58명(56.3%)이며, 이중 현재까지 크기가 5 cm 이상이고 복강경 위절제술을 시행한 2명이 재발되었다. 복강경 수술 군과 개복 수술 군에 따라 수술 시간 및 출혈량, 합병증에는 차이가 없었지만, 두 군 간에 환자의 증상(P<0.001), 종양의 크기 (P<0.001), 수술방법 중 쐐기형 절제술 시행(P=0.037), 술 후 연식섭취 시간(P<0.001), 술 후 퇴원 일(P=0.002)에는 차이가 있었다. 위 점막하종양의 복강경 위절제술은 26예 이상의 수술 경험이 필요하고, 이러한 학습 곡선을 극복함으로써 수술 시간, 출혈량을 줄일 수 있다. 결론: 5 cm 미만의 위 점막하종양에서는 복강경적 치료방법이 개복술보다 안전하고, 효과적인 치료방법으로 생각되며, 다양한 형태의 위 점막하종양을 복강경적 절제술로 시행 할 경우에는 학습 곡선을 먼저 극복하기 위해 노력하는 것이 권장된다.

• 한국의상디자인학회지
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• 제14권4호
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• pp.63-72
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• 2012

In this study, Characteristics of colors on Chinese traditional costume in Tang, Song, Yuan, Ming, and Qing Dynasty were compared. And general colors of Chinese traditional costume and the viewpoint of them were considered. The purpose of this study were to apt colors of Chinese traditional costumes to the sensory appetite of modern people for new things, and make the recreation inspired by new senses be applied into the fashion industry effectively. The results were as followed : Firstly, colors distribution of 5 dynasties were different. In the Tang, R(red) was highest, YR(yellow red) and Y(yellow) followed. In the Song, YR was highest, Y and R followed and PB(purple blue) was increased, In the Yuan, R, YR, PB, B were concentrated at low rates, and other colors were increased, In the Ming, Y, R and B were concentrated at low rates orderly, and other colors were increased, In the Qing, PB was highest and Y, R, YR, B, P(purple) were increased. Secondly, tons distribution of 5 dynasties were different. In the Tang, L(light) was highest, P(pale) and Lgr(light grayish) followed. In the Song, P(pale) was highest, Lgr, Gr(grayish) and Dl(dull) followed In the Yuan, Dp(deep) was highest, P and Lgr followed, and other tones were increased, In the Ming, S(strong) was highest, DI and V(vivid) followed. Thirdly, The general colors of 5 dynasty were R, YR, Y, B, PB colors with vivid, deep and light tones. Forth, the viewpoint of color on Chinese traditional costume was based on the Yin-Yang and the Five Elements theory. Based on results of this study, the successive researches will be carried out about the unique colors of each nation and application traditional colors to modern fashion industry in order to the unique cultural sense.

• 한국의류학회지
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• 제26권6호
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• pp.865-876
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• 2002

The purpose of the study is to clarify yellow image and formative properties in modern fashion. For the study of formative properties 230 kinds of costume samples being visual power in yellow have been selected from photographs in fashion magazines and divided into tones: vivid(S, B, Dp), vague(L, Lgr, D), bright(Vp, P, B). For the study of image 30 kinds of costume samples is used. The Study was measured by using Semantic Differential method. The subjects were 50 students majoring in clothing and textile. The data were analyzed by factor analysis, ANOVA, MDS and regression analysis. The results of analysis are as follow: 1. Factor analysis has extracted 4 factors of yellow image in the fashion. These factor are Attractiveness, Cheerfulness, Hardness and Softness, Gorgeousness. 2. There were significant difference in visual evaluation of yellow tones. 3. Evaluative dimensions of yellow was classified as Soft-Hard, Gorgeous-Unpretentious. 4. The mage effect on Preference, Buying needs, Pleasant and Riches was consist of complicated sensibility.

• 한국의류산업학회지
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• 제3권3호
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• pp.204-210
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• 2001

The purpose of the study is to clarify red image in the modem fashion. 40 kinds of costume samples being visual power in red have been selected from photographs in fashion magazines and divided into tones: pale (Vp, Lgr, L), bright (P, B), vivid (S, B, Dp), dark (Gr, Dl, Dgr, Dk). The study was measured by using Semantic Differential method. The subjects were 50 students majoring in clothing and textile. The data were analyzed by factor analysis, ANOVA, discrimminant analysis, MDS and regression analysis. The results of analysis are as follow; 1. Factor analysis has extracted 5 factors of red image in the fashion. These factor are Attractiveness, Hardness and Softness, Emotion, Attention, Simplicity. 2. There were significant difference in visual evaluation of red tones. 3. The discrimination among 4 red tones was related to attention and weight of red. 4. Evaluative dimensions of red was classified as Soft-Hard, Lively-Decent. 5. The image effect on Preference, Buying needs, Pleasant and Riches was consist of complicated sensibility.

• 한국의류학회지
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• 제26권7호
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• pp.970-981
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• 2002

The purpose of the study is to clarify orange image in the modern fashion. So kinds of costume sample being visual power in orange have been selected from photographs in fashion magazines and divided into the tones : mist(Vp, Lgr, L), bright(P, B), vivid(S, V, Dp). The study was measured by using 27 semantic differential hi-polar scales. The subjects were 50 female students majoring in clothing and textiles, The data was analyzed using the statistical SPSS package. The data were collected using self-administred questionnaires and analyzed by Cronbach $\alpha$, Factor analysis, MDS, ANOVA Sheff test and Regression analysis. The major findings of this research were as follows. 1. Factor analysis has extracted 4 factors of orange image in the fashion. These factor are Attractiveness, Audacity, Hardness and Softness, Cuteness. 2. There were significant difference in visual evaluation of tones. 3. The discrimination among tones was related to cuteness and weight of orange. 4. The image effect on Preference, Buying needs, Pleasant and Riches was consist of complicated sensibility.

• 패션비즈니스
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• 제6권4호
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• pp.163-172
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• 2002

The purpose of this study is to investigate purple image and formative properties in contemporary fashion. For the study of formative properties 152 kinds of costume samples from photographs in fashion magazines. For the study of image 40 kinds of costume samples is used and divided into tones : pale(Vp, Lgr, L), bright(P, B), vivid(S, V, Dp), dark(Gr, Dl, Dgr, Dk). A total 24 pairs of abjective words were used to measure the semantic differential scale in this study. The data were analyzed by factor analysis, ANOVA, MDS and regression analysis. The results are as follows; 1. Factor analysis has extracted 5 factors which consist of purple image in contemporary fashion. The factors are high quality, hardness and softness, simplicity, temperature, maturity. 2. There were significant differences in visual evaluation of purple tones. 3. The discrimination among. 4 purple tones was related to weight of purple 4. The evaluative dimensions of purple image in modern fashion were identified by Light - Heavy and Pale - Strong. 5. The image effect on Preference, Buying needs, Pleasant and Riches was consist of complicated sensibility.

• 패션비즈니스
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• 제15권3호
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• pp.51-66
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• 2011

The purpose of this study is to investigate the effect of the traditional color sentiment on the contemporary clothing color by studying the pictures of street fashion of Dalian in China, in view of the clothing color of women in their 20-30 years of age having highest purchasing power, along with traditional Chinese color. The clothing color is various in frequency depending on the items in street fashion. Due to the seasonal impact of summer, the most frequent item was one-piece dress with the Multi of various color patterns, followed by White, Black, PB, R and B category. In the top color, the White was most prevalent color due to the seasonal factor, followed by Black, Grey, Multi, R, Y, RP category. Achromatic color is more dominant with the ratio of 7:3, comparing with its counterpart, which consists of R and Y category of V, B, P, VP tone. In the bottom color, Dp tone of PB shows most high frequency, followed by Black. This results illustrate that Chinese women prefer blue jeans and to be looked as slimmer by using of the dark colors. In the accessories, colors of bags and shoes show different results. The bag colors show the high frequency of Dk tone, YR category, and the chromatic colors are little bit dominant than achromatic ones with the ratio of 5.3:4.7. On the contrary, the shoes colors show the highest frequency in Black, the achromatic colors are more dominant than chromatic ones with the ratio of 6.6:3.4. These results somewhat diverge from the international color trend. Color trend in Dalian street fashion in which the high frequency of V tone is observed through all the colors of the items followed by P, VP, Lgr tone in sequence. In the light of Chinese traditional color preference, this result denotes that the traditional color preferences of red, yellow are still affecting the contemporary color choices of clothing in Chinese women. The high incidence of PB category in the bottom and one-piece dress does not seem to have its origin form traditional Chinese color sentiment.

• Journal of Veterinary Science
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• 제24권4호
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• pp.53.1-53.12
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• 2023

Background: Mammalian orthoreovirus type 3 (MRV3), which is responsible for gastroenteritis in many mammalian species including pigs, has been isolated from piglets with severe diarrhea. However, the use of pig-derived cells as an infection model for swine-MRV3 has rarely been studied. Objectives: This study aims to establish porcine intestinal organoids (PIOs) and examine their susceptibility as an in vitro model for intestinal MRV3 infection. Methods: PIOs were isolated and established from the jejunum of a miniature pig. Established PIOs were characterized using polymerase chain reaction (PCR) and immunofluorescence assays (IFAs) to confirm the expression of small intestine-specific genes and proteins, such as Lgr5, LYZI, Mucin-2, ChgA, and Villin. The monolayered PIOs and three-dimensional (3D) PIOs, obtained through their distribution to expose the apical surface, were infected with MRV3 for 2 h, washed with Dulbecco's phosphate-buffered saline, and observed. Viral infection was confirmed using PCR and IFA. We performed quantitative real-time reverse transcription-PCR to assess changes in viral copy numbers and gene expressions linked to intestinal epithelial genes and antiviral activity. Results: The established PIOs have molecular characteristics of intestinal organoids. Infected PIOs showed delayed proliferation with disruption of structures. In addition, infection with MRV3 altered the gene expression linked to intestinal epithelial cells and antiviral activity, and these effects were observed in both 2D and 3D models. Furthermore, viral copy numbers in the supernatant of both models increased in a time-dependent manner. Conclusions: We suggest that PIOs can be an in vitro model to study the infection mechanism of MRV3 in detail, facilitating pharmaceutical development.

• 디자인학연구
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• 제16권4호
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• pp.255-266
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• 2003

본 연구는 환경디자인을 통한 대학 캠퍼스의 정체성과 이미지 확립에 바람직한 도움이 되고자 캠퍼스 내의 건축물을 대상으로 하는 색채 사용 기준을 제시하였다. 특히 오랜 역사와 고유의 학풍을 지닌 Y-대학교 S-캠퍼스를 대상으로 향후 건축물조성에 사용할 수 있는 색채 팔레트를 제시함으로써, 전통과 현대의 조화를 통해 다가올 미래의 변화를 수용할 수 있으며, 대학의 특성화 및 차별화 된 환경 디자인의 한 기준을 마련할 수 있을 것으로 기대한다. 연구의 진행은 기초조사, 본 조사, 분석 및 색채 팔레트 제안으로 이루어지는데, 기초조사 단계에서는 문헌을 통해 대학교의 역사와 교육 이념 등의 대학교 이미지를 형용사어를 중심으로 조사하였다. 본 조사에서는 다양한 건축 외장재를 수집하여 측색하고, 현재 캠퍼스 내의 건축물 색채 및 사계절에 해당하는 자연 색채를 계절별로 실측 조사하였다. 이 때에는 측색기와 NCS 표준 색채, 디지털 카메라 등이 보조 수단으로 사용되었다. 분석 단계에서는 위에서 수집된 자료들을 바탕으로 Y 캠퍼스의 지향 이미지 색채를 설정하고, 현재 건축물 색채와 자연 색채와의 조화를 고려한 배색 팔레트를 최종 제시하였다. 이를 바탕으로 설정한 최종 대표 색으로 주조 색은 중 명도/중 채도의 화강암을 주재료로 하는 YR 계열 및 무채색에 해당하는 색을 선정하였고, 보조 색은 고 채도와 어둡고 무거운 색을 제외한 P, Lgr, Dl, Dp에 해당하는 주조 색과 비슷하거나 약간 어두운 중 명도, 중 채도에 해당하는 색들을 지정하였다. 마지막으로 강조 색은 한국인 단색감성척도를 사용하여 추출한 Y 대학교가 지향하는 이미지 색채와 캠퍼스의 자연 색을 함께 사용하기로 하였다. 본 연구를 통해 얻을 수 있는 결과물은 자연 색 체계(NCS System)에 기초하고 색채 조화 원리에 의거한 Y 캠퍼스의 지향 이미지 색채를 설정하고, 현재 건축물 색채 및 자연 색채와의 조화를 고려한 배색 팔레트이다. 또한 건축물, 자연 색, Y대학교 지향 이미지를 바탕으로 향후 종합적인 색채 계획에 필요한 색채 팔레트 메뉴얼 제안이 이루어 질 수 있고, 최종적으로 Y 대학교 캠퍼스 이미지 통합을 위한 연구의 보조적 자료로서의 색채 팔레트 제안이 이루어 질 수 있을 것이다.