• Asian Pacific Journal of Cancer Prevention
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• 제14권3호
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• pp.1597-1599
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• 2013

Since renal failure causes decrease in tumor marker excretion, use of these markers in cancer care and treatment in patients with renal insufficiency or hemodialysis is controversial. The aim of this study was to investigate differences of serum levels of tumor markers CA15-3, AFP, CA19-9 and CEA in patients with impaired renal function. A total of 100 patients referred to the Tabriz Immam Reza and Amiralmomenin hospital from June 2010 to November 2011 were selected for study. Subjects were divided to 3 groups of healthy, dialysis and renal failure but non hemodialysis cases, the last category being re-grouped based on creatinine clearance. No significant relationship between different groups in serum levels of CEA (P=0.99) and CA19-9 (P=0.29) tumor markers was found. A significant correlation was observed between serum levels of AFP (P<0.001) and CA15-3 (P<0.001) and also a tendency between creatinine clearance and CEA (r=0.05, P=0.625). Creatinine clearance significantly correlated with AFP (P<0.001, r=0.53) and CA15-3 (p=0.00, r=-0.412), but not CA19-9 (P=0.089, r=-0.171). According to results of this study it appears that use of tumor markers in patients with impaired renal function should be performed with special precautions.

• 만화애니메이션 연구
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• 통권25호
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• pp.203-225
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• 2011

이 연구는 수용자가 미디어를 이용하는 과정에서 미디어와 맺는 의존관계 유형이 수용자 개개인의 성격유형에 따라 다를 것이라는 기본적인 가정에서 출발했다. 성격유형은 성격연구에서 가장 일반적으로 사용되며 그타당성을 인정받고 있는 PEN 모델(Eysenck, 1981)을 이용했다. PEN 모델은 사람의 성격을 정신병리적 성향(Psychoticism), 외향적 성향(Extraversion), 신경증적 성향(Neuroticism)으로 구분한다. 이와 함께, 개인별 미디어 의존관계 이론에 따르면, 개개인은 목적지향적인 존재로 미디어와 의존관계를 형성한다. 의존관계는 사회적 이해(social understanding), 자기이해(self understanding), 행동 정향(action orientation), 상호작용 정향(interaction orientation), 사회적 놀이(social play), 개인적 놀이(solitary play)의 6가지 유형으로 구분한다. 이를 토대로 이 연구는 PEN 모델의 세 가지 성격유형과 개인별 미디어 의존 유형간의 관계를 검증하는데 그 목적을 두었다. 또한, 이러한 관계는 성별에 따라 다르게 나타나는지를 함께 분석했다. 이를 위해 온라인 설문을 실시했다. 남자 158명과 여자 179명을 포함해 총 337명이 응답에 참여했다. 분석결과, 외향적 성향(E)은 6가지 미디어 의존유형과 전혀 유의미한 관계를 나타내지 않았다. 한편, 정신병리적 성향(P)이 낮을수록 자기이해를 위한 목적으로 미디어를 이용하려는 경향이 강하게 나타났다. 반면, 신경증적 성향(N)이 높을수록 자기이해를 위한 목적으로 미디어를 이용하려는 경향이 강했다. 이러한 성격변인과 미디어의존의 관계는 성별에 따라 차이가 있었다. 남자응답자들일수록 세 가지 성격변인이 6가지 미디어 의존관계 변인과 유의미한 관계를 나타내는 경향이 강했다. 이 연구를 통해 특정 개인성격유형은 개인들이 미디어를 통해 추구하고자 하는 목적과 다양한 형식으로 관련을 맺고 있음을 발견했다. 이 연구가 갖는 함의가 함께 논의됐다.

• Journal of Animal Science and Technology
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• 제64권4호
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• pp.782-791
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• 2022

The purpose of this study is to evaluate the effects of multiple cooling systems and different drinking water temperatures (DWT) on the performance of sows and their hair cortisol levels during heat stress. In this study, the effect of four different cooling systems: air conditioner (AC), cooling pad (CP), snout cooling (SC), and mist spray (MS), and two DWT, namely low water temperature (LWT) and high water temperature (HWT) on 48 multiparous sows (Landrace × Yorkshire; 242.84 ± 2.89 kg) was tested. The experiment is based on the use of eight replicas during a 21-days test. Different behaviors were recorded under different cooling treatments in sows. As a result, behaviors such as drinking, standing, and position change were found to be lower in sows under the AC and CP treatments than in those under the SC and MS treatments. Lying behavior increased under the AC and CP systems as compared with that under the SC and MS, systems. The average daily feed intake (ADFI) in sows and weight at weaning in piglets was higher under the AC, CP, and LWT treatments than under the SC, MS and HWT treatments. Sows subjected to SC and MS treatment showed higher hair cortisol levels, rectal temperature, and respiratory rate during lactation than those under AC and CP treatments. Hair cortisol levels, rectal temperature, and respiratory rate were also higher under the HWT than under the LWT treatment. As per the results of this study, the LWT has no significant effect on any of the behavioral factors. Taken together, the use of AC and CP cooling treatment is highly recommended to improve the behavior and to reduce the stress levels in lactating sows.

• 여성건강간호학회지
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• 제7권4호
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• pp.473-485
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• 2001

This cross-sectional design was to identify the age at menopause of Korean women and the levels of bothersome menopausal symptoms. In addition, examining relationships between the levels of bothersome menopausal symptoms and sociodemographic factors, body mass index, menopause-related factors, and life-style behavior factors including smoking, alcohol use, physical activity, and diet was done. Two thousand eight hundred seven naturally postmenopausal women aged between 41-65 years were recruited by self-selection from 7 metropolitans and 6 provinces in Korea from Dec. 20, 1998 to April 30, 1999. The age at menopause of Korean women was 49.2 years(mean) and 50.0 years (median). The menopausal age of Korean women has slightly increased compared to a previous study. Based on the demographic factors, residential area and socioeconomic status were associated with the bothersome levels of climacteric symptoms. In the case of the life-style behaviors analysis, only alcohol use and a preference for wheat were associated with the bothersome levels of climacteric symptoms, especially physical symptoms.

• Animal Bioscience
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• 제34권4호
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• pp.613-620
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• 2021

Objective: This study aimed at studying the potential use of Flemingia (Flemingia macrophylla) as a protein source fodder to improve nutrients digestibility and ruminal fermentation efficiency in beef cattle. Methods: Four, Thai native beef cattle were randomly assigned in a 4×4 Latin square design. Four levels of Flemingia hay meal (FHM) were used to replace soybean meal (SBM) in the concentrate mixtures in four dietary treatments replacing levels at 0%, 30%, 60%, and 100% of SBM. Results: The experimental findings revealed that replacements did not effect on intake of rice straw, concentrate and total dry matter (DM) intake (p>0.05). However, the apparent digestibilities of DM, organic matter, crude protein, acid detergent fiber, and neutral detergent fiber were linearly increased up to 100% replacement levels. Moreover, the production of total volatile fatty acids, and propionate concentration were enhanced (p<0.05) whereas the concentration of acetate was reduced in all replacement groups. Consequently, the CH4 production was significantly lower when increasing levels of FHM for SBM (p<0.05). Furthermore, rumen bacterial population was additionally increased (p<0.05) while protozoal population was clearly decreased (p<0.05) in all replacement groups up to 100%. In addition, microbial nitrogen supply and efficiency of microbial nitrogen synthesis were enhanced (p<0.05), as affected by FHM replacements. Conclusion: The findings under this experiment suggest that 100% FHM replacement in concentrate mixture enhanced rumen fermentation efficiency, nutrients digestibilities, bacterial population, microbial protein synthesis, and subsequently reduced CH4 production in beef cattle fed on rice straw.

• 한국학교ㆍ지역보건교육학회지
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• 제19권2호
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• pp.53-63
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• 2018

Objectives: This study was intended to provide resources for the development and operation of the elderly's oral health education programs by comparing the difference of oral health behavior, oral health care self-efficacy and oral health levels according to their oral health education experiences and by researching the correlation of oral Health Behavior, self-efficacy, subjective oral health level and oral health education experience. Methods: An interview survey using structured questionaries was done on 180 senior citizens older than 65 years old residing in some areas of Gyeonggi-do from April 19 to May 25, 2018. The data was analyzed with Chi-square, t-test, spearman correlation coefficient with the use of SPSS 20.0. Results: 1. Those who are older than 75 years old and have higher levels of education and finance have more experiences of oral health education. 2. Those who have experiences of oral health education brush their teeth more than three times a day, use more oral health care items and get more regular preventive treatments such as oral examination and scaling. 3. As they has experiences of oral health education, their oral health behaviors, oral health care self-efficacy(tooth care, dietary control, regular checkup) and subjective oral health levels are high. Conclusion: It is necessary to try to improve the elderly's oral health levels by motivating the importance of oral health care and changing their oral health behaviors positively with the implement of oral health education on the elderly. Especially, oral health education programs that are operated on the elderly should be planned with practical programs that can cause the change of their oral health behaviors and should be processed to reinforce oral health care self-efficacy. Furthermore, preventive treatments for the elderly such as oral health education, oral examination and scaling should be implemented systematically and continuously by policy.

• Asian Pacific Journal of Cancer Prevention
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• 제17권10호
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• pp.4761-4767
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• 2016

Objective: The use of Shamma (smokeless tobacco) by certain groups is giving rise to health problems, including cancer, in parts of Saudi Arabia. Our objective was to determine metals levels in Shamma using inductively coupled plasma mass spectrometry (ICP-MS). Methods: Thirty-three samples of Shamma (smokeless tobacco) were collected, comprising four types: brown Shamma (n = 14.0), red Shamma (n = 9.0), white Shamma (n = 4.0), and yellow Shamma (n = 6.0). All samples were collected randomly from Shamma users in the city of Najran. Levels of 11 elements (Al, As, Cd, Co, Cr, Cu, Li, Mn, Ni, Pb, and Zn) were determined by ICP-MS. Results: A mixed standard (20 ppb) of all elements was used for quality control, and average recoveries ranged from 74.7% to 112.2%. The highest average concentrations were found in the following order: Al ($598.8-812.2{\mu}g/g$), Mn ($51.0-80.6{\mu}g/g$), and Ni ($23.2-53.3{\mu}g/g$) in all four Shamma types. The lowest concentrations were for As ($0.7-1.0{\mu}g/g$) and Cd ($0.0-0.06{\mu}g/g$). Conclusions: The colour of each Shamma type reflects additives mixed into the tobacco. Cr and Cu were showed significant differences (P < 0.05) among Shamma types. Moreover, Pb levels are higher in red and yellow Shamma, which could be due to use (PbCrO4) as yellow colouring agent and lead tetroxide, Pb3O4 as a red colouring agent. The findings from this study can be used to raise public awareness about the safety and health effects of Shamma, which is clearly a source of oral exposure to metals.

• Journal of Radiation Protection and Research
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• 제47권2호
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• pp.67-76
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• 2022

Background: We conducted a cross-sectional study of residents within and outside Fukushima Prefecture to clarify their perceptions of the need for smartphone applications (apps) for explaining exposure doses. The results will lead to more effective methods for identifying target groups for future app development by researchers and municipalities, which will promote residents' understanding of radiological situations. Materials and Methods: In November 2019, 400 people in Fukushima Prefecture and 400 people outside were surveyed via a web-based questionnaire. In addition to basic characteristics, survey items included concerns about radiation levels and intention to use a smartphone app to keep track of exposure. The analysis was conducted by stratifying responses in each region and then cross-tabulating responses to concerns about radiation levels and intention to use an app by demographic variables. The intention to use an app was analyzed by binomial logistic regression analysis. Text-mining analyses were conducted in KH Coder software. Results and Discussion: Outside Fukushima Prefecture, concerns about the medical exposure of women to radiation exceeded 30%. Within the prefecture, the medical exposure of women, purchasing food products, and consumption of own-grown food were the main concerns. Within the prefecture, having children under the age of 18, the experience of measurement, and having experience of evacuation were significantly related to the intention to use an app. Conclusion: Regional and individual differences were evident. Since respondents differ, it is necessary to develop and promote app use in accordance with their needs and with phases of reconstruction. We expect that a suitable app will not only collect data but also connect local service providers and residents, while protecting personal information.

• Journal of Preventive Medicine and Public Health
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• 제54권1호
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• pp.37-45
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• 2021

Objectives: Bisphenol A (BPA) is used in the electrical, mechanical, medical, and food industries. Previous studies have suggested that BPA is an endocrine disruptor. Regulation of BPA has led to increased use of bisphenol F (BPF) and bisphenol S (BPS). However, few studies have investigated the associations of BPF and BPS with thyroid dysfunction in children. Our study investigated the associations of prenatal BPA and early childhood BPA, BPF, and BPS exposure with thyroid function in 6-year-old children. Methods: Prenatal BPA concentrations were measured during the second trimester of pregnancy in an established prospective birth cohort. We measured urinary BPA, BPF, and BPS concentrations and thyroid hormone levels (thyroid-stimulating hormone, total T3, and free T4) in 6-year-old children (n=574). We examined the associations between urinary bisphenol concentrations and percentage change of thyroid hormone concentrations using multivariate linear regression. We also compared thyroid hormone levels by dividing the cohort according to BPA, BPF, and BPS concentrations. Results: The associations between prenatal BPA and total T3 levels were statistically significant in all models, except for girls when using a crude model. The associations between urinary BPA and BPS concentrations and levels of all thyroid hormones were not statistically significant. However, we observed that lower free T4 levels (-1.94%; 95% confidence interval, -3.82 to -0.03) were associated with higher urinary BPF concentrations in girls only. Conclusions: Our findings identified significant associations between prenatal BPA exposure and total T3 levels in all children and between BPF exposure and free T4 levels in girls only.

• BMB Reports
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• 제36권1호
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• pp.1-11
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• 2003

The causative role of polycyclic aromatic hydrocarbons (PAH) in human carcinogenesis is undisputed. Measurements of PAH-DNA adduct levels in easily accessible white blood cells therefore represent useful early endpoints in exposure intervention of chemoprevention studies. The successful applicability of DNA adducts as early endpoints depends on several criteria:i.adduct levels in easily accessible surrogate tissues should reflect adduct levels in target-tissues, ii. toxicokinetics and the temporal relevance should be properly defined.iii. sources of inter- and intra-individual variability must be known and controllable, and finally iv. adduct analyses must have advantages as compared to other markers of PAH-exposure. In general, higher DNA adduct levels or a higher proportion of subjects with detectable DNA adduct levels were found in exposed individuals as compared with non-exposed subjects, but saturation may occur at high exposures. Furthermore, DNA adduct levels varied according to changes in exposure, for example smoking cessation resulted in lower DNA adduct levels and adduct levels paralleled seasonal variations of air-pollution. Intra-individual variation during continuous exposure was low over a short period of time (weeks), but varied significantly when longer time periods (months) were investigated. Inter-individual variation is currently only partly explained by genetic polymorphisms in genes involved in PAH-metabolism and deserves further investigation. DNA adduct measurement may have three advantages over traditional exposure assessment: i. they can smooth the extreme variability in exposure which is typical for environmental toxicants and may integrate exposure over a longer period of time. Therefore, DNA adduct assessment may reduce the monitoring effort. ii. Biological monitoring of DNA adducts accounts for all exposure routes. iii. DNA adducts may account for inter-individual differences in uptake, elimination, distribution, metabolism and repair amongst exposed individuals. In conclusion, there is now a sufficiently large scientific basis to justify the application of DNA adduct measurement as biomarkers in exposure assessment and intervention studies. Their use in risk-assessment, however, requires further investigation.