• 동의신경정신과학회지
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• 제19권1호
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• pp.43-54
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• 2008

Objective: The aim of this study is to evaluate the anticonvulsive effects of Gamiheichumhwan extract and to explain its action in GABAergic neuromodulation of the rat brain. Method: The extracts of Gamiheichumhwan were investigated for their inhibitory effect on GABA transaminase activity, their influence on brain GABA and glutamate levels, their agonistic activity on GABA/benzodiazepine receptor and anticonvulsive action using in vitro and in vivo assays. Results: 1. The extract inhibited dose-dependently GABA transaminase (GABA-T) activity by 4.6% and 18.9%, respectively at dosages of 250 mg/kg and 500mg/kg mouse (p.o.). 2. Brian GABA level was increased to 72.0% and brain glutamate level was decreased to 9.6% at a dosage of 500 mg/kg mouse (p.o.). 3. The extract suppressed [3H]Ro15-1788 binding to rat cerebral cortical membrane by $81.4{\pm}0.8%$ at a dosage of 3.2 mg, suggesting its agonistic activity on GABA/benzodiazepin receptor. 4. The extract showed anticonvulsive effect by lengthening the onset time of convulsion, shortening the convulsion duration and diminishing the lethality. Conclusion : It is suggested that Gamiheichumhwan can be used to somnipathy and adapted to treatment and prevention of epilepsy or convulsion.

• 수산해양기술연구
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• 제50권3호
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• pp.396-406
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• 2014

Shrimp beam trawl fishery is one of the important coastal fisheries in Korea. It has a regulation to the length of beam (8m) and wing net (7m) of shrimp beam trawl that has been used in the district of Junlanam-do and Gyungsangnam-do. This regulation was made in relation to the size of shrimp beam trawler of 3-ton class at that time. Now the shrimp beam fishing vessel has a limit not greater than 5 tons in gross ton. Recently, with improvement of fishing industry and fishing vessel fishermen asked the expansion of the length of beam and wing net, therefore it is necessary to investigate the effect of lengthening the beam and wing net length. Three different beams (8m, 10m and 12m in length) and three different wing net (7m, 10m and 13m in length) were made and the experiment was conducted near Narodo of Goheng by two fishing vessels of 4.98 and 4.88 tons in gross ton between June 2011 and October 2012. When the length of wing net was increased from 7m to 10m and 13m, the relative catch ratio in total biomass was increased 25% and 79% for shrimp, (17% and 22% in total), respectively. And when the beam length was increased from 8m to 10m and 12m, the relative catch ratio was increased 35% and 84% for shrimp, (21% and 37% in total), respectively. The force exerted to the iron guide of inhauler's with the beam length of 8m was about 30% greater than that with the beam length of 10m when hauling the shrimp beam trawl net.

• Food Science and Biotechnology
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• 제15권3호
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• pp.399-403
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• 2006

The effect of flour storage conditions on the lipid oxidation of fried products during storage was studied. Wheat flour was stored at $60^{\circ}C$ in the dark and at water activity (Aw) of 0.3, 0.5, or 0.8 for 21 days. The square-shaped dough ($2{\times}2{\times}0.1\;cm$) made with the stored flour and water was fried in soybean oil at $160^{\circ}C$ for 1 min. The fried products were stored at $60^{\circ}C$ for 15 days in the dark. The degree of lipid oxidation of the fried products was evaluated by conjugated dienoic acid (CDA) content and p-anisidine value (PAV). Both CDA content and PAV of the fried products increased with lengthening storage time of the fried products, suggesting that longer storage of the fried products raised the lipid oxidation. Furthermore, the lipid oxidation of the fried products made with flour that had been stored for a longer time tended to be higher than that of those made with unstored or short-term-stored flour. However, Aw at which the flour was stored did not significantly affect the lipid oxidation of either flour or the fried products during storage. The storage time of flour clearly exerted a greater effect than Aw on the lipid oxidation of the fried products during storage at $60^{\circ}C$ in the dark. This suggests that for the storage stability of fried products, the flour storage time is a more important factor than Aw at which the flour is stored.

• 대한치과교정학회지
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• 제49권6호
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• pp.413-426
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• 2019

This study was performed to describe the longitudinal management of recurrent temporomandibular joint (TMJ) ankylosis from infancy to adulthood in perspective of surgical and orthodontic treatment. A 2-year-old girl was referred with chief complaints of restricted mouth opening and micrognathia due to bilateral TMJ ankylosis. For stage I treatment during early childhood (6 years old), high condylectomy and interpositional arthroplasty were performed. However, TMJ ankylosis recurred and symptoms of obstructive sleep apnea (OSA) developed. For stage II treatment during early adolescence (12 years old), gap arthroplasty, coronoidectomy, bilateral mandibular distraction osteogenesis, and orthodontic treatment with extraction of the four first premolars were performed. However, TMJ ankylosis recurred. Because the OSA symptoms reappeared, she began to use a continuous positive airway pressure device. For stage III treatment after completion of growth (20 years old), low condylectomy, coronoidectomy, reconstruction of the bilateral TMJs with artificial prostheses along with counterclockwise rotational advancement of the mandible, genioglossus advancement, and orthodontic treatment were performed. After stage III treatment, the amount of mouth opening exhibited a significant increase. Mandibular advancement and ramus lengthening resulted in significant improvement in the facial profile, Class I relationships, and normal overbite/overjet. The OSA symptoms were also relieved. These outcomes were stable at the one-year follow-up visit. Since the treatment modalities for TMJ ankylosis differ according to the duration of ankylosis, patient age, and degree of deformity, the treatment flowchart suggested in this report could be used as an effective guideline for determining the appropriate timing and methods for the treatment of TMJ ankylosis.

• Journal of Korean Neurosurgical Society
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• 제62권5호
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• pp.577-585
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• 2019

Objective : Comparing the effects of magnetically controlled growing rod (MCGR) and traditional growing rod (TGR) techniques on the sagittal plane in the treatment of early-onset scoliosis (EOS). Methods : Twelve patients were operated using dual MCGR technique in one center, while 15 patients were operated using dual TGR technique for EOS in another center. Patients' demographic characteristics, complications and radiological measurements such as cobb angle, thoracic kyphosis, lumbar lordosis, T1-S1 range (mm), proximal junctional angle, distal junctional angle, sagittal balance, coronal balance, pelvic incidence, sacral slope and pelvic tilt were assessed and compared in preoperative, postoperative and last follow-up period. Results : Age and sex distributions were similar in both groups. The mean number of lengthening in the MCGR group was 12 (8-15) and 4.8 (3-7) in the TGR group. Two techniques were shown to be effective in controlling the curvature and in the increase of T1-S1 distance. In TGR group, four patients had rod fractures, six patients had screw pull-out and four patients had an infection, whereas three patients had screw pull-out and one patient had infection complications in the MCGR group. Conclusion : There was no significant difference between the two groups in terms of cobb angle, coronal and sagittal balance and sagittal pelvic parameters. MCGR can cause hypokyphosis and proximal junctional kyphosis in a minimum 2-year follow-up period. The implant-related complications were less in the MCGR group. However, larger case groups and longer follow-up periods are required for the better understanding of the superiority of one method on other in terms of complications.

• 대한건축학회논문집:계획계
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• 제34권7호
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• pp.99-106
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• 2018

The purpose of this study is to examine adaptation types of urban tissue in Ipjeong-dong area, Seoul. Ipjeong-dong area has urban tissue those were made during Joseon dynasty and this is remaining even in the present time. This area was originally urban hanok residential districts till late 1950s. However, it has changed into machinery manufacture business area after demolition of Cheonggyechon shantytown. After several workshops and stores moved in this area, manufacturer and merchants required for more spaces due to lack of room for machinery. To place more workshops in the block, lot alteration were happened and accessibility to workshops inside the block were required. Adaptive road network which is main form of adaptative urban tissue were made to adapt in this kind of poor urban condition. To research about adaptive urban tissue making, distribution were explored and comparison tasks between various cadastral map of 1940, 1964, 1970s and 2017 were conducted. From these tasks, certain types of adaptive urban tissues and characteristics of these elements were found. First of all, forms of adaptive road depend on the surrounded environment. Connecting internal building corridor with original road system is categorized as Type A. Altering a portion of the buildings to make adaptive roads is categorized as Type B. Second, there were two types of formation of adaptive road. Type 1 is for adaptive road which is independent gesture from original road network. Type 2 is for adaptive road which is altering the form of original road network by lengthening or connecting two different dead-end roads.

• 대한건축학회논문집:구조계
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• 제36권3호
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• pp.121-128
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• 2020

In this paper, the ASCE 7 equivalent static approach for seismic design of non-structural elements is critically evaluated based on the measured floor acceleration data, theory of structural dynamics, and linear/nonlinear dynamic analysis of three-dimensional building models. The analysis of this study on the up-to-date database of the instrumented buildings in California clearly reveals that the measured database does not well corroborate the magnitude and the profile of the floor acceleration as proposed by ASCE 7. The basic flaws in the equivalent static approach are illustrated using elementary structural dynamics. Based on the linear and nonlinear dynamic analyses of three-dimensional case study buildings, it is shown that the magnitude and distribution of the PFA (peak floor acceleration) can significantly be affected by the supporting structural characteristics such as fundamental period, higher modes, structural nonlinearity, and torsional irregularity. In general, the equivalent static approach yields more conservative acceleration demand as building period becomes longer, and the PFA distribution in long-period buildings tend to become constant along the building height due to the higher mode effect. Structural nonlinearity was generally shown to reduce floor acceleration because of its period-lengthening effect. Torsional floor amplification as high as 250% was observed in the building model of significant torsional irregularity, indicating the need for inclusion of the torsional amplification to the equivalent static approach when building torsion is severe. All these results lead to the conclusion that, if permitted, dynamic methods which can account for supporting structural characteristics, should be preferred for rational seismic design of non-structural elements.

• Journal of Animal Science and Technology
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• 제64권2호
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• pp.365-379
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• 2022

The present study was conducted with the aim of investigating the effect of storage length, turning frequency and egg position on internal quality traits of chukar eggs obtained from 56-week-old chukar partridges under the same nutrition and management conditions. A total of 720 eggs were collected and assigned to 36 subgroups according to storage length (7, 14, 21, and 28 d), turning frequency (0, 1, and 24 per day) and egg position (pointed end up, blunt end up and horizontal). As a result of the study, almost all the internal quality traits of chukar eggs were negatively affected by lengthening of storage period especially 21 days and longer (p < 0.001). Internal egg quality traits weren't statistically affected by turning frequency except yolk index (p < 0.01). An improvement was observed in Haugh unit, albumen index and heigh of eggs stored with pointed end up (p < 0.001). Some significant interactions occurred among all internal egg quality traits which were mostly dependent on the eggs stored horizontally, extended storage time more than 21 days and egg turning during storage. The results and interactions showed that internal quality traits would be preserved well for the eggs stored less than 21 days with the position of pointed end up independent of turning. If the storage period was to exceed 21 days, the eggs should be positioned horizontally and turning should be applied to preserve the quality of chukar eggs.

• Clinics in Shoulder and Elbow
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• 제24권3호
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• pp.125-134
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• 2021

Background: To evaluate clinical and radiological outcomes of bony increased offset-reverse total shoulder arthroplasty (BIO-RSA) in the Asian population at mid-term follow-up. Methods: From June 2012 to August 2017 at a single center, 43 patients underwent BIO-RSA, and 38 patients with minimum 2 years follow-up were enrolled. We evaluated the clinical and radiological outcomes, and complications at the last follow-up. In addition, we divided these patients into notching and no-notching groups and compared the demographics, preoperative, and postoperative characteristics of patients. Results: Visual analogue scale, American Shoulder and Elbow Surgeons, University of California-Los Angeles Shoulder Scale, and Simple Shoulder Test scores improved significantly from preoperative (5.00, 3.93, 1.72, 3.94) to postoperative (1.72, 78.91, 28.34, 7.66) (p<0.05) outcomes. All range of motion except internal rotation improved significantly at the final follow-up (p<0.05), and the bone graft was well-incorporated with the native glenoid in all patients (100%). However, scapular notching was observed in 20 of 38 patients (53%). In the comparison between notching and no-notching groups (18 vs. 20 patients), there were no significant differences in demographics, radiological parameters, and clinical outcomes except acromion-greater tuberosity (AT) distance (p=0.003). Intraoperative complications included three metaphyseal fractures and one inferior screw malposition. Postoperative complications included ectopic ossification, scapular neck stress fracture, humeral stem relaxation, and late infection in one case each. Conclusions: BIO-RSA showed improved clinical outcomes at mid-term follow-up in Asian population. However, we observed higher scapular notching compared to the previous studies. In addition, adequate glenoid lateralization with appropriate humeral lengthening (AT distance) might reduce scapular notching.

• 한국음향학회지
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• 제42권1호
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• pp.57-66
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• 2023

본 연구에서 제안한 에너지 하베스팅 장치는 입구가 넓고 출구가 좁은 퍼넬형 에너지 하베스터(Funnel Type Energy Harvester, FTEH)에 Macro Fiber Composite(MFC)가 외팔보 형태로 장착되어 있는 구조로서 MFC의 구조를 변화 시켰을 때 FTEH에 수확하는 에너지양의 특성을 이론과 실험을 통하여 분석하였다. MFC의 길이를 50 % 증가 시켰을 때 진동 변위는 3.5배 증가하였고, 두께를 75 % 감소시 30.9배 증가하였다. 수조 실험에서 최대 전력량은 스파이럴 스크루가 장착된 상태의 유연한 지지대에 수직으로 설치된 MFC가 스파이럴 스크루가 없고 견고한 지지대에 수평으로 설치된 경우보다 약 5배 정도 높았다. FTEH에 최적저항 4,010 kΩ을 적용하여 유속 0.24 m/s일 때 FTEH의 출력을 350 s 동안 커패시터에 에너지를 저장하면 4 ㎼·s에 도달하였다. 빠른 유속으로 유연한 지지대에 수직으로 설치된 대면적 MFC의 커패시터 충전 시간을 길게 하면 충전 에너지를 증가시킬 수 있음을 확인하였다.