• BMB Reports
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• v.29 no.1
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• pp.1-10
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• 1996

The binding interaction of ethidium to a series of synthetic deoxyoligonucleotides containing a B-Z junction between left-handed Z-DNA and right-handed B-DNA, was studied. The series of deoxyoligonucleotides was designed so as to vary a dinucleotide step immediately adjacent to a B-Z junction region. Ethidium binds to the right-handed DNA forms and hybrid B-Z forms which contain a B-Z junction, in a highly cooperative manner. In a series of deoxyoligonucleotides, the binding affinity of ethidium with DNA forms which were initially hybrid B-Z forms shows over an order of magnitude higher than that with any other DNA forms, which were entirely in B-form DNA The cooperativity of binding isotherms were described by an allosteric binding model and by a neighbor exclusion model. The binding data were statistically compared for two models. The conformation of allosterically converted DNA forms under binding with ethidium is found to be different from that of the initial B-form DNA as examined by CD spectra. The ratio of the binding constant was interestingly correlated to the free energy of base unstacking and the conformational conversion of the dinucleotide. The more the base stacking of the dinucleotide is unstable, or the harder the conversion of B to A conformation, the higher the ratio of the binding constant of ethidium with the allosterically converted DNA forms and with the initial B-Z hybrid forms. DNA sequence around a B-Z junction region affects the binding affinity of ethidium. The results in this study demonstrate that ethidium could preferentially interact with unusual DNA structures.

• Proceedings of the KSR Conference
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• 2008.06a
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• pp.849-854
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• 2008

For the running safety assessment of Saemaul train passing through curves, an analysis model for multibody system has been developed. By using this model and ADAMS/Rail, sensitivity analyses depending on the variation of parameters related to the derailment coefficients have been conducted. According to the increase of running speed, the derailment coefficient and unload ratio were increased. At high speed, the derailment coefficient and unload ratio of left wheel showed higher than right wheel. If the cant increased, the derailment coefficient and unload ratio increased. but decreased based on the balance cant value by the curvature and running speed.

• Tunnel and Underground Space
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• v.28 no.2
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• pp.170-185
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• 2018

The effect of fault on the stability of the closely-spaced twin tunnels located in fault zones was investigated by numerical analyses and scaled model tests on condition of varying widths, inclinations and material properties of fault. When obtaining the strength/stress ratios of pillar between twin tunnels, three different stresses were used which were measured at the middle point of pillar, calculated to whole average along the pillar section and measured at the left/right edges of pillar. Among them, the method by use of the left/right edges turned out to be the most conservative stability estimation regardless of the presence of fault and reflected the excavating procedures of tunnel in real time. It was also found that the strength/stress ratios of pillar were decreased as the widths and inclinations of fault were increased and as the material properties of fault were decreased on condition using the stresses measured at the left/right edges of pillar. As a result of scaled model tests, it was found that the model with fault showed less crack initiating pressure than the model without fault. As the width of fault was larger, tunnel stability was decreased. The fault had also a great influence on the failure behavior of tunnels, such as the model without fault showed failure cracks generated horizontally at the left/right edges of pillar and at the sidewalls of twin tunnels, whereas the model with fault showed failure cracks directionally generated at the center of pillar located in the fault zone.

• Journal of Chest Surgery
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• v.10 no.2
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• pp.268-273
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• 1977

During the period from March, 1963, to November, 1977, forty-eight patients with secundum type atrial septal defects have undergone surgical repair using cardiopulmonary bypass with a pump oxygenator at the Seoul National University Hospital. Twenty-six [55 percent] of the patients were females and Twenty-two [45 percent] were males. The patients varied in age from 3 years to 51 years. We have divided secundum defects into three types. These are: 1] the high defect; 2] Ovale type defect; and 3] low defect including the defect in the area of the coronary sinus. An ovale type defect was present in forty-one cases [85 percent]. Partial anomalous pulmonary venous connections were present in two patients in the high defect group. All of the forty-eight patients had had right heart catheterization before operation. The pulmonary to systemic flow ratio [Qp/Qs] was determined in our 38 patients. The Qp/Qs was less than 1.5/1 in only five of the 38 patients. Among the 33 patients with moderate and severe left-to-right shunts [Qp/Qs 1.6-3.5/1], the systolic pulmonary artery pressures. ranged from 30 to 80 mm Hg. Large left-to-right shunts [Qp/Qs>3.6/1] were present in 13 patients. The postoperative complications occurred in 13 patients [27. 1 percent]. Postoperative wound infections were the most frequent complications being present in 6 patients [12.5%]. Forty-six of the patients with secundum atrial septal defects survived surgical repair of their defects. Thus the hospital mortality of surgery was 4.2 percent. The causes of death in the early postoperative period were: 1] low cardiac output syndrome related to severe pulmonary hypertension in one case; and 2] postoperative several bleeding in one case.

• Ecology and Resilient Infrastructure
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• v.6 no.4
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• pp.314-327
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• 2019

This study investigates channel stabilities with groynes by developing the assessment of it and applying a 2-dimensional numerical model, which simulates flow and sediment transport with various flows in the channel. Evaluation inventories are composed of five items, which are width to depth ratio, sinuosity, bed slopes, velocities in the flow flied, Shields number with discharges and geomorphic characteristics in the study reach. The channel stability is evaluated by applying the evaluation indicators to the channel with and without groynes in the study reach between Dalseong-weir and Gangjeonggoryeong-weir in the Nakdong river. Width to depth ratio, sinuosity, and bed slopes, which are index of river characteristics, little affect the channel stability. However, velocities in the flow flied, and Shields number, which is dimensionless tractive, near the banks of the channel strongly affect the stability. The evaluation values of the stability in the channel on the left and right banks decrease as the number of groynes increase in both the left and right banks, which means that the bank stability increases with the groynes.

• The Journal of Korean Academy of Prosthodontics
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• v.29 no.1
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• pp.53-71
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• 1991

This study was performed to investigate the muscular activity of the complete denture wearers compare with subjects with natural teeth. For the study, 10 subjects with natural dentition and 18 upper and lower complete denture wearers selected and the Bio-electric Processor EM2(Myo-tronics Reaserch, Inc., U.S.A.) with the surface electrodes was used to record electromyographic activity from the right and left middle of masseter and anterior temporal muscles of each subject during mandibular postural rest position, tapping of teeth from postural rest position, maximal clench, and right and left gum and raw carrow chewing. This results of this study were as follows : 1. In mandibular postural rest position, the denture wearers produces high muscular activity in contrast to natural objects(P<0.05) but, there was no difference between the state of denture removal and insertion, and the muscle activity of the anterior temporal muscle was high than the middle of masseter muscle in natural objects and denture wearers. 2. In tapping of teeth, there was no difference in muscle activity between natural objects and the state of denture removal of denture wearers. 3. In maximal clench, there was markedly lower denture wearers than natural objects in muscle activity, and the ratio of mean voltages was about 36 percentages. 4. In gum and raw carrow chewing, the activity was lower than natural object, the ratio was about 59 percentages. 5. In chewing, the mean voltages of the middle of masster muscle on the chewing side was highest, followed by the anterior temporal on the chewing side, the anterior temporal and masster muscles on the non-chewing side.

• Journal of Chest Surgery
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• v.19 no.1
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• pp.140-147
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• 1986

A clinical study was made on 72 cases of primary lung cancer operated in the department of thoracic & cardiovascular surgery, Kyungpook national university hospital from January 1975 to May 1985. The ratio of male to female was 13.4: I and mean age was 53. Histologically, squamous cell carcinoma comprised 72.2% of 72 operated cases. Before admission to our hospital, the erroneous diagnoses were made at local clinics on the 43 cases[59.7%] and a large percentage of them was diagnosed as pulmonary tuberculosis. And then, total of 56 cases received inadequate treatment or delayed the operation. For the location of the tumor, right to left ratio is 1.2:1 and the right upper lobe was most often involved [23.6%]. Operation was performed on the 72 cases and resection on the 59 cases[8.2%]. Postsurgical staging showed that stage III was found most frequently [59.4%] and T,N,M, was 28% of total cases. Two common surgical complications were bleeding in 7 and acute respiratory failure in 6 cases, and these 6 cases of acute respiratory failure were all died. On the basis of these experiences, we conclude that aggressive effort is needed for the early accurate diagnosis and adequate treatment of lung cancer.

• Korean Circulation Journal
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• v.53 no.5
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• pp.331-343
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• 2023

Background and Objectives: The prognostic implication of right atrial (RA) and left atrial (LA) size for an immediate success of direct current cardioversion (DCCV) in atrial fibrillation (AF) remains unclear. This study aimed to compare RA and LA size for the prediction of DCCV success. Methods: Between 2012 and 2018, 734 consecutive outpatients were screened for our prospective registry. Each eligible patient received a medical history, blood analysis, and transthoracic echocardiography with a focus on indexed RA (iRA) area and LA volume (iLAV) prior to DCCV with up to three biphasic shocks (200-300-360 J) or additional administration of amiodarone or flecainide to restore sinus rhythm. Results: We enrolled 589 patients, and DCCV was in 89% (n=523) successful. Mean age was 68 ± 10 years, and 40% (n=234) had New York heart association class >II. A prevalence of the male sex (64%, n=376) and of persistent AF (86%, n=505) was observed. Although DCCV success was associated with female sex (odds ratio [OR], 1.88; 95% confidence interval [CI], 1.06-3.65), with absence of coronary heart disease and normal left ventricular function (OR, 2.24; 95% CI, 1.26-4.25), with short AF duration (OR, 1.93; 95% CI, 1.05-4.04) in univariable regression, only iRA area remained a stable and independent predictor of DCCV success (OR, 0.27; 95% CI, 0.12-0.69; area under the curve 0.71), but not iLAV size (OR, 1.16; 95% CI, 1.05-1.56) in multivariable analysis. Conclusions: iRA area is superior to iLAV for the prediction of immediate DCCV success in AF.

• Journal of Chest Surgery
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• v.57 no.4
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• pp.360-368
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• 2024

Background: The left pulmonary artery (LPA) may be kinked and stenotic, especially in tetralogy of Fallot, because of ductal tissue and anterior deviation of the conal septum. If LPA stenosis is not effectively treated during total correction, surgical angioplasty is occasionally performed. However, whether pulmonary artery (PA) angioplasty in adolescents or adults improves perfusion in the ipsilateral lung remains unclear. Methods: This retrospective review enrolled patients who underwent PA angioplasty for LPA stenosis between 2004 and 2019. Among patients who underwent a lung perfusion scan (LPS) or cardiac magnetic resonance imaging (cMRI) pre- and post-pulmonary angioplasty, those aged >13 years with <40% left lung perfusion (p-left) in the pre-angioplasty study were included. Preoperative and postoperative computed tomography, LPS, and cMRI data were collected. The perfusion ratio was analyzed according to the LPA's anatomical characteristics. Results: Seventeen adolescents and 16 adults (≥18 years old) were finally included (median age, 17 years). The most common primary diagnosis was tetralogy of Fallot (87.9%). In all patients, LPA angioplasty was performed concomitantly with right ventricular outflow tract reconstruction. No patients died. Preoperative p-left was not significantly different between adolescents and adults; however, adolescents had significantly higher postoperative p-left than adults. P-left significantly increased in adolescents, but not in adults. Seven patients had significant stenosis (z-score <-2.0) confined only to the proximal LPA and demonstrated significantly increased p-left. Conclusion: PA angioplasty significantly increased ipsilateral lung perfusion in adolescents. If focal stenosis is confined to the proximal LPA, PA angioplasty may improve ipsilateral lung perfusion, regardless of age.

• PNF and Movement
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• v.14 no.1
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• pp.53-57
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• 2016

Purpose: This study aimed to examine the correlation between the asymmetric ratio of occlusal force of the temporomandibular joint and the thickness of the middle scalene muscle. Methods: The study measured the occlusal force of the right and left temporomandibular joints in 30 subjects (12 males and 18 females). Pearson's correlation analysis was performed to examine the effect of occlusal force on the asymmetric ratio of the thickness of their middle scalene muscles by measuring the force using ultrasound after the break. Results: The correlation between the asymmetric ratio of occlusal force and muscle thickness is 0.41, according to Pearson's correlation coefficient. Therefore, the result shows a moderate correlation with the asymmetric ratio of the temporomandibular joint depending on differences in the thickness of the middle scalene muscle. Conclusion: Based on the above results, the asymmetric ratio of occlusal force was found to correlate with the thickness of the middle scalene muscle. Thus, therapeutic intervention is required for the middle scalene muscle in the case of temporomandibular joint disorder.