• Title/Summary/Keyword: Lee Young-choon

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Determination of the minimal sequence of bovine lactoferricin responsible for apoptosis induction

  • Yoo, Yung-Choon;Lee, Kyung-Bok;Lee, Hoi-Young
    • Proceedings of the PSK Conference
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    • 2003.10b
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    • pp.134.2-135
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    • 2003
  • We examined the minimal amino acid sequence of bovine lactoferricin (Lfcin-B), a cationic peptide corresponding to residues 17-41 near the N-terminus of bovine lactoferrin, to induce apoptosis in THP-l human monocytic leukemic cells using synthetic peptides. A synthetic peptide (Lfc-17/29, amino acid sequence; FKCRRWQWRMKKL) which is consist of 13 amino acids near the N-terminus of Lfcin-B induced cell death in THP-1 cells in a dose-dependent manner, showing apparent apoptotic changes such as hypodiploid forms of genomic DNA and apoptotic DNA fragmentation. (omitted)

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$MPP^{+}-induced$ cytotoxicity is attenuated by induction of heme oxygenase

  • Park, Ha-Young;Lee, Seung-Jin;Yang, Sang-In;Jang, Choon-Gon;Lee, Seok-Yong
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.267.2-267.2
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    • 2002
  • MPP$\^$+/ is known to be a neurotoxic substance that induces the degeneration of dopaminergic neurons and a Parkinsonism-like syndrome. MPP$\^$+/ is retained intracellularly or accumulated in dopaminergic neurons via the dopamine-reuptake system. It inhibits mitochondrial electron transport in dopaminergic neurons. In addition. it generates hydroxyl radicals. which cause the peroxidation of membrane lipid or damage DNA. (omitted)

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