• Proceedings of the Korean Society of Agricultural Engineers Conference
• /
• 한국농공학회 2004년도 학술발표논문집
• /
• pp.95-95
• /
• 2004

• KCID journal
• /
• 제2권2호
• /
• pp.27-36
• /
• 1995

Changes of meteorology, hydrological mechanism and discharge phenomena by the regional development have caused many technical, social and economical problems. Therefore, the regional development neglecting such changing parameters can provide considerable

• Proceedings of the KHMA Conference
• /
• 한국가정관리학회 2008년도 제44차 추계학술대회
• /
• pp.271-271
• /
• 2008

• The Korean Journal of Physiology and Pharmacology
• /
• 제21권3호
• /
• pp.327-334
• /
• 2017

Epidemiologic interest in particulate matter (PM) is growing particularly because of its impact of respiratory health. It has been elucidated that PM evoked inflammatory signal in pulmonary epithelia. However, it has not been established $Ca^{2+}$ signaling mechanisms involved in acute PM-derived signaling in pulmonary fibroblasts. In the present study, we explored dust particles PM modulated intracellular $Ca^{2+}$ signaling and sought to provide a therapeutic strategy by antagonizing PM-induced intracellular $Ca^{2+}$ signaling in human lung fibroblasts MRC5 cells. We demonstrated that PM10, less than $10{\mu}m$, induced intracellular $Ca^{2+}$ signaling, which was mediated by extracellular $Ca^{2+}$. The PM10-mediated intracellular $Ca^{2+}$ signaling was attenuated by antioxidants, phospholipase blockers, polyADPR polymerase 1 inhibitor, and transient receptor potential melastatin 2 (TRPM2) inhibitors. In addition, PM-mediated increases in reactive oxygen species were attenuated by TRPM2 blockers, clotrimazole (CLZ) and N-(p-amylcinnamoyl) anthranilic acid (ACA). Our results showed that PM10 enhanced reactive oxygen species signal by measuring DCF fluorescence and the DCF signal attenuated by both TRPM2 blockers CLZ and ACA. Here, we suggest functional inhibition of TRPM2 channels as a potential therapeutic strategy for modulation of dust particle-mediated signaling and oxidative stress accompanying lung diseases.

• KCID journal
• /
• 제1권2호
• /
• pp.22-28
• /
• 1994

The calculation method for the Drought index based on the principal hydrological factors, such as precipitation, reservoir storage and river discharge, can estimate the duration and intensity of drought. It is not easy to establish an universal criteria o

• KCID journal
• /
• 제4권2호
• /
• pp.48-61
• /
• 1997

Drought index calculation method using principal hydrological factors, such as precipitation amount and reservoir storage ratio, can estimate the duration and the intensity of drought. It is not easy to establish an universal criteria of drought, since th

• The Korean Journal of Ceramics
• /
• 제4권4호
• /
• pp.377-381
• /
• 1998

Wear behaviors of unidirectionally oriented $Si_3N_{4w)/Si_3N_4$ composites, sintered at different temperatures with different alignments of whiskers, have been studied in parallel and perpendicular sliding directions with respect to the orientation of the whiskers by using a ball-on-disk reciprocating sliding apparatus. The results show that wear rate in parallel direction is much greater than that in perpendicular direction. With decreasing alignment of the whiskers, the wear rate decreases in parallel sliding direction and increases in perpendicular direction. With increasing sintering temperature, the wear rate increases obviously in both parallel and perpendicular directions.

• The Korean Journal of Physiology and Pharmacology
• /
• 제25권1호
• /
• pp.27-38
• /
• 2021

Excessive salt intake induces hypertension, but several gamma-aminobutyric acid (GABA) supplements have been shown to reduce blood pressure. GABA-salt, a fermented salt by L. brevis BJ20 containing GABA was prepared through the post-fermentation with refined salt and the fermented GABA extract. We evaluated the effect of GABA-salt on hypertension in a high salt, high cholesterol diet induced mouse model. We analyzed type 1 macrophage (M1) polarization, the expression of M1 related cytokines, GABA receptor expression, endothelial cell (EC) dysfunction, vascular smooth muscle cell (VSMC) proliferation, and medial thicknesses in mice model. GABA-salt attenuated diet-induced blood pressure increases, M1 polarization, and TNF-α and inducible nitric oxide synthase (NOS) levels in mouse aortas, and in salt treated macrophages in vitro. Furthermore, GABA-salt induced higher GABAB receptor and endothelial NOS (eNOS) and eNOS phosphorylation levels than those observed in salt treated ECs. In addition, GABA-salt attenuated EC dysfunction by decreasing the levels of adhesion molecules (E-selectin, Intercellular Adhesion Molecule-1 [ICAM-1], vascular cell adhesion molecule-1 [VCAM-1]) and of von Willebrand Factor and reduced EC death. GABA-salt also reduced diet-induced reductions in the levels of eNOS, phosphorylated eNOS, VSMC proliferation and medial thickening in mouse aortic tissues, and attenuated Endothelin-1 levels in salt treated VSMCs. In summary, GABA-salt reduced high salt, high cholesterol diet induced hypertension in our mouse model by reducing M1 polarization, EC dysfunction, and VSMC proliferation.

• Proceedings of the Korea Information Processing Society Conference
• /
• 한국정보처리학회 2006년도 춘계학술발표대회
• /
• pp.489-492
• /
• 2006

IDA(Inter-Domain Authentication)는 한 영역의 클라이언트가 다른 영역의 서버에 접근이 가능하게 하는 인증 메카니즘이다. 기존의 커버러스 인증 메카니즘에는 IRA(Inter-Realm Authentication)를 제공하고 있지만 모든 인증방식이 커버러스로 구현된 경우에만 가능하다. 현재 재버의 표준으로는 커버러스 이외에 다른 인증 메카니즘이 병존할 수 있기 때문에 커버러스의 IRA로는 지원이 불가능하다. 따라서 본 연구에서는 재버의 환경에서 다양한 인증 메카니즘이 존재하는 경우에도 적용할 수 있는 IDA를 제안한다. 이 메카니즘을 사용함으로써 중복저장과 동기화에 대한 문제를 해결하여 분산 응용프로그램을 용이하게 설계 구축 할 수 있다.

• Proceedings of the Korean Institute of Building Construction Conference
• /
• 한국건축시공학회 2008년도 춘계 학술논문 발표대회
• /
• pp.73-77
• /
• 2008

In this study, we would like to study on the application of roof exposure waterproofing method of joint stability through shiplap rubberized asphalt color sheet to complement problem of fracture, exfoliation and water leakage by existing roof exposure sheet waterproofing material joint weakness. Accordingly, examined basis performance and stability for joint that shiplap rubberized asphalt color sheet through test of that tensile strength, bonding strength, water permeability after bonding, peel resistance after bonding, lengthen resistance after bonding and hang resistance after bonding. The results of this study, waterproofing method to using shiplap rubberized asphalt color sheet is judged to solved fracture, exfoliation and water leakage problems happened in joint by problem was joint of exposure sheet by minimizing gap of joint being integration by shiplap.