• 약학회지
• /
• 제47권5호
• /
• pp.261-265
• /
• 2003

Near-infrared (NIR) system was used to determine rapidly and simply indomethacin in buffer solution for a dissolution test of tablets and capsules. Indomethacin standards were prepared ranging from 10 to 50 ppm using the mixture of phosphate buffer (pH 7.2) and water (1 : 4). The near-infrared (NIR) transmittance spectra of indomethacin standard solutions were collected by using a quartz cell in 1 mm and 2 mm pathlength. Partial least square regression (PLSR) was explored to develop calibration models over the spectral range 1100∼1700 nm. The model using 1 mm quartz cell was better than that using 2 mm quartz cell. The PLSR models developed gave standard error of prediction (SEP) of 0.858 ppm. In order to validate the developed calibration model, routine analysis was performed using another standard solutions. The NIR routine analysis showed good correlation with actual values. Standard error of prediction (SEP) is 1.414 ppm for 7 indomethacin samples in routine analysis and its error was permeable in the regulation of Korean Pharmacopoeia (VII). These results show the potential use of the real time monitoring for indomethacin during a dissolution test.

• Management Science and Financial Engineering
• /
• 제14권2호
• /
• pp.89-104
• /
• 2008

Growth curves including Bass, Logistic and Gompertz functions are widely used in forecasting the market demand. Nonlinear least square method is often adopted for estimating the model parameters but it is difficult to set up the starting value for each parameter. If a wrong starting point is selected, the result may lead to erroneous forecasts. This paper proposes a method of selecting starting values for model parameters in estimating some growth curves by nonlinear least square method through grid search and transformation into linear regression model. Resealing the market data using the national economic index makes it possible to figure out the range of parameters and to utilize the grid search method. Application to some real data is also included, where the performance of our method is demonstrated.

• Communications for Statistical Applications and Methods
• /
• 제15권4호
• /
• pp.633-642
• /
• 2008

본 논문에서는 반응변수가 하나 이상이고 설명변수들의 수가 관측치에 비하여 상대적으로 많은 경우에 널리 사용되는 부분최소제곱회귀모형에 벌점함수를 적용하여 모형에 필요한 설명변수들을 선택하는 문제를 고려하였다. 모형에 필요한 설명변수들은 각각의 잠재변수들에 대한 최적해 문제에 벌점함수를 추가한 후 모의담금질을 이용하여 선택하였다. 실제 자료에 대한 적용 결과 모형의 설명력 및 예측력을 크게 떨어뜨리지 않으면서 필요없는 변수들을 효과적으로 제거하는 것으로 나타나 부분최소제곱회귀모형에서 최적인 설명변수들의 부분집합을 선택하는데 적용될 수 있을 것이다.

• 분석과학
• /
• 제16권3호
• /
• pp.185-190
• /
• 2003

회귀식 사용에 따른 불확도 계산의 정확성을 조사하기 위하여, 수정된 방법의 최소제곱법(Modified Least Square Method, MLS)과 회귀식에서 일반적으로 적용되는 불확도 처리 과정을 각각 1차 식에 적용하고 비교하였다. 회귀식에서 일반적으로 적용되는 불확도 처리 과정에서, 대부분의 경우 불확도 값이 크게 계산되고 있어 확률적으로 안전한 범위를 표기할 수 있는 것으로 평가되었다. 그러나, 표준시료 농도의 상대 표준불확도가 클 때 (교정점이 우발적으로 흩어지는 정도의 표준 편차가 5% 수준, 표준시료 농도의 상대 표준불확도가 7% 수준) 회귀식에서 일반적으로 적용되는 불확도 계산 방법으로 얻은 값이 고 농도 측정에서 매우 작게 평가되고 있어 확률적으로 매우 위험한 것으로 평가되었다. 이 경우, 통계학적으로 불확도를 정확히 계산하기 위하여, 수정된 방법의 최소제곱법이 유리하다고 판단하였다.

• 한국수자원학회논문집
• /
• 제41권9호
• /
• pp.943-958
• /
• 2008

본 연구는 수위-유량 관계곡선식의 매개변수 추정을 수행하기 위하여 Bayesian 회귀분석을 적용하였다. 또한 불확실성측면에서의 효과를 탐색하기 위하여 Bayesian 회귀분석에 의한 추정치와 t 분포를 이용하여 산정한 일반 최소자승법(ordinary least square, OLS)에 의한 회귀분석의 추정치를 각각 산정하여 산정결과의 신뢰구간을 비교분석 하였다. 등분산케이스의 통계적 실험결과 t 분포를 이용하여 산정된 평균 추정치와 Bayesian 회귀분석에 의한 평균 추정치는 크게 다르지 않았으나, 비등분산 케이스의 경우에는 Bayesian 회귀분석이 참값에 가까운 추정치를 산정함을 알 수 있었다. 또한 불확실성 측면에서 평가해 볼 때 신뢰구간의 상한추정치와 하한추정치의 차이는 Bayesian 회귀분석을 사용한 경우가 기존 방법을 사용한 경우보다 작은 것으로 나타났으며, 이로부터 수위-유량 관계곡선식의 매개변수를 추정하는 경우 Bayesian 회귀분석이 일반 회귀분석보다 불확실성을 표현하는데 있어서 우수하다는 결과를 얻을 수 있었다. 적용된 두 가지의 추정방법은 비등분산성을 고려한 통계적 실험을 통하여 장점과 단점이 비교되었으며, 안양천 유역의 5개 지점으로부터 얻어진 유량측정성과를 이용하여 적용성을 알아보았다. 현장 적용결과는 참값을 알지 못하므로 정량적 우수성은 평가할 수 없었으나, 기존에 사용되는 불확실성 산정방법보다 Bayesian 회귀 분석 불확실성은 감소시켜 나타냄을 알 수 있었다.

• Journal of the Korean Data and Information Science Society
• /
• 제13권2호
• /
• pp.31-38
• /
• 2002

In the case of multiple survival times which might be censored at each covariate vector, we study the regression quantile estimations in this paper. The estimations are based on the empirical distribution functions of the censored times and the sample quantiles of the observed survival times at each covariate vector and the weighted least square method is applied for the estimation of the regression quantile. The estimators are shown to be asymptotically normally distributed under some regularity conditions.

• Journal of the Korean Data and Information Science Society
• /
• 제18권4호
• /
• pp.995-1004
• /
• 2007

In this paper, we analyse online word-of-mouth and Korean box-office sales data based on kernel regression method. To do this, we consider the regression model with mixed-data and apply the least square cross-validation method proposed by Li and Racine (2004) to the model. We found the box-office sales can be explained by volume of online word-of-mouth and the characteristics of the movies.

• Restorative Dentistry and Endodontics
• /
• 제44권1호
• /
• pp.11.1-11.8
• /
• 2019

In the previous sections, simple linear regression (SLR) 1 and 2, we developed a SLR model and evaluated its predictability. To obtain the best fitted line the intercept and slope were calculated by using the least square method. Predictability of the model was assessed by the proportion of the explained variability among the total variation of the response variable. In this session, we will discuss four basic assumptions of regression models for justification of the estimated regression model and residual analysis to check them.

• Archives of Pharmacal Research
• /
• 제28권5호
• /
• pp.598-603
• /
• 2005

The purpose of this study was to determine the influence of weight with gentamicin assay error on the Bayesian and nonlinear least squares regression analysis in 12 Korean appen dicitis patients. Gentamicin was administered intravenously over 0.5 h every 8 h. Three specimens were collected at 48 h after the first dose from all patients at the following times, just before regularly scheduled infusion, at 0.5 h and 2 h after the end of 0.5 h infusion. Serum gentamicin levels were analyzed by fluorescence polarization immunoassay technique with TDxFLx. The standard deviation (SD) of the assay over its working range had been determined at the serum gentamicin concentrations of 0, 2, 4, 8, 12, and 16 ${\mu}g$/mL in quadruplicate. The polynominal equation of gentamicin assay error was found to be SD (${\mu}g$/mL) = 0.0246-(0.0495C)+ (0.00203C$^2$). There were differences in the influence of weight with gentamicin assay error on pharmacokinetic parameters of gentamicin using the nonlinear least squares regression analysis but there were no differences on the Bayesian analysis. This polynominal equation can be used to improve the precision of fitting of pharmacokinetic models to optimize the process of model simulation both for population and for individualized pharmacokinetic models. The result would be improved dosage regimens and better, safer care of patients receiving gentamicin.

• 대한인간공학회지
• /
• 제20권1호
• /
• pp.45-62
• /
• 2001

This study suggests a genetic algorithm-based partial least squares (GA-based PLS) method to select the design variables for building a usability model. The GA-based PLS uses a genetic algorithm to minimize the root-mean-squared error of a partial least square regression model. A multiple linear regression method is applied to build a usability model that contains the variables seleded by the GA-based PLS. The performance of the usability model turned out to be generally better than that of the previous usability models using other variable selection methods such as expert rating, principal component analysis, cluster analysis, and partial least squares. Furthermore, the model performance was drastically improved by supplementing the category type variables selected by the GA-based PLS in the usability model. It is recommended that the GA-based PLS be applied to the variable selection for developing a usability model.