• Biomolecules & Therapeutics
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• v.22 no.3
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• pp.232-238
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• 2014

Alzheimer's disease (AD) is the most common neurodegenerative disease without known ways to cure. A key neuropathologic manifestation of the disease is extracellular deposition of beta-amyloid peptide (Ab). Specific mechanisms underlying the development of the disease have not yet been fully understood. In this study, we investigated effects of 4-O-methylhonokiol on memory dysfunction in APP/PS1 double transgenic mice. 4-O-methylhonokiol (1 mg/kg for 3 month) significantly reduced deficit in learning and memory of the transgenic mice, as determined by the Morris water maze test and step-through passive avoidance test. Our biochemical analysis suggested that 4-O-methylhonokiol ameliorated $A{\beta}$ accumulation in the cortex and hippocampus via reduction in beta-site APP-cleaving enzyme 1 expression. In addition, 4-O-methylhonokiol attenuated lipid peroxidation and elevated glutathione peroxidase activity in the double transgenic mice brains. Thus, suppressive effects of 4-O-methylhonokiol on $A{\beta}$ generation and oxidative stress in the brains of transgenic mice may be responsible for the enhancement in cognitive function. These results suggest that the natural compound has potential to intervene memory deficit and progressive neurodegeneration in AD patients.

• The Journal of Korean Academic Society of Nursing Education
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• v.16 no.2
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• pp.239-248
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• 2010

Purpose: This study was done to propose the developmental direction of study related to nursing practice education by grasping the trend of study in fundamental and clinical practice. Method: A total of 48 research articles which were published on nursing practice education in Korea from 2002 to 2009 were analyzed with structured analysis forms. Result: Most research was related to clinical practice (n=40). A high percentage of non-experimental research design was related to fundamental practice (75%) and clinical practice (65%). Qualitative research was only used in clinical practice (n=8). Nursing students were predominantly selected as an object of research in fundamental practice (n=6) and clinical practice (n=32). In addition, many of the areas in clinical practice were a general clinical setting without any classification of the specific area. The concepts of research in fundamental practice were related to competency in basic nursing skill and most concepts of research in clinical practice were associated with satisfaction, stress, experience, critical thinking and problem solving ability of the nursing student. Conclusion: There's something to be desired in nursing research related to instructor methods, teaching-learning methods and nursing education programs. Therefore, more specific and continuous research focused on these topics to improve clinical nursing competence of the nursing student is needed.

• Journal of Ginseng Research
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• v.31 no.3
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• pp.117-126
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• 2007

Ginseng, the root of Panax species, a well-known herbal medicine has been used as a traditional medicine for thousands of years and is now a popular and worldwide used natural medicine. Ginseng has been used primarily as a tonic to invigorate weak bodies to help the restoration of homeostasis in a wide range of pathological conditions such as cardiovascular diseases, cancer, immune deficiency and hepatotoxicity. Although conclusive clinical data in humans is still missing, recent research results have suggested that some of the active ingredients ginseng exert beneficial effects on central nervous system (CNS) disorders and neurodegenerative diseases, suggesting it could be used in treatment of psychotic disorders. Data from neural cell cultures and animal studies contribute to the understanding of these mechanisms that involve inhibitory effects on stress-induced corticosterone level increasing and modulating of neurontransmitters, reducing $Ca^{2+}$ over-influx, scavenging of free radicals and counteracting excitotoxicity. In this review, we focused on recently reported medicinal effects of ginseng and summarized the possibility of its applications on psychotic disorders.

• Communications of Mathematical Education
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• v.22 no.3
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• pp.311-335
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• 2008

The importance of students' precise understanding of mathematical definitions, formulas, and theorems can not be underestimated. In this survey research, we attempted to evaluate students' understanding of the concepts of five topics -limit, continuity and intermediate theorem, derivative, application of derivative and integral. On the basis of the research result, this paper suggests that we need to 1) be more inventive and speculative in making test problems, 2) explain the examples and counter-examples more concretely, 3) stress and repeat the basic concepts on the stage of introducing new concepts, 4) develop more effective problems for the measure of students' understanding of mathematical concepts, 5) use developed problems in actual teaching.

• Journal of Digital Convergence
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• v.10 no.7
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• pp.245-251
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• 2012

The significance of this study lies in the fact that it looks into the function of games as one of the important leisure activities at the moment when negative perception on overall game industry is becoming an obstacle in settlement of sound game culture. Game is one of the activities enjoyed in leisure time. The main positive effects of game were analyzed classifying them into 10 types including the stress relief and alleviation of tension, diverse identity experience and positive socialization experience, strengthening of self-respect and ideal self-realization, strengthening of independent thinking and problem-solving capacity, motivation for learning, enhancement in physical capacity, decrease in aggressive tendencies, cultivation of awareness on equality, increase in familiarity with the civilization of technology, and strengthening of individuality based on diversity.

• Journal of the Korean Institute of Educational Facilities
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• v.20 no.6
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• pp.49-56
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• 2013

This study investigated middle school students' perceptions of an optimum class size as well as the relationships between a class size and various aspects of students' lives at school. Data were gathered from 858 students from 8 classes (grade 1 and 2) at 4 middle schools located in Busan by administering survey questionnaires. The average class sizes to which each participating students belonged were 17.88, 30.0, 31.88, 28.0 respectively. A series of comparative analyses were carried out, revealing that the majority of the participating students perceived 25-30 as an optimum size for one class. Also, students in a relatively smaller class tended to show higher levels of satisfaction with school lives and with school and classroom facilities, more positive attitudes towards classroom atmosphere, and greater needs for peer interaction than did their counterparts. Furthermore, it was found out that the actual class size had to do with the students' perceptions of the relationships between school facilities and their levels of stress and pleasure at school. These findings were discussed in order to provide educators, architects, and policy makers with practical implications for bringing about a better school environment that is conducive to learning and living for middle school students.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2010.05a
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• pp.953-955
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• 2010

Most domestic educational mobile contents put special stress on learning foreign languages such as English, and usually the telecommunications companies and the education companies partner to provide mobile terminals with the contents such as video files. Recently the trend of mobile platforms for the educational contents have been changed because of the release the many kinds of smart phones like iPhone and Google Phone. In this paper, we design the educational contents for Korean listening education to aid to study Korean effectively as a foreign language. It carries out a detailed design to realize and run the contents based on the Android OS which is an open source platform backed by Google.

• The Korean Nurse
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• v.33 no.2
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• pp.59-72
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• 1994

This study was conducted to identify an initial clinical experience of nursing students, so to better understanding to students' experience in clinical setting. The study subjects were 39 nursing students working in C department of nursing in C city. This study was approached by phenomenological method, collected data were analyzed by Colaizzi's method. The results were followed. From the protocol, 236 significant statements were organized into 56 formulated meanings. From formulated meanig, 27 themes were identified, organized into 13 theme clusters, and then into 6 categories. Theose nursing students experienced $\mathbb{\ulcorner}$tension$\mathbb{\lrcorner}$ in adjusting themselves to new clinical settings, $\mathbb{\ulcorner}$fear and anxiety$\mathbb{\lrcorner}$ in using unskillful nursing skills. They also went through $\mathbb{\ulcorner}$stress> by difficulties in applying their knowledge and skill to nursing practice, in lack of nursing knowledge and skill, in dealing with making interpersonal relationship with clinical staffs, in insufficiency of clinical instructions and in role ambiguity among nursing students. Physical $\mathbb{\ulcorner}$fatigue$\mathbb{\lrcorner}$ and $\mathbb{\ulcorner}$disappointment and doubt$\mathbb{\lrcorner}$ by the difference between reality and expectation caused by clinical experience. However, clinical experience enabled nursing students to enhance their understanding of human beings, learning, their satisfaction. to nursing practice, to identify the confirmation of nursing identity, so to gain $\mathbb{\ulcorner}$sense of accomplishment$\mathbb{\lrcorner}$. The results of this study are to use as basic data for students attending clinical experience for the first time.

• The Korean Journal of Food & Health Convergence
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• v.6 no.2
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• pp.23-26
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• 2020

Active and therapeutic sport recovery is becoming a popular and important component in approving performance for pro and recreational athletes alike. It is also helping in the realm of injury prevention. In the search of finding modalities that are widely effective, natural, and safe, acupuncture is a viable and cost-effective treatment for helping athletes achieve this goal. More direct related research is needed, but testimonials from pro athletes and the body of research that currently exists provides powerful evidence on acupunctures ability to help with enhancing recovery. Specializing in acupuncture and exercise science, Chris integrates acupuncture into musculoskeletal rehabilitation therapy or fitness training for pain modulation, speedy recovery, and enhanced performance. Clients can choose to focus on one-on-one corrective exercise therapy, manual and massage therapy, or acupuncture. However, for best results, Chris recommends all three. Other modalities that he uses in therapy are acu-taping, herbal therapy, nutrition supplementation, cupping, guasha, and stretching techniques. The corrective exercise component is one-on-one body balancing management, focusing on strength and conditioning, post physical rehab - exercise therapy, integrative sport specific exercise, weight loss, core strengthening, dynamic lumbar stabilization, active recovery techniques, and myo-fascial release techniques. The acupuncture component focuses on sport injuries, myofascial pain, peripheral neuropathy, arthritis, facial rejuvenation, stress, smoking cessation, addiction detoxification program, weight management, sport recovery and performance.

• Phonetics and Speech Sciences
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• v.10 no.4
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• pp.45-52
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• 2018

This study investigates the effect of Japanese (L1) on the production of the Korean rhythmic structure. Korean and Japanese have typologically different rhythmic structure as a syllable-timed language and mora-timed language, respectively. This rhythmic difference comes from the different phonological properties of the two languages. Due to this difference, Japanese speakers that are learning Korean may produce a different rhythm than native Korean speakers' rhythm. To investigate the influence of the native language's rhythm on the target language, we conducted an acoustic analysis using acoustic metrics such as %V, VarcoV, and VarcoS. Four Korean native speakers and ten advanced Japanese Korean learners participated in a production test. The analyzed material consisted of six Korean sentences that contained various syllable structures. The results showed that KS and JS's rhythms are different in %V as well as in VarcoV. In the case of VarcoS, significant rhythmic difference was observed in the VC and CVC syllable, in which the coda segment is nasal sound. This study allowed us to observe the influence of L1 on production of L2 rhythm.