• Archives of Pharmacal Research
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• v.25 no.6
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• pp.759-769
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• 2002

Mutated forms of ras are found in many human tumors and the rate of incidence is significantly higher in colon and pancreatic cancers. The protein product from the ras oncogene is a small G-protein, $p21^{ras}{\;}(Ras)$ that is known to playa key role in the signal transduction cascade and cell differentiation and proliferation. Mutated Ras is unable to regulate itself and remains constantly activated, leading to uncontrolled cell growth. The function of Ras in signal transduction requires its location near the growth factor receptor at the cell membrane. However, Ras does not have a transmembrane domain. Ras requires farnesylation to increase its hydrophobicity and subsequent plasma membrane association for its transforming activity. This key post-translational modification is catalyzed by the enzyme Ras farnesyltransferase (FTase), which transfers a farnesyl group from farnesylpyrophosphate to the C-terminal cysteine of the Ras protein. The requirement has focused attention on FTase as a target for therapeutic intervention. Selective inhibition of FTase will prevent Ras protein from association with the plasma membrane, leading to a disruption of oncogenic Ras function.

• Industrial Engineering and Management Systems
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• v.13 no.3
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• pp.342-355
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• 2014

Organizational dedication to corporate social responsibility (CSR) is set off by a number of driving forces, such as enhancing corporate financial performance, concern for the environment, regulatory compliance, and social equity. This article aims to ascertain the uptake of CSR among firms in the Philippines and Thailand leading to the attainment of sustainable development. The results revealed that CSR is carried out by the companies primarily to enhance their competitive advantage and legal compliance, which are deemed essential to the firms' existence. This study seeks to contribute to understanding how companies undertake their operations based on socially responsible practices so that the theoretical conceptualizations of sustainability can be developed. By determining what prods companies to pursue CSR, it will shed light on the mechanism that promotes the existence of sustainable organizations, linking it with CSR and the companies' objectives and strategies.

• World Technopolis Review
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• v.2 no.2
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• pp.64-80
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• 2013

In "Creating the Technopolis: High Technology Development in Austin Texas," Smilor, Kozmetsky, and Gibson (1988) make the case that in the mid-1980s Austin was becoming a globally competitive high tech region. Indeed over the years and into 2013, Austin has established its reputation as a leading entrepreneurial and technology center and "talent magnet." Delegations from across the US and worldwide visit Austin to better understand how this central Texas city went from being a state government and university town to become a fast growing, globally competitive, technology hotspot leading the state and nation in job creation. Central to the concept of the Triple Helix and Technopolis Frameworks is the importance of university, business, and government cooperation. This paper gives examples of mechanisms, processes, and metrics on how The University of Texas at Austin; regional technology industry; federal, state, and local government policies; and support groups all contributed to growing and sustaining the Austin Technopolis.

• World Technopolis Review
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• v.4 no.2
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• pp.62-78
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• 2015

The importance of university technology transfer has widely been brought to the center of attention over the last decades. Research and practice thereby often concentrate on issues related to patenting and licensing or entrepreneurship but abstract away from relationship- and network-focused initiatives. In this paper, we argue that efforts to systematically develop close, long-term collaboration partnerships - although complex and resource intensive - are likely to be more beneficial for both universities and industry in the long run. Drawing on data derived from interviews with technology transfer executives of 22 leading European and U.S. universities, we analyze and discuss well-established practices of network and relationship management and their possible impact on technology transfer success. Our findings indicate that dedicated relationship management approaches can yield a sustainable competitive advantage for universities. We thereby shift the focus away from transaction-orientation towards more forward-looking relationship-centric approaches and discuss their institutionalization in great detail.

• BMB Reports
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• v.44 no.4
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• pp.232-237
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• 2011

Human respiratory syncytial virus (HRSV) is a major cause of upper and lower respiratory tract illness in infants and young children worldwide. Despite its importance as a respiratory pathogen, there is currently no licensed vaccine for prophylaxis of HRSV infection. There are several hurdles complicating the development of a RSV vaccine: 1) incomplete immunity to natural RSV infection leading to frequent re-infection, 2) immature immune system and maternal antibodies of newborn infants who are the primary subject population, and 3) imbalanced Th2-biased immune responses to certain vaccine candidates leading to exacerbated pulmonary disease. After the failure of an initial trial featuring formalin-inactivated virus as a RSV vaccine, more careful and deliberate efforts have been made towards the development of safe and effective RSV vaccines without vaccine-enhanced disease. A wide array of RSV vaccine strategies is being developed, including live-attenuated viruses, protein subunit-based, and vector-based candidates. Though licensed vaccines remain to be developed, our great efforts will lead us to reach the goal of attaining safe and effective RSV vaccines in the near future.

• IE interfaces
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• v.15 no.4
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• pp.432-438
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• 2002

When the trailing edge and leading edge of an airfoil contour of high pressure compressor blades are measured, there exists a measurement error due to the size of the probe stylus ball diameter. In the paper an experimental study is provided to determine the optimum diameter of the probe stylus in inspecting the airfoil of the high pressure compressor blade. The measurement and analysis procedure suggested in this paper will be helpful to those who are involved in measuring and inspecting various types of blades.

• IE interfaces
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• v.10 no.2
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• pp.99-107
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• 1997

The purpose of accident analysis is to obtain accurate and objective information about the causes of accidents in order to prevent accidents from reoccurring. This study investigated the characteristics and causes of occupational accidents in Korean industry by comparison with those of Japan and U.S.A The results show that there are some characteristics in the accidents of Korean industry; (1)larger companies tend to have lower accident rates than the smaller ones; (2) inexperience is related to high accident rates; (3) 'awkward or sudden movement' and 'caught in and between object' represents the leading accident type; (4) the body sites most vulnerable to injury are the hands and fingers; and (5) 'fractures' is the leading injury type. These findings identified in this study can be used to prevent the industrial accidents.

• Korean Management Science Review
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• v.33 no.4
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• pp.33-49
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• 2016

The market of platform business is typically served by a few dominant players, presenting "winner-takes-all" phenomenon. This study aims to find service characteristics leading to the phenomenon. Six different service-characteristics were considered : Same-side network effect, cross-side network effects, entry barrier, multi-homing cost, switching cost, and heterogeneity of preference. To assess the degree of concentration of market share, HHI (Herfindahl-Hirschman Index) is calculated for top three major players. Based on the HHI value, 10 most eminent platform businesses are classified into three different segments and each segment is characterized with key factors. The results from this study provide some insight into the strategic management of platform business.

• Ocean and Polar Research
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• v.24 no.1
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• pp.93-114
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• 2002

Legal regimes of major countries actively involved in wetland programs including USA, Japan, Germany, Netherlands, and Denmark, show that these leading nations have developed their own legal regimes and policies for the conservation and restoration of wetlands since early 1990s. The main feature of their position is to preserve, create and restore wetlands, including tidal flats. However, this approach, so called 'mitigation' policy, is thus far, not a fully established policy but an evolving one. For Korea, there are only a few laws and policies which hint at the importance of creating coastal wetlands as a conservation measure, however, most of those systems only exist as vague provisions which lack any tangible and compulsory implementing procedures and technical guidelines. It seems that it is necessary to strengthen the legal measures for conserving coastal wetlands in Korea including specifying economic assessment methods and funding sources for the creation, restoration and rehabilitation of tidal flats to firmly establish a national wetland mitigation policy.

• Structural Engineering and Mechanics
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• v.16 no.1
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• pp.47-62
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• 2003

The nonlinear dependence aspect of various conical tool indentation parameters leading to an optimum tool semi angle value for easiest perforation is plotted and discussed explicitly in this work with the conclusion that tool angle has an optimum response towards most of the indentation parameters. Around this optimum angle, the aluminium sheets showed minimum fracture toughness as well as minimum work input to overcome the offered resistance. At the end, the mechanism leading to this phenomenon is presented with the conclusion that plastic flow dominates as the dimple semi cone angle reaches 35 and both pre and post plastic flow perforations lead the tool semi cone angle value towards this dimple cone semi angle of plastic flow initiation for its optimum performance. It is also concluded that specimen material failure is solely under tensile hoop stress and hence results into radial cracks initiation and propagation.