• YAKHAK HOEJI
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• v.19 no.1
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• pp.21-29
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• 1975

The activity of $\delta$-aminolevlinic acid dehydratase (ALAD) in red cell of rabbit inhibited by addition of $Pb(Ac)_{2}$(50mg/kg) to rabbit caused to diminish completely the ALAD activity in blood within shr. Pretreatment of ascorbic acid and methionine decreased the increment of $\delta$-aminolevulinic acid output in urine by lead poisoning.

• Journal of Preventive Medicine and Public Health
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• v.13 no.1
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• pp.41-46
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• 1980

In order to study the effect of lead exposure on the hematocrit and hemoglobin values in accordance with the level of lead exposure, twenty-four Sprague-Dawley rats were equally divided into four groups of six rats each. Lead acetate disolved in glucose was injected intraperitoneally six times a week, for four weeks with dose of 0.05 mg/kg/day for group I, 0.5 mg/kg/day for group II, and 5 mg/kg/day for group III. Control group was injected glucose only. Blood samples for the checking of the hematocrit and hemoglobin values, were taking from tail vein of rats before lead injection and on the third, seventh, fourteenth, twenty-first, and twenty-eighth days after lead injection. And also, the concentration of lead and ALA in urine were checked for evaluating the lead absorption. The results were as follows: 1. The alteration of the hematocrit and hemoglobin values of the group I was not significant as that of the control group. 2. In group II, the hematocrit values were significantly decreased from the fourteenth day after lead injection, and the hemoglobin values were decreased from the twenty-first day after lead injection when the concentration of lead in urine was elevated more than $260{\mu}g/liter$. 3. In group III, the hematocrit values were decreased from the seventh day after lead injection, and the hemoglobin values were decreased even from the third day after lead injection. And the hemoglobin values were more rapidly decreased than the hematocrit values. 4. In all groups, the correlation coefficient between hematocrit and hemoglobin was highly significant. And the difference between the correlation coefficient of the group III and that of the others was highly significant.

• The Korean Journal of Nuclear Medicine Technology
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• v.22 no.1
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• pp.46-50
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• 2018

Purpose Generally, a collimator that installed in front of detector set a direction of gamma ray and remove a scatter ray. By the way, a lateral or oblique scatter ray is detected into crystal through collimator. At this study, we will evaluate a mount of count and spectrums of lateral scatter ray. Materials and Methods We used the SKY LITE (philips, netherlands) as a gamma camera, and $^{99m}Tc$, 1.11 GBq point source as a phantom. we put this point source at backside 50 cm of detector. After acquiring this for 1 min, we turned a detector next 10 degrees. Likely this, we acquired images at every 10 degrees from $0^{\circ}$ to $360^{\circ}$, analyzed images and spectrums. In case of patient study, we choose a 3 phase bone scan patient who had a hand disease, because scatter rays from body would detect on crystal. After acquiring blood flow and blood pool images, we analyzed images and spectrums. Additional, we put a lead gown on patient's hand, body. And then we compared and evaluated 3 type blood pool images (non lead gown, lead gown on a hand and on body). Results In case of phantom study, scatter ray counts at backside ($270^{\circ}-90^{\circ}$) are same with a background count. By the way, counts of scatter ray of oblique side ($0^{\circ}-50^{\circ}$, $220^{\circ}-270^{\circ}$) are 100-600 cps, furthermore, counts at frontside are over 4 Mcps. In case of patient study, a counts of hand blood pool scan are 1510 cps. But counts of hand with lead gown on hands and on body are each 1554 cps, 1299 cps. Conclusion Therefore, even though there is a collimator in front of detector, lateral scatter rays detect on crystal and affect to images and spectrums. Especially, if there is a high activity source at outside of detector when we examine low activity organs like hands or foot, we have to shield and remove the source at outside for a good image.

• Journal of Nutrition and Health
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• v.45 no.4
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• pp.347-361
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• 2012

Limited studies are available concerning the effect of heavy metal exposure on cardiovascular diseases. As environmental pollution increases, food contamination, including heavy metal contamination of fish, also increases. However, researches based on the intake of heavy metals, cardiovascular disease, and fish intakes are inconclusive. We assessed an association of heavy metal exposure with cardiovascular disease and fish intake in a nationally representative group of general Korean adults. We used data from the combined 2008-2010 Korean National Health and Nutrition Examination Survey (KNHANES), and analyzed the data of 5,139 Koreans who participated in KNHANES. All participants were older than 20 years, and were diagnosed with stroke, ischemic heart disease, or hypertension. The mean blood cadmium, lead concentration, and mercury concentration of subjects were $1.07{\pm}0.01{\mu}g/L$, $2.49{\pm}0.02{\mu}g/dL$, and $5.19{\pm}0.08{\mu}g/L$, respectively. We used the survey logistic regression model to account for the complex sample design of the cardiovascular disease risk in order to estimate the odds ratios (OR). After adjusting for age, education, income, alcohol, smoking, and BMI, the increase of serum cadmium in blood was associated with the increase in the prevalence of hypertension. Further, the increase in blood cadmium concentration was associated with the increase of both systolic blood pressure (SBP) and diastolic blood pressure (DBP). Although higher fish intakes were significantly associated with higher blood mercury concentration (p for trend < 0.0001), fish intakes did not affect either blood cadmium or lead concentration. Comparing the highest fish intake group with the lowest intake group, the OR of hypertension was 0.31 (95% CI: 0.19-0.59) in the crude model for total fish. However, these associations were no longer significant after the adjustment for potential confounding factors. In conclusion, cadmium in blood was associated with an increased risk of hypertension in the general Korean adult population. However, we found no evidence of a clear relationship between cardiovascular disease and frequency of fish consumption.

• Journal of Yeungnam Medical Science
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• v.7 no.1
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• pp.133-144
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• 1990

This study was performed to guide the effective utilization of blood and optimal blood ordering schedule for various elective surgeries, based on the analysis of 1.462 transfused surgical procedures and 5.933 blood units transfused during operation in the period of two years through January, 1987 to December, 1988 at Yeungnam University Hospital. The frequency of transfusion, and mean transfused units were evaluated and recommended blood unit for each surgical procedure was proposed. We assure that the successful establishment of this guideline can lead to substantial monetary saving, reduced blood outdation, and a decreased blood bank workload with a more appropriate allocation of the technician's time and effort.

• The Korean Journal of Emergency Medical Services
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• v.25 no.1
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• pp.243-249
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• 2021

A decrease in coronary blood flow leads to an imbalance between the supply of oxygen to the myocardium and its demand, and reversible or irreversible damage to the myocardium could occur depending on the severity of the resultant ischemia and the duration of the imbalance. This imbalance results in a cascade of ischemic reactions in the following order: metabolic abnormalities, diastolic dysfunction, systolic dysfunction, and electrocardiogram changes. Variant angina is caused by the closure of the coronary artery due to reversible coronary artery spasm, resulting in myocardial ischemia and subsequent chest pain as a clinical symptom. Variant angina may be observed as ST segment elevation in electrocardiogram measured when present in chest pain. However, 12-lead electrocardiogram performed after the patient's chest pain resolves does not help in the diagnosis. Since the duration of chest pain appears to be <15 minutes, it is important to perform the 12-lead electrocardiogram when clinical symptoms are present. If nitroglycerin is administered without performing 12-lead electrocardiogram by 119 pre-hospital paramedics, the chest pain would be resolved, making it impossible to identify changes in the ST segment. Before administration of nitroglycerin, changes in the ST segment must be recorded by performing 12-lead electrocardiogram.

• The Journal of the Korea Contents Association
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• v.9 no.7
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• pp.225-232
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• 2009

This study conducted the following experiment to examine effects of cardiovascular function on lumbar stabilization exercise(LSE) in floor or swiss ball. This experiment was conducted to compare heart rate, systolic blood pressure, diastolic blood pressure and peripheral vascular oxygen saturation effects by lumbar stabilization exercise in floor or swiss ball with 18 normal adult and it divided 9 subjects. experiment group (1) is applying LSE on floor group and (2) is applying LSE on swiss ball group. Heart rate was measured by portable heart rate manometer, blood pressure was measured by hemodynamometer, and peripheral vascular oxygen concentration was measured using a computerized NURYTEC measuring apparatus analysis. These result lead us to the conclusion that systolic blood pressure and peripheral vascular oxygen concentration were influenced by LSE. but there was not differential effect between each groups. These results suggest that LSE has the capability to improve heart rate, blood pressure, peripheral vascular oxygen concentration. Consequently, LSE would be lead to increment of cardiovascular function.

• Journal of the Korean Society of Visualization
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• v.17 no.2
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• pp.10-16
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• 2019

Considering the role of viscosity in the hemorheology, the characteristics of non-Newtonian fluid are important in the pulsatile blood flows. Stenosis, with an abnormal narrowing of the vessel, contributes to block blood flows to downstream tissue and lead to plaque rupture. Therefore, systematic analysis of blood flow around stenosed vessels is crucial. In this study, non-Newtonian behaviors of blood analog fluids around the micro-stenosis with 60 % severity in diameter of $500{\mu}m$ was examined by using CFX under the pulsatile flow conditions with the period of 10 s. Viscosity information of two non-Newtonian fluids were obtained by fitting the value of normal blood and highly viscous blood. As the Newtonian fluid, the water at room temperature was used. During the pulsatile phase, wall shear stress (WSS) is highly oscillated. In addition, high viscous solution gives rise to increases the variation in the WSS around the micro-stenosis. Highly oscillating WSS enhance increasing tendency of plaque instability or rupture and damage of the tissue layer. These results, related to the influence on the damage to the endothelium or stenotic lesion, may help clinicians understand relevant mechanisms.

• Analytical Science and Technology
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• v.7 no.4
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• pp.427-434
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• 1994

For the analysis of the relatively volatile lead in blood by GFAAS(graphite furnace atomic absorption spectrophotometer), one can not raise the ashing temperature beyond certain degree due to the elevation of the baseline. Previous investigations showed that background is stabilized when the ashing temperature is raised to $700^{\circ}C$ using a matrix modifier. In this study, same result was obtained at the ashing temperature of around $550^{\circ}C$ even when the matrix modifier is not used and only Triton X-100 is used as a diluent, on an instrument which is equipped with both temperature and current controller(Shimadzu, AA-6501S) and thus the temperature control is fast and accurate. Background correction methods of $D_2$ arc and SR(self reversal) were reviewed. The results show that the absorbance is higher for the $D_2$ arc method, but the background correction is higher for the SR method.

• Journal of the Korean Society for Precision Engineering
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• v.33 no.6
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• pp.509-516
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• 2016

A blood flow simulator is one of the experimental devices used to better understand the cardiovascular system. Time-Domain analysis is not sufficient to understand the cardiovascular system because of the effects related to pulsating flows. Even when the mean pressure and mean flow rate of the blood flow simulators are satisfied, the dynamic properties can differ from the desired performance. In this paper, the Windkessel model, a well-known mathematical model of the cardiovascular system, was employed to obtain optimized pressure using initial values. The Windkessel parameters, including flow resistance, R, are expected to lead to a better understanding of the dynamic behavior of cardiovascular systems.