• Earthquakes and Structures
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• v.4 no.2
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• pp.133-155
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• 2013

The earthquake responses are studied for the tall flexible structures such as TV towers when the vertical eccentricities between the discrete nodes and the corresponding centroids of investigated lumps are considered. In practical analyses, the tall flexible structures can be made into a spatial-discrete system of some certain length of beam elements with different lengths and cross-sectional areas. These elements are used to construct the investigated lumps in this paper. The different cross-sectional areas and the different lengths of two adjacent elements lead to the appearance of vertical eccentricity between the discrete node and the centroid of investigated lump within the same investigated lump. Firstly, the governing equations are established for a typical investigated lump. Secondly, the calculating formulae of the forces and moments acting on the investigated lump are derived and provided. Finally the new dynamic equilibrium equations with modified mass matrix and assemblage of stiffness matrix have been derived for the stick MDOF model based on beam theory when the existing vertical eccentricities are considered. Numerical results demonstrate that these vertical eccentricities should be considered in order to obtain the accurate earthquake responses for the tall flexible structures.

• Structural Engineering and Mechanics
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• v.74 no.6
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• pp.747-756
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• 2020

High-strength concrete (HSC) generally is made with high amount of cement which may release large amount of hydration heat at early age. The hydration heat will increase the internal temperature of slab and may cause potential cracking. In this study, slab specimens with a dimension of 600 × 600 × 100 mm were cast with concrete incorporating silica fume for test. The thermistors were embedded in the slabs therein to investigate the interior temperature development. The test variables include water-to-binder ratio (0.25, 0.35, 0.40), the cement replacement ratio of silica fume (RSF; 5 %, 10 %, 15 %) and fly ash (RFA; 10 %, 20 %, 30 %). Test results show that reducing the W/B ratio of HSC will enhance the temperature of first heat peak by hydration. The increase of W/B decrease the appearance time of second heat peak, but increase the corresponding maximum temperature. Increase the RSF or decrease the RFA may decrease the appearance time of second heat peak and increase the maximum central temperature of slab. HSC slab with the range of W/B ratio of 0.25 to 0.40 may occur cracking within 4 hours after casting. Reducing W/B may lead to intensive cracking damage, such as more crack number, and larger crack width and length.

• Wind and Structures
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• v.11 no.4
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• pp.257-273
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• 2008

A number of passive aerodynamic drag reduction methods were applied separately and then in different combinations on an intercity bus model, through wind tunnel studies on a 1:20 scale model of a Mercedes Benz Tourismo 15 RHD intercity bus. Computational fluid dynamics (CFD) modelling was also conducted in parallel to assist with flow visualisation. The commercial CFD package $CFX^{TM}$ was used. It has been found that dramatic reductions in coefficient of drag ($C_D$) of up to 70% can be achieved on the model using tapered and rounded top and side leading edges, and a truncated rear boat-tail. The curved front section allows the airflow to adhere to the bus surfaces for the full length of the vehicle, while the boat-tails reduce the size of the low pressure region at the base of the bus and more importantly, additional pressure recovery occurs and the base pressures rise, reducing drag. It is found that the CFD results show remarkable agreement with experimental results, both in the magnitude of the force coefficients as well as in their trends. An analysis shows that such a reduction in aerodynamic drag could lead to a significant 28% reduction in fuel consumption for a typical bus on intercity or interstate operation. This could translate to a massive dollar savings as well as significant emissions reductions across a fleet. On road tests are recommended.

• Earthquakes and Structures
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• v.5 no.5
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• pp.527-552
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• 2013

Development of flexural yielding and large rotation ductilities in the plastic hinge zones of frame members is synonymous with the spread of bar reinforcement yielding into the supporting anchorage. Yield penetration where it occurs, destroys interfacial bond between bar and concrete and reduces the strain development capacity of the reinforcement. This affects the plastic rotation capacity of the member by increasing the contribution of bar pullout. A side effect is increased strains in the compression zone within the plastic hinge region, which may be critical in displacement-based detailing procedures that are linked to concrete strains (e.g. in structural walls). To quantify the effects of yield penetration from first principles, closed form solutions of the field equations of bond over the anchorage are derived, considering bond plastification, cover debonding after bar yielding and spread of inelasticity in the anchorage. Strain development capacity is shown to be a totally different entity from stress development capacity and, in the framework of performance based design, bar slip and the length of debonding are calculated as functions of the bar strain at the loaded-end, to be used in calculations of pullout rotation at monolithic member connections. Analytical results are explored parametrically to lead to design charts for practical use of the paper's findings but also to identify the implications of the phenomena studied on the detailing requirements in the plastic hinge regions of flexural members including post-earthquake retrofits.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.6
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• pp.2949-2953
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• 2012

The glutathione S transferase (GST) family is a major part of cellular defense mechanisms against endogenous and exogenous substances, many of which have carcinogenic potential. Alteration in the expression level or structure of the glutathione-S-transferase (GST) enzymes may lead to inadequate detoxification of potential carcinogens and consequently contribute to cancer development. A member of the glutathione-S-transferase (GST) family, GSTP1, is an attractive candidate for involvement in susceptibility to carcinogen-associated colorectal cancer. An $Ag{\rightarrow}G$ transition in exon 5 resulting in an Ile105Val amino acid substitution has been identified which alters catalytic efficiency. The present study investigated the possible impact of Ile105Val GSTP1 polymorphism on susceptibility to colorectal cancer. in Jordan We examined 90 tissue samples previously diagnosed with colorectal carcinoma, and 56 non-cancerous colon tissues. DNA was extracted from paraffin embedded tissues and the status of the GSTP1 polymorphism was determined using a polymerase chain reaction restriction fragment length polymorphism (RFLP) method. No statistically significant differences were found between colorectal cancer cases and controls for the GSTP1 Ile/Ile, Ile/Val and Val/Val genotypes. The glutathione S-transferase polymorphism was not associated with risk in colorectal cancer cases in Jordan stratified by age, sex, site, grade or tumor stage. In conclusion, the GSTP1 Ile105Val polymorphism is unlikely to affect the risk of colorectal cancer.

• Sleep Medicine and Psychophysiology
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• v.1 no.1
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• pp.3-8
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• 1994

With the recent development of sleep medicine, insomnia has been perceived as a disease from a simple symptom. As there are various causes in a disease, proper treatment according to each cause is necessary for a more effective treatment In general, insomnia is classified into five categrories of physical, physiological, psychological, psychiatric and pharmacological aspects. However, such categorizations are often insufficient in treating insomnia. Furthermore understanding of the developmental mechanisms of insomnia is required. The function of sleep is developed and maintained through the balance of the reciprocal forces of sleep and arousal. These forces are contantly regulated by what is called a circadian rhythm. Sleep is induced by this rhythm which is affected by factors such as awakening time in the morning, amount of intellectual function, amount and time length of physical exercise and sunlight Insomnia could develop when this rhythm is delayed and leads to a "forbidden zone" which is a very difficult period for inducing sleep about two to four hours before the routine bedtime. Whereas sleep gradually develops in line with the circardian rhythm, arousal can occur very abruptly by any cause triggered by emotional discomfort or anxiety. Such characteristic and emotional factors as perfectionism, separation anxiety, secondary gain, insecurity, and negative cognition may provoke the inner anxiety and fear for insomnia, which can lead acute insomnia to a chronic one. As chronic insomnia is developed by multiple causes and factors, integrated approaches through analysis of above mentioned factors will be more effective in the treatment of insomnia than a simple administration of hypnotics.

• Journal of the Korea Concrete Institute
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• v.12 no.1
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• pp.79-88
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• 2000

Usually, the expansive additives is used to prevent the occurrence of drying shrinkage in concrete. However it may sometimes be over-added in field due to the insufficient cognition of constructor's, which may cause the serious problems in concrete structures. In this study the experiments are performed to present the expansion properties of concrete by varying the water to binder ratios, unit contents of expansive additives and curing conditions. By the results, the strength showed an increase with the addition of expansion additives from 30kg/㎥ up to 50kg/㎥, and a great decrease by contraries if the larger amount are added. Also the more the expansion additives were used, the more length change occurred in concrete. In view of the curing conditions, the concrete by air cured appeared a little expansion even the unit expansion additives increased, which showed an opposite inclination of that with standard curing. This could be explained by the less occurrence of hydration in air condition which also lead to the little expansion of concrete. Hence the expansion concrete to be cured in water or moisture condition became an especial important thing. concrete using expansive additives showed that high expansion was taken place with the rise of temperature.

• Journal of the Korean Ceramic Society
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• v.47 no.6
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• pp.503-508
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• 2010

$Eu^{2+}$-doped $\beta$-SiAlONs ($Si_{6-z}Al_zO_zN_{8-z}:Eu_y$) are recognized as promising phosphor materials to build an white LED for lighting application due to its excellent absorption/emission efficiency in the long wave length region. In this research, the fabrication of $\beta$-SiAlON:Eu plate phosphor by sintering was investigated with fixed Eu content(y) and varied composition of the host lattice(z). The addition of the activator $Eu_2O_3$ lead to enhanced densification by forming the transient liquid phase. The refinement of a composition by the calculated lattice parameter indicated that the measured composition of the fabricated specimens is nearly same to that of designed one. The single phase $\beta$-SiAlON:Eu plate with relative density of 96.4% was achieved by addition of 2 wt% CaO, which implies the possibility of full densification by adjusting the processing variables.

• The KSFM Journal of Fluid Machinery
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• v.14 no.5
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• pp.48-54
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• 2011

Structural modifications of a ship may cause a fatal accident such as sinking and wrecking of ship. Especially, barge ship can be easily reconstructed to load more bulk cargo. In this study, for a real accident case, change of mooring force due to structural modification was analyzed to evaluate accident risk. A two dimensional dynamic model for the barge ship was constructed to compute mooring forces with related to floating motion. The equation of motion was established in Matlab code and buoyancy was calculated by using direct integration of submerged volume. The results showed that wind force, current force, and mooring force after rebuilding was approximately 4.3 kN, 14 kN, 1,561 kN respectively. The maximum force of mooring force according to the length of mooring cable were 1,614 kN at 30 m of mooring cable. Thus, an arbitrary modification of ship lead instability and unreliable result so that illegal rebuilding of ship should be avoided.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2004.11a
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• pp.77-85
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• 2004

A significant portion (about 8% in human genome) of mammalian mRNA sequences contains AU(Adenine and Uracil) rich elements or AREs at their 3' untranslated regions (UTR). These mRNA sequences are usually stable. ARE motifs are assorted into three classes. The importance of AREs in biology is that they make certain mRNA unstable. We analyzed the occurrences of AREs and Alu, and propose a possible mechanism on how human mRNA could acquire and keep A REs at its 3' UTR originated from Alu repeats. Interspersed in the human genome, Alu repeats occupy 5% of the 3' UTR of mRNA sequences. Alu has poly-adenine (poly-A) regions at the end that lead to poly -thymine (poly-T) regions at the end of its complementary Alu. It has been discovered that AREs are present at the poly -T regions. In the all ARE's classes, 27-40% of ARE repeats were found in the poly -T region of Alu with mismatch allowed within 10% of ARE's length from the 3' UTRs of the NCBI's reference m RNA sequence database. We report that Alu, which has been reported as a junk DNA element, is a source of AREs. We found that one third of AREs were derived from the poly -T regions of the complementary Alu.