• 대한의생명과학회지
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• 제15권1호
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• pp.9-15
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• 2009

Early age at menarche, which is indicator of early biological maturity, has been shown to be associated with increased adult body mass index. Early menarche has also been associated with many cardiovascular disease risk factors and metabolic syndrome. To evaluate the impact of menarche to cardiovascular risk factor, we assessed by age at menarche, brachial-ankle pulse wave velocity (baPWV), which represents arterial stiffness, in women with or without metabolic syndrome. The subjects recruited for this study were three hundred one women. Relatively early menarche and relatively late menarche were classified according to less than $50^{th}$ percentile for relatively early menarche, and great than the $50^{th}$ percentile for relatively late menarche. Subject were divided four group, 1) women who had not adulthood metabolic syndrome and relatively early menarche, 2) women who had not adulthood metabolic syndrome and relatively late menarche, 3) women who had adulthood metabolic syndrome and relatively early menarche, 4) women who had adulthood metabolic syndrome and relatively late menarche. Women who had a relatively early menarche with adulthood metabolic syndrome had significantly high levels of blood pressure, triglyceride, fasting insulin and homeostatic model assessment of insulin resistance (HOMA-IR) levels than women with late menarche with adulthood metabolic syndrome, and had significantly lower HDL-cholesterol levels. And also, women who underwent a relatively early menarche with metabolic syndrome had highest level of baPWV in adult. In this study we found effect of age at menarche on adulthood metabolic risk factors for cardiovascular disease (e.g., baPWV, insulin resistance, hyperlipidemia) in Korean women.

• Neonatal Medicine
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• 제25권1호
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• pp.7-15
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• 2018

We need to understand the outcomes into adulthood for survivors born either extremely low birthweight (ELBW; <1,000 g) or extremely preterm (EP; <28 weeks' gestational age), particularly their blood pressure and cardiovascular metabolic status,respiratory function, growth, psychological and mental health performance, and functional outcomes. Blood pressure is higher in late adolescence and early adulthood in ELBW/EP survivors compared with controls. In some studies, expreterm survivors have higher insulin and blood lipid concentrations than controls, which may also increase their risk for later cardiovascular disease. ELBW/EP survivors have more expiratory airflow obstruction than do controls. Those who had bronchopulmonary dysplasia (BPD) in the newborn period have even worse lung function than those who did not have BPD. As a group, they are unlikely to achieve their full lung growth potential, which means that more of them are likely to develop chronic obstructive airway disease in later life. Although they are smaller than term born controls, their weight gradually rises and ultimately reaches a mean z-score close to zero in late adolescence, and they ultimately attain a height z-score close to their mid-parental height z-score. On average, ex-preterm survivors have intelligence quotient (IQ) scores and performance on tests of academic achievement approximately 2/3 SD lower than do controls, and they also perform less well on tests of attention and executive function. They have similar high rates of anxiety and depression symptoms in late adolescence as do controls. They are, however, over-represented in population registries for rarer disorders such as schizophrenia and Autism Spectrum Disorder. In cohort studies, ex-preterm survivors mostly report good quality of life and participation in daily activities, and they report good levels of self-esteem. In population studies, they require higher levels of economic assistance, such as disability pensions, they do not achieve education levels as high as controls, fewer are married, and their rates of reproduction are lower, at least in early adulthood. Survivors born ELBW/EP will present more and more to health carers in adulthood, as they survive in larger numbers.

• 한국콘텐츠학회논문지
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• 제17권5호
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• pp.100-113
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• 2017

본 연구의 목적은 노년기 활동 참여가 삶 만족과 자아통합감에 미치는 영향을 확인하고, 활동 참여와 삶 만족, 활동참여와 자아통합감의 관계에서 삶의 의미의 매개효과를 확인하는 것이다. 은퇴한 55세 이상의 성인 700명(남자 350명, 여자 350명)이 설문조사에 응답하였다. AMOS를 활용하여 구조방정식 모형을 분석한 결과, 제안된 모형이 적절한 것으로 나타났다. 분석 결과 활동 참여의 수준이 높을수록 삶 만족이 높으며, 자아통합감이 높은 것으로 나타났다. 또한 활동 참여와 삶 만족, 활동 참여와 자아통합감의 관계에서 삶의 의미가 매개효과를 가지는 것으로 확인되었다. 마지막으로 노년기 삶 만족과 자아통합감에 있어서 활동 참여와 삶의 의미가 가지는 역할과 본 연구의 한계점에 대해 논의하였고 후속 연구에 대해 제안하였다.

• 정신신체의학
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• 제30권2호
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• pp.187-195
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• 2022

Objectives : We aimed to explore weekend catch-up sleep (CUS) by age and to find out the association between CUS and depression by the age group and weekday sleep duration (SD). Methods : Using data from the 2016-2018 Korean National Health and Nutrition Examination Survey, the CUS by age of 16,174 subjects was investigated, and the depression data of 11,088 subjects were analyzed. CUS was calculated as the weekend sleep duration minus weekday sleep duration (SD). The mean of CUS and weekday SD in depression group and non-depression group was compared by early, middle, and late adulthood groups, and logistic regression analysis was performed to investigate the effect of CUS on the depression by age group when weekday SD was insufficient. Results : The CUS tended to decrease continuously with age, the mean of CUS in the late adult group was the shortest. However, the average SD, adjusted for weekend CUS, was the shortest in the middle adulthood group. Overall, the sleep durations were shorter in the depression group than in the non-depression group, but the CUS difference between the two groups was significantly only in the middle adulthood. The risk of depression was significantly higher when weekend CUS was less than 1hour with a short weekday SD of less than 6hours (OR 2.44, 95% CI: 1.78-3.35), and this finding was significant in all adult groups. Conclusions : The findings of this study suggest that short weekday SD and inadequate weekend CUS are associated with depression and that CUS is an option to compensate for sleep deprivation and prevent depression.

• 한국노년학
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• 제25권2호
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• pp.245-266
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• 2005

본 연구는 18세 이상의 자녀를 둔 1,882명의 부모들을 대상으로 전생애과정의 부모자녀관계와 성인기의 발달, 그리고 중노년기 심리적 복지감 간의 관계를 이해하기 위해 심리사회 발달적 관점과 생애과정 발달적 관점을 적용하여 연구를 진행하였다. 구체적으로 회상된 성인기 이전 부모자녀관계가 성인기 부모자녀관계와 생산감 발달에 어떠한 영향을 미치는지를 알아보고, 이러한 성인기 전후의 경험들이 중노년기 심리적 복지감에 어떠한 역할을 하는지를 밝히는데 목적을 두었다. 연구결과는 성인기 이전에 부모로부터 호의적인 양육을 받았다고 회상할수록 성인기에 더 긍정적인 부모자녀관계를 갖고, 생산감도 더 많이 발달되며, 중노년기의 심리적 복지감도 더 높은 것으로 나타났다. 또한 성인기 부모자녀관계가 긍정적일수록 생산감이 많이 발달하였고 심리적 복지감도 높았다. 마지막으로, 생산감이 높을수록 심리적 복지감도 증진하는 것으로 나타났다. 성인기 이전에 부모로부터 받았다고 회상하는 양육방식이 중년기 이후 심리적 복지감에 미치는 영향은 성인기 부모자녀관계와 생산감 발달에 의해 부분적으로 매개되었다. 따라서 성인기 이전의 부모로부터 호의적인 양육을 받지 못했어도 성인기에 긍정적인 부모자녀관계를 형성하거나 높은 생산감을 발전시킨 경우는 높은 심리적 복지감을 형성한다는 것이다. 이러한 연구결과들은 성인기 이전 경험들이 지속적으로 성인기 심리적 복지감에 영향을 주며 그 영향력이 현재의 가족관계에 영향을 미치지만, 이는 성인기 경험들에 의해 변할 수도 있다는 사실을 시사한다.

• 생물정신의학
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• 제2권2호
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• pp.295-300
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• 1995

Late-onset schizophrenia(LOS) is a controversial entity. It has been thought that onset of schizophrenia is limited to early adulthood, but many European psychiatrists have reported on the occurrence of schizophrenia in late life. DSM-III restricted the diagnosis of schizophrenia to patients with onset of illness before age 45 years. But, DSM-III-R, DSM-IV, and ICD-10 recognize no upper limit to the age at onset of schizophrenia. Patients with LOS have more visual, tactile, and olfactory hallucinations. Patients with LOS have more persecutory delusions, premorbid schizoid personality traits, and less affective blunting. The course of illness was favorable in LOS. We present four cases of LOS. Their detailed clinical features are reported hear with brief review.

• Clinical and Experimental Pediatrics
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• 제57권11호
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• pp.472-478
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• 2014

Kawasaki disease (KD), an acute vasculitis that primarily affects young children, is the most common acquired paediatric cardiovascular disease in developed countries. While sequelae of arterial inflammation in the acute phase of KD are well documented, its late effects on vascular health are increasingly unveiled. Late vascular dysfunction is characterized by structural alterations and functional impairment in term of arterial stiffening and endothelial dysfunction and shown to involve both coronary and systemic arteries. Further evidence suggests that continuous low grade inflammation and ongoing active remodeling of coronary arterial lesions occur late after acute illness and may play a role in structural and functional alterations of the arteries. Potential importance of genetic modulation on vascular health late after KD is implicated by associations between mannose binding lectin and inflammatory gene polymorphisms with severity of peripheral arterial stiffening and carotid intima-media thickening. The changes in cholesterol and lipoproteins levels late after KD further appear similar to those proposed to be atherogenic. While data on adverse vascular health are less controversial in patients with persistent or regressed coronary arterial aneurysms, data appear conflicting in individuals with no coronary arterial involvements or only transient coronary ectasia. Notwithstanding, concerns have been raised with regard to predisposition of KD in childhood to accelerated atherosclerosis in adulthood. Until further evidence-based data are available, however, it remains important to assess and monitor cardiovascular risk factors and to promote cardiovascular health in children with a history of KD in the long term.

• 대한유전성대사질환학회지
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• 제22권1호
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• pp.15-20
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• 2022

The most common urea cycle disorder is ornithine transcarbamylase deficiency. More than 80 percent of patients with symptomatic ornithine transcarbamylase deficiency are late-onset, which can present various phenotypes from infancy to adulthood. With no regards to the severity of the disease, characteristic fluctuating courses due to hyperammonemia may develop unexpectedly, and can be precipitated by various metabolic stressors. Late-onset ornithine transcarbamylase deficiency is not merely related to a type of genetic variation, but also to the complex relationship between genetic and environmental factors that result in hyperammonemia; therefore, it is difficult to predict the prevalence of neurological symptoms in late-onset ornithine transcarbamylase deficiency. Most common acute neurological manifestations include psychological changes, seizures, cerebral edema, and death; subacute neurological manifestations include developmental delays, learning disabilities, intellectual disabilities, attention-deficit/hyperactivity disorder, executive function deficits, and emotional and behavioral problems. This review aims to increase awareness of late-onset ornithine transcarbamylase deficiency, allowing for an efficient use of biochemical and genetic tests available for diagnosis, ultimately leading to earlier treatment of patients.

• Journal of Preventive Medicine and Public Health
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• 제46권5호
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• pp.249-260
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• 2013

Objectives: Previous observations propose that risk-taking behaviors such as cigarette smoking are prevailing among young people with chronic conditions including diabetes. The purpose of this study was to examine whether cigarette smoking is more prevalent among diabetics than non-diabetics and whether it differs by age at the time of diagnosis with diabetes from young adulthood (YAH) to adulthood (AH). Methods: We used US panel data from the National Longitudinal Study of Adolescent Health (Add Health Study) during the years 2001 to 2002 (Wave III, YAH) and 2007 to 2008 (Wave IV, AH). Multivariate logistic regression models were applied to estimate odds ratios (ORs) and 95% confidence intervals (CIs) of cigarette use behaviors according to age at the time of diagnosis with diabetes, after adjusting for demographic and selected behavioral factors. Results: Of 12 175 study participants, 2.6% reported having been diagnosed with diabetes up to AH. Early-onset diabetics (age at diagnosis <13 years) were more likely than non-diabetics to report frequent cigarette smoking (smoking on ${\geq}20$ days during the previous 30 days) in YAH (OR, 3.34; 95% CI, 1.27 to 8.79). On the other hand, late-onset diabetics (age at diagnosis ${\geq}13$ years) were more likely than non-diabetics to report heavy cigarette smoking (smoking ${\geq}10$ cigarettes per day during the previous 30 days) in AH (OR, 1.54; 95% CI, 1.03 to 2.30). Conclusions: The current study indicated that diabetics are more likely than non-diabetics to smoke cigarettes frequently and heavily in YAH and AH. Effective smoking prevention and cessation programs uniquely focused on diabetics need to be designed and implemented.

• Journal of Preventive Medicine and Public Health
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• 제40권5호
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• pp.381-387
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• 2007

Objectives: This study was conducted in order to determine how the association between socioeconomic position(SEP) and health status changes with age among Seoul residents aged 25 and over. Methods: We utilized the 2001 and 2005 Seoul Citizens Health Indicators Surveys. We used self-rated 'poor' health status as an outcome variable, and family income as an indicator of SEP. In order to characterize the differential effects of socioeconomic position on health by age, we conducted separate multivariate analyses by 10-year age groups, controlling for sociodemographic covariates. In order to assess the relative health inequality across socioeconomic groups, we estimated the Relative Index of Inequality (RII). Results: The risk of 'poor health' is significantly high in low family income groups, and this increased risk is seen at all ages. However, the magnitude of relative socioeconomic inequality in health, as measured by the odds ratio and RII, is not identical across age groups. The difference in health across income groups is small in early adulthood (ages 25-34), but increases with age until relatively late in life (ages 35-64). It then decreases among the elderly population (ages more than 65). When the RII reported in 2005 is compared to that reported in 2001, RII can be seen to have increased across all ages, with the exception of individuals aged 25-34. Conclusions: The magnitude of health inequality is the greatest during mid- to late adulthood (ages 45-64). In addition, health inequalities have worsened between 2001 and 2005 across all age groups after economic crisis.