• Journal of Chest Surgery
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• 제56권1호
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• pp.1-5
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• 2023

Background: The number of patients with incidentally identified pulmonary nodules is increasing. This study attempted to confirm the usefulness and safety of video-assisted thoracic surgery (VATS) core needle biopsy of pulmonary nodules. Methods: Data from 18 patients diagnosed with pulmonary nodules who underwent VATS core need biopsy were retrospectively reviewed. Results: Of the 18 patients, 15 had malignancies (primary lung cancer, n=14; metastatic lung cancer, n=1), and 3 had benign nodules. Mortality and pleural metastasis did not occur during the follow-up period. Conclusion: In patients with solitary pulmonary nodules that require tissue confirmation, computed tomography-guided percutaneous cutting needle biopsy or diagnostic pulmonary resection sometimes may not be feasible choices due to the location of the solitary pulmonary nodule or the patient's impaired pulmonary function, VATS core needle biopsy may be performed in these patients as an alternative method.

• 대한세포병리학회지
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• 제2권1호
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• pp.43-50
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• 1991

A case of malignant epithelial mesothelioma of the peritoneum diagnosed by fine needle aspiration cytology is described. The smear showed many Individually scattered or clustered large round malignant epithelial cells intermingled with relatively small nonneoplastic mesothelial and mesenchymal cells. Papillary configurations with thick fibrous core were also seen. The malignant cells were virtually reminiscent of reactive mesothelial cells but they were larger in size and had more prominent nucleoli and more frequent binucleated or multinucleated cell formations than reactive mesothelial cells. The characteristic features of malignant cell of mesothelioma compared with the metastatic adenocarcinoma were relatively uniform cellular size, prominent round nucleoli, large round vesicular nuclei with finely granular chromatin pattern, smooth nuclear membrane, abundant glassy cytoplasm rather than bubbly mucin-containing cytoplasm and fuzzy cell border.

• 대한세포병리학회지
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• 제1권1호
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• pp.85-92
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• 1990

We present the cytologic features of a case of solid and papillary neoplasm of the pancreas. Cytologically, the tumor was composed of a monotonous population of polygonal cells containing eccentrically located round nuclei with one or two distinct small nucleoli and a finely stippled chromatin pattern. The tumor cells were similar to those of the islet cell tumor and showed isolated loosely aggregated and solid sheets or large cell clumps. The large cell clumps revealed a branching papillary structure containing fibrovascular central core, which is characteristic histologic feature of solid and papillary neoplasm of the pancreas. This case was confirmed by tissue examination including histochemical, immunohistochemical and electron microscopical studies. Ultrastructurally, the tumor cells contained a few membrane- bound electron dense granules.

• 한국자동차공학회논문집
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• 제12권5호
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• pp.73-78
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• 2004

The liquid phase LPG injection (LPLi) system (the third generation technology) has been considered as one of the next generation fuel supply systems for LPG vehicles, since it has a very strong potential to accomplish the higher power, higher efficiency, and lower emission characteristics than the mixer type(the second generation technology) fuel supply system. To investigate the durability property of core part of injector in liquid phase LPG injection system, leakage test, SEM test of injectors and analysis of unvaporized fuel components with various LPG fuel qualities were tested. The experimental results showed that no serious problem in durability test using favorable LPG fuel quality, while high leakage amount due to the large scratches in the needle and nozzle of the injector were found using LPG fuel with highly containing olefin components, especially butadiene species.

• Investigative Magnetic Resonance Imaging
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• 제19권3호
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• pp.191-195
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• 2015

We present a 53-year-old woman with a large chest wall mass in the interpectoral space, which was eventually confirmed as a lipogranuloma resulting from hydrogel implant rupture. Ultrasonography (US) showed reduced implant volume with surrounding peri-implant fluid collection, suggesting the possibility of implant rupture. A heterogeneously hypoechoic mass was found between the pectoralis major and minor muscles adjacent to the ruptured implant. On magnetic resonance imaging (MRI), there was a large mass in the left interpectoral space of the upper inner chest wall. The mass showed slightly high signal intensity (SI) on pre-contrast T1-weighted image (WI) with mixed iso and high SI on T2-WI. The signal of the mass was suppressed using the water suppression technique but not with the fat suppression technique on T2-WI. The mass showed diffuse enhancement upon contrast enhancement. The enhancing kinetics showed persistent enhancement pattern. US-guided core needle biopsy revealed a lipogranuloma and removal confirmed a ruptured PIP hydrogel implant.

• Investigative Magnetic Resonance Imaging
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• 제17권2호
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• pp.101-109
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• 2013

목적: 초음파 유도 하 중심부 침생검으로 진단된 2 cm 이상의 관상피내암종 저평가 수술 전 예측에 역동적 유방 자기공명 영상 및 확산강조영상의 역할을 규명하고자 한다. 대상과 방법: 14 gauge침을 이용한 초음파 유도 하 중심부 침생검을 통해 관상피내암종으로 진단된 22명의 환자를 대상으로 하였다. 환자는 조직병리 결과에 의거하여 관상피내암종 저평가 유무에 따라 두 군으로 나뉘었다. 모든 환자에서 역동적 유방 자기공명 영상 및 확산강조영상을 포함한 3 테슬라 유방 자기공명 영상을 획득하였다. 생검으로 확인된 악성 종괴에 대해, 병변의 형태 (종괴 혹은 비종괴), 조영 증강 형태, 조영 증강 최고점, 및 현성 확산 계수를 CADstream 소프트웨어를 이용하여 획득 하였으며, Fisher's exact test및 Mann Whitney test 이용하여 이 항목을 비교, 분석하였다. 결과: 총 22명의 환자 중 8명의 환자가 저평가 군으로 분류되었다. 병변의 형태 및 조영증강 형태는 두 군의 통계학적 차이가 없었다 (P values = 1.000 및 0.613). 조영 증강 최고점의 중앙값은 저평가 군에서 159.5% 로 저평가 되지 않은 군의 133.5% 보다 높았으나 통계학적 유의한 차이를 보이지 않았다 (P value = 0.413). 저평가 군의 현성 확산 계수는 $1.26{\times}10^{-3}mm^2/sec$로 저평가 되지 않은 군의 $1.35{\times}10^{-3}mm^2/sec$ 보다 낮았다 (P value = 0.094). 결론: 현성 확산 계수는 초음파 유도한 중심부 침생검에 의한 관상피내암종 저평가 수술 전 예측에 도움이 될 가능성 있으며 추후 전향적 연구를 통해 이 연구 결과를 확인하는 것이 필요하겠다.

• Korean Journal of Radiology
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• 제24권9호
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• pp.903-911
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• 2023

Objective: Regrowth after radiofrequency ablation (RFA) of symptomatic large thyroid nodules, initially treated as benign, sometimes turns out to be malignancies. This study aimed to assess the ultrasound (US) characteristics of thyroid nodules initially treated as benign with RFA and later diagnosed as cancers, predictive factors for cancers masquerading as benign, and methods to avoid RFA in these cancers. Materials and Methods: We reviewed the medical records of 134 consecutive patients with 148 nodules who underwent RFA between February 2008 and November 2016 for the debulking of symptomatic thyroid nodules diagnosed as benign using US-guided biopsy. We investigated the pre-RFA characteristics of the thyroid nodules, changes at follow-up after RFA, and the final surgical pathology. Results: Nodule regrowth after RFA was observed in 36 (24.3%) of the 148 benign nodules. Twenty-two of the 36 nodules were surgically removed, and malignancies were confirmed in seven (19.4% of 36). Of the 22 nodules removed surgically, pre-RFA median volume (range) was significantly larger for malignant nodules than for benign nodules: 22.4 (13.9-84.5) vs. 13.4 (7.3-16.8) mL (P = 0.04). There was no significant difference in the regrowth interval between benign and malignant nodules (P = 0.49). The median volume reduction rate (range) at 12 months was significantly lower for malignant nodules than for benign nodules (51.4% [0-57.8] vs. 83.8% [47.9-89.6]) (P = 0.01). The pre-RFA benignity of all seven malignant nodules was confirmed using two US-guided fine-needle aspirations (FNAs), except for one nodule, which was confirmed using US-guided core-needle biopsy (CNB). Regrown malignant nodules were diagnosed as suspicious follicular neoplasms by CNB. Histological examination of the malignant nodules revealed follicular thyroid carcinomas, except for one follicular variant, a papillary thyroid carcinoma. Conclusion: Symptomatic large benign thyroid nodules showing regrowth or suboptimal reduction after RFA may have malignant potential. The confirmation of these nodules is better with CNB than with FNA.