• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2006.11a
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• pp.139-145
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• 2006

LRE(Liquid propellant Rocket Engine) is one of the important parts to control the trajectory and dynamics of rocket. The purpose of control of LRE is to control the thrust according to requiredthrust profile and control the mixture ratio of propellants fed into gas generator and combustor for constant mixture ratio. It is not easy to control thrust and mixture ratio of propellants since there are co-interferences among the components of LRE. In this study, the dynamic model of LRE was constructed and the dynamic characteristics were analyzed with control system as PID control and PID+Q-ILC(Iterative Learning Control with Quadratic Criterion) control. From the analysis, it could be observed that PID+Q-ILC control logic is more useful than standard PID control system for control of LRE.

• Proceedings of the KSME Conference
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• 2007.05a
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• pp.1143-1148
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• 2007

LRE(Liquid propellant Rocket Engine) is one of the important parts to control the motion of rocket. For operation of rocket in error boundary of the set-up trajectory, it is necessarily to control the thrust of LRE according to the required thrust profile and control the mixture ratio of propellants fed into combustor for the constant mixture ratio. It is not easy to control thrust and mixture ratio of propellants since there are co-interferences among the components of LRE. In this study, the dynamic model of LRE was constructed and the dynamic characteristics were analyzed with control system as PID control and PID+Q-ILC(Iterative Learning Control with Quadratic Criterion) control. From the analysis, it could be observed that PID+Q-ILC control logic is more useful than standard PID control system for control of LRE.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.13
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• pp.5117-5121
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• 2014

Endocrine-disrupting chemicals (EDCs) have been reported to interfere with estrogen signaling. Exposure to these chemicals decreases the immune response and causes a wide range of diseases in animals and humans. Recently, many studies showed that licorice (Glycyrrhiza glabra) root extract (LRE) commonly called "gamcho" in Korea exhibits antioxidative, chemoprotective, and detoxifying properties. This study aimed to investigate the mechanism of action of LRE and to determine if and how LRE can alleviate the toxicity of EDCs. LRE was prepared by vacuum evaporation and freeze-drying after homogenization of licorice root powder that was soaked in 80% ethanol for 72 h. We used 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) as an EDC, which is known to induce tumors or cancers; MCF-7 breast cancer cells were used as a tumorigenic model. These were treated with TCDD and various concentrations of LRE (0, 50, 100, 200, $400{\mu}g/mL$) for 24, 48, and 72 h. As a result, TCDD stimulated MCF-7 cell proliferation, but LRE significantly inhibited TCDD-induced MCF-7 cell proliferation in a dose- and time-dependent manner. Expression of TCDD toxicity-related genes, i.e., aryl hydrocarbon receptor (AhR), AhR nuclear translocator, and cytochrome P450 1A1, were subsequently down-regulated by LRE in a dose-dependent manner. Analysis of cell cycle distribution after treatment of MCF-7 cells with TCDD and various concentrations of LRE showed that LRE inhibited the proliferation of MCF-7 cells via G2/M phase arrest. Reverse transcription-polymerase chain reaction and Western blot analyses also revealed that LRE dose-dependently increased the expression of the tumor suppressor genes p53 and p27 and down-regulated the expression of cell cycle-related genes. These data suggest that LRE can mitigate the tumorigenic effects of TCDD in breast cancer cells by suppression of AhR expression and cell cycle arrest. Thus, LRE can be used as a potential toxicity-alleviating agent against EDC-mediated disease.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.12
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• pp.4809-4813
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• 2014

Endocrine-disrupting chemicals (EDCs) have been reported to interfere with estrogen signaling. Exposure to these chemicals decreases the immune response and causes a wide range of diseases in animals and humans. Recently, many studies showed that licorice (Glycyrrhiza glabra) root extract (LRE) commonly called "gamcho" in Korea exhibits antioxidative, chemoprotective, and detoxifying properties. This study aimed to investigate the mechanism of action of LRE and to determine if and how LRE can alleviate the toxicity of EDCs. LRE was prepared by vacuum evaporation and freeze-drying after homogenization of licorice root powder that was soaked in 80% ethanol for 72 h. We used 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) as a representative EDC, which is known to induce tumors or cancers; MCF-7 breast cancer cells, used as a tumor model, were treated with TCDD and various concentrations of LRE (0, 50, 100, 200, $400{\mu}g/mL$) for 24, 48, and 72 h. As a result, TCDD stimulated MCF-7 cell proliferation, but LRE significantly inhibited TCDD-induced MCF-7 cell proliferation in a dose- and time-dependent manner. The expression of TCDD toxicity-related genes, i.e., aryl hydrocarbon receptor (AhR), AhR nuclear translocator, and cytochrome P450 1A1, was also down-regulated by LRE in a dose-dependent manner. Analysis of cell cycle distribution after treatment of MCF-7 cells with TCDD showed that LRE inhibited the proliferation of MCF-7 cells via G2/M phase arrest. Reverse transcription-polymerase chain reaction and Western blot analysis also revealed that LRE dose-dependently increased the expression of the tumor suppressor genes p53 and p27 and down-regulated the expression of cell cycle-related genes. These data suggest that LRE can mitigate the tumorigenic effects of TCDD in breast cancer cells by suppression of AhR expression and cell cycle arrest. Thus, LRE can be used as a potential toxicity-alleviating agent against EDC-mediated diseases.

• Journal of Oriental Neuropsychiatry
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• v.24 no.3
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• pp.309-320
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• 2013

Objectives : There is a possibility LRE as remedy in Alzheimer disease (AD), but it's nerve protection effect and mechanism have to be elucidate. In this research, we applied LRE on $A{\beta}_{25-35}$ pre-treated SH-SY5Y cells, to find out the nerve protection effect and mechanism in AD cell model. Methods : We tried to confirm that effect by experimenting with 20, 50, and $100{\mu}g/ml$ concentration of LRE as a medicine. Next experiment, we assessed damage effect which induced $A{\beta}_{25-35}$, known to cause AD, on SH-SY5Y cell. In addition, cellular viability test is executed under $H_2O_2$ treatment condition in a SH-SY5Y cell. Results : 1. In $A{\beta}_{25-35}$ treated SH-SY5Y cell, LRE exhibited an anti-phosphorylation effect about tau protein, JNK, and IKB. 2. LRE prevent nerve cell apoptosis, which indued $A{\beta}_{25-35}$ and oxidative stress, modify JNK engaged synaptic structure and $NF{\kappa}B$ induced p75-neurotrophin receptor polymorphism. Conclusions : We found that LRE prevented oxidative stress-induced cellular destruction, for example, increased SOD activity of $A{\beta}_{25-35}$ treated SH-SY5Y cell and reduced toxicity of oxygen free radical. Consequently, the ingredients of LRE have a role as a catalyzer for $A{\beta}_{25-35}$ clearance and as scavenger for active oxygen free radical.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2007.11a
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• pp.178-182
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• 2007

This paper reviews on the LRE health monitoring and emergency protection system to protect test object engine system and engine test facility, in case of various fault occurrence at LRE testing. General composition and major technical consideration of LRE health monitoring system and emergency protection system are reviewed. Moreover, some application of LRE health monitoring/emergency protection system to development test of major LRE component such as turbopump testing, gas generator and combustion chamber test are reviewed.

• Journal of the Korean Society of Propulsion Engineers
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• v.7 no.2
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• pp.54-61
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• 2003

This paper describes a general design procedure of regenerative cooling system for liquid rocket engine(LRE). From this design logic, cooling channels are designed and fabricated. The measured heat flux from firing test is similar to the heat flux predicted by design logic. Therefore, proposed design procedure of cooling channel can be applied to real LRE system. Also the result of firing test indicates that soot from combustion products have strong influence on the cooling characteristics of LRE.

• Aerospace Engineering and Technology
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• v.7 no.2
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• pp.170-175
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• 2008

In this study, it was investigated that the characteristics of startup and compatibility using several type hot and cold gases. The characteristics of starting LRE by pyro starter was compared with that by a Helium spinner. The compatibility of pyro gas, a gaseous Helium, Hydrogen+Nitrogen mixture gas, and air was investigated by a simple 1D turbine analysis considered the properties of each gas and turbine efficiency. Most of them were compatible to start up the LRE however air was properly used only for low power mode of turbine.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2006.11a
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• pp.216-220
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• 2006

In this study, it was investigated that the characteristics of startup and compatibility using several type hot and cold gases. The characteristics of starting LRE by pyro starter was compared with that by a He spinner. The compatibility of pyre gas, a gaseous He, H2+N2 mixture gas, and air was investigated by a simple 1D turbine analysis considered the properties of each gases and turbine efficiency. Most of them were compatible to start up the LRE but air was properly used only when the turbine was low power mode.

• Journal of the Korean Society of Propulsion Engineers
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• v.6 no.4
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• pp.25-35
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• 2002

A calculation procedure for designing LRE regenerative cooling system is introduced. In LRE thrust chamber, heat is transfered from the hot gas to the wall by convection and radiation, then conduction through the wall and finally convection to the liquid coolant. A cooling channel is designed on the basis of heat transfer rate calculated by using criterial method and integral method. The result is compared with existing Russian cooling channel design code. Also a design logic and quantitative effect of various parameters were introduced to help better understanding for those who is not familiar to LRE system.