• Journal of Acupuncture Research
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• v.32 no.3
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• pp.41-51
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• 2015

Objectives : This study was performed to investigate the effects of $LR_3$ and $SP_6$ acupuncture on renal damage in streptozotocin(STZ)-induced diabetic mice. Methods : ICR male mice were stabilized for a week and divided into four groups: a normal mice group(N), no-acupuncture diabetic mice group(Control), $LR_3$ acupuncture diabetic mice group($LR_3$), and $SP_6$ acupuncture diabetic mice group($SP_6$). Diabetes was experimentally induced by intraperitoneal injection of STZ(150 mg/kg) in citrate buffer(pH 4.5). For two weeks, $LR_3$ and $SP_6$ acupunctures were administered bilaterally at each point once a day. After two weeks, the animals' weight was measured and they underwent a laparotomy. Serum glucose and blood urea nitrogen(BUN) were measured from the blood taken from the heart. We measured glucose, reactive oxygen species(ROS), peroxynitrite($ONOO^-$) and thiobarbituric acid reactive substances(TBARS) in the kidney and compared expression levels of superoxide dismutases(SOD), glutathione peroxidase(GPx), nuclear factor-kappa B(NF-${\kappa}B$), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase(iNOS) and Interleukin-1 beta(IL-$1{\beta}$). Results : BUN significantly decreased in $LR_3$, $SP_6$ compared to the control group. $LR_3$ showed significantly decreased glucose compared to the control group. $LR_3$, $SP_6$ significantly decreased in ROS and $ONOO^-$ compared to the control group. $LR_3$ significantly decreased in TBARS compared to the control group. $SP_6$ significantly increased in expressions of SOD-1, catalase, and GPx compared to the control group. $LR_3$, $SP_6$ significantly decreased in COX-2 compared to the control group. $SP_6$ significantly decreased in IL-$1{\beta}$ compared to the control group. Conclusions : This study suggests that $LR_3$ acupuncture may be effective in controlling glucose and lipid peroxidation and that $SP_6$ acupuncture may have anti-oxidative and anti-inflammatory effects on renal damage in STZ-induced diabetic mice.

• Radiation Oncology Journal
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• v.31 no.2
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• pp.97-103
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• 2013

Purpose: To investigate the patterns of locoregional recurrence of pathologic T3N0 (pT3N0) lower rectal cancer omitting postoperative radiotherapy (RT) and explore the potential of modification of a RT field. Materials and Methods: From Jan 2003 to Nov 2011, 35 patients omitting preoperative or postoperative RT for pT3N0 lower rectal cancer were included. We defined the lower rectal cancer as the tumor with the inferior margin located below the virtual line-a convergent level between rectal wall and levator ani muscle. All patients had radiologic examinations for recurrence evaluation during the follow-up duration. Results: The median follow-up duration was 66.4 months (range, 1.4 to 126.1 months). Eight (22.9%) of the 35 patients had recurrence. Three (8.6%) was local recurrence (LR) only, 3 (8.6%) was distant metastasis (DM) only, and 2 (5.7%) was LR with DM. All LR were located at primary tumor sites. The overall survival rate, LR-free survival rate, and DM-free survival rate at 5 years was 79.8%, 83%, and 87%, respectively. All LR developed from tumors over 5 cm. However, there was no statistical significance (p = 0.065). There was no other risk factor for LR. Conclusion: Even though the patients included in this study had pathologically favorable pT3N0 rectal cancer, LR developed in 14.3% of patients. Most of the LR was located at primary tumor sites prior to surgery. Based on these findings, it might seem reasonable to consider postoperative RT with a smaller radiation field to the primary tumor site rather than the conventional whole pelvic irradiation.

• Journal of the Korean Data and Information Science Society
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• v.28 no.1
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• pp.49-56
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• 2017

Among the techniques for analyzing big data, the association rule mining is a technique for searching for relationship between some items using various relevance evaluation criteria. This associative rule scheme is based on the direction of rule creation, and there are positive, negative, and inverse association rules. The purpose of this paper is to investigate the applicability of various types of relatively causal strength measures to the types of association rules from the point of view of interestingness measure. We also clarify the relationship between various types of confidence measures. As a result, if the rate of occurrence of the posterior item is more than 0.5, the first measure ($RCS_{IJ1}$) proposed by Good (1961) is more preferable to the first measure ($RCS_{LR1}$) proposed by Lewis (1986) because the variation of the value is larger than that of $RCS_{LR1}$, and if the ratio is less than 0.5, $RCS_{LR1}$ is more preferable to $RCS_{IJ1}$.

• Journal of the Korean Magnetic Resonance Society
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• v.19 no.2
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• pp.67-73
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• 2015

The microcystin is a cyclic heptapeptide from metabolites of cyanobacteria in the genera mycrocystis, anabaeba as a result of eutrophication. It has been known that microcystin-LR is a potent inhibitor of the catalytic subunits of protein phosphatase-1 (PP-1) as well as powerful tumor promoter. The active site of microcystin actually has two metal ions $Fe^{2+}/Zn^{2+}$ close to the nucleophilic portion of PP-1-microcystin complex. We report the isolation and purification of this microcystin-LR from cyanobacteria (blue-green algae) obtained from Daechung Dam in Chung-cheong Do, Korea. Microcystin-LR was extracted from solid-phase extraction (SPE) sample preparation using a CN cartridge. The cyanobacteria extract was purified to obtain microcystin-LR by HPLC method and identified by LC/MS. The detail structural studies that can elucidate the possible role of monovalent and divalent metal ions in PP-1-microcystin complexation were carried out by utilizing molecular dynamics. Conformational changes in metal binding for ligands were monitored by molecular dynamic computation and potential of mean force (PMF) using the method of the free energy perturbation. The microcystin-metal binding PMF simulation results exhibit that microcystin can have very stable binding free energy of -10.95 kcal/mol by adopting the $Mg^{2+}$ ion at broad geometrical distribution of $0.5{\sim}4.5{\AA}$, and show that the $K^+$ ion can form a stable metal complex rather than other monovalent alkali metal ions.

• Food Science and Biotechnology
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• v.18 no.5
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• pp.1091-1095
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• 2009

The aim of this study investigated the fluctuations of 3 characters from 3 ecotypes [early ripening (ER), middle ripening (MR), and late ripening (LR)] of 20 Korean brown rice cultivars in different storage systems [time: 12 and 24 weeks, temperature: low ($10^{\circ}C$) and room ($25^{\circ}C$)]. With increase of storage time and temperature, lipoxygenase activity, and fat acidity increased, whereas germination rate was reduced. ER cultivars exhibited the highest lipoxygenase activity of $35.49{\pm}2.46$ unit/mg protein during 24 weeks storage at $25^{\circ}C$, followed by LR ($32.73{\pm}1.33$) and MR ($32.66{\pm}1.62$) cultivars. The amounts of fat acidity also were observed by the same order (ER: $20.40{\pm}2.12$>LR: $19.68{\pm}1.86$>MR: $19.64{\pm}1.35$ mg KOH/100 g). Germination rate slightly decreased with increase of time and temperature (MR>LR>ER), but MR and LR cultivars showed the most significant changes (ER: $60.90{\pm}23.47%$, MR: $32.66{\pm}13.95%$, and LR: $32.53{\pm}5.87%$). On the basis of above results, MR cultivars were evaluated the highest quality, because high lipoxygenase activity, high fat acidity, and low germination rate have deteriorated in quality and generated off-odor. Thus, MR cultivars might be very important sources in food processing and stored dietary supplement aspects.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.2
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• pp.733-738
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• 2021

Recently, people's interest in marine leisure has been increasing, and research and development on leisure boats are actively being carried out to pioneer overseas markets. These days, the materials used for leisure boats are fiber-reinforced plastic (FRP) and aluminum alloy. However, FRP is hygroscopic and causes environmental problems, and aluminum alloy has high thermal conductivity and fire susceptibility. Therefore, titanium alloy is being adopted as a material for leisure boats instead. In this study, hull thicknesses and design pressures were calculated while considering dynamic effects for titanium boats. Four sets of rules and regulations were used: ISO 12215-5, RINA Pleasure Yacht, LR Special Service Craft, and KR High-speed Light Craft. The maximum bottom slamming loads were in the order of ISO, KR, LR, and RINA, and the required hull thicknesses were in the same order. This research might be helpful for understanding the rules, regulations, and overseas export of leisure boats.

• Parasites, Hosts and Diseases
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• v.60 no.5
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• pp.317-325
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• 2022

Hypoxia-inducible factor-1 alpha (HIF-1α) is one of the master regulators of immune and metabolic cellular functions. HIF-1α, a transcriptional factor whose activity is closely related to oxygen levels, is a target for understanding infectious disease control. Several studies have demonstrated that HIF-1α plays an important role during the infectious process, while its role in relation to parasite virulence has not been addressed. In this work, we studied the expression levels of HIF-1α and related angiogenic vascular endothelial growth factor A (VEGF-A) in human macrophages infected with promastigotes of hypo- or hyper-virulent Leishmania major human isolates. L. major parasites readily subverted host macrophage functions for their survival and induced local oxygen consumption at the site of infection. In contrast to hypo-virulent parasites that induce high HIF-1α expression levels, hyper-virulent L. major reduced HIF-1α expression in macrophages under normoxic or hypoxic conditions, and consequently impeded the expression of VEGF-A mRNA. HIF-1α may play a key role during control of disease chronicity, severity, or outcome.

• ETRI Journal
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• v.29 no.6
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• pp.808-810
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• 2007

We demonstrate 10 Gbps optical signal transmission via long-range surface plasmon polaritons (LR-SPPs) in a very thin metal strip-guided geometry. The LR-SPP waveguide was fabricated as a 14 nm thick, 2.5 ${\mu}m$ wide, and 4 cm long gold strip embedded in a polymer and pigtailed with single-mode fibers. The total insertion loss of 16 dB was achieved at a wavelength of 1.55 ${\mu}m$ as a carrier wave. In a 10 Gbps optical signal transmission experiment, the LR-SPP waveguide exhibits an excellent eye opening and a 2.2 dB power penalty at $10^{-12}$ bit error rate. We confirm, for the first time, that LR-SPPs can efficiently transfer data signals as well as the carrier light.

• IEMEK Journal of Embedded Systems and Applications
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• v.2 no.1
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• pp.43-52
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• 2007

IEEE 802.15.4 specification which defines low-rate wireless personal area network(LR-WPAN) has application to home or building automation, remote control and sensing, intelligent management, environmental monitoring, and so on. Recently, it has been considered as an alternative technology to provide multimedia services such as automation via voice recognition, wireless headset and wireless camera for surveillance. In order to evaluate capability of voice traffic on the IEEE 802.15.4 LR-WPAN, we supposed two scenarios, voice traffic only and coexistence of voice and sensing traffic. For both cases we examined delay and packet loss rate in case of with and without acknowledgement, and various beacon period varying with beacon and superframe order values. In LR-WPAN with voice devices only, total 5 voice devices could be applicable and in the other case, i.e., coexisted cases of voice and sensor devices, a voice device was able to coexist with about 60 sensor devices.

• Journal of Information Processing Systems
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• v.13 no.5
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• pp.1052-1070
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• 2017

For the autoencoder (AE) implemented as a construction component, this paper uses the method of greedy layer-by-layer pre-training without supervision to construct the stacked autoencoder (SAE) to extract the abstract features of the original input data, which is regarded as the input of the logistic regression (LR) model, after which the click-through rate (CTR) of the user to the advertisement under the contextual environment can be obtained. These experiments show that, compared with the usual logistic regression model and support vector regression model used in the field of predicting the advertising CTR in the industry, the SAE-LR model has a relatively large promotion in the AUC value. Based on the improvement of accuracy of advertising CTR prediction, the enterprises can accurately understand and have cognition for the needs of their customers, which promotes the multi-path development with high efficiency and low cost under the condition of internet finance.