• Journal of Pharmacopuncture
• /
• 제22권2호
• /
• pp.95-101
• /
• 2019

Objectives: Angiotensin II (AngII), a major product of renin-angiotensin system (RAS) has important role in induction of hypertension and antihypertensive effect of several medicinal plant was mediated by effect on this agent. Therefore, this study examined the possible effect of hydroalcoholic extract of Crocus sativus (C. sativus) on hypertension induced by AngII. Methods: Six groups (n = 6) of rats were used as follow: 1) Control, 2) AngII (300 ng/kg), 3) Losartan (Los, 10 mg/kg) + AngII and 4-6) C. sativus extract (10, 20 & 40 mg/kg,) + AngII. The femoral artery and vein were cannulated for recording cardiovascular parameters and drugs administration, respectively. All drugs were injected intravenously (i.v). Los and all doses of C. sativus injected 10 min before AngII. Systolic blood pressure (SBP), mean arterial blood pressure (MAP) and heart rate (HR) were recorded throughout the experiment and those peak changes (${\Delta}$) were calculated and compared to control and AngII. Results: AngII significantly increased ${\Delta}MAP$, ${\Delta}SBP$ and ${\Delta}HR$ than control (P < 0. 01 to P < 0.001) and these increments were significantly attenuated by Los. All doses of C. sativus significantly reduced peak ${\Delta}MAP$, ${\Delta}SBP$, and ${\Delta}HR$ than AngII group (P < 0. 05 to P < 0.001). In addition, peak ${\Delta}MAP$, ${\Delta}SBP$ in doses 10 and 20 were significant than Los + AngII group (P<0.05 to P< 0.01) but in dose 40 only MAP was significant (P<0.05). Peak ${\Delta}HR$ in all doses of C sativus was not significant than Los+ AngII. Conclusion: Regarding the improving effect of the C. sativus extract on AngII induced hypertension, it seems that this ameliorating effect partly mediated through inhibition of RAS.

• JOURNAL OF ELECTRICAL WORLD
• /
• 통권402호
• /
• pp.61-64
• /
• 2010

• Journal of the Korean Dietetic Association
• /
• 제5권1호
• /
• pp.48-53
• /
• 1999

This study was prospectively conducted to investigate any relationship of nutritional status at the time of admission to length of hospital stay and mortality. All patients admitted to the Asan Medical Center between October 13 and November 12, 1997 who met the study criteria were included in the study. Patients were classified as Not-at-risk, At-risk Ⅰ or At-risk Ⅱ based on the levels of serum albumin and total lymphocyte count in a computerized nutrition screening program. Sixty three percent of the patients were classified as Not-at-risk Group, 29% as At-risk Group Ⅰ and 8% as At-risk Group Ⅱ. Significant correlation was observed between nutritional status and LOS (P＜0.01) as well as mortality rate (P＜0.05). The more the patient had the nutritional risk factors, the longer the LOS and the higher the mortality rate were. Further studies have to be done in order to demonstrate cost-effectiveness of medical therapy for the malnourished hospitalized patients.

• Journal of Korean Society for Quality Management
• /
• 제39권3호
• /
• pp.391-399
• /
• 2011

Our study was carried out to analyze the variation factors of severity-adjusted length of stay(LOS) in coronary artery bypass graft(CABG). The subjects were 932 CABG inpatients of the Korean National Hospital Discharge In-depth Injury Survey from 2004 through 2008. The data were analyzed using $x^2$ test and the severity-adjusted model was developed using data mining technique. The results of the study were as follows: male(71.1%), older than 61 years of age(61.6%), more than 500 beds(92.8%) and admitting via ambulatory care(70.0%) appeared to have higher rate than otherwise. In-hospital mortality of CABG inpatients was 2.8%. In addition, 46.4% of the patients received their care in other residence. The angina pectoris(45.6%) was found to be the highest in principle diagnosis, followed by chronic ischemic heart disease(36.9%) and acute myocardial infarction(12.0%). We developed severity-adjusted LOS model using the variables such as gender, age and comorbidity. Comparison of adjusted values in predicted LOS revealed that there were significant variations in LOS by location of hospital, bed size, and whether patients received the care in their residences. The variations of LOS can be explained as the indirect indicator for quality variation of medical process. It is suggested that the severity-adjusted LOS model developed in this study should be utilized as a useful method for benchmarking in hospital and it is necessary that national standard clinical practice guideline should be developed.

• Journal of Korean Society of Transportation
• /
• 제34권2호
• /
• pp.168-179
• /
• 2016

This study describes an improved model for estimating pedestrian LOS (Level of Service) by utilizing the space occupied by pedestrians. The method introduced the concept of conflict along the bi-directional pedestrian flow which enables calculating conflict area and average travel time in walking. Especially, the method incorporates the idea of generalized density concept which can consider effective walking area and pedestrian flow rates that might vary during the analysis period. After establishing methodology, adjustments of pedestrian LOS criteria in term of walking space occupied by pedestrians were performed. As a result, walking-occupied space at capacity level is 0.68 and corresponding pedestrian flow rate was calculated as 80 persons/min/m, while different pedestrian-occupied spaces were ordered to classify LOS at the points where the gradient changes. Furthermore, the statistical verification of service levels has shown that there is significant difference among all LOS categories at 5% significance level.

• Journal of Korean Society of Transportation
• /
• 제24권7호
• /
• pp.115-128
• /
• 2006

The analytic methodology of a merging area in KHCM(2004) supposes that congestion nay occur when traffic demand is more than capacity However, in many cases, congestion on merging area occurs when summation of traffic demand of main line and ramp is less than capacity, and in present methodology analysis of how main line and ramp flow effect on congestion occurrence is difficult. In this study, the model that is able to estimate traffic flow condition on merging area in accordance with the combination of main line and ramp demand flow is developed. Main characteristic of the model is estimation of maximum possible throughput rate and maximum throughput rate according to the combination of main line and ramp demand flow. Through the estimation of maximum possible throughput rate and maximum throughput rate. it was Possible to predict whether congestion would occur or not and how much maximum throughput rate and congestion would be on merging area. On one hand, in present LOS evaluation methodology on merging area, congestion state is determined as un-congested flow if demand flow is less than capacity. Therefore, to establish more reasonable In evaluation method, new criterion of LOS evaluation on merging area was searched based on the model of this study.

• International Journal of Control, Automation, and Systems
• /
• 제3권3호
• /
• pp.486-492
• /
• 2005

A practical recursive WLS (weighted least squares) algorithm is proposed to estimate relative range using LOS (line-of-sight) information for ASM (anti-ship missile) application. Apart from the previous approaches based on the EKF (extended Kalman filter), to ensure good convergence properties in long range engagement situations, the proposed scheme utilizes LOS rate measurements instead of conventionally used LOS angle measurements. The estimation error property for the proposed filter is investigated and a simple error compensator is devised to enhance its estimation error performances. Simulation results indicate that the proposed filter produces very accurate range estimates with extremely small computations.

• 제어로봇시스템학회:학술대회논문집
• /
• 제어로봇시스템학회 2003년도 ICCAS
• /
• pp.1822-1825
• /
• 2003

A practical range estimator based on the robust Kalman filter is proposed to solve the range estimation problem for surface to air missile(SAM) homing guidance. Apart from the previous works based on the extended Kalman filter(EKF) with bearing only measurement, the proposed scheme makes use of line-of-sight(LOS) rate to ensure the fast convergency at long-range. In this reason, the robust Kalman filter is considered to deal with LOS rate measurement error. The recursive linear structure of proposed filter is easy to implement and make it possible to reduce computational burdens. Moreover, it shows good estimation performance without specific guidance law such as oscillation proportional navigation guidance(OPNG).

• 제어로봇시스템학회:학술대회논문집
• /
• 제어로봇시스템학회 2001년도 ICCAS
• /
• pp.125.5-125
• /
• 2001

Until now, many guidance laws have been developed. They mainly used the classical tail-pursuit guidance method based on geometric angle information, the proportional navigation method based on the line of sight(LOS) rate, and the optimal guidance law based on optimal control theorem. In the augmented guidance law, target acceleration information and autopilot characteristics are added the guidance command. In this study, new guidance laws considering geometric angle are proposed. Two guidance laws are developed for the midcourse guidance law, and a guidance law is developed for the terminal guidance respectively. The proposed guidance laws utilize the LOS rate and the geometric angle information simultaneously. In the midcourse guidance, the guidance command is ...

• Proceedings of the KIEE Conference
• /
• 대한전기학회 2003년도 하계학술대회 논문집 D
• /
• pp.2088-2090
• /
• 2003

A practical recursive weighted least square(WLS) solution is proposed to solve the passive ranging problem. Apart from the previous works based on the extended Kalman filter(EKF), to ensure the convergency at long-range, the proposed scheme makes use of line-of-sight(LOS) rate instead of bearing information. The influence of LOS rate measurement errors is investigated and it is asserted that the WLS estimates contain bias and scale factor errors. Together with simple compensation algorithm, the estimation errors of proposed filter can be reduced dramatically.