• The Korea Journal of Herbology
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• v.24 no.4
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• pp.49-53
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• 2009

Objectives : The protective effect of Vasopurus, a mixture of three medicinal plants, on atherosclerosis induced by dietary cholesterol in low density lipid (LDL) receptor deficient mice was studied. Methods : Experimental groups were divided into three groups of six animals each; a normal group (N); a high cholesterol group (HC), a high cholesterol plus Vasopurus group (HCVA). The experimental groups were fed for 6 months. Results : Vasopurus supplementation significantly lowered plasma total cholesterol and LDL cholesterol conc entrations compared with the high.cholesterol (HC) diet group. In addition, supplementation with Vasopurus significantly increased fecal cholesterol contents compared to mice fed a HC diet. Mice whose diet was supplemented by Vasopurus showed considerably fewer atherosclerotic plagues in the aortic values of heart and aortas compared to mice receiving the HC diet. Conclusions : These results indicate that Vasopurus has efficacy in anti.atherosclerosis medication.

• Proceedings of the Korean Society of Toxicology Conference
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• 2001.10a
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• pp.128-129
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• 2001

Tilianin, purified from acrial part of Agastache rugosa Kuntze, reduces progression and may induce some regression of aortic foam cell formation in low density lipoprotein receptor deficient mice (LDLR -/- mice). We investigated whether tilianin can prevent high fat diet-induced atherosclerosis. Twenty-six male mice were divided into three groups.(omitted)

• BMB Reports
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• v.48 no.1
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• pp.48-53
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• 2015

Oxidized LDL (oxLDL) performs critical roles in atherosclerosis by inducing macrophage foam cell formation and promoting inflammation. There have been reports showing that oxLDL modulates macrophage cytoskeletal functions for oxLDL uptake and trapping, however, the precise mechanism has not been clearly elucidated. Our study examined the effect of oxLDL on non-muscle myosin heavy chain IIA (MHC-IIA) in macrophages. We demonstrated that oxLDL induces phosphorylation of MHC-IIA (Ser1917) in peritoneal macrophages from wild-type mice and THP-1, a human monocytic cell line, but not in macrophages deficient for CD36, a scavenger receptor for oxLDL. Protein kinase C (PKC) inhibitor-treated macrophages did not undergo the oxLDL-induced MHC-IIA phosphorylation. Our immunoprecipitation revealed that oxLDL increased physical association between PKC and MHC-IIA, supporting the role of PKC in this process. We conclude that oxLDL via CD36 induces PKC-mediated MHC-IIA (Ser1917) phosphorylation and this may affect oxLDL-induced functions of macrophages involved in atherosclerosis.

• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2001.10b
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• pp.128-129
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• 2001

• 한국약용작물학회:학술대회논문집
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• 2008.11a
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• pp.388-389
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• 2008

• 한국약용작물학회:학술대회논문집
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• 2008.05a
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• pp.168-169
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• 2008