• 제목/요약/키워드: LDL/HDL-cholesterol

검색결과 1,531건 처리시간 0.025초

한국인에서 유산균 발효유의 섭취가 혈중 콜레스테롤에 미치는 영향 (Effect of Fermented Milk on the Blood Cholesterol Level of Korean)

  • 이용욱
    • 한국식품위생안전성학회지
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    • 제12권1호
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    • pp.83-95
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    • 1997
  • This study showed the effect of fermented milk on the cholesterol level of Korean. 130 persons among the teachers of elementary, middle and high schools, professors and graduate school students were divided into two groups according to their cholesterol level and provided with fermented milk 300 $m\ell$ dairly from Sep.25 to No. V3. They were given blood test at 20 days and 40 days after drinking fermented milk, and surveyed about their ordinary life style and the change of fecal condition. Cholesterol, LDL and the ratio of LDL and HDL in blood were significantly decreased in both high cholesterol group and normal group while HDL cholesterol was notably increased. TG showed slightly tendency of decrease in normal group while no changed in high group. There is no significant change in cholesterol level after drinking fermented milk among groups which are divided by factors of dringking, smoking, caffeine, B.M.I. and family history. The research also showed that drinking fermented milk improved the fecal frequency and fecal condition.

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성장기 암컷 흰쥐에서 이소플라본 첨가 식이가 지질 농도와 간 LDL 수용체의 유전자 발현정도에 미치는 영향 (Effects of Isotlavones Supplemented Diet on Lipid Concentrations and Hepatic LDL Receptor mRNA Level in Growing Female Rats)

  • 최미자;조현주
    • Journal of Nutrition and Health
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    • 제38권5호
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    • pp.344-351
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    • 2005
  • The purpose of this study was to examine the impact of isoflavones on lipid concentrations and hepatic LDL receptor mRNA level in growing female rats. Twenty four rats (body weight $75\pm5g$) were randomly assigned to one of two groups, consuming control diet or isoflavones supplemented diet (57mg isoflavones/100g diet). All rats has been fed on experimental diet and deionized water ad libitum for 9 weeks. The concentration of triglyceride and total cholesterol were measured in serum and liver. Serum HDL cholesterol was measured. Hepatic LDL receptor mRNA level was tested by RT-PCR. Supplementation of isoflavones did not affect weight gain, mean food intake and food efficiency ratio. Serum total cholesterol and non-HDL cholesterol of isoflavones supplemented rats were significantly lower than those of control rats (p<0.05). But hepatic cholseterol was not influenced by supplementation of isoflavones. Hepatic LDL receptor mRNA level not significantly different between control group and isoflavones supplemented group. Therefore, isoflavones may be beneficial on serum cholesterol and non-HDL cholesterol lowering in growing female rats.

유산소성 운동이 콜레스테롤식이 흰쥐의 혈청지질에 미치는 효과 (Effects of Aerobic Exercise on Serum Lipid in Cholesterol-Dietary Rats)

  • 김귀원;남태호;백영호
    • 생명과학회지
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    • 제8권1호
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    • pp.72-84
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    • 1998
  • 본 연구는 생후 4주령의 Sprague Dawley 흰쥐 47마리를 대상으로 2% 콜레스테롤 식이와 정상식이 그리고 여러가지 강도의 유산소운동(트래드밀 런닝)과 비운동을 실시하여 혈청지질과 adipose tissue를 분석해서 다음과 같은 경과를 얻었다. 1. 콜레스테롤식이에 의해 형중T-C치가 유의하게 증가되었으나 유산소성운동에 의해 감소하는 경향을 나타내었다. 2. 콜레스테롤식이에 의해 혈중 HDL-C와 LDL이 약간 증가야였으나, 유산소성운동에 의해 모두 감소하는 경향을 나타내었다. LDL/HDL-C는 간한 운동을 한 CRA군에서만 감소하는 경향을 나타내었다. 3. 콜레스테롤식이에 의해 혈액중의 phospholipid 및 triglyceride는 감소하는 경향을 나태내었으나, 유산소성운동에 의해 약간 증가하는 경향을 나태내었다. 4. 정상식이군에서 유산소성운동에 의해 adipose tissue가 유의하게 감소되었으며, 콜레스테롤 식이군에서도 유산소성운동에 의해 adipdse tissue가 감소하는 경향을 나타내었다. 이상과 같은 연구결과를 통하여 유산소성운동이 콜레스테롤식이에 의해 증가도니 혈중 총콜레스테롤을 저하시키며, 동백경과 위험인자인 LDL은 낮추어 동맥경화성 질병을 예방할 것으로 사료된다.

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양파의 고지혈증 효과에 대한 메타분석 (The effect of onion on hyperlipidemia: Meta-analysis)

  • 최기헌
    • Journal of the Korean Data and Information Science Society
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    • 제23권6호
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    • pp.1103-1115
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    • 2012
  • 본 연구는 고지혈증에 대해 양파추출물을 투여한 무작위 대조군 전-후 실험설계 연구 12편을 대상으로 체중, 간 무게, 신장 무게, 심장 무게, 혈당, 총콜레스테롤, 트리글리세리드, HDL-콜레스테롤, LDL-콜레스테롤의 평균비교를 통해 양파의 효능에 대해 알아보았다. 고정효과모형을 적용시킨 결과 체중과 심장 무게를 제외한 간 무게, 신장 무게, 혈당, 총콜레스테롤 농도, 트리글리세리드 농도, LDL-콜레스테롤 농도는 유의한 감소를 보였고, HDL-콜레스테롤 농도는 유의하게 증가하였다. 갈브레스 그림으로 동질성 여부를 알아보았고 동질성을 만족하지 않은 변수에 대해 랜덤효과모형을 적용시킨 결과 간 무게와 혈당, 총 콜레스테롤 농도, 트리글리세리드 농도의 감소에 대해 유의한 효과를 나타냈고, HDL-콜레스테롤 농도는 유의하게 증가하였다. 각 변수에 대해 출판편의의 존재를 알아보았고, 출판편의의 존재를 확인 후 절단과 보충 방법으로 대체값을 추정하였다.

유산균발효유 장기음용시 혈중 콜레스테롤에 미치는 영향 (Long-term Effect of a Fermented Milk Product on the Level of Blood Cholesterol in Korean)

  • 이용욱;김종규;노우섭;김판기;나승식
    • 한국식품위생안전성학회지
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    • 제14권1호
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    • pp.122-128
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    • 1999
  • The cholesterol-lowering effect of a fermented milk was studied for long-term period (56 weeks) in 206 Korean adults (106 normal cholesterol group and 100 hypercholesterol group) 300 $m\ell$ of the fermented milk was taken daily to all subjects for 10 weeks. 24 subjects drinking the fermented milk for 56 weeks and 42 subjects no-drinking for 40 weeks and then re-drinking from 50 th week for 6 weeks were followed up. Paired t-test, Duncan's multiple range test, and GLM repeated measure were used for statistical analysis. The level of total blood cholesterol and LDL after drinking the fermented milk for 10 weeks were decreased significantly in both group and affected by total cholesterol level at baseline, BMI, smoking and drinking. there is no significant change in triglyceride, HDL, and LDL/HDL ratio by drinking the fermented milk. The fermented milk intake for long-term period (56 weeks) did not show any more effect after 10 week on the level of TC, TG, HDL, LDL.

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아포리포 단백질 E 유전자의 E2와 E4 변이형이 정상 한국여성의 혈중 지질 수준 분포에 미치는 영향 (Apolipoprotein E2 & E4 Alleles Influence on the Distribution of the Human Plasma Lipid Profiles in Mormolipidemic Korean Women)

  • 이명숙
    • Journal of Nutrition and Health
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    • 제29권6호
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    • pp.642-650
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    • 1996
  • ApoE 유전자의 다형성은 인체 혈중 콜레스테롤 농도의 정상분포를 설명하는 중요한 인자이다. 특히, E2 와 E4 allele들은 고지혈증환자의 혈중에 현저히 나타나며, 각 다른 인종간의 이틀의 상대빈도수가 관상 동맥 질환 유발 위험도와의 상관관계가 아주 높다. Apo E 유전자의 다형성이 혈중 지질 대사변화 에 미치는 영향에 관한 실험은 105명의 건강한 한국여성을 대상으로 시행되었다. Apo E alleles의 한국 인 상대빈도수는 E3가 0.848, E4가 0.087, 그리고 E2는 0.067이었다. 본 연구에서는 E2/2 표현형이 나 타나지 않았지만, 중국 및 일본인과 같이 E4와 E2 allele가 아주 낮았다 최고및 최저혈압, 맥박(p

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한국인의 일부 도시인에서 비만, 이상혈당, 이상지질혈증의 집락과 고혈압의 관련성 (Association of Hypertension with Cluster of Obesity, Abnormal glucose and Dyslipidemia in Korean Urban Population)

  • 이강숙;김정아;박정일
    • Journal of Preventive Medicine and Public Health
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    • 제31권1호
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    • pp.59-71
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    • 1998
  • To examine the association of hypertension with cluster of obesity, abnormal glucose and dyslipidemia in Korean urban population, we conducted this cross-sectional study among 3027 men and 2127 women age 20-85 years who visited a prevention center between May 1991 and June 1995 for a multiphasic health check at St. Mary's Hospital, Seoul. By the self-administered questionnaire, the informations of educational attainments, monthly income, alcohol consumption, cigarette smoking, and physical excercise level were obtained. Height, weight, and blood pressure were measured by a trained nurse. The fasting blood sugar (FBS), total cholesterol, high density lipoprotein (HDL) cholesterol and triglyceride were tested by enzyme method. Low density lipoprotein (LDL) cholesterol was calculated by 'total cholesterol - HDL cholesterol - triglyceride/5'. For testing the differences of cardiovascular risk factors between hypertension and normotension group, 1-test and $\chi^2$-test were performed. For the age adjusted odds ratios of hypertension in persons with obesity, abnormal glucose, and dyslipidemia compared with normal, logistic regression was performed by using SAS pakageprograme. The results obtained were as follows: 1. Age, weight, body mass index(BMI), blood glucose, total cholesterol, LDL cholesterol, and triglyceride of hypertension group in men and women were significantly higher than normotension group, but height and HDL cholesterol of hypertension group only in women significantly lower than normotension group. The frequency of obesity $(BMI\geq25kg/m^2)$, abnormal glucose $(\geq\;120mg/dl)$, hypercholesterolemia $(\geq\;240mg/dl)$, lower HDL cholesterol (<45 mg/dl in women only), higher LDL cholesterol $(\geq\;160mg/dl)$, and hyper hypertriglyceridemia $(\geq\;250mg/dl)$ in hypertension group of men and women were significantly higher than normotension group. 2. Systolic and diastolic blood pressure were negatively correlated with hight, but positively with age, weight, BMI, total cholesterol, LDL cholesterol, and triglyceride in men and women. BMI was positively correlated with fasting blood sugar, total cholesterol, LDL cholesterol and triglyceride but negatively with HDL cholesterol. 3. The age adjusted odds ratios of hypertension were as follows in men and women : among persons who were obese compared with those nonobese, 2.53 (95% Confidence Intervals [C.I.] 2.08-3.07) and 2.22 (95%C.I. 1.71-2.87): among persons who were abnormal glucose compared with those normoglycemic, 1.43 (95%C.I 1.13-1.82) and 2.01 (95%C.I 1.36-2.94): and among persons who were dyslipidemia (hypercholesterolemia or lower HDL cholesterol or higher LDL cholesterol or hypertriglyceridemia) compared with those normal lipid, 1.59 (95%C.I 1.30-1.95) and 1.51 (95%C.I 1.16-1.96). After combined more than one risk factor, the odds ratios were increased. Among persons with cluster of obesity, abnormal glucose, and dyslipidemia, the odds ratio of hypertension was 2.25 (95%C.I 1.47-3.37) in men and 3.02 (95%C.I 1.71-5.30) in women. In conclusion, it was suggested that hypertension was associated with cluster of obesity, abnormal glucose, dyslipidemia in this Korean urban population.

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중공업근로자의 체질량지수 상승요인 (The Risk Factors Associated with Increased Body Mass Index in Heavy Industry Workers)

  • 이미화
    • 대한임상검사과학회지
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    • 제42권3호
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    • pp.129-135
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    • 2010
  • This study was performed to determine the risk factors associated with increased body mass index (BMI) in 672 heavy industry men workers. Subjects were examined in March, 2010 to September, 2010 in Gyeongnam province. Height, weight, systolic blood pressure, and diastolic blood pressure were measured. And fasting blood glucose, total cholesterol, HDL-cholesterol, LDL-cholesterol, and triglyceride levels were measured by Olympus AU 680, and their BMIs calculated. Age, smoking statue, and alcohol drinking of the workers were surveyed by questionnairs. The mean total cholesterol levels were $190.06{\pm}36.62mg/dL$, HDL-cholesterol $53.65{\pm}11.92mg/dL$, LDL-cholesterol $104.28{\pm}30.31mg/dL$, triglyceride $151.11{\pm}99.53mg/dL$, and fasting blood glucose $96.92{\pm}19.53mg/dL$. Mean systolic blood pressure was $126.08{\pm}13.78mmHg$, and diastolic blood pressure $71.88{\pm}10.45mmHg$. Subjects were categorized into two BMI groups, BMI ${\geq}23$ and BMI ${\leq}22.9$. The subjects with BMI of 23 or above had significantly higher levels of LDL-cholesterol, systolic blood pressure, and triglyceride, with lower levels of HDL-cholesterol. BMI showed the highest level at the age of thirties, increasing with age. BMI of smokers was higher than BMI of non-smokers, not showing a link between alcoholics and non alcoholics. In conclusion, age, systolic blood pressure, and HDL-cholesterol are mostly relevant to the increase of BMI in this study.

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한국 성인에서 혈중 LDL 입자의 크기에 영향을 미치는 관련 인자 연구 (Plasma LDL Particle Sizes Affect the Blood Lipid Profile and Dietary Intakes among Korean Adults)

  • 서연경;김형숙;김정숙;김철호;최혜미
    • 대한지역사회영양학회지
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    • 제9권1호
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    • pp.58-65
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    • 2004
  • The purpose of this research was to examine the relationship between the plasma LDL particle size and blood lipid profile, dietary factors and anthropometric values (body mass index, waist circumference and waist/hip ratio). The subjects were 173 adults aged 23 to 81 years, selected from the Outpatient Clinic and Cardiovascular Department of the Seoul Municipal Hospital. Dietary data were obtained using a 3-day food record and analyzed using Korean and US nutrient databases. The subjects were divided into three groups by LDL particle size : type A (large buoyant LDL, > 25.5 nm, n=96), type I (Intermediate LDL,$25.2\leq-\leq25.5$ nm, n=18), and type B (small dense LDL, < 25.2 nm, n=59) groups. The type B group had higher age, waist circumference, and waist/hip ratio (WHR) than the type A and type I groups. Serum concentration of triglyceride, Apo B, LDL/HDL cholesterol ratio and atherogenic index were significantly higher in the type B group as compared to those in the other two groups. HDL cholesterol level and Apo A-I/Apo B ratio were significantly lower in the type B group than the other two groups. The plasma LDL particle size was highly correlated with triglyceride (r= -0.450), Apo B (r= -0.402) and HDL cholesterol (r= 0.418). However, there was no correlation between plasma LDL particle size and dietary intakes. This study showed that small dense LDL was an important biochemical risk factor that was associated with other risk factors.

방풍통성산가미방(防風通聖散加味方)이 비만유도(肥滿誘導) 백풍(白嵐)와 지방세포(脂肪細胞) 분화(分化)에 미치는 영향(影響) (Anti-obestic Effects of Bangpoongtongsungcankamibang(BTSK) in 3%3-L1 preadipocyte cells and the Lipid Metabolism of Obesity induced Rats)

  • 이진용;김덕곤;안홍식
    • 대한한방소아과학회지
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    • 제20권1호
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    • pp.219-240
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    • 2006
  • Objective : This experimental study was designed to determine the anti-obestic effects of Bangpoongtongsungcankamibang(BTSK). Method : In vitro, BTSK extracts of various concentration (50,100, 200 $200{\mu}g/ml$)were added examination. The protein and mRNA expression of $C/EBP{\alpha}$ and $PPAR{\gamma}$ receptor was measured by western blot assay and RT-PCR. In vivo, BTSK extracts of various concentration (100, $200{\mu}g/ml$) were orally administered to induced hyperlipidemic rats by poloxamer-407 for consecutive four weeks and serum triglyceride, total cholesterol were measured. This method applied to induced hyperlipidemic rats by triton WR-1339, too. Obesity induced rats by the high fat-diet for six weeks were orally administered BTSK extracts of various concentration (100, $200{\mu}g/ml$) and serum triglyceride, total cholesterol, LDL-cholesterol, triglyceride, LDL-cholesterol, triglyceride, HDL-cholesterol, hydroxy radical, superoxide dismuatse activity were measured. Results : I. In vitro 1. The 3T3-L1 cells' differentiation was significantly decreased by BTSK. 2. expression of $C/EBP{\alpha}$ and $PPAR{\gamma}$ was was significantly decreased by BTSK. II. In vitro 1. BTSK significantly reduced serum triglyceride, total cholesterol, contents in poloxamer-407 treated rat. 2. BTSK significantly reduced serum triglyceride, contents in Triton WR-1339 treated rat. But Total cholesterol did not show a significant change. 3. BTSK significantly reduced body weight gain of rat and adipose tissue mass of rats and serum triglyceride, LDL-cholesterol, contents and significantly increased HDL-cholesterol, HTR(HDL-cholesterol/Total-cholesterol) in rats with obesity induced by the high fat-diet. 4. BTSK reduced blood lipid peroxide, hydroxy radical and increased superoxied dismuatse(SOD) activity.

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