• Toxicological Research
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• v.20 no.4
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• pp.321-324
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• 2004

Lethal dose 50% ($LD_{50}$) has been commonly used as a parameter for the estimation of acute toxicity not only in animal experiment, but also in human study. Several methods to estimate $LD_{50}$ had been introduced, but Spearman-Karber and Berens-Karber method have been widely used due to their relative convenience and accuracy. However, $LD_{50}$ values estimated from the two methods showed inconsistency and variation depending on the characteristics of mortality data. In this study, the two methods were comparatively investigated in terms of accuracy and stability for the estimation of $LD_{50}$.

• Korean Journal of Optics and Photonics
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• v.7 no.4
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• pp.375-385
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• 1996

Recently interest in the fabrication of LD operated by low current is gradually increasing as fabrication techniques of MQW-LD are progressed. In this viewpoint, theoretical estimation for decreasing the amount of threshold current will be helpful to design and make LD in case that active layer of conventional bulk type RWG-LD structure is replaced with MQW structure. Therefore, the optimum design condition of RWG MQW-LD was obtained from theoretical analysis in order to operate in the weakly index-guided LD and low threshold current. The lateral effective index step has been obtained in RWG MQW-LD structure. Waveguide mechanism including this index step has been investigated by solving the carrier diffusion equation and lateral wave equation. From these theoretical results, the optimum design condition of RWG MQW-LD have been suggested.

• Proceedings of the Korea Institute of Convergence Signal Processing
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• 2001.06a
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• pp.221-224
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• 2001

In this paper we propose a shift-invariant uHMT estimation for wavelet-based image denoising. The proposed estimation have just nine meta-parameter (independent of the size of the image and the number of wavelet scales) and requires no kinds of training. Also it solve visual artifacts resulted in the lack of shift-invariance in the DWT. The experimental results show that the proposed estimation is more effective than the other wavelet-based denoising by 0.5-ldB (PSNR) and allows an Ο(nlog n) in terms of performance speed.

• Animal Bioscience
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• v.37 no.5
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• pp.795-806
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• 2024

Objective: Karan Fries (KF), a high-producing composite cattle was developed through crossing indicine Tharparkar cows with taurine bulls (Holstein Friesian, Brown Swiss, and Jersey), to increase the milk yield across India. This composite cattle population must maintain sufficient genetic diversity for long-term development and breed improvement in the coming years. The level of linkage disequilibrium (LD) measures the influence of population genetic forces on the genomic structure and provides insights into the evolutionary history of populations, while the decay of LD is important in understanding the limits of genome-wide association studies for a population. Effective population size (N_e) which is genomically based on LD accumulated over the course of previous generations, is a valuable tool for e valuation of the genetic diversity and level of inbreeding. The present study was undertaken to understand KF population dynamics through the estimation of N_e and LD for the long-term sustainability of these breeds. Methods: The present study included 96 KF samples genotyped using Illumina HDBovine array to estimate the effective population and examine the LD pattern. The genotype data were also obtained for other crossbreds (Santa Gertrudis, Brangus, and Beefmaster) and Holstein Friesian cattle for comparison purposes. Results: The average LD between single nucleotide polymorphisms (SNPs) was r² = 0.13 in the present study. LD decay (r² = 0.2) was observed at 40 kb inter-marker distance, indicating a panel with 62,765 SNPs was sufficient for genomic breeding value estimation in KF cattle. The pedigree-based N_e of KF was determined to be 78, while the N_e estimates obtained using LD-based methods were 52 (SNeP) and 219 (genetic optimization for N_e estimation), respectively. Conclusion: KF cattle have an N_e exceeding the FAO's minimum recommended level of 50, which was desirable. The study also revealed significant population dynamics of KF cattle and increased our understanding of devising suitable breeding strategies for long-term sustainable development.

• Journal of the Korean Statistical Society
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• v.28 no.2
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• pp.265-277
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• 1999

Classical and inverse estimation methods are two well known methods in statistical calibration problems. When there are outliers, both methods have large MSE's and could not estimate the input value correctly. We suggest median calibration estimation based on the LD-statistics. To investigate the robust performances, the influence function of the median calibration estimator is calculated and compared with other methods. When there are outliers in the response variables, the influence function is found to be bounded. In simulation studies, the MSE's for each calibration methods are compared. The estimated inputs as well as the performance of the influence functions are calculated.

• Genomics & Informatics
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• v.7 no.1
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• pp.1-12
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• 2009

An alternative way of constructing ancestral graphs, which is different from the coalescent-based approach, is proposed using population linkage disequilibrium (LD) data. The main difference from the existing method is the construction of the ancestral graphs based on variants instead of individual sequences. Therefore, the key of the proposed method is to use the order of allele ages in the graphs. Distinct from the previous age-estimation methods, allele ages are estimated from full haplotype information by examining the number of generations from the initial complete LD to the current decayed state for each two variants depending on the direction of LD decay between variants. Using a simple algorithmic procedure, an ancestral graph can be derived from the expected allele ages and current LD decay status. This method is different in many ways from previous methods, and, with further improvement, it might be a good replacement for the current approaches.

• 한국방재학회:학술대회논문집
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• 2011.02a
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• pp.219-219
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• 2011

순 장파복사량은 지표면으로 입사되는 하강 장파복사량(Downward Longwave Radiation, $R_{ld}$)과 지표면에서 반사되는 상승 장파복사량(Upward Longwave Radiation, $R_{lu}$)의 차이로 정의되는데 이는 에너지 수지 및 농업기상 연구의 중요한 주제 중 하나로서 다루어져 온 순복사량의 중요한 요소이다. 일반적으로 $R_{lu}$의 경우 지표면 온도와 방사율(emissivity)를 이용하여 산출되므로 정확히 추정이 가능하나, $R_{ld}$의 경우 대기 최상층에서 관측되는 방사량과 지표면 근처의 방사량을 함께 고려해야 하므로 실측이 어렵다. $R_{ld}$는 야간 복사계(pyrgeometer)를 이용하여 직접적으로 측정할 수 있지만 관측기기 자체가 구비되어있는 관측소가 적어 매우 드물게 이용된다. 또한 단파 복사 에너지 측정 기기에 비해 비용이 많이들고 종종 관측값이 큰 오차를 가지고 있기 때문에 실무에 적용하기 힘든 단점이 있다. 따라서 기상 관측소에서 얻어지는 증기압과 온도 관측치를 물리식, 경험식 등에 적용하여 산정하게 된다. 현재는 $R_{ld}$의 추정은 관측된 방사량간의 관계를 나타내는 경험식을 기반으로 지표면 근처의 대기 온도와 습도를 이용하여 산출하는 방법이 널리 사용되고 있다. 본 연구에서는 증발산 산정 알고리즘 개발의 시발점으로써 $R_{ld}$를 먼저 구하고 $R_{lu}$를 구하였다. 신뢰성 높은 방법을 이용하여 $R_{ld}$를 구하게 되면 정확도 높은 $R_N$을 구하는 데 기여할 수 있으며, 궁극적으로 보다 정확한 증발산을 산정할 수 있게 된다. $R_{ld}$는 일반적으로 clear sky 조건 하에서의 복사 에너지 플럭스($R_{ldc}$)를 구한 후 구름의 양에 따라 보정한다. 하강 장파복사량의 경우 널리 사용되는 공식 중 하나인 Brutsaert의 공식을 사용하였다. 광릉, 해남에 위치한 플럭스 타워지점에서 실측된 기온과 실제 수증기압을 입력인자로 사용하여 지점별 $R_{ldc}$를 먼저 구하고 Moderate Resolution Imaging Spectroradiometer(MODIS) 영상자료를 이용하여 검증한 뒤 최종적으로 남한지역을 대상으로 순 장파복사량 지도를 작성하였다. 이를 위해 MODIS 07 대기 프로파일 산출물(Atmospheric Profile Product)중 기온 및 이슬점온도를 추출하여 산정식의 입력자료로서 사용하였다. 상승 장파복사량의 경우 MODIS 11 지표면 온도 산출물(Land Surface Temperature product)를 이용하여 산정하였다. 이는 남한 지역의 증발산량 추정 및 에너지 수지 연구를 위한 중요한 기본 자료로서 유용하게 사용될 수 있으리라 사료된다.

• Journal of the Korea Society for Simulation
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• v.16 no.1
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• pp.1-9
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• 2007

The development of efficient Qualify of Service (QoS) routing algorithms in high speed networks is extremely difficult to achieve, because in order to operate, divergent services require various quality conditions. If the parameter of concern is to measure the delay on a specific link, the routing algorithm obtains the Least Delay (LD) path. Meanwhile, if the parameter is to measure the link cost, the Least Cost (LC) path is calculated. The Delay Constrained Least Cost (DCLC) path problem of the mixed issues on the LD and LC has been shown to be NP-hard. The path cost of LD path is relatively more expensive than that of the LC path, and the path delay of the LC path is relatively higher than that of the LD path in the DCLC problem. In this paper, we introduce the new factor for balancing cost and delay. The simulation result shows that our introduced factor is satisfied to solve the DCLC problem.

• Archives of Pharmacal Research
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• v.29 no.12
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• pp.1132-1139
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• 2006

Single nucleotide polymorph isms (SNPs) in the MDR1 gene that are responsible for drug efflux can cause toxicity. Therefore, this study determined the SNPs of the Korean MDR1 gene, and analyzed the haplotypes and a linkage disequilibrium (LD) of the SNPs determined. The frequency of 9 SNPs from the MDR1 gene was determined by PCR-RFLP analyses of 100 to 500 healthy individuals. The frequcies of the SNPs were C3435T (47.7%), G2677T (37.6%), G2677A (4.4%), T1236C (21.7%), T129C (8%), A2956G (2.5%), T307C (1.5%), A41aG (9.2%), C145G (0%), and G4030C (0%). Analyses of the haplotype structure and an estimation of the LD of the combined polymorph isms demonstrated that the frequency of the 1236T-2677G-3435T haplotype is much higher in Koreans (14.1%) than in Chinese and western black Africans and the C3435T SNP in Koreans appears to have LD with T129C in Koreans for the first time. These results provide insight into the genetic variation of MDR1 in Koreans, and demonstrated the possibility of a new LD in this gene.

• Korean Journal of Optics and Photonics
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• v.18 no.4
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• pp.235-240
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• 2007

A ceramic stem based TO package incorporating a coplanar waveguide feed-line has been proposed allowing for 10 Gbps grade data transmission. The frequency response of a cylindrical feed-line fer a conventional metal based TO package was first analyzed, and compared with that of the CPW feed-line used for a ceramic based package such as a butterfly package. For the case where a DFB LD chip is packaged to an LD module, the measured 3 dB frequency bandwidths for the conventional and proposed packages were 3.5 GHz and 7.8 GHz respectively, which agree well with the theoretical results obtained from the modeling based on the small signal equivalent circuits. Consequently, we proposed a novel ceramic based TO package with a CPW feed-line in ceramic material as a stem to improve the frequency characteristics of the conventional one. And, its performance was theoretically observed to confirm that the proposed package provides even wider frequency bandwidth compared to the conventional one.