• Korean Journal of Microbiology
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• v.23 no.4
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• pp.291-296
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• 1985

Leptospira isolated from patients and natural paddy water were further studied to confirm their serologic specificity with the bacteria in infected animal tissue and autopsied tissue of patients died with leptospirosis. And pathologic patterns of the inoculated antimal and the virulence of the bacteria in the animals were also studied. The findings are summarized as follows; $LD_{50}$ dose of the bacteria in guinea-pig were $1-2{\times}10^9$ cells and mice were found to be susceptible to them even though the degree of susceptibilities were much inferior to guinea pig. The bacteria were recovered from various organs; demonstrated massive hemorrages due to diapedesis and monocyte infiltration were observed, in some cases, intramedullary hemorrages of the infected kidnies and hematuria were recognized. All of the hyperimmune sera were strongly reacted with the tissues from autopsied human case who died of EPHF(Epidemic Pulmonary Hemorrhagic Fever) in immunofluorescent antibody tests.

• Asian-Australasian Journal of Animal Sciences
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• v.31 no.12
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• pp.1843-1851
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• 2018

Objective: We aimed to characterize linkage disequilibrium (LD) and effective population size ($N_e$) in a Korean Yorkshire population using genomic data from thousands of individuals. Methods: We genotyped 2,470 Yorkshire individuals from four major Grand-Grand-Parent farms in Korea using the Illumina PorcineSNP60 version2 BeadChip, which covers >61,565 single nucleotide polymorphisms (SNPs) located across all chromosomes and mitochondria. We estimated the expected LD and inferred current $N_e$ as well as ancestral $N_e$. Results: We identified 61,565 SNP from autosomes, mitochondria, and sex chromosomes and characterized the LD of the Yorkshire population, which was relatively high between closely linked markers (>0.55 at 50 kb) and declined with increasing genetic distance. The current $N_e$ of this Korean Yorkshire population was 122.87 (106.90; 138.84), while the historical $N_e$ of Yorkshire pigs suggests that the ancestor $N_e$ has decreased by 99.6% over the last 10,000 generations. Conclusion: To maintain genetic diversity of a domesticated animal population, we must carefully consider appropriate breed management methods to avoid inbreeding. Although attenuated selection can affect short-term genetic gain, it is essential for maintaining the long-term genetic variability of the Korean Yorkshire population. Continuous and long-term monitoring would also be needed to maintain the pig population to avoid an unintended reduction of $N_e$. The best way to preserve a sustainable population is to maintain a sufficient $N_e$.

• Korean Journal of Agricultural Science
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• v.50 no.4
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• pp.861-867
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• 2023

Lairages serve several functions, such as providing post-mortal inspections and providing a reservoir of animals to ensure the slaughter line runs efficiently. High stress lairage conditions can contribute to the accumulation of transport stress in pigs, causing poor pork quality and still stressed pigs at slaughter. The objective of this study was to investigate meat quality, blood profile and behavior changes according to lairage stocking density in in high temperature. Density treatments were as follows: LD, low density (lower than 0.5 m²/100 kg); ND, normal density (0.5 m²/100 kg to 0.83 m²/100 kg); HD, high density (higher than 0.83 m²/100 kg). Air temperature treatment was as follows: HT, high temperature (higher than 24℃). Pigs stocked with LD showed lower pH, WHC (water holding capacity), and higher DL (drip loss) and CL (cooking loss) than those stocked with HD. Pigs stocked with LD showed lower cortisol level than those stocked with HD. Therefore, Pigs exposed to high stock density (lower than 0.5 m²/100 kg) in high air temperature during pre-slaughter caused acute stress and lead to PSE (pale, soft, exudative) pork incidence. Based on obtained results, stocking of too high (lower than 0.5 m²/100 kg) density is generally not good for meat quality and animal welfare at high temperatures.

• Horticultural Science & Technology
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• v.28 no.5
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• pp.796-801
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• 2010

This study was carried out to establish a system for mutation breeding by irradiation of gamma-ray in $Rosa$ $hybrida$ Hort. The rooted cuttings of two roses, 'Spidella' and 'Cabernet' were irradiated with different gamma-ray doses (0, 30, 50, 70, 90, 110, 130, 150 and 170 Gy) from a $^{60}Co$ source to reveal an optimal dose for induction of mutants. The irradiated plants were planted in a greenhouse, and investigated on the appearance of petal color mutants and shoot growth by gamma ray dose. The 50% lethal doses ($LD_{50}$) of plant were 110 Gy for 'Spidella' and 150 Gy for 'Cabernet', respectively. The 50% decrease dose of shoot length was observed at 70-90 Gy dose for 'Spidella', and 110 Gy dose for 'Cabernet'. Solid, chimeric and mosaic petal mutants with various colors were induced from pink petal of 'Spidella' and red petal of 'Cabernet' when 30-170 Gy dose was irradiated. The mutants obtained from 'Spidella' had white, ivory, pinky ivory, light pink and deep pink petal colors. The mutants obtained from 'Cabernet' had pink, deep pink, purple red (magenta), orange red and purple petal colors. It was suitable to irradiate 70-90 Gy dose for 'Spidella' and 90-110 Gy dose for 'Cabernet' for the induction of various mutants considering plant survival rate, shoot growth and mutant occurrence rate.

• Journal of environmental and Sanitary engineering
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• v.20 no.3 s.57
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• pp.44-50
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• 2005

Studies on the insecticides susceptibility of adults females Culex pipiens pallens were carried out in 2003. The pupae were emerged originated wild-caught larvae in Ansan city, Korea. The test methods employed, using 7 organophosphorous insecticides, four synthetic pyrethroides, and fipronil penyrazole were evaluated. The following results were obtained 1. Fipronil has showed the most strong value in $LD_{50}\;0.00075{\mu}g/female$, out of 12 kind of insecticides, and followed by deltamethrin 0.0071, $\delta-cyhalothrin\;0.008$, profenofos 0.0082 and $\beta-cyfluthrin$ 0.0088, respectively 2. The killing effect of lambdacyhalothrin and profenophos against adult females Culex pipiens pallens was examined using thermal fogging. The mortality rate were lambdacyhalothrin $41.1\%$ and profenophos $50.7\%$, respectively. The killing effect of thermal fogging was highly effectiveness to distance 6m from nozzle

• Toxicological Research
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• v.11 no.1
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• pp.133-136
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• 1995

HRccine(HFRS-virus vaccine) was administered subcutaneously or intragastrically to Spargue Dawley rats and subcutaneously to Japanese white rabbits to investigate the acute toxicity. $LD_50$ values were above 600 times the expected clinical dose in both animals. There were no differences in body weight changes, clinical signs and autopsy findings between all treated groups and control group in both animals. Therefore, it was concluded that HRccine is a very safe substance.

• Journal of Acupuncture Research
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• v.15 no.2
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• pp.357-367
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• 1998

This experiment was carried out to study on the acute toxicity of Thesium Chinese Turczaninow solution for aqua-acupuncture. Test material was manufactured by 'Water Alcohol method'. Mice and rats were used for this test. According to this experimental results, there were not observed any acute toxicity with Thesium Chinese Turczaninow solution for aqua-acupuncture. So Thesium Chinese Turczaninow solition for aqua-acupuncture is considered a have level of cliniccal safety. It is expected to be clinically helpful, and it is considered that continuous study is necessary.

• Archives of Pharmacal Research
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• v.14 no.1
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• pp.93-95
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• 1991

Alcoholic extract of the leaves of Andrographis paniculata Ness (=AAP) was obtained by cold maceration. A dose of 300 mg/kg $(1/6of\;LD_{50})$ of the extract was selected to study hepatoprotective action against carbon tetrachloride-induced liver damage. The extract was found to be effective in preventing liver damage which was evident by morphological, biochemical and functional parameters.

• Toxicological Research
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• v.13 no.4
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• pp.323-325
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• 1997

Ag-Os, water treatment agent, was administered orally to ICR mice and Sprague-Dawley rats to investigate the acute oral toxicity. $LD_{50}$ values were above 5 g/kg, 2,000 fold higher than the expected concentration in water, in both species with oral administration. There were also no differences in body weight changes, clinical signs and atopsy findings between all treated groups and control group. Therefore, it was concluded that Ag-Os is a very safe compound.

• Defense and Technology
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• no.2 s.264
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• pp.43-53
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• 2001

우리 군도 2000년 6월 전략화 심의를 통과한 후, 2006년부터 도입될 신형 해독제 주사기인 KHI-6에 대한 개발을 업체가 추진하고 있다. 이 HI-6 과련 해독제는 기존 PAM 관련 KMARK-1 보다 Soman 신경 작용제에 해독 능력이 증강되고, LD50 수치가 높고(자체 독성이 낮음을 의미), 이원화 자동 주사기로써 간편성을 더한다고 한다. 이에 우리도 신형 해독제 주사기에 대한 기본 구조와 해독 효과, 장점과 단점, 도입에 관련된 사전 지식, 외국군의 운용 실태 등에 대해 알아보았다