• YAKHAK HOEJI
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• v.57 no.2
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• pp.95-100
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• 2013

This study was performed to analyze in vitro and in vivo activities of LCB01-0183, a new oxazolidinone, against clinical isolates of bacteria. In vitro antibacterial activity of LCB01-0183 was tested by the two fold agar dilution method. In vivo activity of LCB01-0183 was determined against systemic infections in mice. LCB01-0183 showed most potent activity among the test compounds against clinical isolates of Gram-positive bacteria. Furthermore, the protective activity of LCB01-0183 was very effective against systemic infections in mice by oral or subcutaneous administration. In time kill study, LCB01-0183 showed a bacteriostatic activity during 24 hours. LCB01-0183 had potent in vitro and in vivo activity against Gram-positive bacteria including drug-resistant strains.

• YAKHAK HOEJI
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• v.58 no.1
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• pp.7-11
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• 2014

To study the resistance mechanism of E. faecalis to LCB01-0371, several resistant mutants to LCB01-0371 or linezolid were isolated by step-wise selection. The frequency of spontaneous mutations resistant to LCB01-0371 was lower than that of linezolid in E. faecalis. The genetic variations in resistant mutants were analyzed by DNA sequencing of domain V of 23S rRNA in each mutant. The first-step mutant to LCB01-0371 had a G2576T point mutation in V domain of 23S rRNA. However, no resistant mutant to LCB01-0371 was isolated in second-step mutant selection.

• Applied Chemistry for Engineering
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• v.22 no.6
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• pp.679-684
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• 2011

Branched polypropylenes (LCB-PP) with a long chain branch were prepared by the solid-state and molt-state reaction. Divinylbenzene (DVB), 1,4-benzenediol (RES), and furfuryl sulphide (FS) were used as branching agents of fabricate LCB-PP/silicate composites. Chemical structures, thermal properties, and rheological properties of the LCB-PP were determined by FT-IR, DSC, TGA, and dynamic rheometer (ARES). The chemical structure of the LCB-PP was confirmed by the existence of =C-H stretching peak of the branching agent at $3100cm^{-1}$. From DSC and TGA results, the melting reaction was more effective than the solid state reaction in the manufacture of LCB-PP, which was additionally certified by rheological properties. Based on rheological properties, FS was the best for branching efficiency of PP. Compared to PP, LCB-PPs indicated an increase of complex viscosity in the low frequency and shear thinning tendency, and G'-G" plot represented an increase in elasticity and the heterogeneousness in a melt state. Rheological properties of LCB-PP/silicate composites were observed with the silicate content. When 5 wt% silicate was added in LCB-PP, distinct changes in the shear thinning and the slope of G'-G" plots were observed.

• 전자공학회논문지 IE
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• v.44 no.2
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• pp.47-53
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• 2007

The inverter using level control block (LCB) was developed to drive LCD TV backlight using FFL light source. The FFL striking time, time for brightness stabilization, and lamp current of FFL backlight were shown to improve by applying LCB in the inverter. It was also shown that the stable driving of LCD TV FFL backlight with the inverter using LCB was possible over the wide temperature range.

• The Transactions of the Korea Information Processing Society
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• v.5 no.12
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• pp.3127-3137
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• 1998

COBRA 표준명세는 표준을 만족하는 구현에서 제공해야 할 기능뿐만 아니라 서비스 제공 모듈의 사용자 인터페이스도 IDL을 사용하여 엄격하게 정의하고 있다. CORBA 표준에 대한 확신과 신뢰성을 가지기 위해서는 IDL(Interface Definition Language)로 기술된 표준명세를 정형화하고 수학적으로 엄격히 증명할 필요가 있다. 본 논문에서는 CORBA 표준을 정형적으로 명세하고 검증할 방법을 제시한다. 먼저 표준모듈을 Larch/CORBA IDL(LCB)를 사용하여 정형적으로 명세하고, LCB의 의미론에 준하여 LCB 명세를 LSL(Larch Shared language)로 변환한다. 변환한 LCB 명세와 LSL 증명논리를 사용하여 특성을 수학적으로 증명한다. 변환기반의 LCB 의미론을 정립하여 제안한 방법의 이론적 바탕을 마련하고 CORBA 이름서비스명세에 실제 적용하여 그 효용성을 보인다.

• Journal of Applied Biological Chemistry
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• v.66
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• pp.197-203
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• 2023

Callus cultivation is a method for producing a large amount of tissue of a plant in the laboratory, regardless of the environment. Lycoris chejuensis, a plant species native to jeju island, is a member of the Lycoris family has been used as a traditional medicine for the treatment of diverse diseases. In this study, we evaluated anti-inflammatory effect of biorenovated Lycoris chejuensis callus (LCB) in lipopolysaccharide (LPS)-induced RAW264.7 cells. As a result, LCB was less toxic to the cells in the concentration range of 25, 50, and 100 ㎍/mL as shown by the improved viability of LCB treated cells than compared to Lycoris chejuensis callus (LC) treatment. In addition, LCB inhibited the generation of NO and prostaglandin E₂ through the suppression of inducible nitric oxide synthase and cyclooxygenase-2 protein expression. LCB also attenuated the expression of interleukin-1β, interleukin-6 and tumor necrosis factor-α induced by LPS. The results suggest that LCB has anti-inflammatory activity on the LPS-induced inflammatory response and may be suitable for the development of potent functional cosmetic material.

• International Journal of Naval Architecture and Ocean Engineering
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• v.9 no.3
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• pp.292-304
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• 2017

High-speed vessels are prone to the surf-riding in adverse quartering seas. The possibility of mitigating the surf-riding of the ITTC A2 fishing vessel in the design stage is investigated using the 6-DOF weakly non-linear model developed for surf-riding simulations in quartering seas. The longitudinal position of the ship's center of buoyancy (LCB) is chosen as the design parameter. The adjusting of LCB is achieved by changing frame area curves, and hull surfaces are reconstructed accordingly using the Radial Basis Function (RBF). Surf-riding motions in regular following seas for cases with different LCBs and Froude numbers are simulated using the numerical model. Results show that the surf-riding cannot be prevented by the adjusting of LCB. However, it occurs with a higher threshold speed when ship's center of buoyancy (COB) is moved towards stem compared to moving towards stern, which is mainly due to the differences on wave resistance caused by the adjusting of LCB.

• Journal of the Society of Naval Architects of Korea
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• v.45 no.5
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• pp.502-512
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• 2008

CFD tools were intensively used to develop a bulk carrier hull form of 180,000 DWT. HCAD and WAVIS were utilized to vary and evaluate the hull forms. LCB and framelines were systematically changed starting from a mothership. Resistance characteristics have been assessed by evaluating the wave-pattern resistance and viscous pressure drag along with the wave profile and wake distribution. It was found that the hull forms obtained from LCB variations were not good enough to satisfy the target resistance coefficient because of large wave generation at the design speed. After choosing the appropriate one from the LCB variation series, bow and stern framelines have been modified to improve wave-making characteristics and wake distribution, respectively. Model tests were performed to confirm the CFD results. Furthermore, the effect of free surface on CFD application was investigated, and a few comments are given on the difference between WAVIS version 1.4 and 2.0.

• KSBB Journal
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• v.18 no.6
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• pp.479-484
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• 2003

34 strains were isolated from dyeing wastewater in order to improve treatment efficiency of dyeing wastewater containing PVA. Two strains of them were finally selected through the PVA degrading test, and identified as Microbacterium barkeri LCa and Paenibacillus amylolyticus LCb. As a result, optimal conditions for microbial growth and PVA degradation were 30$^{\circ}C$, neutral pH, starch as a carbon source, and peptone as a nitrogen source. And it was concluded that these two strains have good ability for PVA degradation. And 90% over PVA was degraded by single culture as well as a mixed culture of 2 different strains.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2007.06a
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• pp.323-323
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• 2007

Influence of $La_2O_3$ addition to $CaO-B_2O_3$-based glass on the water leaching resistance of the glass was first investigated. The optimized $La_2O_3-CaO-B_2O_3$(LCB) glass was ball milled for varying time, followed by mixing with $Al_2O_3$ crystalline phase to form $Al_2O_3$-LCB glass composites at $875^{\circ}C$ for 1h. Microwave dielectric properties of the composites were investigated as a function of the ball milling time of the LCB glass. Dielectric constant and quality factor of the composites were 6.31 and 13856 GHz, respectively, when the LCB glass was ball milled for 2h prior to mixing with $Al_2O_3$.