• 화약ㆍ발파
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• 제17권1호
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• pp.27-55
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• 1999

The excavation works for deep foundation in urban areas have recently increased complaints of blasting vibration and settlement of ground level. Foundation must be excavated approximately up to 24-28m depths from the surface. The roads and subway line pass through the excavation area. The Dae-chung station is also located at the nearest distance 5-35m from the working site. To protect subway station and adjacient some structures from blasting and settlement, the level of ground vibration, displacements and stress were monitored and analyzed. The results can be summarized as follows ; 1. An empirical particle velocity equation were obtained by test blasts at Nassan Missi 860 Office tel construction site. $V{\;}={\;}K(D/\sqrt{W})^{-n}$, where the values for n and k are estimated tobe 0.371 and 1.551. From this ground vibration equation, the max. charge weight per delay time against distance from blasting point is calculated. Detailed blasting method is also presented. 2. To measure the horizontal displacement in directions perpendicular to the borehole axis, 6 inclinometers installed around working sites. The displacement at the begining was comparatively high because the installation of struts was delayed, but after its installation the values showed a stable trend. Among them, the displacement by 3 inclinometers installed on a temporary parking area showed comparatively high values, for example, the displacement measured at hole No. IC-l recoded the max. 47.04mm for 6 months and at hole No. IC-2 recorded the max. 57.33mm for 7 months. So, all of these data was estimated below a safe standard value 103mm. 3. Seven strain gauge meter was installed of measure the magnitude and change of stress acted on structs. The measured value of maximum stress was $-465{\;}kgf/\textrm{cm}^2,{\;}-338.4{\;}kgf/\textrm{cm}^2,{\;}302.3{\;}kgf/\textrm{cm}^2$ respectively. In compareto the allowable stress level of steel, they are estimated to be safe.

• 생태와환경
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• 제41권2호
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• pp.247-263
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• 2008

A two-dimensional (2D) reservoir hydrodynamics and water quality model, CE-QUAL-W2, is employed to simulate the hydrothermal behavior and density current regime in Andong Reservoir. Observed data used for model forcing and calibration includes: surface water level, water temperature, dissolved oxygen and suspended solids concentration. The model was calibrated to the year of 2003 and verified with continuous run from 2000 till 2004. Without major adjustments, the model accurately simulated surface water levels including the events of large storm. Deep-water reservoirs, like Andong Reservoir, located in the Asian Monsoon region begin to stratify in summer and overturn in fall. This mixing pattern as well as the descending thermocline, onset and duration of stratification and timing of turnover phenomenon were well reproduced by the Andong Model. The temperature field and distinct thermocline are simulated to within $2^{\circ}C$ of observed data. The model performed well in simulating not only the dissolved oxygen profiles but also the metalimnetic dissolved minima phenomenon, a common1y occurring phenomenon in deep reservoirs of temperate regions. The Root Mean Square Error (RMSE) values of model calibration for surface water elevation, temperature and dissolved oxygen were 0.0095 m, $1.82^{\circ}C$, and $1.13\;mg\;L^{-1}$, respectively. The turbid storm runoff, during the summer monsoon, formed an intermediate layer of about 15 m thickness, moved along the metalimnion until being finally discharged from the dam. This mode of transport of density current, a common characteristic of various other large reservoirs in the Asian summer monsoon region, was well tracked by the model.

• 천문학회지
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• 제31권2호
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• pp.161-171
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• 1998

We have mapped about 1.5 square degree regions of Lynds 1299, a well isolated dark cloud in the Outer Galaxy (l = $122^{\circ}$, b = $-7^{\circ}$), in the J = 1- 0 transition of $^{12}CO$ and $^{13}CO$ with the 13.7 m radio telescope at Taeduk Radio Astronomy Observatory (TRAO). We found that there are two velocity components in the molecular emission, at $V_{LSR} = -52 km S^{-1}$ (Cloud A) and -8.8 km $s^{-1}$ (Cloud B), respectively. We have derived physical parameters of two molecular clouds and discussed three different mass estimate techniques. We found that there are large discrepancies between the virial and LTE mass estimates for both clouds. The large virial mass estimate reflects the fact that both are not gravitationally bound. We adopt the mass of $5.6 {\times}10^3 \;M{\bigodot}$ for Cloud A and $1.2{\times}10^3 \;M{\bigodot}$) for Cloud B using conversion factor. Cloud A is found to be associated with a localized star forming site, and its morphology is well matching with that of far-infrared (FIR) dust emission. It shows a clear ring structure with an obvious velocity gradient. We suggest that it may be a remnant cloud from a past episode of massive star formation. Cloud B is found to be unrelated to Cloud A (d = 800 pc) and has no specific velocity structure. The average dust color temperature of the uncontaminated portion of Cloud A is estimated to be 24$\~$27.4 K. The low dust temperature may imply that there is no additional internal heating source within the cloud. The heating of the cloud is probably dominated by the interstellar radiation field except the region directly associated with the new-born B5 star. Overall, the dust properties of Cloud A are similar to those of normal dark cloud even though it does have star forming activity.

• 천문학회보
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• 제36권2호
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• pp.103.1-103.1
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• 2011

Recent observations by Hinode show weakly-attenuated coronal loop oscillations in the presence of background flow (Ofman & Wang 2008, A&A, 482, L9). We study the vertical kink oscillations in solar coronal loops, considering field aligned flows inside the loops as well as surrounding the loops environment. The two dimensional numerical model of straight slab is used to explore the excitation and attenuation of the impulsively triggered fast magnetosonic standing kink waves. A full set of time dependent ideal magnetohydrodynamics equations is solved numerically taking into account the value of flow of the order of observed flows detected by SOT/Hinode. We find that relaxing the assumption of the limited flows within the loops enhances the damping rate of the fundamental mode of the standing kink waves by 2 - 3 % as compared to flow pattern which is basically localized within the loops. We further notice that extending the flow pattern beyond the loop thickness also enhances the strength of the shock associated with slow magnetoacoustic waves, recognized as an addition feature detected in the numerical simulation. The wider out-flow pattern destroys the oscillation patterns early as compared to narrower flow pattern, in other words we can say that it affects the durability of the oscillation. However, for the typical coronal loops parameters we find that the observed durability periods of the SOT/Hinode observation can be achieved with an out-flow Gaussian patterns for which half-width is not greater than factor 2.0 of the loop-half-width. explain a possible relation between electric current structure and sigmoid observed in a preflare phase.

• Journal of Ginseng Research
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• 제28권1호
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• pp.60-66
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• 2004

“The Regional complex long-term program of restoration (reintroduction) of Primoryes ginseng population up to 2005” elaborated by Primorye governor administration, Regional Committee of Natural Resources and Russian Academy of Sciences operates in Russian Primorye. The Institute of Biology and Soil Science (IBSS) provides the scientific implementation of the program including the genetic analysis of extant ginseng populations, plant reproduction and off-spring identification. According to our investigations, the genetic resource of P. ginseng in Primorye is represented by three populations of wild-growing ginseng and a few pritate plantations. The results obtained by RAPD allowed concluding that the resource is dispersed among the wild and cultivated ginseng sub-populations in such a way that each of sub-populations studied has to be represented as a stock material to maintain species genetic variability. The allozyme analyses also showed that the small sub-populations of wild ginseng are characterized by unique genetic diversity and, therefore, they all need to be represented in reintroduction centers. Additionally the allozyme analysis discovered that the Blue Mountain and Khasan populations possess the most genetic diversity. So, at least one more reproductive ginseng unit has to be created besides two already existing reintroduction centers representing the Sikhote-Alin and the Blue Mountain populations.

• 한국식품영양과학회지
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• 제30권4호
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• pp.569-573
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• 2001

본 연구는 유자 과즙 제조시 부산물로 생기는 유자박의 효율적인 활용을 위해 펙틴 물질을 추출하여 그 수율을 측정하였고, 추출된 펙틴의 특성을 조사하였다. 추출용매로서 무기산은 HCl을, 그리고 유기산은 citrate 와 tartrate를 사용하였다. 각각의 용매에 대하여 추출비율을 달리하여 펙틴을 추출한 결과 1:20이 가장 좋은 비율(건조 유자박: 용매, w/v)로 나타났으며, 사용한 추출용액의 최적 농도는 무기산인 경우는 0.05N, 유기산인 경우는 0.1N이었다. 펙틴 추출과정에서 펙틴에 잔존하는 당을 제거하기 위해 95% ethanol로 1차 펙틴을 침전시킨 후, 65% ethanol로 6회 세척하였다. 펙틴의 추출 수율은 0.05N HCl은 18.7%, 0.1N citrate는 15.5%, 그리고 0.1N tartrate는 11.4%이였다. 추출한 펙틴의 DE는 42.97~47.55%로 low methoxyl pectin으로 분류될 수 있으며, intrinsic viscosity는 0.94~2.63의 범위였다. 분리한 펙틴의 당조성은 무기산으로 추출된 펙틴(4.2~4.7%)이 유기산으로 추출된 펙틴(15~19%)에 비하여 arabinose가 적은 함량을 나타내었고, rhamnose, xylose, glucuronic acid, galacturonic acid, galactose 그리고 glucose의 당 함량은 추출된 세 종류의 펙틴에서 큰 차이를 보이지 않았다.

• 한국임상약학회지
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• 제19권1호
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• pp.43-49
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• 2009

토브라마이신은 그람음성균 감염에 사용하는 아미노글리코사이드계 항생제로 이독성 및 신독성 등의 부작용과 큰 개인차로 혈중농도 모니터를 통한 투여계획이 필요한 약물이다. 본 연구에서는 16명의 위암환자에서 비선형 최소자승 회귀분석과 베이시안 분석에 의한 토브라마이신의 약물동태에 분석오차의 영향에 대하여 연구하였다. 약물투여는 토브라마이신 1-2 mg/kg을 30분에 걸쳐 8시간 간격으로 등속 주입하였으며, 혈액 채취는 정상상태에 도달되었다고 판단되는 첫 약물투여 72시간 후에, 약물 주입 5분전과 주입이 끝난 뒤 30분과 2시간에서 세차례 채취하였다. 혈청중 약물농도는 형광편광면역법으로 측정 하였다. 분석오차를 위해 0, 1, 2, 4, 8 및 12 ${\mu}g/mL$에 해당하는 토브라마이신 혈중농도(C)을 네차례 측정하여 각 혈중농도의 표준편차 (SD)을 구하였다. 토브라마이신 분석오차를 구하기 위한 다항식이 SD = 0.0224+0.0540C+0.00173C2, $R^2$ = 0.935이었다. 이 식에서 구한 SD 값으로 분석시 가중치를 주었을 때, 비선형 최소자승 회귀분석에 의한 토브라마이신의 약물동태학적 파라메타 ($V_d$, $K_{el}$, $K_{slpoe}$, $t_{1/2}$)에 유의성있는 영향을 주었으나, 베이시안 분석에 의한 토브라마이신의 약물동태학적 파라메타에는 영향이 없었다. 이 다항식으로 부터 구한 분석오차를 토브라마이신의 비선형 최소자승 회귀분석을 이용한 약물동태 연구 및 파라메타 분석에 적용하여 좀 더 정확한 투여용량을 결정할 수 있으며, 더 나아가 토브라마이신 약물동태 시뮬레이션 연구에 응용할 수 있다.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2009년도 제38회 동계학술대회 초록집
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• pp.381-381
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• 2010

$(ZrO_2)_{0.66}(HfO_2)_{0.34}$ thin films as gate dielectrics have been proposed to overcome the problems of tunneling current and degradation mobility inachieving a thin equivalent oxide thickness. An extremely thin $SiO_2$ layer is used in order to separate the carrier in MOSFET channel from the dielectric field fluctuation caused by phonons in the dielectric which decreases the carrier mobility. The electronic and optical properties influenced the device performance to a great extent. $(ZrO_2)_{0.66}(HfO_2)_{0.34}$ dielectric films on p-Si (100) were grown by atomic layer deposition method, for which the conduction band offsets, valence band offsets and band gapswere obtained by using X-ray photoelectron spectroscopy and reflection electron energy loss spectroscopy. The band gap, valence and conduction band offset values for $(ZrO_2)_{0.66}(HfO_2)_{0.34}$ dielectric thin film, grown on Si substrate were about 5.34, 2.35 and 1.87 eV respectively. This band alignment was similar to that of $ZrO_2$. In addition, The dielectric function (k, $\omega$), index of refraction n and the extinction coefficient k for the $(ZrO_2)_{0.66}(HfO_2)_{0.34}$ thin films were obtained from a quantitative analysis of REELS data by comparison to detailed dielectric response model calculations using the QUEELS-$\varepsilon$(k, $\omega$)-REELS software package. These optical properties are similar with $ZrO_2$ dielectric thin films.

• Molecules and Cells
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• 제37권3호
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• pp.202-212
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• 2014

ClC-1 is a member of a large family of voltage-gated chloride channels, abundantly expressed in human skeletal muscle. Mutations in ClC-1 are associated with myotonia congenita (MC) and result in loss of regulation of membrane excitability in skeletal muscle. We studied the electrophysiological characteristics of six mutants found among Korean MC patients, using patch clamp methods in HEK293 cells. Here, we found that the autosomal dominant mutants S189C and P480S displayed reduced chloride conductances compared to WT. Autosomal recessive mutant M128I did not show a typical rapid deactivation of Cl- currents. While sporadic mutant G523D displayed sustained activation of $Cl^-$ currents in the whole cell traces, the other sporadic mutants, M373L and M609K, demonstrated rapid deactivations. $V_{1/2}$ of these mutants was shifted to more depolarizing potentials. In order to identify potential effects on gating processes, slow and fast gating was analyzed for each mutant. We show that slow gating of the mutants tends to be shifted toward more positive potentials in comparison to WT. Collectively, these six mutants found among Korean patients demonstrated modifications of channel gating behaviors and reduced chloride conductances that likely contribute to the physiologic changes of MC.

• 대한유전성대사질환학회지
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• 제13권2호
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• pp.104-110
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• 2013

Purpose: Phenylketonuria (PKU) is the first inherited metabolic disease of which treatment is known. We performed this study to find out clinical symptoms and prognosis of tetrahydrobiopterin (BH4) responsive PKU patients and genetic relation. Methods: Clinical, biochemical, genetic analysis were done retrospectively in 23 patients diagnosed BH4 responsive PKU in Soonchunhyang University Hospital from March 2000 to September 2012. Results: Patients were classified to mild hyperphenylalaninemia and mild phenylketonuria with initial plasma phenylalanine level below 20 mg/dL. After BH4 loading, blood phenylalanine decrease level ranged between 37% and 99%. Initial treatment with low phenylalanine formula or BH4 was started before 2 month after birth except 2 patients. And one of them resulted in developmental delay in language and social activity. The others showed satisfactory progress without developmental delay. In genetic analysis, of 46 allele, R241C allele mutation was identified most commonly (41%). R241C/A259T, R241C/R243Q, R241C/V388M, R241C/T278I was detected in 5 (21.7%), 3 (13%), 2 (8%), 2 (8%) patients, respectively. Conclusion: R241C mutation was detected most frequently in this study group and R243Q mutation which is known to be prevalent in Korean PKU patients was found in 4 patients (8.6%). Early diagnosis and treatment is important in PKU patients.