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Does oral doxycycline treatment affect eradication of urine vancomycin-resistant Enterococcus? A tertiary hospital study

  • Kim, Yoonjung;Bae, Sohyun;Hwang, Soyoon;Kwon, Ki Tae;Chang, Hyun-Ha;Kim, Su-Jeong;Park, Han-Ki;Lee, Jong-Myung;Kim, Shin-Woo
    • Journal of Yeungnam Medical Science
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    • 제37권2호
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    • pp.112-121
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    • 2020

  • Background: Vancomycin-resistant Enterococcus (VRE) has become more common in nosocomial infections, especially in urine samples. However, until now, no treatment regimen has been proven to effectively eradicate urine VRE colonization. Therefore, to evaluate the efficacy of doxycycline in eradicating urine VRE and shortening VRE isolation period, we compared VRE colony detection period between doxycycline-treated and untreated patients. Methods: A retrospective cohort study of 83 patients with VRE colonization in urine cultures was conducted at a tertiary academic hospital from January 2011 to February 2018. Kaplan-Meier survival analysis was used to evaluate eradication rates in the treatment and non-treatment groups. Factors affecting urine VRE colonization persistence were analyzed by multiple logistic regression analysis. Results: The overall rate of VRE eradication during the entire hospital stay was higher in the doxycycline treatment group (90.5%) than in the non-treatment group (58.1%, p=0.014). Survival analysis showed that the 5-, 10-, and 20-day cumulative eradication rates were 78.3%, 100%, and 100% in the doxycycline treatment group, and 18.5%, 45.7%, and 67.8% in the non-treatment group, respectively, thereby indicating that eradication rates were higher in the doxycycline treatment group than in the non-treatment group (p<0.001). Only doxycycline treatment was shown to affect urine VRE colonization persistence in multivariate logistic regression analysis. Conclusion: Doxycycline treatment enhanced the eradication rate of urine VRE colonization and appeared to be useful in shortening VRE isolation period.

  • https://doi.org/10.12701/yujm.2019.00430 인용 PDF KSCI

Activity of PKC is required for chondrocyte maturation

  • Lim, Young-Bin;Shu, Jo-Young;Shu, Jo-Young;Chung, Yun-Hye;Sonn, Jong-Kyung
    • 한국동물학회:학술대회논문집
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    • 한국동물학회 2001년도 한국생물과학협회 학술발표대회
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    • pp.194.2-194
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    • 2001

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Plume Rise : Observations and Model

  • Yoon, Ill-Hee;Song, Eun-Young;Kim, Jong-Suk;Moon, Young-Soo
    • 한국환경과학회:학술대회논문집
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    • 한국환경과학회 1996년도 가을 학술발표회 초록집
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    • pp.18-18
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    • 1996

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