• 한국작물학회:학술대회논문집
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• 한국작물학회 2006년도 한국약용작물학회 공동춘계학술발표회
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• pp.650-651
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• 2006

• 한국응용곤충학회:학술대회논문집
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• 한국응용곤충학회 2005년도 춘계 학술발표회
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• pp.137-137
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• 2005

• 한국약용작물학회:학술대회논문집
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• 한국약용작물학회 2011년도 춘계학술발표회
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• pp.290-291
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• 2011

• Biomolecules & Therapeutics
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• 제7권3호
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• pp.205-209
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• 1999

Stability of the $\beta$-sitosterol glycoside from Schima wallichii sp. at various physical conditions were investigated, mutagenecity of the steroid saponin was determined by Ames test. When exposed in pH 3 to pH 8, the $\beta$-sitosterol glycoside was stable on antimicrobial activity against yeasts. The antimicrobial activity of the $\beta$-sitosterol glycoside also stable in high temperature, $N_2$, $O_2$ gas and light exposure, and metal ion. Ames test result revealed that $\beta$-sitosterol glycoside did not have any mutagenic activity. These results suggest that the $\beta$-sitosterol glycoside might be a promising candidate as a natural antimicrobial compound.

• 대한한의학원전학회지
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• 제21권3호
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• pp.307-355
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• 2008

This thesis make a study on the sixteen chapters from 9 to 24 of "Maekgyeong(脈經)" Vol.Ⅶ. In this volume indications for several curative procedures, especially physical procedures, prognoses for fevers and symptoms hard to cure such as Eumyanggyo(陰陽交) are reviewed by Wang(王). The physical procedures include acupuncture, moxibustion, hydrotherapy, thermotherapy etc. The contents mainly quoted from "Sanghallon(傷寒論)", "Geumgweyoryak(金匱要略)", "Yeongchu(靈樞)" and "Somun(素問)".

• 약학회지
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• 제50권5호
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• pp.332-337
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• 2006

Type 2 diabetes mellitus is a chronic and hard to control disease. In order to develop the therapeutic agent for type 2 DM, many researchers investigated natural products using an in vitro and in vivo assay. In this study, we tried to explore the anti-diabetic activity and mechanisms of ginsam, which is a vinegar-processed ginseng radix. The db/db mice were randomly divided into four groups. The diabetes control (DC) group was orally administrated with distilled water, ginseng radix (GR) or ginsam (GS) was administrated orally at a dose of 150 mg/kg, and the positive control group was orally injected with metformin (MET) at a dose of 300 mg/kg for 5 weeks in db/db mice and measured body weight and blood glucose level every week. All treatment groups decreased the plasma glucose levels compared with diabetic control and GS group significantly lowered the insulin resistance index. GS group also reduced the plasma lipid levels mainly due to reduce the lipogenesis and increase the lipolysis in the fat tissue. In addition, GS group increased the GLUT4 mRNA expression levels in the fat and muscle tissues by 10 fold probably due to increase a $PPAR_{-\gamma}$ mRNA expression in fat tissue. Taken together, GS showed the anti-hyperglycemic and anti-hyperlipidemic activities and those activities may ascribe to over-expression of GLUT4 mRNA level and decrease the lipogenesis in fat tissue.

• 대한한의학회지
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• 제15권2호
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• pp.321-333
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• 1994

1. Autum-dryness syndrome(秋燥) is caused by dry-warm or dry=-cool weather condition when lower-warmer Eumfen(下焦陰分) was injured by jung hyoul hatal(精血下脫) or taking medicines of dryness in autumn. 2. The symptoms of autum-dryness syndrome are headach, fever, chilling, anhydrosis, dry cough, tinnitis, dry lip, dry skin, chest discomfort in cool-dryness syndrome(凉燥) and headach, fever, dry cough, paroxymal cough, dry skin, chest pain, polydipsia, tinnitis, eye redness, sore throat in heat-dryness syndrome(溫燥). 3. Hyangsochongsitang(香蘇蔥頭湯) chn be applied for terating cool-dryness syndrome(凉燥) and chungjogoopyetang(淸燥救肺湯) for heat-dryness syndrome(溫燥). Sang Hang Tang(桑杏湯) can be administered when the evils located in the upper-warmer, and Yukmihwan(六味丸) can be administered when located in the lower-warmer(下焦) 4. According the determination of treatment based on the differentiation of symptoms and signs. When the symptoms of Weifen syndrome(衛分證) are headach, fever, dry lip or chilling or dypsia and the treatment of weifen syndrome apply Hangsosan(行蘇散) or Sang hang tang(桑杏湯). When the symptoms of Qifen syndrome(氣分證) are tinnitis, eye redness, sore throat, chest discomfort, polydipsia, dry cough, watery diarrhea, constipation and Jibaekjihwang(知栢地黃丸) when Ohingulpitang(五仁橘皮湯) Chungjogupyetang(淸燥救肺湯) can are applied for treating Qifen syndrome(氣分證). When the symptoms of younghylfen syndrome(營血分證) are dry cough, watery diarrhea, dypsia, chest discomfort, hematemesis, epistaxis and agyohwang keum tang(阿膠湯) Oknyujun(玉女煎) can be applied for treating Younghyulfen syndrome(營血分證).

• Food Science and Biotechnology
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• 제17권6호
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• pp.1228-1234
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• 2008

Having idea to develop more effective anti-diabetic agent from ginseng root, we comprehensively assessed the anti-diabetic activity and mechanisms of ginsam in C57BL/KsJ db/db mice. The db/db mice were divided into 4 groups; diabetic control (DC), ginsam at a dose of 300 or 500 mg/kg (GS300 or GS500) and metformin at a dose of 300 mg/kg (MT300). Ginsam was orally administered for 8 weeks. GS500 reduced the blood glucose concentration and significantly decreased an insulin resistance index. In addition, GS500 reduced the plasma non-esterified fatty acid, triglyceride, and increased high density lipoprotein-cholesterol as well as decreased the hepatic cholesterol and triglyceride. More interestingly, ginsam increased the plasma adiponectin level by 17% compared to diabetic control group. Microarray, quantitative-polymerase chain reaction and enzyme activity results showed that gene and protein expressions associated with glycolysis, gluconeogenesis, and fatty acid oxidation were changed to the way of reducing hepatic glucose production, insulin resistance and enhancing fatty acid $\beta$-oxidation. Ginsam also increased the phosphorylation of AMP-activated protein kinase and glucose transporter expressions in the liver and skeletal muscle, respectively. These changes in gene expression were considered to be the mechanism by which the ginsam exerted the anti-diabetic and anti-dyslipidemic activities in C57BL/KsJ db/db mice.

• 한국산학기술학회논문지
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• 제15권4호
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• pp.2225-2234
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• 2014

본 연구는 감정노동과 조직문화가 임상간호사의 자아효능감에 미치는 영향을 파악하기 위해 시도되었다. 이를 위해 C와 D지역에 소재한 6개 병원에 근무하는 간호사 475명을 대상으로 구조화된 설문지를 통해 일반적 특성, 감정노동, 간호조직문화, 자아효능감에 대한 자료를 수집하였다. 자료분석은 서술적 통계, t-test, ANOVA 및 Pearson's correlation coefficient, hierachial multiple regression으로 분석하였다. 본 연구 결과, 감정노동, 간호조직문화와 자아효능감은 중등도 이상으로 나타났으며, 자아효능감과 감정노동(r=-.24, p<.001), 감정노동과 간호조직문화(r=-.15, p=.001)는 음의 상관관계를, 자아효능감과 간호조직문화(r=.33, p<.001)는 양의 상관관계를 나타내었다. 또 전체 자아효능감에 유의한 설명력(27. 6%)을 가진 변수는 간호조직문화와 일반적 변수 중 학력, 직무만족, 이직경험이었다. 본 연구결과 간호사의 정서적 요인과 환경적 요인이 자아효능감에 직접적으로 영향을 주었으므로 간호사의 자아효능감을 관리하기 위한 프로그램과 더불어 환경관리중재가 필요할 것으로 보인다.

• Natural Product Sciences
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• 제17권1호
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• pp.33-37
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• 2011

The plant species reported here are used by traditional healers in Gabon for different ailments such as wounds, malaria, fever, gonorrhea or diarrhea. The aim of this study was to evaluate the antimicrobial activities of 7 plants (Strombosiopsis tetrandra, Tetraberlinia bifoliolata, Dichapetalum barbatum, Guibourtia demeusii, Dacryodes normandii, Manniophytum fulvum, Paropsia grewoides) against different strains of both Methicillin-Resistant Staphylococcus aureus (MRSA) and Salmonella. Disc diffusion was first used to determine the antimicrobial effectiveness of the plants' ethanolic extracts. Then the minimum inhibitory concentrations of the crude extracts of either leaves or stem barks of the 7 plants were determined using broth micro-dilution. The ethanolic plant extracts showed very good activity against both MRSA and Salmonella strains where the MICs ranged from $250\;{\mu}g/ml$ to $1000\;{\mu}g/ml$. The study shows that many of the tested plants used by Gabonese traditional healers have antimicrobial activities and give support to their traditional use.