• 한국의학물리학회지:의학물리
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• 제28권1호
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• pp.1-10
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• 2017

The difference between three-dimensional (3D) and four-dimensional (4D) dose could be affected by factors such as tumor size and motion. To quantitatively analyze the effects of these factors, a phantom that can independently control each factor is required. The purpose of this study is to develop a deformable lung phantom with the above attributes and evaluate the characteristics. A phantom was designed to simulate diaphragm motion with amplitude in the range 1~7 cm and period up to ${\geq}2s$ of regular breathing. To simulate different tumors sizes, custom molds were created using a 3D printer and filled with liquid silicone. The accuracy of the phantom diaphragm motion was assessed by comparing measured motion with predicted motion. Because the phantom diaphragm motion is not identical to the tumor motion, the correlation between the diaphragm and tumor motions was calculated by a curve fitting method to emulate user-intended tumor motion. Tumors of different sizes were located at same position, and tumor set-up positions were evaluated. The accuracy of phantom diaphragm motion was better than 1 mm. The diaphragm-tumor correlation showed that the tumor motion in the superior-inferior direction increased with increasing diaphragm motion. The tumor motion was larger in the $10cm^3$ tumor than in the $90cm^3$ tumor. The range of difference between the tumor set-up positions was 0 to 0.45 cm. This phantom showed independently adjusting factors such as tumor size and motion to facilitate quantitative analysis of the dosimetric impact of respiratory motion according to these factors.

• 정보처리학회논문지B
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• 제14B권4호
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• pp.295-302
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• 2007

테이블 형태로 이루어진 이력서 양식이나 인터넷 회원 가입에서 개인의 신상 정보를 매번 입력하는 일은 매우 반복적이고 번거로운 일이다. 개인의 신상 정보를 컴퓨터에 저장하고 있다가 인터넷 회원 가입 페이지에 자동으로 채워 주는 몇 개의 시스템이 나와 있으나 필드와 필드 값이 잘못 매치되는 등 정확도가 떨어지는 면이 있다. 본 연구는 컴퓨터에 개인의 신상정보를 저장하고 있다가 개인 데이터 온톨로지를 이용하여 회원가입 페이지(목표 페이지)에서 요구하는 사용자의 정보를 추론하고 자동으로 채워주는 시스템을 제안하였다. 추론의 과정에서 먼저 목표 페이지를 분석하여 요구하는 필드명을 추출하고, 유사어 온톨로지를 이용하여 요구 필드명을 표준 필드명으로 변환한다. 표준 필드명으로 변환된 요구 필드는 온톨로지 매치 메이킹을 이용하여 개인 데이터 온톨로지 상의 적절한 레벨을 찾아서 최종적인 필드값을 생성한다. 본 시스템은 목표 페이지와 유사한 필드를 가져올 뿐만 아니라 온톨로지 계층 상에 해당되는 필드를 추론하여 정확한 필드값을 가져오게 된다. 몇 개의 회원 가입 페이지를 대상으로 실험한 결과 본 시스템이 기존의 시스템에 비해 정확도에서 우수함을 보였다. 본 시스템은 이력서 양식 등 반복적으로 동일한 정보를 채우는 경우에도 쉽게 적용 가능하다.

• 대한토목학회논문집
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• 제38권2호
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• pp.215-226
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• 2018

본 연구에서는 도시지역 관망 내 수위 관측자료를 이용하여 도시지역 유출해석 및 관망해석의 정확도를 높이고자 한다. 이를 위해 도시유출해석의 주요 매개변수별 민감도 분석을 수행하고, 매개변수의 보정을 수행하였다. 매개변수의 민감도는 관의 조도계수, 불투수지역의 조도계수, 유역폭, 투수지역의 조도계수 순으로 나타났다. 민감도가 높은 4개의 매개변수를 이용하여 매개변수 고려 개수와 종류에 따라 6가지 시나리오를 구성하였으며, 자동보정기법인 PEST를 도시유출 모형인 SWMM과 연계 해석하여 분석하였다. 각 조건을 2013년 7월 21일 집중호우로 인하여 침수피해가 발생한 서초3, 4, 5, 역삼, 논현 배수분구에 적용하였다. 민감도 결과를 이용하여 시나리오별 분석을 실시하였을 때 SWMM 모형만을 이용하였을 때 보다 불확실성이 줄어든 결과를 보였다. 모의결과 RMSE는 최대 2.41cm가 감소하였으며, 상대첨두오차는 13.7%가 감소하였다. 민감도가 낮은 투수지역의 지표면 조도계수를 고려한 시나리오의 경우가 고려하지 않은 시나리오의 경우보다 정확도가 소폭 낮아졌으며 계산시간도 많이 소요되었다. 본 연구 결과 대상 유역에 대한 민감도 분석 후 민감도가 높은 매개변수만을 고려하여 시나리오를 구성하였을 때 보다 효율적인 모의가 될 수 있다는 것을 알 수 있었으며 향후 추가적인 강우사상과 침수해석을 연계할 시에는 도시지역의 침수예경보 연구에 기여할 수 있을 것으로 판단된다.

• Nutrition Research and Practice
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• 제10권6호
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• pp.629-634
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• 2016

BACKGROUND/OBJECTIVE: The aim of this experiments was to show anti-obesity effects of Korean solar salt from different salt fields in diet-induced obese mice. MATERIALS/METHODS: Diet-induced obesity (DIO) was induced by a high-fat diet (HFD; 45% cal from fat) in C57BL/6J mice for eight weeks. The mice were fed with the designated diets (chow diet for Normal, HFD for Control, 0.47%-salt-mixed HFD for purified salt (PS), Guerande solar salt from France (SS-G), solar salt from Y salt field (SS-Y), solar salts from T salt field (SS-T) and S salt field (SS-S)) for another eight weeks. We checked body weight, food efficiency ratio (FER) and tissue weights (liver and epididymal adipose tissue (EAT)), and observed serum concentrations of triacylglycerol (TG), total cholesterol (TC), leptin and insulin. We also evaluated gene expressions of adipogenic / lipogenic mRNAs of $C/EBP{\alpha}$, $PPAR{\gamma}$ and FAS and beta-oxidation-related factors ($PPAR{\alpha}$ and CPT-1) in liver and EAT. The mineral composition of salt samples were analyzed using inductively coupled plasma optical emission spectrometry (ICP-OES). RESULTS: SS-T and SS-S significantly reduced body weight gain, FER, and weight of EAT compared to control and other samples (P < 0.05). SS-T and SS-S also significantly decreased serum levels of TG, TC, leptin and insulin (P < 0.05). SS-T and SS-S suppressed expressions of adipogenic / lipogenic mRNAs in liver and EAT, while promoting expression of beta-oxidation-related factors. The lowest sodium concentration was observed in SS-T ($30.30{\pm}0.59%$), and the lowest sodium-to-potassium (Na/K) ratio was found in SS-S (17.81). CONCLUSIONS: Our study shows that well-processed Korean solar salt may have anti-obesity effects in vivo, probably owing to its differences in mineral composition and other components, presumably resulting from the manufacturing processes. Further research is needed into the mechanism and to explore optimal manufacturing processes.

• 대한방사선기술학회지:방사선기술과학
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• 제42권6호
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• pp.447-454
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• 2019

In order to improve and supplement the shielding method for electron beam treatment, we designed a patient-specific shielding method using a 3D printer, and evaluated the usefulness by comparing and analyzing the distribution of electron beam doses to adjacent organs. In order to treat 5 cm sized superficial tumors around the lens, a CT Simulator was used to scan the Alderson Rando phantom and the DICOM file was converted into an STL file. The converted STL file was used to design a patient-specific shield and mold that matched the body surface contour of the treatment site. The thickness of the shield was 1 cm and 1.5 cm, and the mold was printed using a 3D printer, and the patient customized shielding block (PCSB) was fabricated with a cerrobend alloy with a thickness of 1 cm and 1.5 cm. The dosimetry was performed by attaching an EBT3 film on the surface of the Alderson Rando phantom eyelid and measuring the dose of 6, 9, and 12 MeV electron beams on the film using four shielding methods. Shielding rates were 83.89%, 87.14%, 87.39% at 6, 9, and 12 MeV without shielding, 1 cm (92.04%, 87.48%, 86.49%), 1.5 cm (91.13%, 91.88% with PSCB), 92.66%) The shielding rate was measured as 1 cm (90.7%, 92.23%, 88.08%) and 1.5 cm (88.31%, 90.66%, 91.81%) when the shielding block and the patient-specific shield were used together. PCSB fabrication improves shielding efficiency over conventional shielding methods. Therefore, PSCB may be useful for clinical application.

• 대한바이러스학회지
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• 제28권3호
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• pp.275-285
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• 1998

Based on the geographic range and distribution of its rodent reservoir host, the European common vole (Microtus arvalis), Tula virus is likely to be widespread throughout Eurasia. Tula virus-infected voles have been captured in Central Russia, Austria, Czech and Slovak Republics, and the former Yugoslavia. Although serologic evidence for Hantaan (HTN) or Seoul (SEO) virus infection can be found in the vast majority of the more than 300 cases of hemorrhagic fever with renal syndrome (HFRS) occurring annually in Korea, approximately 4% of Korean patients with HFRS show a more than 4-fold higher antibody titer to Puumala (PUU) virus than to HTN or SEO virus by double-sandwich IgM ELISA, suggesting the existence of pathogenic Puumala-related hantaviruses in Korea. To further define the geographic distribution and genetic diversity of Tula virus in Eurasia and to investigate the existence of previously unrecognized Microtus-borne hantavirus in Korea, arvicolid rodents were captured in Lodz, Poland in 1995 and in Yunchon-kun, Kyungki-do during April to May, 1998. In addition, sera from 18 Korean HFRS patients who showed higher (or the same) antibody titer to Tula virus than HTN and SEO viruses were examined for hantavirus RNA by RT-PCR. Hantaviral sequences were not detected in any of the 18 patients or in 35 reed voles (Microtus fortis) in Korea. Alignment and comparison of a 208-nucleotide region of the S segment, amplified from lung tissues of two hantavirus-seropositive Marvalis captured in Poland, revealed $80.8{\sim}83.2%$ sequence similarity, respectively, with Tula virus strains from Central Russia and the Czech and Slovak Republics. Phylogenetic analysis indicated that the newfound Tula virus strains from Poland were closely related to other Tula hantaviruses from Eurasia.

• Asia pacific journal of information systems
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• 제17권2호
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• pp.1-28
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• 2007

The success of new product development is a key factor for getting competitive advantages. Marketing research has been investigating marketing capability, manufacturing technical capability, cross-functional integration, market knowledge competence, market orientation, and competitive environment as the key success factors of new product development. Recently, the role of IT infrastructure in enhancing new product advantage is assumed in the literature. However, the empirical studies on the role of IT infrastructure are lacking. The purpose of this study is to empirically exam the impacts of IT infrastructure on new product competitive advantage. In this study, IT infrastructure is conceptualized as the flexibility of IT infrastructure. Based on previous research, a conceptual model is established by incorporating the direct impact of IT infrastructure flexibility and its indirect impact through the key success factors on new product development. To empirically test the research model, data are surveyed from a pair of IS department and Marketing department of 92 consumer goods manufacturers. By employing PLS technique, the measurement reliability and reliability of research variables are tested and the path analysis is conducted to do the hypothesis testing. The path analysis shows that IT infrastructure flexibility has no direct effect on new product advantage, However, the indirect effect of IT infrastructure is found, which is mediated by marketing capability, manufacturing technical capability, cross-functional integration, and market orientation respectively. Hence, The flexible IT infrastructure increases cross-functional integration (H1), market orientation (H3), marketing capability (H5), and manufacturing technical capability (H6). All success factors of new product development excepts for competitive environment have a positive association with new product competitive advantages (from H10 to H14). Finally, the path from IT infrastructure flexibility to cross-functional integration, to market orientation, to market knowledge capability, and to new product advantage is found as the strongest path. These results indicate that the flexible IT infrastructure enhances information sharing with multiple departments and collaboration within a distributed innovation environment. The collaboration among departments positively affects the level of customer and competitor intelligence. The ability to obtain knowledge about customers and competitors makes firms to adapt to a changing environment quickly and to respond to customers' demands adequately. The flexible IT infrastructure also enhances the capability of organization to more rapidly respond to the changes in product design resulting in faster product development and reduced costs. In addition to, it enhances marketing capability by the two-way communications with customers and the analyses of various kinds of customer data. In brief, the finding of this study suggests that the flexible IT infrastructure allows many firms to pursue sustained new product competitive advantages. This study advances research on IT infrastructure in two important aspects. First, by Integrating marketing research and IS research, this study develops a conceptual model on the role of IT infrastructure in enhancing new product advantage. Second, it empirically finds the indirect impacts of IT infrastructure on new product advantage, which confirms the potential for the IS field to contribute to new product development research. The limitations of this study are also discussed to provide research directions for future research.

• 한국어병학회지
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• 제18권3호
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• pp.247-258
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• 2005

이매패류의 각종 화학적 유해인자에 대한 반응특성을 이해하기 위한 연구의 일환으로 화학적 오염물질의 하나인 N-methyl-N-nitro-N-nitrosoguanidine (MNNG)을 바지락에 개체당 1.0 mg씩 단회 주사한 후 240시간 동안 조직손상의 과정을 경시적으로 추적하였다. MNNG에 의하여 조직변화를 보인 곳은 위, 중장 및 후장, 소화맹낭, 생식소로 한정되어 있었다. MNNG를 주사한 후 가장 먼저 변성변화를 보인 조직은 중장상피였으며, 주사 후 12시간째부터 조직학적 변화를 인정할 수 있었다. 소화관 상피 내에는 혈구 (hemocyte)를 포함한 단핵성 괴사세포가 상피에 대량으로 침윤하는 동시에 부분적이거나 완전한 상피파괴 소견이 실험종료까지 확인되었다. 가장 마지막으로 조직학적 변화를 보인 장기는 생식소였으며, 주사 후 144시간째부터 생식상피의 괴사성 탈락을 인정할 수 있었다. 또한, 혈구에 특이적으로 결합하는 Ricinus communis (RCA-Ⅰ) lectin으로 조직화학염색을 실시한 결과에서 이들 소화상피에 침윤하는 세포가 대부분 혈구임이 강하게 시사되었다. 이상의 결과에서, 소화기계가 MNNG의 비경구적 노출에 의해 손상받기 쉬우며, MNNG에 의해 야기되는 소화상피 파괴에는 혈구가 깊이 관여하는 것으로 사료되었다.

• Journal of Preventive Medicine and Public Health
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• 제28권1호
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• pp.225-243
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• 1995

Benzidine Industry in Korea has started after Japan has banned its production in early 1970's, and it has been in operation in Korea for over 20 years. However, it is not known yet whether any bladder cancer has developed from benzidine exposure. This study was done to screen benzidine-exposed workers for bladder cancer, and to examine the feasibility of employing screening test at the workplace. All the workplaces that manufacture or use benzidine for more than 20 years in Korea have been covered in this study, and they include 2 benzidine manufacturing factories, 5 benzidine using factories, as well as 2 benzidine free factories as an outside control. In total, 516 workers were screened with urine stick test and urine cytology test for the evidence of hematuria and abnormal urothelial cells. Each worker was also asked about risk factors and symptoms of bladder cancer including past medical history, smoking, medication and occupational history Benzidine in the air was measured by personal and area sampling. Out of 516 screened workers, 84(16.3%) workers showed positive hematuria in urine stick test, and 7(1.4%) workers showed degenerative cells in urine cytology tests. Those workers with abnormal urine test results who have been exposed to benzidine fo more than 10 years were further screened, and, in total, 23 workers were examined with intra-venous pyelography and cystoscopy. None of those screened had any evidence of bladder cancer When workers with only past hematuria history were included in the positive hematuria group, 96(18.5%) had positive hematuria. On the multiple logistic regression analysis, positive hematuria was significantly associated with benzidine exposure, history of other occupations with elevated bladder cancer risk, pyuria and glycosuria. The association got stronger as direct benzidine exposure was accounted through individual task analysis, and as exposure duration was accounted with tenure analysis. For those with benzidine exposure with more than 10 years of tenure, the odds of having positive hematuria was elevated 2.14(95%C.I is 1.08 to 4.25) times more than for those without exposure. Even though bladder cancer was not detected for several limitations including short observation period, majority of studied workers with short latency, healthy worker effect, and low sensitivity of single screening test in a cross-sectional study, the study results suggest that hematuria screening is a feasible and very useful test for bladder cancer screening among benzidine exposed workers.

• Weed & Turfgrass Science
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• 제4권3호
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• pp.236-242
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• 2015

제주도의 밭을 대상으로 141지점을 선정하여 조사를 진행하였다. 제주도 밭에 발생하는 외래잡초 조사결과 18과 50속 64종 2변종, 총 66분류군의 외래잡초가 조사되었고 동계작물 재배지에서는 18과 45종, 하계작물 재배지에서는 16과 50종, 다년생 작물 재배지에서는 17과 39종이 출현하였다. 외래잡초의 생활형은 하계일년생 잡초가 39.4%, 동계일년생은 잡초는 36.4%, 하계일년생과 동계일년생이 모두 가능한 잡초는 7.6%, 다년생 잡초는 16.7%로 분석되었다. 특히 하계작물 재배지에서 하계일년생 잡초의 비율이 높았다. 종의 과별 분포순위는 국화과, 벼과, 아욱과가 우점하는 것으로 분석되었으나 다년생 작물 재배지에서는 아욱과는 출현하지 않았다. 제주도의 동계작물 재배지에서 우점하는 외래잡초는 흰명아주, 청비름, 개쑥갓, 냄새냉이, 들개미자리였고 하계작물 재배지에서는 흰명아주, 청비름, 개쑥갓, 방가지똥이었다. 다년생 작물 재배지에서는 큰망초, 선풀솜나물, 개쑥갓, 흰명아주로 조사되어 다른 작물과 차이를 보였다. 제주도 전체 밭에서 발생하는 외래잡초의 우점종은 흰명아주, 청비름, 개쑥갓, 큰망초, 방가지똥 등으로 분석되었다. 제주도에 발생하는 외래잡초의 발생정보는 밭의 지속적인 관리방안을 수립하는데 도움이 될 것이다.