• Journal of Acupuncture Research
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• 제26권3호
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• pp.165-170
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• 2009

목적 : 복합부위 통증증후군은 사고나 외상 이후 한 쪽 사지에서 시작되는 신경병증성 통증이다. 그 기전은 명확히 밝혀지지 않아 추천되는 치료도 아직 없는 실정이다. 이에 한의학적인 치료 방법을 적용하여 그 효과를 보고자 하였다. 방법 : 전통 한의학에서 이 환자의 상태는 통비로 볼 수 있다. 양쪽 무릎과 왼쪽 발의 통증을 호소하는 26세 남자 환자가 3년 전 복합부위 통증증후군 제1형으로 진단 받은 후 봉독약침, 침, 뜸으로 4주 동안 주 2회씩 치료를 받았다. 치료 효과는 DITI, VAS를 통해 평가하였다. 결과 : DITI, VAS를 통하여 환자의 통증에 호전이 있었다. 결론 : 침, 봉독, 뜸을 이용하여 복합부위 통증증후군 환자 1명을 치료한 결과 효과가 있는 것으로 나타났다.

• Journal of Acupuncture Research
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• 제21권6호
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• pp.299-309
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• 2004

Objective : The etiology and treatment of the avascular necrosis of the femoral head continiue to be controversial and the pathogenesis remains obscure. And its clinical study and report about oriental treatment are absolutely insufficient. Therefore, we report a case of avascular necrosis of the femoral head. Methods : The patient was treated with Bee-Venom therapy, Electro Acupuncture and Sopungwhalhyul-tang(疎風活血湯). Results : After 26days of Oriental treatments, there was remarkable improvement in condition of the patient. Conclusions : In this case, oriental treatments for avascular necrosis of the femoral head was effective. Futher studies are required to prove effectiveness of oriental treatments for treating avascular necrosis of the femoral head.

• 동의생리병리학회지
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• 제18권5호
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• pp.1347-1355
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• 2004

In this study, the immunological effect of a traditional Korea herbal acupuncture, that has been widely used for the treatment of various immunological disorders including inflammation in Korea, was examined in vitro and in vivo. In our previous study demonstrated that BV increased the expression of IFN-γ mRNA, that plays pivotal role in T cell response. This study was designated to evaluate the effect of BV on helper T cell development by monitoring Th1/Th2 specific cytokine secretion patterns in artificially induced Th1/Th2 polarized condition and in vivo. The results demonstrated that BV didn't have mitogenic effects on the unstimulated CD4+ T cell, but increased the CD4+ T cell proliferation upon activation with anti-CD3/CD28 antibody. The Th1 cells were over-populated dramatically in Th1 driven condition with BV treatment, while the Th2 cells were increased slightly in Th2 skewed condition. Furthermore, under Th1-skewed conditions, the level of IFN-γ was considerably increased with BV treatment. Besides, the expression of T-bet, a transcription factor that plays pivotal role in Th1 lineage programming, was increased with BV treatment. The expressions of IFN-γ and T-bet were also significantly increased in vivo. The results that Th1 specific cytokine secretion were considerably increased and Th2 specific cytokine secretion were not significantly changed in vitro and in vivo indicated that BV enhances Th1 lineage development, Therefore, these results suggest that BV might be desirable agent for correction of Th1 dominant pathological disorders.

• 대한약침학회지
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• 제13권1호
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• pp.15-35
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• 2010

연구목적 : 이 연구는 봉약침의 봉독이 NF-${\kappa}B$ 활성억제와 안드로겐 수용체 조절 단백질 및 세포자멸사 조절 단백질의 발현을 통하여 세포자멸사를 유도하고, 전립선 암세포를 이식한 쥐에서의 세포자멸사 유도 효과를 확인함으로써, 봉약침의 봉독이 생체 내에서도 세포자멸사를 유도하여 전립선암에 효과를 나타냄을 확인하고자 하였다. 실험방법 : 세포자멸사의 관찰에는 DAPI, TUNEL staining assay를 시행하였으며, 세포자멸사 조절 단백질의 변동 관찰에는 western blot analysis를 시행하였고, 세포자멸사와 연관된 NF-${\kappa}B$의 활성 변화를 관찰하기 위해 EMSA를 시행하였다. 결과 : 1. DAPI, TUNEL staining assay 결과 봉독 및 melittin을 처리한 LNCaP 세포 모두에서 세포자멸사 유도율이 유의한 증가를 나타내었다. 2. LNCaP 세포에 봉독이나 melittin을 처리한 결과, 안드로겐 수용체 조절 단백질 중 p-Akt, COX-2, calpain은 봉독과 melittin 모두에서 유의한 감소를 나타내었고, Akt는 melittin에서 유의한 감소를 나타냈으며, 봉독에서 증가하는 경향을 보였고, MMP-9은 증가하였다. 3. 생체 내에서의 봉독의 항암효과를 확인하기 위해 전립선암세포가 이식된 쥐에 봉독을 처리한 후 암세포의 부피와 무게, 쥐의 체중을 측정한 결과, 봉독을 처리한 군에서 암 세포 부피비율 및 무게는 감소하였고, 쥐의 체중은 증가하였다. 4. 전립선암세포가 이식된 쥐에 봉독을 처리한 결과, NF-${\kappa}B$ 활성에서 유의한 감소를 나타내었다. 5. 전립선암세포가 이식된 쥐에 봉독을 처리한 결과, 세포자멸사 조절 단백질 중 Bax/Bcl-2, p53, caspase-3, caspase-9, calpain은 유의한 증가를, COX-2는 유의한 감소를 나타냈으며, MMP-9는 증가를 나타내었다. 결론 : 이상의 결과는 봉독이 시험관 내에서 뿐만 아니라 생체 내에서도 NF-${\kappa}B$의 활성을 억제하고 안드로겐 수용체 조절 단백질 및 세포자멸사 조절 단백질의 조절을 통하여 인간 전립선암 세포주인 LNCaP의 세포자멸사를 유도함으로써 전립선암 세포 증식억제 효과 및 호르몬 비의존적인 전립선암으로의 전이를 지연시키는 경향이 있을 것으로 사료되고, 봉독이 전립선암의 예방과 치료에 효과적으로 활용될 수 있을 것으로 기대된다.

• 대한약침학회지
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• 제9권3호통권21호
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• pp.79-88
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• 2006

Objectives : This systematic review summarizes the existing evidence on anti-tumor herbal acupuncture in South Korea. Methods : Literature searches were conducted in four databases. All studies of anti-tumor herbal acupuncture which has been published in South Korea until May, 2006 were included. Data were extracted according to pre-defined criteria by two independent reviewers. Results : We found 73 papers related to anti-tumor herbal acupuncture in South Korea. Seventy of seventy-three papers are trial research and only three papers are clinical research. Herb materials which were used in those papers are Bee-venom, Wild-ginseng, Ginseng, Houttuynia cordata Thunb, Lonicerae Flos, Carthami Tinctorii Juglans sinensis, Euphorbiae Radix, Ecliptae Herba, Crotonis Semen, Juglans sinensis, Armeniaceae Amarum, so on. From those papers, Anti-tumor herbal acupunctures are effective to tumor cell line and tumor in vivo. Clinical research papers reported that Anti-tumor herbal acupunctures are useful to improve cancer related symptoms and quality of life(QOL) of cancer patients. Conclusions : From the above results, we make sure of that anti-tumor herbal acupuncture is useful therapeutics for cancer patients. If we conceive complex-herb materials and carry out more advanced research, Anti-tumor Herbal Acupuncture is one of those major therapeutics to improve clinical symptoms and quality of life(QOL) of cancer patients.

• Journal of Acupuncture Research
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• 제20권2호
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• pp.77-84
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• 2003

Objective : In order to study the effects of bee venom(BV) on the pain, edema, and acute inflammatory reactant of rheumatoid arthritis(RA) patients. Methods : Patients with RA who met the ACR(American College of Rheumatology) 1987 revised criteria for the diagnosis of RA were treated with the BV therapy twice a week for 3 months. Tender joint counts, swollen joint counts, Visual analog scale(VAS), morning in stiffness, ESR, C-reactive protein(CRP) were analyzed before and after BV therapy. Results : The results as follows: 1. Tender joint counts in patients after BV therapy were significantly lower than those before BV therapy($9.0{\pm}7.9$ vs $15{\pm}11.4$, p=0.002). 2. Swollen joint counts of the patients after BV therapy were significantly lower than those before BV therapy ($5.0{\pm}6.1$ vs $1.5{\pm}2.3$, p=0.001). 3. VAS in patients after BV therapy was significantly lower than before BV therapy($60.8{\pm}17.6$ vs $38.0{\pm}15.9$, p=0.000). 4. Duration of morning stiffness in patients after BV therapy was significantly reduced compared with that before BV therapy($119.1{\pm}112.6min$ vs $59.0{\pm}89.7min$, p=0.009). 5. ESR and CRP were not significantly changed before and after BV therapy, suggesting BV itself could make inflammatory reaction as well as therapeutic effect. Conclusions: BV therapy improved tender joint counts, swollen joint counts and duration of morning stiffness in this study, and further study is needed in log-term effect of BV therapy.

• 한방안이비인후피부과학회지
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• 제28권2호
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• pp.121-129
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• 2015

Objectives : The purpose of this study is to report the effect of Korean medical treatment for viral warts. Methods : All patients were treated by Bojungikki-tang gami. One of them was treated with only herbal medicine. The others were treated with herbal medicine, acupuncture, sweet bee venom acupuncture and moxibustion. To evaluate the results of these treatments, we observed condition of the patients and took the photos of lesions. Results : After Korean medical treatment, the viral warts of all patients remarkably disappeared and there have been no recurrence at all. Conclusions : We suggest that viral warts can be treated by Korean medical treatment.

• 척추신경추나의학회지
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• 제3권2호
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• pp.43-52
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• 2008

Objective : The purpose of this study is to evaluate the conservative treatment for supraspinatus tendinitis with kyphotic cervical curvature patient. Methods : We used chuna, Herbal medication, Acupuncture, Bee Venom Acupuncture, Physical Therapy for this patient. And we measured of VAS score, ROM and Extent of the subjective symptoms of shoulder pain to evaluate treatment effects. Result : Patient's shoulder pain and cervical curvature has improved. VAS score and Extent of the subjective symptoms of shoulder pain score were also decreased.

• Journal of Acupuncture Research
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• 제26권3호
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• pp.149-163
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• 2009

Objectives : The purpose of this study is to review RCTs on pharmacopuncture treatment for musculoskeletal diseases and to establish standards of pharmacopuncture treatment model. Methods : We searched articles up to date of March 2009 via computerized databases of Pubmed, The Journal of Korean Acupuncture & Moxibustion, Journal of Korean institute of Herbal Acupuncture, Journal of Oriental Rehabilitation and Journal of Korean Oriental Medicine. Only Randomized Controlled Trials (RCT) concerning the effects of pharmacopuncture on musculoskeletal diseases. The pharmacopuncture treatment methods were assessed based on STRICTA and items considering the feature of pharmacopuncture. And the methodological quality of the trials was assessed by FEAS and modified Jadad score. Results : Eighteen trials of pharmacopuncture on musculoskeletal diseases were analyzed. Except for 4 trials comparing the effect of SBV and BV, positive outcome was reported in ten trials. Among eighteen trials; most of the trials were about Bee Venom acupuncture, and most of the trials used about five acupuncture points, mainly local acupuncture points. But, the amount of injection to each point and total injection were various. And most of trials were lack in the information about method of stimulation. The adjusted FEAS score ranged from 0 to 12, and modified Jadad scoreranged from 1 to 5. Conclusions: To standardize pharmacopuncture treatment, we need more well-designed, high quality clinical trials. And methodological assessment tools designed for pharmacopuncture treatment are also needed.

• 대한약침학회지
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• 제7권1호
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• pp.63-69
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• 2004

Objective : This study was designed to find out whether NS(normal saline) is able to be constituted as an appropriate control group for CC(Cervi Cornu Parvum herbal acupuncture), CF(Carthami-Flos herbal acupuncture) and BV(bee venom herbal acupuncture). Method : NS and three herbal acupuncture were inserted into Quchi(LI 11) of the subjects. After 5 minutes the subjects completed a questionnaire rating the intensity of 21 kinds of acupuncture sensation; hurting, penetrating, sharp, aching, intense, spreading, radiating, tingling, pricking, stinging, pulling, heavy, dull, numb, electric, shocking, hot, burning, cool, pulsing, and throbbing. We compared subjective evaluations of acupuncture sensation between or among the groups. Results : As for CC half items of the acupuncture sensation were significantly different from NS. As for CF all items were not significantly different from NS. As for CC all items were significantly different from NS except one item. In general the score of CF acupuncture sensation was lower than the others and the score of BV acupuncture sensation was higher than the others from comparison of sensation among herbal acupunctures(CC, CF, BV). Conclusion : We found that NS is able to be an appropriate placebo herbal acupuncture for CF. Further study is needed for new placebo herbal acupuncture for CC and BV.