• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.2
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• pp.269-277
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• 2009

"Kenjurok" is a set of medical records of Todo Yoshimasu, a Japanese docotr in the eighteenth century, who suggested that all diseases have originated from a poison, which is his own pathological term describing abnormal states of the body, The 54 records in "Kenjurok" were analyzed in statistical respects, including gender ratio, demographic distribution of patients, types of diseases, and herbal prescriptions used. Among 54 cases, male patients outnumbered female, as much as four times. The patients were quite evenly distributed according to ages. In 23 cases out of 54, abdomen palpation data were mentioned, Majority of the prescriptions used were originated from Sanghanron(傷寒論:Treaties on Febrile Diseases)/Geumgeyoryak(金匱要略: Synopsis of Golden Chamber). In frequency of use of prescriptions, however, showed somewhat different result, that is although Sanghan/Geumge prescriptions were used most often, esoteric prescriptions handed down in his family also composed significant part. The speculations derived from these statistical results are: Although Todo favored abdommen palpation to locate the poison and to decide a prescription, the proportion of abdomen palpation was not as high as expectation, He did use prescriptions not only in Sanghan/Geumge, but also other diverse prescriptions, rather often than not, which are regarded unique Japanese traditional prescriptions including poisonous minerals such as mercury and arsenic.

• Herbal Formula Science
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• v.22 no.1
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• pp.47-64
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• 2014

Objectives : Bi-jeung is a traditional oriental medical name. Bi-jeung is similar to rheumatoid arthritis(RA). This study was investigated to get the practical use of Bi-jeung prescriptions in Byunjeungrok. Methods: Original records related Bi-jeung in Byunjeungrok are interpreted and contemplated. Results: Bi-jeung prescriptions in Byunjeungrok are put stress on Byunjeung in conformity with entrails good energy enforcing as well as evil energy eliminating removing damp-evil among wind-evil cold-evil and damp-evil showing concrete prognosis. Conclusions: This study indicates that Bi-jeung prescriptions in Byunjeungrok have an influences for RA. It may also suggest that Bi-jeung prescriptions may expand therapy field for treatment of RA. and its complications.

• Herbal Formula Science
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• v.19 no.2
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• pp.1-10
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• 2011

Objectives : Since its enactment in 1987, the 56 standard prescriptions covered by insurance have remained unchanged from its original version. In this study, we tried to discover most frequently used herbal combinations by analyzing prescriptions used in actual clinical settings. Methods : We have built Structured Query Language to analyze herbal combination and progressed this analysis through analyzing the frequencies of medicinal herb combinations in medical prescription slips. Results : We have found out that traditional Korean medical doctors use about 13 herbs in a prescriptions and usually use 253 kinds of herb. And We have found out the most frequently used herbal combination. Conclusions : In this study, We can suggest new method to decide what do we need on insurance prescriptions.

• The Korea Journal of Herbology
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• v.38 no.6
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• pp.53-60
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• 2023

Objectives : The objective of present study was to investigate the vasorelaxant effects of 10 traditional Korean Herbal Prescriptions (KHP) on isolated rat thoracic aorta precontracted with potassium chloride (KCl). Methods : An electric extractor was used to extract KHP in distilled water for 3h. Rat aorta rings were isolated and were precontracted using KCl in organ chambers containing 10 ml Krebs Henseleit (KH) buffer. KHP extracts were added in increasing concentrations (10-1000 ㎍/㎖) to investigate vasorelaxant effects. The vasorelaxant responses induced by KHP were expressed as a percentage in response to contraction generated by KCl. Results : Among the 10 KHP, Gamisoyo-san, Galgeun-tang, Gyeji-tang, Gwakhyangjeonggi-san, Daeyoung-jeon, and Socheongryong-tang showed significant vasorelaxant effect at high concentration. In contrast, Gyejibokryeong-hwan constricted more the aorta rings precontracted by KCl. And Gumiganghwal-tang, Guibi-tang, Saengmaek-san showed no significant effect. Also, rat aorta rings treated with Gyejibokryeong-hwan or Gyeji-tang after pre-relaxation by amlodipine did not cause any significant change. Conclusion : Thus, these results provide the experimental evidence as useful herbal prescriptions for the treatment of hypertension and suggest guidelines in conjunction with other western drugs, including amlodipine.

• The Journal of Korean Medicine
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• v.44 no.3
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• pp.189-200
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• 2023

Objectives: The purpose of this study is to analyze the current state of quantitative literature evidence for the prescription of 56 herbal medicines covered by health insurance that have been studied in Korea for the past 30 years, to evaluate the reliability of the evidence, and to find out the research direction of herbal medicine prescription in the future. Methods: 56 kinds of herbal medicine prescriptions were searched in domestic literature search databases OASIS, DBpia, and overseas PubMed, classified into chemistry, toxicity, cells, animals, clinical cases, and clinical trial studies, and built into an EBM pyramid structure. Results: When classified according to research contents, there were 61 cases (7.5%) of physicochemical analysis to identify constituent substances, 80 cases (9.8%) of toxicity evaluation, and 672 cases (82.7%) of efficacy evaluation. The efficacy evidence was classified according to the evidence-based medical pyramid structure: 196 cell trials (29.1%), 372 animal trials (55.4%), 89 case and case reporting series (13.3%), 7 comparative case studies (1.1%), and 8 randomized control clinical trials (1.2%). In the pyramid composition, the basis for the validity of 56 kinds of herbal medicines prescribed was 568 cases (84.5%) in cell and animal units, which could not be said to be highly reliable. There was no relationship between the ranking of quantitative literature evidence for herbal medicine prescriptions and the ranking of salary administration. Conclusions: In an era that continues to require scientific evidence for herbal medicine, traditional herbal medicine should secure the basis for safety validity even for the 10th most frequent prescription among 56 herbal medicine prescriptions for consumers. In particular, traditional herbal medicine should increase the quantitative and qualitative level of case reports on related herbal medicine prescriptions, focusing on each clinical society, and move toward comparative case studies and randomized clinical trial so that traditional herbal medicine is positioned as Evidence-based medicine.

• Korean Journal of Pharmacognosy
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• v.8 no.1
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• pp.1-15
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• 1977

In an attempt to deduce which plants might have been used for their anticancer activities in traditional oriental herb medicine, 127 prescriptions were selected from 'Dong-Eui-Bo-Gam', the Classic Handbook of Korean Traditional Medicine, written by $H_{UH}$ Jun and published in 1613. These are the prescriptions indicated for the systemic treatment of various tumors and some conditions resembling tumors, e.g. inflammatory masses and indurations, and they include 150 natural products of plant origin. The frequency of appearance of each medicinal plant in these selected prescriptions was compared with the frequency of its appearance in all prescriptions listed in 'Bang-Yak-Hap-Pyon', another popular Oriental Medicine Formulary in Korea, written by $H_{WANG}\;Pil-Su$ in 1885. From the latter book, $H_{ONG}$ has recently enumerated frequencies of 235 medicinal plants included in a total of 467 prescriptions. Chi-square tests revealed that 11 plant remedies appear with significantly higher frequency in the prescriptions for "tumors", and 10 for "inflammations". The plants with potential antitumor activities, in decreasing order of statistical significance, are Scirpus maritimus, Curcuma zedoaria, Prunus persica, Rheum coreanum, Foeniculum vulgare, Rhus vernifera, Daphne pseudogenkwa, Galarhaeus sieboldiana, Croton tiglium, Raphanus sativus and Galarhaeus pekinensis. The drugs for potential antibacterial or anti-inflammatory activities are Olibanum(Frankincense), Forsythia coreana, Lonicera japonica, Gleditchia officinalis, $M_{YRRH}$, Trichosanhes kirilowii, Astragalus membranaceus, Rheum coreanum, Platycodon grandiflorum and Fritillaria verticillata. Despite the uncertainties involved in the terminology of various diseases used in pre-modern medicine, and the reservations about the efficacy of remedies used for those diseases, it would be worthwhile to investigate these few selected plants for anticancer, antibacterial, anti-inflammatory or antifungal effects, employing modern scientific methodology.

• The Journal of Korean Medicine
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• v.19 no.1
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• pp.220-233
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• 1998

This study was made to objectify the principle of oriental medical prescriptions so that we could obtain the principle and the formulation of them For that purpose, we analysed the formula and rule of 205 prescriptions recorded in Gum-goe-yo-rak, which have a few of components, and are widely used in clinical from ancient times to these days. At first we classified those prescriptions by their effect. Then we re-classified the herbs of the effect groups into four natures (cold, hot, warm and cool) and five kinds of flavors (sour, bitter, sweet, acrid and salty). And we classified the herbs into three grades - superior, medium, and inferior - which were used in Shen Nong's Herbal Classic. By these means, we statistically evaluated the prescriptions recorded in Gum-goe-yo-rak based on the Four Regular Components(Monarch, Minister, Assistant, and Laborer). As a result we could obtain some facts about the prescriptions recorded in Gum-goe-yo-rak, those are what kind of herbal material was used frequently and distribution of the natures flavors and grades according to thier effects. And we are sure that these results can be great help for establishment of fundamental formulation of theory of traditional herbal medicinal polyprescription.

• The Journal of Korean Medical History
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• v.20 no.1
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• pp.96-111
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• 2007

The tea culture is one of East Asia's traditional drink cultures and its variety, recipe, and effects are specifically recorded in East Asian documents. But the variety and applications of teas that are different from food and not entirely included in the medicine family has not been studied thoroughly yet. This study, through extracting and organizing the variety of teas and their recipes, aims to revive the methods of improving health by using ancient tea.

• Herbal Formula Science
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• v.28 no.4
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• pp.351-363
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• 2020

Objectives : The purpose of this paper is to describe how Wu Kun(吳昆) understood Huangdineijing 『黃帝內經』 and implemented his understanding when writting Yifangkao 『醫方考』. Methods : From Yifangkao 『醫方考』, we collected all paragraphs including "經曰", "內經曰" while excluding the ones with "論曰" to filter out Sanghanlun 『傷寒論』's perspective. The contents of Huangdineijing·Suwen 『黃帝內經·素問』 and Huangdineijing·Lingshu 『黃帝內經·靈樞』, cited in Wu Kun's Yifangkao 『醫方考』 were extracted, identified from which part it comes and sorted into headings under RyuPyeon Huangjenaegyung 『類編黃帝內經』. Results : The most cited traditional chinese medical classic in Yifangkao 『醫方考』 was Huangdineijing·Suwen 『黃帝內經·素問』 Yinyangyingxiangdalun 「陰陽應象大論篇」 which was cited 41 times. Zhizhenyaodalun 「至眞要大論篇」 had a total of 39 citations followed by Shengqitongtianlun 「生氣通天論篇」 and Liuyuanzhengjidalun 「六元正紀大論篇」 which were cited 13 times and 11 times each. In addition, it was confirmed that other 28 chapters from Huangdineijing·Suwen 『黃帝內經· 素問』, 3 chapters from Huangdineijing·Lingshu 『黃帝內經·靈樞』, 3 chapters from Nanjing 『難經』 and one chapter from Zhenjiujiayijing 『鍼灸甲乙經』 were also cited. Also the analysis of the classification of the Huangdineijing·Suwen 『黃帝內 經·素問』 showed that 57 citations were classified as 'treatment', 41 citations were classified as 'Yin and Yang and Five phases', 39 citations were calssified as 'Cause and Mechanism of Disease'. Conclusion : 1. Yifangkao 『醫方考』 have explained prescriptions by implementing principles from 5 kinds of traditional chinese medical classic including Huangdineijing·Suwen 『黃帝內經·素問』, Huangdineijing·Lingshu 『黃帝內經·靈樞』 etc. 2. According to table 3, Yifangkao 『醫方考』 have cited Huangdineijing·Suwen 『』 to explain how each compounds were used and how the Korean medical principle of Yin and Yang was applied in the prescriptions. 3. It can be suggested in formula study there is utility to understand principles of traditional chinese medical classic to comprehend prescriptions.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.1
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• pp.26-34
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• 2010

"Yifangjijie" is a collection of prescription in Traditional Medicine, which was published in Qing dynasty. In this book, effectiveness of prescriptions 1s described by means of Meridians uniquely compared with any others. Therefore, I tried to pay attention to those explanations and arrange by Meridians and effectiveness of prescriptions. Classification by effectiveness of prescriptions has a few points of emphasis in Meridians and Classification of Meridians by effectiveness of prescriptions has intent in somehow. In this paper, authors will explain those classification.