• Molecular & Cellular Toxicology
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• v.3 no.3
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• pp.165-171
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• 2007

Mitomycin C (MMC), an antitumor antibiotic isolated from Streptomyces caespitosus, is used in chemotherapy of gastric, bladder and colorectal cancer. MMC is activated in vivo to alkylate and crosslink DNA, via G-G interstrand bonds, thereby inhibiting DNA synthesis and transcription. This study investigates gene expression changes in response to MMC treatment in order to elucidate the mechanisms of MMC-induced toxicity. MMC was admistered with single dose (0.32 and 1.6 ${\mu}M$) to TK6 cells. Applied Biosystem's DNA chips were used for identifying the gene expression profile by MMC-induced toxicity. We identified up- or down-regulated 90 genes including cyclin M2, cyclin-dependent kinase inhibitor 1A (p21, cip1), programmed cell death 1, tumor necrosis factor (ligand) superfamily, member 9, et al. The regulated genes by MMC associated with the biological pathways apoptosis signaling pathway. Further characterization of these candidate markers related to the toxicity will be useful to understand the detailed mechanism of action of MMC.

• Journal of Digital Convergence
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• v.14 no.12
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• pp.245-256
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• 2016

The purpose of this study was to determine the trends of health related intervention researches for married immigrant women in order to develop health promotion programs for married immigrant women. Among ninety six health related research papers published between 2000 and 2015, nine intervention researches were reviewed and analyzed. Among these researches, three were related to pregnancy and delivery and one was related to the prevention of infections in children and women's diseases respectively. Four researches provided information pertaining to the intervention and handling of mental and social or physical health issues, two researches pertained to only mental health and three researches covered only physical health. The researches related to physical health for married immigrant women needed to take into consideration various issues related to life span including child birth and child rearing. Also, researches that focused on social and mental health issues required additional planning to enhance relationships with others in addition to personal coping skills.

• Journal of Fisheries and Marine Sciences Education
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• v.24 no.2
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• pp.246-262
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• 2012

This study analyzed the trend of researches regarding parenting involvement of fathers with early childhood children in terms of research period, research content and research method. Forty master's thesis and doctoral dissertation and 22 articles were selected for final analysis. Collected data were analyzed using frequency and percentage ratio. The results of this study showed that research on the parenting involvement of fathers has been rapidly increased since 2005. From the perspective of research content, studies dealing with parenting involvement of fathers as an independent variable focused on early children and social and emotional variables. Most of studies dealing with parenting involvement of fathers as an dependent variable consistently dealt with demographic variables. From the perspective of research method, most researches were quantitative and non-experimental. No research was done using qualitative method and all researches except one were done using non-experimental method. The number of participants in most researches were over 100 and less than 400. Most researches used participants from one particular district. Research instruments validated in Korea were used in most researches. These results were discussed with suggestions for further study.

• Nuclear Engineering and Technology
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• v.56 no.5
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• pp.1667-1671
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• 2024

This paper presents a neutron/gamma detector based on a micropixel avalanche photodiode and a plastic scintillator that monitors the status of the accelerator-driven intense resonance neutron source (IREN) facility by measuring the neutron/gamma intensity in the target hall. The electronics of the neutron/gamma detector has been designed and developed. The size of the plastic scintillator was selected to be 3.7 × 3.7 × 30 mm³ due to the sensitive area of the MAPD. The experimental results demonstrated a dependence between the count rate of the detector and the frequency of the accelerator. The detector is sensitive to intermediate and fast neutrons. The minimum detectable energy was determined to be 200 keV using Cs-137 point gamma source. The maximum counting rate of the detector from TTL out is about 2.2⋅10⁶ counts/sec, but for analogue output it is about 2⋅10⁷ counts/sec. The detector can not allow discriminating neutrons and gamma rays by charge integration method.

• The Journal of Information Technology and Database
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• v.8 no.2
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• pp.115-135
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• 2001

The objective of this paper is to develop a knowledge assets measurement model in Korea. There are relatively many researches on measuring knowledge assets of an organization. These previous researches, however, lack of comprehensive view of knowledge management and view of Korean organizational culture. We surveyed and analyzed previous researches, and found common factors to measure knowledge assets. We developed an updated version of knowledge assets index. The developed model has been validated for its fitness with real data of Korean companies. The result of this research can be used as a measurement tool for knowledge assets of public institutions as well as private companies.

• Research in Community and Public Health Nursing
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• v.15 no.3
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• pp.419-437
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• 2004

Purpose: This study aims to analyze the trends of the gerontological nursing researches in Korea and suggest the direction for research in this nation. Method: A total of 241 dissertations and other published articles in Korea from 1997 to 2003 were analyzed in this study focusing on the design of the research, key words, measurement tools for basic concepts, and the intervention outcomes in the case of the experimental research. Result: Of those analyzed researches. it was found that 80.9% accounted for the published articles and 19.1% dissertations. There were no clear criteria for the classification of the old men. The most popular research design was an exploratory/descriptive study (54.4%). The major concepts were about 'physical and mental health'. Most of the measurement tools used were developed by foreigners. which were translated into Korean. Among 56 experimental studies, nursing intervention programs in 22 studies were based on physical exercise programs. Conclusion: It is necessary to analyze the trend of gerontological health research in comparison with multidisciplinary researches for elderly people. In addition, the experimental researches for both development and verification of nursing intervention programs are needed. Also, accumulation of research outcomes and development of a standardized instrument for the measurement of Korean elderly people are required.

• Research in Community and Public Health Nursing
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• v.25 no.2
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• pp.146-157
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• 2014

Purpose: The objective of this study is to analyze systematically the trends of experimental researches in the area of community health nursing. Methods: This is a study based on literature review, which analyzed 137 experimental research papers in the Journal of Korean Academy of Community Health Nursing, from the first issue in 1989 to those in 2012. Results: 1) The proportion of experimental researches in the total published papers was 14.9%. 2) The mainly used research method was quasi-experiment, which was 60.6% of them, and there was no RCT. 3) Convenient sampling was used in 95.6% of the researches. 4) Only 5.1% were reviewed for keeping the ethical standards for the study objects by the IRB. 5 When classified by the Omaha Classification System, psycho-social researches were most frequent, which were followed by physiological, health-related behavioral, and environmental ones in order of frequency. Conclusion: This study found that the proportion of experimental research papers was increasing in the 2000s and ethical standards were required more rigorously. However, it was suggested that the research design be more elaborated and sampling methods be manifested to reduce research bias and errors.

• Journal of the Korean housing association
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• v.23 no.4
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• pp.19-31
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• 2012

The main objectives of this research are to compile all the researches published in the registered academic journals to study the trends of researches and analyze the relationships between research contents and the social factors so that the accomplishments of community related researches and future tasks can be identified. For this purpose, 97 papers published between 1973 and July 2011 were chronologically organized and analyzed in terms of research methods, main contents, and their relationship with social factors. The key findings are as follows; 1) Researches on multi-family-housing community started in 1973 mainly focusing on the social factors of neighbors in a complex; since 2000, however, the researches on physical factors were increased the most followed by psychological and social factors accordingly. 2) The research findings were not fully developed to give a guidance for appropriate space programs or an analysis of residents' preference on facilities. The cause of this shortfall is due to the fact that there was a lack of studies on residents' usage of community facilities based on quantified database. 3) More comprehensive researches should be conducted in the future for vitalizations of community through facility supply system and design guidelines, development and operation of community programs and measures to enhance community awareness targeted on public housing and more diverse types of housing being apart from typical multi-family-houisng provide by private sector.

• Journal of Korean Institute of Industrial Engineers
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• v.34 no.2
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• pp.181-189
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• 2008

Survivability of a network is one of the most important issues in designing present-day communication networks. For the past few decades, a lot of researches have proposed the mathematical models to evaluate the survivability of networks. In this paper, we attempt to survey such researches and classify them based on how these researches measure the survivability of a network.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 1994.04a
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• pp.112-121
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• 1994

Studies on visual fatigues were activated after VDTs were rapidly introduced into the office works in 1980s. Various measurement methods and its measures were developed from those studies. Early studies frequently used simple measures such as near point of accommodation, near point of vergence, and CFF. Current researches focus on dark focus, dark vergence, and VEP which have a good relevance to the visual fatigues. In spite of the merit they also have some limits and disagreements. This survey summarizes the measures, measurement methods and relevant researches. Finally several topics are proposed for the future researches in Korea.