• Proceedings of the Korean Society of Developmental Biology Conference
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• 2004.07a
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• pp.22-22
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• 2004

• Proceedings of the Korean Society of Embryo Transfer Conference
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• 2004.10a
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• pp.98-99
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• 2004

• The Korean Journal of Physiology and Pharmacology
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• v.24 no.3
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• pp.193-201
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• 2020

Chromosomal region maintenance 1 (CRM1) is associated with an adverse prognosis in glioma. We previously reported that CRM1 inhibition suppressed glioma cell proliferation both in vitro and in vivo. In this study, we investigated the role of CRM1 in the migration and invasion of glioma cells. S109, a novel reversible selective inhibitor of CRM1, was used to treat Human glioma U87 and U251 cells. Cell migration and invasion were evaluated by wound-healing and transwell invasion assays. The results showed that S109 significantly inhibited the migration and invasion of U87 and U251 cells. However, mutation of Cys528 in CRM1 abolished the inhibitory activity of S109 in glioma cells. Furthermore, we found that S109 treatment decreased the expression level and activity of MMP2 and reduced the level of phosphorylated STAT3 but not total STAT3. Therefore, the inhibition of migration and invasion induced by S109 may be associated with the downregulation of MMP2 activity and expression, and inactivation of the STAT3 signaling pathway. These results support our previous conclusion that inhibition of CRM1 is an attractive strategy for the treatment of glioma.

• Proceedings of the KSAR Conference
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• 2004.06a
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• pp.201-201
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• 2004

In this study we examined whether vitrified Hanwoo (Korean cattle) IVM/IVF/IVC blastocysts can survive in vitro/in vivo by a quick one-step dilution method and these embryos result in live births. Blastocysts produced in vitro were vitrified by serial exposure to glycerol (G) and/or ethylene glycol (EG) mixtures of 10% (v/v) G for 5 min, 10% G plus 20% EG (v/v) for 5 min, and 25% G plus 25% EG (v/v) for 30 see. (omitted)

• Journal of Gastric Cancer
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• v.23 no.2
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• pp.365-373
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• 2023

• 대한생식의학회:학술대회논문집
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• 2004.11a
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• pp.85.1-85.1
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• 2004

• Journal of Acupuncture Research
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• v.40 no.2
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• pp.162-166
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• 2023

This study aimed to demonstrate a safe and effective procedure targeting the A1 pulley with ultrasound-guided acupotomy in patients with a trigger finger. Six ultrasound-guided acupotomy procedures were performed on 1 patient. The Numerical Rating Scale (NRS) score, Quinnell's classification of triggering, Tanaka score, and A1 pulley thickness were measured using ultrasonography before and after treatment. This study revealed reduced NRS score, Quinnell's classification of triggering, Tanaka score, and thickness of the A1 pulley, with no side effects during the procedure. This indicates ultrasound-guided acupotomy as an effective and safe treatment method for patients with a trigger finger. Further studies are required to evaluate the beneficial effects of this treatment.

• 대한생식의학회:학술대회논문집
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• 2004.06a
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• pp.76-76
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• 2004

• Journal of Korean Neurosurgical Society
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• v.30 no.1
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• pp.89-94
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• 2001

Skull or brain metastasis from thyroid carcinoma is rare. Between Jan. 1993. and Jan. 2000. the authors experienced 7 cases of skull(4 cases) or brain(3 cases) metastasis from thyroid carcinoma. Clinical characteristics, radiologic findings and pathologic features were analyzed retrospectively. Among 4 cases of skull metastasis, 3 cases were follicular carcinoma and one was papillary carcinoma with follicular variant. All cases of brain metastasis were papillary carcinoma. We treated the patients by combination with surgical resection, radioactive iodine therapy and radiation therapy. Characteristics of skull or brain metastasis from thyroid carcinoma is reviewed with a pertinent literature.

• 대한핵의학회:학술대회논문집
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• 2000.05a
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• pp.54.2-54.2
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• 2000