• 한국대기환경학회지
• /
• 제32권1호
• /
• pp.114-126
• /
• 2016

Many cohort studies have reported associations of individual-level long-term exposures to $PM_{10}$ and health outcomes. Individual exposures were often estimated by using exposure prediction models relying on $PM_{10}$ data measured at national regulatory monitoring sites. This study explored spatial and temporal characteristics of regulatory $PM_{10}$ measurement data in South Korea and suggested $PM_{10}$ concentration metrics as long-term exposures for assessing health effects in cohort studies. We obtained hourly $PM_{10}$ data from the National Institute of Environmental Research for 2001~2012 in South Korea. We investigated spatial distribution of monitoring sites using the density and proximity in each of the 16 metropolitan cities and provinces. The temporal characteristics of $PM_{10}$ measurement data were examined by annual/seasonal/diurnal patterns across urban background monitoring sites after excluding Asian dust days. For spatial characteristics of $PM_{10}$ measurement data, we computed coefficient of variation (CV) and coefficient of divergence (COD). Based on temporal and spatial investigation, we suggested preferred long-term metrics for cohort studies. In 2010, 294 urban background monitoring sites were located in South Korea with a site over an area of $415.0km^2$ and distant from another site by 31.0 km on average. Annual average $PM_{10}$ concentrations decreased by 19.8% from 2001 to 2012, and seasonal $PM_{10}$ patterns were consistent over study years with higher concentrations in spring and winter. Spatial variability was relatively small with 6~19% of CV and 21~46% of COD across 16 metropolitan cities and provinces in 2010. To maximize spatial coverage and reflect temporal and spatial distributions, our suggestion for $PM_{10}$ metrics representing long-term exposures was the average for one or multiple years after 2009. This study provides the knowledge of all available $PM_{10}$ data measured at national regulatory monitoring sites in South Korea and the insight of the plausible longterm exposure metric for cohort studies.

• 대한지리학회지
• /
• 제47권1호
• /
• pp.98-120
• /
• 2012

본 연구의 주된 목적은 다지역 코호트-요인법을 적용하여 우리나라의 시도별 장래 인구 추계를 실행하는 것이다. 마르코프 연쇄 모델과 Rogers의 다지역 인구 추계 모델에 대한 검토를 바탕으로 실행 가능한 다지역 코호트-요인법의 프레임워크를 설정하였다. 이 프레임워크를 우리나라 데이터에 적용하여 2005~2030년에 대한 5년 단위의 시도별 인구 추계를 실행하였으며, 그 결과에 대한 타당성을 검토하였다. 중요한 연구 결과는 다음과 같다. 첫째, 본 연구의 추계치를 기존 통계청의 추계치 및 경험 데이터와 비교해 본 결과 제안된 추계 기법의 방법론적 타당성이 매우 높은 것으로 드러났다. 둘째, 본 연구의 방법론은 미래의 지역간 인구이동 매트릭스를 산출한다는 측면에서 추계 결과의 유용성이 매우 높은 것으로 판단되었다. 미래의 지역간 인구이동에 대한 정보는 지역별 인구변동을 이해하고 실질적인 정책 대안을 제시하는데 핵심적인 역할을 할 수 있다. 본 연구는 국가 전체의 인구변동 보다는 인구 이동을 통해 상호 연결되어 있는 하위 지역 인구들의 진화 과정을 더욱 강조하는 다지역 관점의 중요성을 예증하고 있다.

• Journal of Preventive Medicine and Public Health
• /
• 제30권2호
• /
• pp.267-278
• /
• 1997

The purpose of this study was to investigate the incidence rate of hepatitis B in the military service and to examine the effect of the asymptomatic hepatitis B surface antigen(HBsAG) carries on the incidence of hepatitis B. The subject were 223,270 men who were conscripted to the Korean Army from 1991 to 1994. According to the conscripted year, four conscription cohort were constructed. At the screening examination for military service no test for hepatitis B were performed in 1991 and 1992. In 1993, a screening test for hepatitis B were performed and those who were confirmed as HBsAg positive o. showed high titers $(\geqq100IU)$ of nm glutamic-pyruvic transaminase(SGPT) were excluded from conscription. In 1994, the criteria for conscription was changed and those who were HBsAg positive were not excluded from conscription. Only those who showed $\geq$ SGPT 100IU were excluded. The main results were as follows ; 1. The positive rate of HBsAg is 5.5% in the conscripted men. 2. The incidence rates of the hepatitis B in 1991 and 1992 conscription cohort were 9.96 and 8.10 per ten thousand person-year, respectively. The incidence rate of the hepatitis B was 1.34 per ten thousand person-year in 1993 conscription cohort which was confirmed as HBsAg negative at the screning test, and 7.41 per ten thousand person-year in 1994 conscription cohort which included the HBsAg positive. 3. The incidence rate of hepatitis B was 99.98 per ten thousand person-year in HBsAg positive group and 2.25 per ten thousand person-year in HBsAg negative group. The incidence rate of the group with high SGPT and HBsAg positive was 255 times higher than that of normal population. 4. The incidence of hepatitis B in HBsAg negative group did not increase even though the probability of personal contact with HBsAg positive had been increased. from the above results, the men who have high SGPT with HBsAg positive should be excluded from military service, and it can not be said that asymptomatic HBsAg carriers influence on the hepatitis B incidence among the HBsAg negative through personal contact.

• 대한영상의학회지
• /
• 제81권3호
• /
• pp.608-609
• /
• 2020

• Journal of Preventive Medicine and Public Health
• /
• 제38권4호
• /
• pp.425-430
• /
• 2005

Objectives : To investigate the prevalence of Clonorchis Sinensis infestation and to determine the associated risk factors among a population in a part of the rural area of Gyeongsangnam-do, Korea, which is an area known to have a high mortality from liver cancer and a high infection of C. sinensis. Methods : The study populat ion consisted of those people who have lived in rural areas and who were over 40 years old. This study was performed in 5 areas during the period from 1999 to 200 3. Informed consents were obtained from the 2,381 study participants, and these people were interviewed about their life style habits with using the structured questionnaire that was administered by trained staff members. The subjects underwent blood sampling and their stool specimens were examined by using the Formalin-ether sedimentation technique. Results : Among the study subjects (N=2,381), the positivity for C. sinensis in the stool was 34.4% (95% CI=36.3-42.5); it was 39.4% (95% CI=36.3-42.5) in the males and 30.9% (95% CI=28.5-33.3) in the females . The positivity for C. sinensis was associated with current alcohol drinking (odds ratio=1.8, 95% CI: 1.5-2.1) and raw fish consumption (odds ratio 1.2, 95% CI: 0.9-1.6). Conclusion : The present study confirmed the high prevalence of C. sinensis in the study subjects. It is necessary to establish consistent medical management and education programs for the treatment and prevention of C. sinensis infestation in the rural inhabitants of Korea.

• Tuberculosis and Respiratory Diseases
• /
• 제84권4호
• /
• pp.317-325
• /
• 2021

Background: Hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) are significant public health issues in the world, but the epidemiological data pertaining to HAP/VAP is limited in Korea. The objective of this study was to investigate the characteristics, management, and clinical outcomes of HAP/VAP in Korea. Methods: This study is a multicenter retrospective cohort study. In total, 206,372 adult patients, who were hospitalized at one of the 13 participating tertiary hospitals in Korea, were screened for eligibility during the six-month study period. Among them, we included patients who were diagnosed with HAP/VAP based on the Infectious Diseases Society of America (IDSA)/American Thoracic Society (ATS) definition for HAP/VAP. Results: Using the IDSA/ATS diagnostic criteria, 526 patients were identified as HAP/VAP patients. Among them, 27.9% were diagnosed at the intensive care unit (ICU). The cohort of patients had a median age of 71.0 (range from 62.0 to 79.0) years. Most of the patients had a high risk of aspiration (63.3%). The pathogen involved was identified in 211 patients (40.1%). Furthermore, multidrug resistant (MDR) pathogens were isolated in 138 patients; the most common MDR pathogen was Acinetobacter baumannii. During hospitalization, 107 patients with HAP (28.2%) had to be admitted to the ICU for additional care. The hospital mortality rate was 28.1% in the cohort of this study. Among the 378 patients who survived, 54.2% were discharged and sent back home, while 45.8% were transferred to other hospitals or facilities. Conclusion: This study found that the prevalence of HAP/VAP in adult hospitalized patients in Korea was 2.54/1,000 patients. In tertiary hospitals in Korea, patients with HAP/VAP were elderly and had a risk of aspiration, so they were often referred to step-down centers.

• 한국사회정책
• /
• 제23권2호
• /
• pp.173-200
• /
• 2016

본 연구는 크게 두 가지의 연구목적을 갖는다. 첫째, 생애과정관점에 따라 중고령자들의 연령집단별 삶의 만족과 노화불안의 수준을 살펴봄으로써 대도시에서 노년기를 맞이한 사람들의 삶의 현황을 파악한다. 둘째, 노화과정에서 심리적 안녕감을 나타내는 삶의 만족 제고와 노화불안 감소에 기여하는 영향요인, 즉 개인의 객관적인 삶의 조건을 의미하는 인구사회학적 변수들의 영향력과 고령친화 환경의 영향력을 상호 검토함으로써 고령친화환경 조성을 통한 시사점을 제안한다. 이를 위해 본 연구는 서울에 거주하는 베이비부머를 포함하는 노년기 세대를 대상으로 비례층화표집 방법을 활용하여 조사한 4,000명의 자료를 분석하였다. 주요 분석결과를 중심으로 논의를 정리하면 다음과 같다. 첫째, 연령집단의 연령대가 증가함에 따라 삶의 만족 수준은 낮아지는 반면, 노화불안의 수준은 높아지는 것으로 나타났다. 둘째, 연령집단의 연령대가 높아질수록 삶의 만족과 노화불안에 대한 개인의 객관적 삶의 조건들의 설명 분산은 높아지는 경향성을 나타냈으며, 연령집단별 영향변수는 상이하게 나타남에 따라 노년기 연구에 있어서 생애과정 관점의 유용성을 보여주었다. 셋째, 인구사회학적 변수들을 통제한 상태에서 연령집단별 고령친화환경 요인들이 삶의 만족에 대한 설명분산이 높게 나타난 반면, 노화불안에 대한 설명분산은 상대적으로 낮게 나타났으며, 후기노인의 경우 장년층에 비해 설명분산이 높게 나타났다. 한편 연령집단별 삶의 만족과 노화불안에 영향을 미치는 고령친화환경 요인들은 연령집단별 공통적인 요인들이 존재하는 반면, 연령집단별 상이한 요인들도 존재하는 것으로 나타났다. 이와 같은 결과들에 따라 노년기를 보내는 개인의 삶의 만족을 제고하고 노화불안을 감소시키기 위한 정책설계 방향에 대해 논의하였다.

• Annals of Occupational and Environmental Medicine
• /
• 제35권
• /
• pp.41.1-41.11
• /
• 2023

Background: Shift work has been reported to have several harmful effects on the human body. However, a small number of studies have evaluated the association between shift work and adverse effects on the thyroid. In our longitudinal study, we examined the causal association between shift work and the risk of hypothyroidism. Methods: A Kangbuk Samsung Cohort Study was conducted on 112,648 men without thyroid disease at baseline who were followed up at least once between 2012 and 2019. Shift work status and shift schedule types were categorized using standardized questionnaires. Hypothyroidism was defined using the reference ranges of serum thyroid-stimulating hormones and free thyroxine levels. Hazard ratios (HRs) and 95% confidence intervals (CIs) for incident hypothyroidism were estimated using Cox proportional hazards regression analyses with the daytime work group as the reference. Results: During the 501,237 person-years of follow-up, there were 6,306 incident cases of hypothyroidism (incidence density, 1.26 per 100 person-years). The multivariable-adjusted HR of incident hypothyroidism for the shift work total group that included all shifts compared with the daytime work group was 1.27 (95% CI: 1.15-1.40). For the fixed evening, fixed night, rotating shift, and other shift workers, the multivariable-adjusted HRs (95% CI) were 1.11 (0.76-1.61), 2.18 (1.20-3.93), 1.39 (1.23-1.56), and 1.00 (0.82-1.22), respectively. In subgroup analyses by age, the association between shift work and hypothyroidism was more pronounced in younger participants (< 40 years; HR: 1.31; 95% CI: 1.16-1.47). Conclusions: Our large-scale cohort study showed an association between shift work and the incidence of hypothyroidism, especially in younger workers with night shifts.

• 대한예방의학회:학술대회논문집
• /
• 대한예방의학회 2001년도 제53차 추계 학술대회 연제집
• /
• pp.433-433
• /
• 2001

• 대한예방의학회:학술대회논문집
• /
• 대한예방의학회 2005년도 제57차 추계 학술대회 연제집
• /
• pp.317-317
• /
• 2005