• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2009.06a
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• pp.315-316
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• 2009

본 논문에서는 1W 급 이상의 고출력 LED 용 패키지로서 세라믹 LTCC 적층 패키지의 방열 특성을 평가하고 열해석 결과와의 차이에 대해 고찰하였다. 특히, 세라믹 패키지의 방열 특성을 향상시키기 위해 Thermal Via와 Heat slug를 LED Chip 하단부에 위치시켰을 때 방열 특성을 평가하기 위해 Transient Thermal Test를 이용하여 각각의 경우에 대한 열저항을 평가하여 방열 특성의 항상 정도를 확인하였으며, 열해석 시뮬레이션을 통해 얻은 결과와 비교하였다. 평가 결과 Heat slug를 배치한 패키지가 열저항이 $8^{\circ}C/W$로서 가장 우수한 특성을 보여주었으며, 열해석 결과와의 차이에 대해서는 광출력으로 방출된 전력을 계산하여 보정함으로써 $1^{\circ}C$ 이하의 편차를 보여주는 결과를 얻을 수 있었다.

• Proceedings of the Korean Nuclear Society Conference
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• 1997.05a
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• pp.368-373
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• 1997

The transition from a statified wavy to a slug flow has been analyzed considering the mechanistic forces acting on the wave crest in a nearly horizontal air-water countercurrent flow. To verify the results of the analysis, a series of experiments have been performed changing the inclination angle of the test section. Comparisons of the theoretical predictions with experimental data show a good agreement and the results show that the present model gives similar results of Taitel and Dukler's in the case of inclined pipes. However, at high superficial liquid velocity, the results of present work agree more closely with data than that of Taitel and Dukler's. Also, predictions of the present model gives a very close agreement with the experimental data for various tube sizes obtained by others.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.30 no.3
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• pp.451-458
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• 1997

The oxygen transfer coefficient was not significantly affected by either flow pattern, initial bubble size or the wastes present in the water studied. Surface active substances in the water did however influence the transition from bubble to slug flow. Airlift with length to diameter ratios less than 50 suffered from considerable losses in efficiency. When properly designed, airlift pumping efficiencies were comparable to those of conventional centrifugal pumps and the oxygen transfer efficiency were as high as or higher than those of diffused aeration systems.

• Journal of Power System Engineering
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• v.16 no.1
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• pp.30-37
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• 2012

공기 양수 펌프는 재생 에너지 분야, 부식 및 마모 특성의 유체의 활용 등 높은 신뢰성과 낮은 유지보수 비용을 필요로 하는 분야에서 그 사용이 증대되고 있다. 본 연구에서는 소형 공기 양수 펌프의 성능 평가 및 기초 데이터를 얻기 위한 연구로, D=0.012~0.019m, L=0.933m인 배관의 침수 깊이(${\beta}$=0.55,0.60,0.65,0.70)에 따른 수치해석을 수행하였다. 수치 해석 및 실험 결과는 유사성을 뛰었으며, 펌프의 사양과 효율은 공기의 질량 유속 비, 침수 깊이 비와 양수 배관의 길이에 관한 함수로 나타났다. 그리고 최대 물과 공기 질량 유속의 비는 각 배관에서 서로 다른 침수 깊이의 비로 나타났으며, 공기 양수 펌프의 최대 효율이 발생되는 운전조건은 슬러그(slug)와 슬러그 교반 정도(slug-churn flow regime)에 따라 나타남을 알 수 있었다.

• Applied Microscopy
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• v.26 no.3
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• pp.305-313
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• 1996

Acinous gland cells (A, B, C, D and E-type cells) and duct cell (G-type cell) are observed in acinus and in duct of salivary gland of Korean Slug respectively by electron microscope. The type-A gland cells are numerous and are packed with medium electron dense granules (diameter, $3{\mu}m$) in cytoplasm. The circular shaped nucleolus and evenly developed chromatins are observed in the nucleus of type-B cell, and cytoplasm includes medium electron dense granules (diameter, $2.5X3.7{\mu}m$). The type-C gland cell has a round nucleus, and thin elongated-shaped heterochromatins are evenly distributed in the nucleoplasm and many net shaped endoplasmic reticulums and oval serous granules of middle electron density (diameter, $3.5X5{\mu}m$) fill the cytoplasm. The type-D gland cell is the largest and the most numerous of the gland cells consisting the salivary gland and heterochromatins in nucleus are well developed in the nucleoplasm. Most of granules (diameter, $0.8X2.5{\mu}m$) in cytoplasm are round, and look dark for the high electron density, and cytoplasm is filled with net-shaped endoplasmic reticulums. The type-E gland cells are rarely existent around the salivary gland, and the granules of those cells are irregular in shape and size and are vacuolized in cytoplasm. Intralobular salivary duct is composed of the high electron dense squamus endotheliums, while the other interlobular salivary duct is filled with irregular columnar epitheliums. The interlobular duct cell contains the high electron dense granules (size, $0.3{\sim}1.5{\mu}m$) in cytoplasm and those granules are secreted into cilia of salivary lumen.

• Radiation Oncology Journal
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• v.33 no.4
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• pp.328-336
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• 2015

Purpose: Past studies have reported that S-allylcysteine (SAC) inhibits the migration and invasion of cancer cells through the restoration of E-cadherin, the reduction of matrix metalloproteinase (MMP) and Slug protein expression, and inhibition of the production of reactive oxygen species (ROS). Furthermore, evidence is emerging that shows that ROS induced by radiation could increase Met activation. Following on these reports of SAC and Met, we investigated whether SAC could suppress Met activation. Materials and Methods: Wound healing, invasion, 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium (MTT), soft agar colony forming, western blotting, and gelatin zymography assays were performed in the human nasopharyngeal cancer cell lines HNE1 and HONE1 treated with SAC (0, 10, 20, or 40 mM) and hepatocyte growth factor (HGF). Results: This study showed that SAC could suppress the migration and invasion of HNE1 and HONE1 cell lines by inhibiting p-Met. An increase of migration and invasion induced by HGF and its decrease in a dose dependent manner by SAC in wound healing and invasion assays was observed. The reduction of p-Met by SAC was positively correlated with p-focal adhesion kinase (p-FAK) and p-extracellular related kinase (p-ERK in both cell lines). SAC reduced Slug, MMP2, and MMP9 involved in migration and invasion with the inhibition of Met-FAK signaling. Conclusion: These results suggest that SAC inhibited not only Met activation but also the downstream FAK, Slug, and MMP expression. Finally, SAC may be a potent anticancer compound for nasopharyngeal cancer treated with radiotherapy.

• Journal of Mechanical Science and Technology
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• v.17 no.10
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• pp.1507-1519
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• 2003

The two-phase flow patterns for both non-loop and loop type oscillating capillary tube heat pipes (OCHPs) were presented in this study. The detailed flow patterns were recorded by a high-speed digital camera for each experimental condition to understand exactly the operation mechanism of the OCHP. The design and operation conditions of the OCHP such as turn number, working fluid, and heat flux were varied. The experimental results showed that the representative flow pattern in the evaporating section of the OCHP was the oscillation of liquid slugs and vapor plugs based on the generation and growth of bubbles by nucleate boiling. As the oscillation of liquid slugs and vapor plugs was very speedy, the flow pattern changed from the capillary slug flow to a pseudo slug flow near the annular flow. The flow of short vapor-liquid slug-train units was the flow pattern in the adiabatic section. In the condensing section, it was the oscillation of liquid slugs and vapor plugs and the circulation of working fluid. The oscillation flow in the loop type OCHP was more active than that in the non-loop type OCHP due to the circulation of working fluid in the OCHP. When the turn number of the OCHP was increased, the oscillation and circulation of working fluid was more active as well as forming the oscillation wave of long liquid slugs and vapor plugs in the OCHP. The oscillation flow of R-142b as the working fluid was more active than that of ethanol and the high efficiency of the heat transfer performance of R -142b was achieved.

• Journal of dental hygiene science
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• v.18 no.3
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• pp.188-193
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• 2018

The aim of the current study was to demonstrate the potential therapeutic efficacy of resveratrol in oral cancer patients. Lysophosphatidic acid (LPA) intensifies cancer cell invasion and metastasis, whereas resveratrol, a natural polyphenolic compound, possesses antitumor activity, suppressing cell proliferation and progression in various cancer cell lines (ovarian, gastric, oral, pancreatic, colon, and prostate cancer cells). In addition, resveratrol has been identified as an inhibitor of LPA-induced proteolytic enzyme expression and ovarian cancer invasion. Furthermore, resveratrol was shown to inhibit oral cancer cell invasion by downregulating hypoxia-inducible factor $1{\alpha}$ and vascular endothelial growth factor expression. Recently, we demonstrated that LPA is important for the expression of transcription factors TWIST and SLUG during epithelial-mesenchymal transition (EMT) in oral squamous carcinoma cells. In this study, we treated serum-starved cultures of oral squamous carcinoma cell line YD-10B with resveratrol for 24 hours prior to stimulation with LPA. To identify an optimal resveratrol concentration that does not induce apoptosis in oral squamous carcinoma cells, we determined the toxicity of resveratrol in YD-10B cells by assessing their viability using the MTT assay. Another assay was performed using Matrigel-coated cell culture inserts to detect oral cancer cell invasion activity. Immunoblotting was applied for analyzing protein expression of SLUG, TWIST1, E-cadherin, and GAPDH. We demonstrated that resveratrol efficiently inhibited LPA-induced oral cancer cell EMT and invasion by downregulating SLUG and TWIST1 expression. Therefore, resveratrol may potentially reduce oral squamous carcinoma cell invasion and metastasis in oral cancer patients, improving their survival outcomes. In summary, we identified new targets for the development of therapies against oral cancer progression and characterized the therapeutic potential of resveratrol for the treatment of oral cancer patients.

• Nuclear Engineering and Technology
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• v.35 no.4
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• pp.356-368
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• 2003

Material properties such as coolant specific heat, film heat transfer coefficient, cladding thermal conductivity, surface diffusion coefficient of the multi-bubble are improved in MACSIS-Mod1. The axial power and flux profile module was also incorporated with irradiation history. The performance and feasibility of the updated driver fuel pin have been analyzed for nominal parameters based on the conceptual design for the KALIMER breakeven core by MACSIS-MOD1 code. The fuel slug centerline temperature takes the maximum at 700mm from the bottom of the slug in spite of the nearly symmetric axial power distribution. The cladding mid-wall and coolant temperatures take the maximum at the top of the pin. Temperature of the fuel slug surface over the entire irradiation life is much lower than the fuel-clad eutectic reaction temperature. The fission gas release of the driver fuel pin at the end of life is predicted to be $68.61\%$ and plenum pressure is too low to cause cladding yielding. The probability that the fuel pin would fail is estimated to be much less than that allowed in the design criteria. The maximum radial deformation of the fuel pin is $1.93\%$, satisfying the preliminary design criterion ($3\%$) for fuel pin deformation. Therefore the conceptual design parameters of the driver fuel pin for the KALIMER breakeven core are expected to satisfy the preliminary criteria on temperature, fluence limit, deformation limit etc.

• Nuclear Engineering and Technology
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• v.56 no.5
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• pp.1712-1724
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• 2024

Spiral tubes are used in a wide range of applications and it is significant to understand the vibration introduced by two-phase flow in spiral tubes. In this paper, the numerical method is used to study the vibration induced by the gas-liquid two-phase flow in a spiral tube with different flow regimes. The pressure fluctuation characteristics at the pipe wall and the solid vibration response characteristics are obtained. The results show that the motion of small bubbles in bubbly flow leads to small pressure fluctuations with low-frequency broadband (0-50 Hz). The motion of the gas plug in the plug flow causes small amplitude periodic pressure fluctuation with a shortened low-frequency broadband (0-15 Hz) compared to the bubbly flow. The motion of the gas slug in the slug flow causes large periodic fluctuations in pressure with a significant dominant frequency (6-7 Hz). The wavy flow is very stable and has a distinct main frequency (1-2 Hz). The vibration regime in the bubbly flow and wave flow are close to the first-order mode, and the vertical vibrating component is dominant. The plug flow and slug flow excite higher-order vibration modes, and the lateral vibration component plays more important part in the vibration response.