• 한국수산과학회지
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• 제41권3호
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• pp.170-175
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• 2008

We made sand-lance meat paste containing 0.1-0.5% propolis to improve the quality of the product. The quality characteristics were analyzed by the acid value, peroxide value, volatile basic nitrogen, pH, viable cell count, and sensory evaluation. The fried sand-lance meat paste made with added propolis had a lower acid value, peroxide value, and volatile basic nitrogen content after frying compared to the control prepared with potassium sorbate. The antioxidant and antispoiling effect of propolis on the fried fish meat paste increased with the amount of propolis added. The fried sand-lance meat paste made with 0.2% added propolis was very acceptable. In addition, the bitter taste of the sand-lance meat paste containing 0.2% propolis was blocked by adding 2% sweet amber powder to the paste.

• 한국식품과학회지
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• 제31권5호
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• pp.1153-1158
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• 1999

밀원식물을 달리하여 채집된 두 종류의 국내산 propolis의 향기성분을 Aroma Scan과 GC/MS로 분석하였다. Aroma Scan으로 아까시나무와 밤나무 유래의 두 propolis는 서로 다른 향기를 지닌 것을 확인하였다. GC/MS 분석한 propolis의 향기 성분은 아까시나무 유래 Propolis의 44종과 밤나무 유래 propolis의 47종을 포함한 총 55종이 검출되었다. Aldehydes 5종, alcohols 8종. ketones 5종, esters 3종. fatty acid 1종을 비롯하여 27종의 hydrocarbons과 2종의 terpenes 및 4종의 phenolic derivatives가 검출되었다. Benzaldehyde, cinnamyl alcohol, eudesmol 및 benzyl benzoate 등을 포함한 36종의 화합물은 두 시료에서 공통적으로 검출되었고, geraniol과 n-undecane을 포함한 8종의 성분은 아까시나무 유래의 propolis에서만 동정되었으며, piperitenone과 valencene을 포함한 11종의 화합물은 밤나무 유래의 propolis에서만 검출되어 밀원 식물에 따라 향기성분에 차이가 있는 것으로 나타났다.

• 한국동물위생학회지
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• 제42권2호
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• pp.85-92
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• 2019

The study was conducted to investigate the effect of propolis on the increase of the immunity of honeybee bees by gradually administering the bees' propolis to bees. 0.16% and 0.3% 0.6% Propolis were administered at intervals of 2 weeks for 2 months, respectively, and 16 kinds of representative diseases of bees were tested. As a result, less bee disease was observed directly in the 0.3% propolis-administered group. In the next year, bees and a newborn bee showed a decrease in the incidence of bee disease and American foulbrood in bees administered with propolis. Based on the results of these studies, it was confirmed that propolis administration in bees helps to enhance immunity of bees and is effective in controlling American foulbrood.

• 한국식품영양과학회지
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• 제37권4호
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• pp.485-489
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• 2008

본 연구에서는 프로폴리스를 명태 연육에 각각 0.17%, 0.34%, 0.51%, 0.67% 및 0.84%로 수분함량을 조절하여 첨가한 명태 연육 튀김어묵을 제조한 다음 과산화물가, 색도, 총 균수 변화 및 관능검사를 실시하여 프로폴리스 첨가 튀김어묵제품에서의 항균.항산화효능을 분석 평가하였다. 튀김어묵의 과산화물가는 저장기간이 증가됨에 따라 대조구에 비하여 프로폴리스 첨가 명태 연육 튀김어묵의 과산화물가가 낮은 함량을 나타내었고, 프로폴리스 함량이 증가할수록 과산화물가 함량이 낮아지는 경향을 나타내었다. 명태 연육튀김어묵의 겔 강도를 측정해 본 결과, 대조구에 비하여 프로폴리스 첨가군에서 겔 강도가 높게 나타났으며 프로폴리스 함량이 증가할수록 겔 강도도 증가함을 알 수 있었다. 색도에서는 명태 연육 튀김어묵의 프로폴리스 첨가량이 증가할수록 L값은 감소하였으나 a값과 b값은 증가하였다. 관능검사를 측정한 결과 0.17% 프로폴리스 첨가 튀김어묵에서 전체적으로 기호도가 높게 나타났다. 이상의 결과로부터 프로폴리스를 함유한 고품질 어묵의 제조 가능성을 확인할 수 있었다.

• Journal of the Korean Data and Information Science Society
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• 제21권3호
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• pp.447-459
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• 2010

본 연구는 메타분석에서 헤지의 표준화된 평균차를 이용하여 당뇨에 걸린 쥐들에게 프로폴리스를 투여하여 체중, 혈당량, 콜레스테롤, 트리글리세리드의 평균비교를 통해 프로폴리스의 항-당뇨 효과에 대해 알아보았다. 고정효과모형을 적용시킨 결과 혈당량의 감소, 콜레스테롤 농도의 감소, 트리글리세리드 농도의 감소에 대해 유의한 효과를 보였고, 동질성 검정을 통해 동질성을 만족하지 않은 모든 변수에 대해 랜덤효과모형을 적용시킨 결과 혈당량의 감소와 트리글리세리드 농도의 감소에 대해 유의한 효과를 나타냈다. 또한 프로폴리스의 투여기간과 투여량에 대해 메타회귀분석을 실시한 결과, 투여기간이 체중, 혈당량, 콜레스테롤에 유의한 변수로 나타났다.

• 한국식품영양학회지
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• 제29권1호
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• pp.73-78
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• 2016

Propolis possesses antimicrobial, anti-inflammatory, anaesthetic and immunostimulating activities. The aim of this study was to evaluated chemical composition and in vitro anti-Helicobacter pylori activity of eight propolis ethanolic extracts form different region in Korea. The chemical composition of eight Korean propolis was investicated by absorption spectrophotomety and UHPLC. Total penolic and total flavonoids content ranged between $21{\pm}1.5$ and $31{\pm}1.8$ gallic acid g/100 g and $7.2{\pm}0.9$ and $24.4{\pm}1.9$ quercetin g/100 g, respectively. The p-coumaric acid as standard components content ranged between $0.29{\pm}0.00$ and $2.34{\pm}0.02mg/g$ using UHPLC. Cinnamic acid content between $0.43{\pm}0.00$ and $1.33{\pm}0.01mg/g$. 80% ethanolic extract of propolis against H. pylori was evaluated by using the disc diffusion method. Ethanol was used as a control. Mean diameters of H. pylori growth inhibition using $10{\mu}g/mL$, $50{\mu}g/mL$ or $100{\mu}g/mL$ ethanol propolis per disc were 0, ranging from 0.9 to 2.1 mm and from 1.9 to 3.5 mm, respectively. In conclusion, variation in the chemical composition of Korean propolis were mainly due to the difference in the preferred regional plants visited by honeybees. Also Korean propolis possesses considerable antibacterial activity against H. pylori. There was not confirmed a correlation between the chemical composion contens and anti-H. pylori effect. The potential of propolis in the prevention or treatment of H. pylori infection is worth further extensive evaluation.

• Mycobiology
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• 제31권2호
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• pp.99-104
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• 2003

Bee propolis ethanolic extract with some plant essential oils was investigated for its antidermatophytic properties. The tested plant essential oils included jasmine, clove, lemon, Arabian jasmine, mint, rosa, olive and basil. The antidermatophytic activity has been compared to Naftifine-HCl and Clotrimazole used for dermatophyte treatment. Experimental model has been tested using sheep hoof plate for the in vitro tests to stimulate human nails. Mint, clove and basil with 4 mg/ml of bee propolis have a comparable efficacy to those of Naftifine-HCl and Clotrimazole. There is a great necessity for new effective low price and safe antidermatophyte agents to avoid recurrent infection. Propolis synergistic could be of great importance with essential oils of plants in dermatophyte therapy.

• Biomolecules & Therapeutics
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• 제7권4호
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• pp.362-370
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• 1999

Propolis, a natural resinous compound collected from honey bees, contains many biochemical constituents(wax, flavonoids, phenolic compounds, etc.) and has been used in traditional medicines as early as 300 B.C. It was been demonstrated that ethanol, acetylsalicylic acid, ischemia reperfusion, non-steroidal antiin-flammatory drugs and stress induce gastric lesions by promoting the generation of reactive oxygen metabolites. Therefore, some drugs that are capable of scavenging or inhibiting the generation of reactive oxygen radicals might be expected to prevent the gastric mucosal injury. The aim of this study was 1) to examine the antiulcer effect of propolis, 2) to investigate the mechanism of action by determining gastric acid secretion, lipid per-oxidation, mucus content and proton pump ($H^+$/$K^+$-ATPase) activity on gastric mucus in varios experimental models, and finally, 3) to isolate and identify the pure compounds that exert antiulcer activity. Step 2-1 and 2-3 sub-sub fraction shoed a significant reduction of severity of gastirc damage at the dose of 25 mg/kg in various experimental models. We isolated 4 sub-sub-sub fractions by flash column chromatography of Step 2-1 sub-sub fraction and one sub-sub-sub fraction by recrystalization of Step 2-3 sub-sub fraction. The protective effects of propolis sub-sub-sub fraction manifested sifnificant effects in HCl-ethanol induced gastric erosion model and aspirin induced gastric ulcer model. These results showed that the gastric mucosal protective effect of propolis might result from the increase of mucus secretion, free radical scavenging effect as well as the reduction of acid secretion in accordance with the reduction of $H^+$/$K^+$-ATPase activitv. Three compounds were isolated and identified from sub-sub fraction of propolis which showed antiulcer effects. Subsequently, these compounds were identified as a flavonoid, namely, 2-acetoxy-5,7,-dihydroxy-flavanone, galangin and chrysin.

• 한국축산식품학회지
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• 제24권2호
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• pp.198-201
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• 2004

천연발효물질인 프로폴리스를 이용하여 숙취 해소 음료를 개발하고 그에 따른 알콜 대사에 미치는 효과를 알아보고자 하였다. 프로폴리스 농축액과 다양한 약용식물의 농축액을 사용하여 숙취 해소 음료를 개발하였다. 배합원료 각각의 알콜 분해 능력을 검토한 결과, 프로폴리스와 가시오가피 추출액이 가장 큰 분해 능력을 보였다. 타 회사 제품과의 알콜 분해 능력을 비교한 경우 급성 주정 중독량 (kg당 4g)을 경구 투여하였을 때 유의적인 차이를 보이지 않았다. 그러나 주정중독량 지표보다 약 1/3을 감소시킨 kg당 1.8 L의 술을 경구 투여한 경우, 프로폴리스 음료는 270분이 경과했을 때 0.026%, 360분이 경과했을 때에는 0.000%의 혈중알콜농도를 나타내었다. 이것으로 보아 프로폴리스 음료는 섭취알콜의 양이 많을 경우에는 큰 차이가 없었지만, 일정량의 알콜을 섭취할 경우에는 매우 뛰어난 알콜 분해 효능이 있음을 알 수 있었다.

• 한국축산식품학회지
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• 제42권2호
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• pp.280-294
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• 2022

This study aimed to evaluate the effectiveness of propolis extract as a natural preservative for livestock products in term of chemical and microbiological characteristics by meta-analysis. The stages carried out in this study were identification, selection, checking suitability, and the resulting selected articles were used in the meta-analysis. The selection results obtained a total of 22 selected journal articles consisting of 9 articles for analysis of the antimicrobial activity of propolis extract and 13 articles for analysis of the chemical and mirobiological characteristics of livestock products. The articles were obtained from electronic databases, namely Science Direct and Google Scholar. The model used in this study is the random-effect model involving two groups, control and experimental. Heterogeneity and effect size values were carried out in this study using Hedge's obtained through openMEE software. Forest plot tests and data validation on publication bias was obtained using Kendall's test throught JASP 0.14.1 software. The results showed that there is a significant relationship between propolis extract with the results of the antimicrobial activity (p<0.05). In addition, the results of the application of propolis extract on the livestock products for the test microbes and the value of thiobarbituric acid reactive substances (TBARs) showed significant results (p<0.05). Conclusion based on the random-effect model on the effectiveness of antimicrobial activity of propolis extract and their apllication as a natural preservative of the chemical and microbiological characteristics of livestock products is valid by Kendall's test (p>0.05). Propolis in this case effectively used as natural preservatives in livestock products.