• Journal of Acupuncture Research
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• 제30권5호
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• pp.77-86
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• 2013

Objectives : The aim of the study was to investigate the characteristics of Ryodoraku score according to dyspepsia in diagnosed as Soeumin by 'portable Ryodoraku device'. Methods : Using Mann-Whitney U test, we divided 34 'Soeumin' patients into two group(normal and with chronic dyspepsia) and analyzed Ryodoraku score, especially in 'the spleen meridian' and 'the stomach meridian' which is belived to be related with dyspepsia. Soeumin subjects are classified by 'Sasang constitutional program' in portable Ryodoraku device. All of them complete the questionnaire regarding their Digestive conditions. 'short from leeds dyspepsia questionnaire(SF-LDQ)' made by rome III diagnostic is chosed as questionnaire. Results: 1. We found the RS measured from a group of people who has chronic dyspepsia was significantly greater than that from control group. 2. Regarding the effect of 'dyspepsia' in Ryodoraku, the mean score of the F6(stomach meridian) in the chronic dyspepsia group was significantly higher than that in the control group. 3. The mean score of the F6(stomach meridian RS) in the chronic dyspepsia group was not significantly higher than that in the control group. 4. In cases where people has chronic dyspepsia, the difference between RS measured in the right-side of a body and that in the left-side of a body was mostly greater than 40, whereas the case of difference that is less than 2 was rare. Conclusions : Portable Ryodoraku device might be used to classify enforce 'Sasang constitution', and also it might be used to analyze 'Ryodoraku data' based on characteristic clinical symptoms of four constitution diagnosis alone.

• Journal of Acupuncture Research
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• 제30권3호
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• pp.135-140
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• 2013

Objectives : The purpose of this study is to investigate the repeatability and reproducibility of the Ryodoraku acupuncture device. For such device to be accepted as a good apparatus for clinical diagnosis, the score it provides should be stable no matter who measure it or when it is measured, assuming all other conditions equal. Materials and Methods : Three oriental medical doctors who were well trained and fully aware of the usage of the Ryodoraku acupuncture device examined ten randomly selected patients three times. Each doctor measured the Ryodoraku scores three times from each of the 10 selected patients. Three doctors were involved in this experiment to investigate the reproducibility and each of them measured the Ryodoraku scores three times from each patient to investigate the repeatability. Data was analyzed with Friedman test, Spearman correlation test, and intra-class correlation coefficient(ICC) in SPSS ver. 18. Results : 1. The Friedman test showed that there is no statistically significant difference between the 1st, 2nd and 3rd Ryodoraku scores measured by the same examiner. It indicates that the Ryodoraku acupuncture device provides the repeatability. 2. Spearman correlation test confirmed the results obtained by the Fiedman test by showing that there exists a strong positive correlation between the three Ryodoraku scores measured by the same examiner. 3. A very high ICC among the three examiner assured that the Ryodoraku acupuncture device achieves the reproducibility. Conclusions : The Ryodoraku acupuncture device achieves the repeatability and reproducibility. However, we still recommend that a doctor trained to a certain level use the Device to carry out the diagnosis. Also, to improve the device in terms of Reproducibility even more, it should be considered to provide a manual for the exact usage.

• 동의생리병리학회지
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• 제22권3호
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• pp.540-541
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• 2008

The aim of the present study is to determine clinical efficacy and adverse reaction of yugan-tang. We compared symptoms and liver function test results of 160 patients with damp-heat type liver disease in before and after taking yugan-tang. The patients took 200ml yugan-tang two times daily for three months. Then we analyzed these datas statistically. The overall therapeutic effect was "markedly improved" in 70 of 160 patients (43.75%) and "improved" in 75 of 160 patients (46.88%). yugan-tang markedly improved damp-heat type liver disease, especially jaundice, abdominal distention, hypochondriac pain, nause, vomiting and anorexia. Alanine aminotransferase (ALT) level and total bilirubin (TBIL) level were within normal limits at baseline. But albumin-globulin ratio (A/G) level was not changed markedly. I think that yugan-tang is worth applying widely to clinic.

• Journal of Acupuncture Research
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• 제31권2호
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• pp.75-85
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• 2014

Objectives : We investigated whether bee venom(BV) inhibit cell growth through enhancement of death receptor expressions in the human cervix cancer C33A cells. Methods : BV($1{\sim}5{\mu}g/ml$) inhibited the growth of cervix cancer C33A cells by the induction of apoptotic cell death in a dose dependent manner. Results : Consistent with apoptotic cell death, expression of Fas, death receptor(DR) 3, 4, 5 and 6 was increased concentration dependently in the cells. Moreover, Fas, DR3 and DR6 revealed more sensitivity to BV. Thus, We reconfirmed whether they actually play a critical role in anti-proliferation of cervix cancer C33A cells. Consecutively, expression of DR downstream pro-apoptotic proteins including caspase-8, -3, -9 was upregulated and Bax was concomitantly overwhelmed the expression of Bcl-2. NF-${\kappa}B$ were also inhibited by treatment with BV in C33A cells. Conclusions : These results suggest that BV could exert anti-tumor effect through induction of apoptotic cell death in human cervix cancer C33A cells via enhancement of death receptor expression, and that BV could be a promising agent for preventing and treating cervix cancer.

• 한국의사학회지
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• 제17권2호
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• pp.99-110
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• 2004

This study makes SoGanEum(疎肝飮), which is included in YoYak(要略) [JangBuPyoBonHeoSil MaekYakChongBang (臟腑標本虛實脈藥摠方)], its object. It elucidates the origin of this prescription from Chinese medical texts, and examines the characteristics shown in the process of reception through Joseon's exemplary medical texts.

• Journal of Acupuncture Research
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• 제31권2호
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• pp.87-98
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• 2014

Objectives : We investigated whether snake venom toxin(SVT) from Vipera lebetina turanica sensitizes HT29 human epithelial colorectal cancer cells to tumor necrosis factor(TNF)-related apoptosis-inducing ligand(TRAIL) induced apoptosis in cancer cells. Methods : Cell viability assay was used to assess the inhibitory effect of TRAIL on cell growth of HT29 human colorectal cancer cells. And 6-diamidino-2-phenylindole(DAPI), terminal deoxynucleotidyl transferase mediated dUTP nick end labeling assay(TUNEL) staining assay were used to evaluate cell-apoptosis. Western blot analysis were conducted to observe apoptosis related proteins and death receptor. To assess whether the synergized inhibitory effect of SVT and TRAIL on reactive oxygen species(ROS) generation was reversed by strong anti-oxidative agent. Results : SVT with TRAIL inhibited HT29 cell growth different from TRAIL alone. Consistent with cell growth inhibition, the expression of TRAIL receptors; Expression of death receptor(DR)4 and DR5 was significantly increased and intrinsic pro-apoptotic cleaved caspase-3, -9 was subsequently increased together with increase of Bax/Bcl-2 ratio and extrinsic pro-apototic caspase-8 was also activated. In addition, the expression of anti-apoptotic survival proteins, a marker of TRAIL resistance(eg, cFLIP, survivin, X-linked inhibitor of apoptosis protein(XIAP) and Bcl-2) was suppressed by the combination treatment of SVT and TRAIL. Pretreatment with the ROS scavenger N-acetylcysteine abolished the SVT and TRAIL-induced upregulation of DR4 and DR5 expression and expression of the intrinsic pro-apoptotic caspase-3 and-9. Conclusion : The collective results suggest that SVT facilitates TRAIL-induced apoptosis in $HT_{29}$ human epithelial colorectal cancer cells through up-regulation of the TRAIL receptors; DR4 and DR5 and consecutive induction of bilateral apoptosis via regulating apoptosis related proteins.

• Journal of Acupuncture Research
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• 제31권2호
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• pp.99-109
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• 2014

Objectives : The purpose of this study was to analysis the relationship between hours of smartphone use and neck pain in university students. Methods : A survey of 2,353 university students was conducted in Gyeonggi province and Incheon city using a self report questionnaire from April 1 to 11 2013. The questionnaire of questions regarding the hours of using smartphone, mainly used function in participant's smartphone and neck discomfort degree. Neck disability index(NDI) was used to evaluate degree of pain. The collected data were analyzed with the t-test and Kendall's tau test using the SPSS 21.0 program and R 3.1.0, respectively. Results : 1. Almost all of the survey participants(99.07 %) were smartphone users. 66.97 % of them answered that they use their smartphone daily more than 2 hours and 48.18 % of them answered that they use their smartphone 10 to 30 minutes everytime they use it. 2. The overall distribution of NDI scores was 'no disability(0~4 score, 62.92 %)', 'mild disability(5~14 score, 32.85 %)', 'moderate disability(15~24 score, 1.19 %)'. As a result of t-test, we found that the average NDI score for female students was significantly higher than the average NDI score for male students(p<0.05). 3. The Kendall's tau test revealed that total time spent daily using smartphones has a strong positive correlation with 'pain intensity', 'lifting', 'reading' 'headache', 'concentration', and 'driving'(p<0.05) in NDI. Also, time duration of one time smartphone usage has a strong positive correlation with 'pain intensity', 'lifting', 'reading', 'headache', 'concentration', 'work', and 'recreation'(p<0.05). 4. The Kendall's tau test revealed that total NDI scores have a significantly strong positive correlation with both of total time spent daily using smartphones(p<0.05) and time duration for one time smartphone usage(p<0.05). This results imply that long-time use of smartphone has a strong relationship with neck pain. Conclusions : The results of the study would be a good starting point for future studies to reduce the risks of chronic neck pain caused by smartphone usage.

• Journal of Acupuncture Research
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• 제24권5호
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• pp.219-228
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• 2007

Objectives: The purpose of this study was to investigate the effect of Ganjeonggyeok and eye exercise therapy in primary school students who have myopia. Methods : 76 primary school students were divided into 2 groups. Experimental group was treated with eye exercise therapy along side with Ganjeonggyeok, while control group was treated with only eye exercise therapy. We compared and analyzed the rate of recovery of eyesight after 3 months. Results & Conclusions : 1. Right eyesight of the experimental group was improved from $.59{\pm}.41$ to $.70{\pm}.48$ and it was statistically significant. Left eyesight was improved from $.63{\pm}.40$ to $.66{\pm}.45$, but it was not statistically significant. In case of control group, right eyesight was improved from $.98{\pm}.33$ to $.99{\pm}.34$, and left eyesight, from $.66{\pm}.34$ to $1.04{\pm}.44$. In both cases, the variation was not statistically significant. 2. We compared VFQ scores of each group before and after the treatment. In experimental group, the score changed from $61.54{\pm}6.8$ to $61.83{\pm}6.3$, and in control group, the score changed from $61.74{\pm}4.0$ to $60.50{\pm}.11.9$. However, there were no statistical significance in both cases. 3. Eye exercise therapy alone can help recovering eyesight. However, Ganjeonggyeok in parallel with eye exercise showed significant recovery of myopia.

• 한국한의학연구원논문집
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• 제1권1호
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• pp.335-345
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• 1995

The clinical study was done as apreliminary to treat Rhinitis with orinetal medicine. We analysed 73 patients with sneezing, nasal discharge and nasal obstruction, who had visited Kept. of Internal Medicine. Hospital of Oriental Medicine, Dongui University from Jan, 1, 1993 to Dec, 31, 1993. The result swere obtained as follows. 1. In the sex ratio, man was higher than woman as 2.31:1 and in age distribution, below 10s was the top as 30.14% 2. In duration of hestory, over one year was the top as 64.38% 3. The most complained symptoms were nasal discharge and nasal obstruction as 94.52% 4. In the frequency of treatments, the cooler season was more than the warmer season 5. In the treatments of Medi-acupunctrer, most of acupuncture therapy was oden less than 5 times and Seonotanggami was most rsed in presciptions. 6. In the case of applying to Seonotanggami, nasal discharge was the most relieved symptom.

• 대한한방내과학회지
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• 제21권4호
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• pp.655-660
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• 2000

철결핍성 빈혈치료에 있어서 변증(辨證)에 따라 익기보혈탕(益氣補血湯)에 녹용(鹿茸)을 가(加)해서 투여하여 임사증상과 혈액검사상 유의할 만한 치료효과를 볼 수 있었으며, 향후 양방적인 처치와 함께 유효성에 대한 비교분석 및 임상연구가 필요할 것으로 사료(思料)된다.