• Journal of Acupuncture Research
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• 제36권1호
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• pp.12-20
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• 2019

Background: This study was conducted to verify the effectiveness and effectiveness-related factors of Korean medicine (KM) treatment for patients who have been involved in traffic accidents (TA). Methods: The medical records of 150 TA patients hospitalized in Dongguk University Bundang Oriental Medicine Hospital from September 2017 to May 2018 were reviewed. Medical records included information on patient demographic characteristics, TA situations, use of KM treatment, clinical characteristics, 4 scales [numeric rating scale (NRS), visual analogue scale (VAS), EuroQol-visual analogue scale (EQ-VAS) and neck disability index (NDI)]. Statistical analyses were performed to determine the effectiveness and effectiveness-related factors of treatment. Results: The 150 patients (almost 1:1 gender ratio) were typically in their 40's (26.67%), had rear impact to their vehicle (37.33%), were in the driver's seat (70.00%), and without head trauma and loss of consciousness (83.33%). The main symptoms were neck pain (60.66%) and lower back pain (54.00%). All 150 patients showed significant improvement after KM treatment. 4 scales significantly improved when the treatment started within 3 days from the accident and patients were hospitalized longer and took more diverse treatments. The patients experiencing a higher initial pain level (NRS 8-10, $VAS{\geq}70$) showed significant improvement of NRS and VAS scores with faster and longer inpatient treatments than the other patients. The patients with higher initial pain levels ($VAS{\geq}70$) also showed significant improvement in EQ-VAS scores. Conclusion: KM treatment was effective for TA patients in this study. Treatment initiation time, hospitalization period, treatment diversity and initial pain level are related to the degree of improvement of a patient's symptoms.

• 동의생리병리학회지
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• 제28권1호
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• pp.76-81
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• 2014

The aim of this study was to build the diagnosis criteria of Qi deficiency using distribution of sum of 11 items for Qi deficiency in stroke patients. Between September 2006 and December 2010, 2,994 patients from 11 Korean medical hospitals were asked to complete the Korean Standard Pattern Identification for Stroke (K-SPI-Stroke) questionnaire as a part of project 'Fundamental study for the standardization and objectification of pattern identification in traditional Korean medicine for stroke (SOPI-Stroke). Each patient was independently diagnosed by two experts (traditional Korean medicine physicians) from the same site according to one of five patterns. 2,994 patients were divided modeling and testing in 70:30 ratio by stratification of pattern identification. We calculated the sensitivity, specificity, accuracy and odds ratio (OR) using distribution of sum of 11 items (signs and symptoms) for Qi deficiency. More than four from 11 items of Qi deficiency in modeling dataset, sensitivity, specificity, accuracy and OR was 70.07%, 74.94%, 73.92% and 7.00, respectively. In testing dataset, 78.31%, 73.45%, 74.47% and 9.98, respectively. Although this values are not high, after values of sensitivity, specificity, accuracy and OR should be more than current value, and then we should be able to suggest as objective diagnosing criteria.

• Natural Product Sciences
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• 제21권2호
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• pp.134-140
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• 2015

The present study aims to investigate the effect of methanol extract of Korean mistletoe (KM; Viscum album var. coloratum), on amyloid $\beta$ protein ($A\beta$) (25-35), a synthetic 25-35 amyloid peptide, -induced neurotoxicity in cultured rat cerebral cortical neurons and memory impairment in mice. Exposure of cultured neurons to $10{\mu}M$ $A\beta$ (25-35) for 24 h induced a neuronal cell death, which was measured by a 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide (MTT) assay and Hoechst 33342 staining. KM (10, 30 and $50{\mu}g/ml$) significantly inhibited the $A\beta$ (25-35)-induced apoptotic neuronal death. KM ($50{\mu}g/ml$) inhibited 10 μM Aβ (25-35)-induced elevation of intracellular calcium concentration ([Ca²⁺]_i), which was measured by a fluorescent dye, Fluo-4 AM. Glutamate release into medium and generation of reactive oxygen species (ROS) induced by $10{\mu}M$ $A\beta$ (25-35) were also inhibited by KM (10, 30 and $50{\mu}g/ml$). These results suggest that KM may mitigate the $A\beta$ (25-35)-induced neurotoxicity by interfering with the increase of [Ca²⁺]_i and then inhibiting glutamate release and generation of ROS in cultured neurons. In addition, orally administered KM (25 and 50 mg/kg, 7 days) significantly prevented memory impairment induced by intracerebroventricular injection of $A\beta$ (25-35) (8 nmol). Taken together, it is suggested that anti-dementia effect of KM is due to its neuroprotective effect against $A\beta$ (25-35)-induced neurotoxicity and that KM may have therapeutic role in prevention of the progression of Alzheimer's disease.

• 대한한의학회지
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• 제44권1호
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• pp.76-87
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• 2023

Objectives: The purpose of this study is to draw priorities for candidate projects so that future inter-Korean traditional medicine cooperation can be promoted efficiently and effectively. Methods: This study used the Delphi-AHP method to derive priorities for the inter-Korean traditional medicine cooperation project. First, 33 candidate projects were selected through a data survey. In addition, the priority importance score was calculated through a 2-round mini-Delphi survey of 20 experts. The importance of 33 candidate projects was calculated by three evaluation criteria, and the weights for these three evaluation criteria were derived through the AHP method. Results: As for the weight by item, 'feasibility' was the highest with 0.6749 points, followed by 'social ripple effect' (0.1811) and 'instrumentality' (0.1439). As a result of calculating the importance score by reflecting the weight of the evaluation criteria for each project, the South's sole project, "Understanding the Status of North Korea's Korean Medicine," was the top priority, followed by the "Establishment of Strategy for Inter-Korean Traditional Medicine and Cooperation." Conclusions: As a result of this study, experts now believe that it is important to prioritize the highly feasible South Korean independent project in the field of traditional medicine between the two Koreas. This will serve as the basis for promoting cooperative projects in the event of future changes in the inter-Korean situation.

• 대한한의학원전학회지
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• 제32권1호
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• pp.133-143
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• 2019

Objectives : In this study, we analyze the medical significance of feces symptoms so that the daily records of the feces of individuals can be not only used as a measure of individual health monitoring in daily life, but also more actively connected to the medical treatment of the Korean Medicine (KM). Methods : Categories and clinically significant attributes for symptoms of Urination and defecation in the KM ontology DB are determined, and connected to KM related dialectical indicators by experts' common criteria including Viscera and Bowels [臟腑], eight principles [八綱], Qi Blood fluid and humor phlegm-retained fluid static blood [氣血津液痰飮瘀血], six excesses [六淫]. Results : The analysis of the symptoms of feces in the Korea Medicine ontology shows that the symptoms of stool in categories of 'stool stiffness', 'blood swelling', 'discomfort' are highly ranked among the overall clinical symptom categories. In the case of urine symptoms, symptoms corresponding to 'urine color,' 'urine discomfort,' and 'urine volume' are the top rankers among other total clinical symptoms. In the case of stool, the relationship between the symptom of stool and the categories of spleen, stomach, and colon is increased as the weighted symptom is considered. The relationship between the symptom of urine and the categories of the small intestine and the bladder is increased in the same way. Conclusions : This study could help better utilize the personal generated health records of feces in clinical practice of Korean Medicine.

• Journal of Acupuncture Research
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• 제40권1호
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• pp.67-77
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• 2023

This study individually analyzed the effects of Korean Facial Chuna Manual Treatment (K-FCMT) combined with Korean medicine (KM) treatment (acupuncture, electroacupuncture, pharmacopuncture, and herbal medicine) on five patients with acute Bell's palsy who visited Dongsuwon Korean Medicine Hospital between August 1 and 31, 2022. During inpatient treatment, two of the five patients received K-FCMT 5-6 times a week, and the other three received the same frequency during outpatient treatment for approximately 2 weeks. Patients with a House-Brackmann grading scale (HBGS) score of ≤4 and Yanagihara unweighted grading system (Y-score) ≥7-8 began to recover after the 2nd-3rd sessions of K-FCMT, which entered the recovery phase quickly. As patients entered the recovery phase (7-9th sessions of K-FCMT), symptoms improved to HBGS scores of 1-2 and Y-scores of 35-40 points. This study suggests the possibility of applying K-FCMT combined with KM treatment to patients in the acute stage of Bell's palsy.

• 사상체질의학회지
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• 제34권2호
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• pp.1-14
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• 2022

Objectives The aim of this study was to investigate the change in Sasang constitution prediction value in 2 years and find the factors associated with it. Methods Cohort data from Korean medicine data center was used. Using Korean Sasang Constitutional Diagnostic Questionnaire (KS-15) which consist of questions related to body shape, temperament, and symptoms, participants were categorized into Tae-Yang (TY), Tae-Eum (TE), So-Yang (SY), and So-Eum (SE). Sasang constitution was assessed on the baseline and after two years. Result Total 5,784 participants were analyzed. (TE 3, 341; SE 911; SY 1,532). Among them, 1,402 participants (24.2%) showed different prediction value in KS-15 after two years. The proportion of participants showing different prediction value in two years was the highest in SY, and the lowest in TE group. The factors associated with the change in Sasang constitution prediction value were different by constitution type. The change in feeling after sweating was significantly associated with the change in prediction value in TE and SY groups, not in SE group. Although temperament was not significantly associated with the change in prediction value from TE to SE, it was significantly associated with that in the change from TE to SY. The change in BMI and appetite were associated with the change in constitution prediction value in all three constitution types. Conclusion Although the factors associated with the change in prediction value of Sasang constitution were different by each constitution type, BMI and appetite were significant in all three types. These factors could be useful for developing Sasang constitution questionnaire and deciding re-prediction needs of Sasang constitution. Further research about the factors related to Sasang constitution diagnosis need to be conducted.

• 대한예방한의학회지
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• 제20권2호
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• pp.1-15
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• 2016

Objectives : This is a study for technological forecasting, aiming to find out the promising future technologies in KM(Korean Medicine) and deduce implications for the research and development of KM. Methods : The first pool of 145 technological tasks related to KM were composed by reviewing the existing data related to technological forecasting. The steering committee for the research set 99 final technological tasks. With the deduced technological tasks, mini-Delphi(2-round) method was conducted and 6 research items were used-the importance, realization time, urgency, technological competitiveness, the main agent that will push forward the task, and obstacles. Results : As a result on the time when the technology will be realized, 58 out of 99 technologies(59%) were predicted to be realized in the same year domestically and globally. The average of the importance of the 99 technological tasks was 72.9. Among them. As for the main agent to push forward the research and development of future technologies, 'industry-academic cooperation' took the highest portion at 58.7%, and regarding the obstacles to realize technological tasks, the lack of infrastructure(research funds) was the highest at 33.6%. Conclusions : This study shows that the development of basic technologies in the technologies of Korean medicine is insufficient and it is believed that the development of basic technologies is urgent to promote the development of application technologies.

• 대한예방한의학회지
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• 제21권1호
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• pp.41-48
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• 2017

Objectives : The aims of the current study were to assess the reliability and validity of the CoRe-Ditec-BS Questionnaire-II (BSQ-II; Blood stasis questionnaire-II) with 8 items including 5 items related women added to BSQ-I that was consisted of 36 items and developed in 2013. Methods : Between May 2014 and November 2014, 411 patients from 3 traditional Korean medical hospitals were asked to complete the BSQ-II. Each patient was independently diagnosed with BSS by two traditional Korean medical physicians from the same site. We estimated the internal consistency using Cronbach's ${\alpha}$ coefficient, the discriminant validity using the means score of BSS, and the predictive validity using logistic regression (sensitivity and specificity). Results : The BSQ-II had satisfactory internal consistency (Cronbach's ${\alpha}$ coefficient=0.765) and validity, with significant differences in the mean scores between the BSS($63.60{\pm}9.56$) and non-BSS groups($48.36{\pm}5.93$). The area under the receiver operating curve was about 98%, and the sensitivity and specificity were 91.4% and 94.9%, respectively. Conclusions : These results suggest that the CoRE-Ditec-BSQ-II is more reliable and valid instrument for estimating BSS than BSQ-I.

• 대한한의학회지
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• 제43권4호
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• pp.145-158
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• 2022

Objectives: To identify changes in the subjects and methods of Herbal Medicine Consumption Survey, and analyze trend of the key results Methods: The population, methods, and items of the basic reports of all Surveys on Consumption of Herbal Medicine(HM) were organized in a time-series manner. The analysis items were trend in the purchase of standardized HM; consumption value share, and price of prepared HM; type of herbal dispensary; and awareness of HM policy in Koran Medicine(KM) institutions. Results: The price of HM preparations showed an upward trend in 2011, 2014, and 2017 surveys, and decreased in the 2020 survey. However, despite this recent decrease, the 2021 survey also saw the highest proportion of HM users reporting that price of herbal decoction is expensive. Furthermore, the demand for expanded coverage of herbal decoction was the greatest for the expansion of health insurance benefits. Efforts such as adjusting the number of covered diseases and the cost of health insurance coverage would be necessary. Regarding decoction dispensaries the proportion of HM hospitals using only extramural herbal dispensaries increased. Finally, the consumption of HM and the size of the HM industry has continued to expand due to the large-scale branding of KM institutions and the expansion of health insurance coverage. Conclusion: Future surveys must standardize and unify the items for the time-series continuity and compare the results with government statistics reports on HM to increase reliability. Moreover, specialized survey items may be developed for KM, to establish a better and efficient distribution system for domestic HMs.