• Korean Journal of Oriental Medicine
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• v.1 no.1
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• pp.101-125
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• 1995

The terminology used for oriental medicine has not yet been standardized so far and this might cause the problems in developing theories and clinical research of oriental medicine. To establish scientific backgroupd of oriental medicine, it is required that all the terminology used for oriental medicine should be standardized and unified. For more efficient oriental medical practice, the standardization, unification of the terms and conditions used for diagnosis in oriental medicine should be achieved. The aim of this study are as follows; 1. To provide clear and logical systems for the diagnosis of symptoms and diseases. 2. To provide the theoritical clearmess of oriental medicine and to promote the public facilities for study. 3. To provide ways of idea exchange and understanding between oriental medicine and various biological sciences. 4. To provide practical basis for hospital administration for oriental medicine.

• Molecules and Cells
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• v.42 no.12
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• pp.906-918
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• 2019

MicroRNA-223-3p (miR-223-3p) is one of the potential microRNAs that have been shown to alleviate inflammatory responses in pre-clinical investigations and is highly encased in exosomes derived from bone mesenchymal stem cells (MSC-exosomes). MSC-exosomes are able to function as carriers to deliver microRNAs into cells. Autoimmune hepatitis is one of the challenging liver diseases with no effective treatment other than steroid hormones. Here, we examined whether MSC-exosomes can transfer miR-223-3p to treat autoimmune hepatitis in an experimental model. We found that MSC-exosomes were successfully incorporated with miR-223-3p and delivered miR-223-3p into macrophages. Moreover, there was no toxic effect of exosomes on the macrophages. Furthermore, treatments of either exosomes or exosomes with miR-223-3p successfully attenuated inflammatory responses in the liver of autoimmune hepatitis and inflammatory cytokine release in both the liver and macrophages. The mechanism may be related to the regulation of miR-223-3p level and STAT3 expression in the liver and macrophages. These results suggest that MSC-exosomes can be used to deliver miR-223-3p for the treatment of autoimmune hepatitis.

• Clinical and Experimental Emergency Medicine
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• v.5 no.4
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• pp.264-271
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• 2018

Objective For patients with acute myocardial infarction (AMI), symptoms assessed by emergency medical services (EMS) providers have a critical role in prehospital treatment decisions. The purpose of this study was to evaluate the diagnostic accuracy of EMS provider-assessed cardiac symptoms of AMI. Methods Patients transported by EMS to 4 study hospitals from 2008 to 2012 were included. Using EMS and administrative emergency department databases, patients were stratified according to the presence of EMS-assessed cardiac symptoms and emergency department diagnosis of AMI. Cardiac symptoms were defined as chest pain, dyspnea, palpitations, and syncope. Disproportionate stratified sampling was used, and medical records of sampled patients were reviewed to identify an actual diagnosis of AMI. Using inverse probability weighting, verification bias-corrected diagnostic performance was estimated. Results Overall, 92,353 patients were enrolled in the study. Of these, 13,971 (15.1%) complained of cardiac symptoms to EMS providers. A total of 775 patients were sampled for hospital record review. The sensitivity, specificity, positive predictive value, and negative predictive value of EMS provider-assessed cardiac symptoms for the final diagnosis of AMI was 73.3% (95% confidence interval [CI], 70.8 to 75.7), 85.3% (95% CI, 85.3 to 85.4), 3.9% (95% CI, 3.6 to 4.2), and 99.7% (95% CI, 99.7 to 99.8), respectively. Conclusion We found that EMS provider-assessed cardiac symptoms had moderate sensitivity and high specificity for diagnosis of AMI. EMS policymakers can use these data to evaluate the pertinence of specific prehospital treatment of AMI.

• The Korean Journal of Cytopathology
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• v.11 no.2
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• pp.103-108
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• 2000

Pulmonary alveolar proteinosis(PAP) is a rare disease in which the alveolar spaces are filled with an eosinophilic, PAS-positive material, whereas the interstitial architecture of the lung usually remains unaffected. Although a definitive diagnosis is usually made by an open lung biopsy, bronchoalveolar lavage(BAL) cytology may play a decisive role in the diagnosis and therapy of these patients and may spare a patient a more invasive diagnostic procedure. The author presents a patient in whom BAL cytology specimen contained the characteristic globules of amorphous proteinaceous PAS-positive material accompanied by background of rare macrophages and inflammatory cells. Ultrastructural study using BAL specimen can confirm the diagnosis of PAP.

• Quality Improvement in Health Care
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• v.12 no.2
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• pp.84-92
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• 2006

Background : To examine the difference between ICD-10 and The Korean standard classification of disease(oriental medicine), and to aim at improve the practical use as statistical data. It is one of the reason of disease classification. On that account we convert the many to many correspondence presenting classification of oriental medicine into many to one correspondence. Method : The study tracked out 155 patients discharged from the university hospital which is located in Gyeonggi Province and managing hospital and oriental medicine hospital from July to October this year. The period of this study was from August 1 to November 18. We compared correspondence between the two services' diagnosis(hospital services and oriental medicine hospital services) at the same time and attempted many to one correspondence classification. That is for production of statistical data. Result : We investigated the group which have had medical treatment experience of two kinds of services at the same time. The result of this investigation was that the same oriental medicine diagnosis used differently in western medicine diagnosis. 44.5% was accorded with western medicine diagnosis. Correspondence of the western medicine diagnose with the top of the Korean standard classification of disease(oriental medicine) list's western medicine diagnosis was 13.5%. For many to one correspondence classification for statistics, one western medicine diagnosis was selected for one oriental medicine diagnosis. In case of the main diagnosis(I sign) was not enough to explain oriental medicine diagnosis' characteristic, we chose multiple other diagnosis, so other diagnosis(II sign) about patient's cause of disease could be selected for supplement after we examined the patient's records. The statistics was possible with this many to one correspondence. Conclusion : The result of this study about correspondence between western medicine diagnoses and those of oriental medicine confirms that The Korean standard classification of disease(oriental medicine) is hard to be standardized with western medicine diagnosis. Therefore, according to this study, we use new many to one correspondence classification, multiple oriental medicine diagnoses with one ICD-10, which can be used by statistical data.

• Korean Journal of Radiology
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• v.2 no.3
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• pp.175-178
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• 2001

We describe the imaging features of two cases of biliary ascariasis. Ultrasonography and CT showed no specific abnormal findings, but MR cholangiography clearly demonstrated an intraductal linear filling defect that led to the correct diagnosis. MR cholangiography is thus a useful technique for the diagnosis of biliary ascariasis.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.1
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• pp.262-266
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• 2008

We plan to make the standardization of the pattern identifications for stroke and differentiate them by tongue diagnosis. We make a case report form which has questionnaires for tongue diagnosis in stroke patients. And we collected cases from the multi center network which consists of twelve university hospitals and one local hospital. The cases confirmed by diagnosis of medical specialists and residents are 321 cases. They are divided into Qi Defficiency 30.84%, Dampness& Phlegm 25.55%, Fire & Heat 22.43%, Eum Defficiency 18.69% and Blood Stasis 2.49%. We analyzed the markers which classified into the color of tongue body, the color of fur, the quality of fur, the dryness of tongue, the shape of tongue. To make a stroke pattern identification standard, we must try variable ways.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.5 no.1
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• pp.108-115
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• 2005

Inherited metabolic diseases (IMD) comprise a large class of genetic diseases involving disorders of metabolism. The majorities are due to defects of single genes that code for enzymes that facilitate conversion of various substances into others. Because of the multiplicity of conditions, many different diagnostic tests are used for screening of IMD. Molecular genetic diagnosis is the detection of pathogenic mutations in DNA and/or RNA samples and is becoming a much more common practice in medicine today. The purpose of molecular genetic testing in IMD includes diagnostic testing, pre-symptomatic testing, carrier screening, prenatal diagnosis, preimplantation testing, and population screening. However, because of the complexity, difficulty in interpreting the result, and the ethical considerations, an understanding of technical, conceptual, and practical aspects of molecular genetic diagnosis is mandatory.

• Journal of Korean Medical classics
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• v.23 no.5
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• pp.51-54
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• 2010

Since ${\ll}$Hwangjenaegyeong(黃帝內經)${\gg}$ and ${\ll}$Nangyeong(難經)${\gg}$, there has been various methods in pulse diagnosis. The Chon-gu(寸口)/Inyeong(人迎) Pulse Comparison Diagnosis which is dealt with in many chapters of the ${\ll}$Hwangjenaegyeong${\gg}$, has not been as widely applied as the Chon-gu Pulse Diagnosis due to several limitations. In this paper, we will review these limitations and suggest an alternative method. In the Chon-gu/Inyeong Pulse Comparison Diagnosis, we compare the Chon-gu Pulse and the Inyeong Pulse to see which is larger than the other by times, and diagnose illness of the 12 Meridian Pulse. It is fairly clear which is larger than the other, but to determine by how much accurately is quite difficult to say. However if we combine the Five Viscera Pulse in application, it becomes far more easier to determine which viscera and bowel is ill. First, study the pulse of the Chon-gu and In-yeong, then determine the Viscera Pulse. Next, determine the larger pulse between the Chon-gu and In-yeong pulse.

• Applied Microscopy
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• v.51
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• pp.18.1-18.12
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• 2021

Hair, having distinct stages of growth, is a dynamic component of the integumentary system. Nonetheless, derangement in its structure and growth pattern often provides vital clues for the diagnosis of systemic diseases. Assessment of the hair structure by various microscopy techniques is, hence, a valuable tool for the diagnosis of several systemic and cutaneous disorders. Systemic illnesses like Comel-Netherton syndrome, Griscelli syndrome, Chediak Higashi syndrome, and Menkes disease display pathognomonic findings on hair microscopy which, consequently, provide crucial evidence for disease diagnosis. With minimal training, light microscopy of the hair can easily be performed even by clinicians and other health care providers which can, thus, serve as a useful tool for disease diagnosis at the patient's bedside. This is especially true for resource-constrained settings where access and availability of advanced investigations (like molecular diagnostics) is a major constraint. Despite its immense clinical utility and non-invasive nature, hair microscopy seems to be an underutilized diagnostic modality. Lack of awareness regarding the important findings on hair microscopy may be one of the crucial reasons for its underutilization. Herein, we, therefore, present a comprehensive overview of the available methods for hair microscopy and the pertinent findings that can be observed in various diseases.