• 한국임상약학회지
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• 제34권2호
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• pp.118-125
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• 2024

Background: Numerous studies have consistently demonstrated that depression can be associated with cognitive function decline, primarily focusing on older adults due to the neurodegenerative characteristics of dementia. With persistent depression frequently reported in patients with early-onset or young-onset dementia, this study aimed to assess the impact of depression, specifically the changes in depressive symptoms over time, on the risk of cognitive function decline in middle-aged adults in Korea. Methods: This retrospective study utilized data from the first four waves (2006-2012) of the Korean Longitudinal Study of Aging (KLoSA), focusing on middle-aged adults with normal cognitive function at baseline. Changes in depressive symptoms were categorized into four groups based on the CES-D score, and their association with cognitive function decline was evaluated using a multivariate logistic regression model. Results: Of the initial 10,254 participants, 3,400 were included in the analysis. Depressive status, particularly newly onset (adjusted odds ratio [aOR] 1.96; 95% confidence interval [CI] 1.32-2.93) and persistent depression groups (aOR 5.59; 95% CI 2.90-10.78), were significantly associated with cognitive function decline. In contrast, recovery from depressive symptoms was not significantly associated with cognitive function decline (p=0.809). Conclusions: Our study showed a significant association between changes in depressive symptoms and cognitive function decline in middle-aged Korean adults. This suggests that management of depressive symptoms could be crucial for the prevention of cognitive function decline in this population.

• 대한간호학회지
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• 제53권4호
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• pp.453-467
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• 2023

Purpose: This study investigated the cumulative effects of depressive symptoms on cognitive function over time in community-dwelling older adults. Methods: Data were investigated from 2,533 community-dwelling older adults who participated in the Korean Longitudinal Study of Aging (KLoSA) from the 5th (2014) to the 8th wave (2020). The association between cumulative depressive symptoms and cognitive function was identified through multiple regression analysis. Results: When the multiple regression analysis was conducted from each wave, the current depressive symptoms scores and cognitive function scores were negatively associated, regardless of the waves (B5th = - 0.26, B6th = - 0.26, B7th = - 0.26, and B8th = - 0.27; all p < .001). Further, when all the previous depressive symptoms scores were added as explanatory variables in the 8th wave, the current one (B8th = - 0.09, p < .001) and the previous ones (B5th = - 0.11, B6th = - 0.09, and B7th = - 0.13; all p < .001) were also negatively associated with the cognitive function score. The delta R², which indicates the difference between the model's R² with and without the depressive symptoms scores, was greater in the model with all the previous and current depressive symptoms scores (6.4%) than in the model with only the current depressive symptoms score (3.6%). Conclusion: Depressive symptoms in older adults have a long-term impact. This results in an accumulated adverse effect on the cognitive function. Therefore, to prevent cognitive decline in older adults, we suggest detecting their depressive symptoms early and providing continuous intervention to reduce exposure to long-term depressive symptoms.

• 지역사회간호학회지
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• 제26권4호
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• pp.372-379
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• 2015

Purpose: This research was conducted to examine the successful aging and identify factors influencing successful aging in the Korean elderly. Methods: The subjects were 4,507 elders and data were collected from the 4th Korean Longitudinal Study of Ageing in 2012. The data were analyzed using frequencies, weighted percentage, ${\chi}^2$ test, and logistic regression. Results: The results of this study showed that 19.6% of the participants were categorized to successful aging. The domains of the absence of disease and disability and maintaining physical and mental functioning showed a high rate of achievement, while the domain of active engagement with life showed a low rate of achievement compared to others. Successful aging was influenced by gender, age, subjective economic status, subjective health status, and family support, particularly spouse's support. Conclusion: Intervention programs to increase the prevalence of successful aging are required. Especially programs for strengthening spouse's support and enhancing subjective health status are required.

• Asian Pacific Journal of Cancer Prevention
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• 제15권23호
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• pp.10531-10537
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• 2015

Background: To examine whether offspring improve or reduce quality of life (QOL) among cancer patients and survivors. Materials and Methods: We used data from the Korean Longitudinal Study of Aging (KLoSA) from 2008 to 2011. There were 490 research subjects in our study: 245 cancer patients and survivors and 245 controls matched using propensity scores. Results: For cancer patients and survivors with no offspring, the QOL estimate was -2.831 lower (SE: 5.508, p-value: 0.623) than that of those with two offspring, while for those with five or more offspring, the QOL estimate was 7.336 higher (SE: 2.840, p-value: 0.036). For non-cancer patients and survivors with one child, the QOL estimate was -11.258 lower (SE: 2.430, p-value: 0.002) than that of those with two offspring, while for those with five or more offspring, the QOL estimate was -4.881 lower (SE: 2.484, p-value: 0.090). Conclusions: This article provides evidence for a beneficial effect of offspring upon QOL in cancer patients and survivors, indicating that offspring are important for them.

• 한국노년학
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• 제32권4호
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• pp.993-1011
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• 2012

본 연구의 목적은 각 집단별 노년기 장애발생과 변화에 관련이 있는 영향요인들을 분석하는 것으로 노동연구원의 "한국고령화연구패널(Korea Longitudinal Study of Aging: KLOSA)" 1차(2006년)와 2차(2008년) 기본조사자료를 사용하였다. 연구대상은 65세 이상 남성노인 1,454명(41.7%), 여성노인 2,032명(58.3%)으로 총 3,486명이다. 노년기 장애는 ADL장애와 IADL장애를 측정하였으며 전체노인을 정상노인, 만성질환노인, 치매의심노인, IADL장애노인, ADL장애노인으로 나누어 장애발생과 변화를 분석하였다. 연구결과를 살펴보면 2006년에 장애가 없는 노인들이 2008년에 장애가 발생하는데 영향을 미치는 요인들로는 부상, 시력제한, 인지능력저하, 우울, 건강행태, 사회경제적 특성, 연령 등을 들 수 있다. 부상과 시력으로 인한 일상생활제한 등의 경험은 2006년에 정상노인들이 2년 후 치매의심증상 발생이나 장애발생에 유의미한 영향을 미치고 있으며, 2006년에 인지능력저하를 경험한 노인들은 2년 후 치매의심증상이 나타날 확률이 정상노인의 2배 이상으로 나타났다. 2006년의 만성질환자가 우울증을 갖고 있는 경우는 그렇지 않은 경우에 비해 2년 이후 장애가 발생할 확률이 1.8배 높게 나타났다. 그 외에 흡연과 규칙적 운동의 경험뿐만 아니라 사회경제적 특징들도 비장애노인의 장애발생에 유의미한 영향을 미치고 있음을 알 수 있다. 2006년에 장애를 이미 갖고 있는 장애노인들의 2년 후 장애수준변화에서는 ADL장애노인의 경우는 유의미한 변수가 나타나지 않았으나 IADL장애노인의 경우는 도구적 지지를 적게 받을수록, 연령이 증가할수록 장애수준이 악화되는 가능성이 높게 나타났다. 본 연구결과를 바탕으로 노년기장애발생을 예방하고, 장애악화를 지연시키기 위해서 다양한 수준의 개입이 필요함을 제시하고 있다.

• 한국치위생학회지
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• 제22권5호
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• pp.333-340
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• 2022

Objectives: This study aimed to confirm the association between cognitive function and oral health status in the elderly. Methods: In this study, 5,794 respondents, aged 55 or older, who had participated in the 7th aging research panel survey were used. Statistical analyses were performed using a complex samples cross-tabulation analysis, complex samples general linear model, and a complex sample multinomial logistic regression analysis. Results: After analyzing the cognitive function of the elderly according to their oral health conditions, it was found that suspicions of dementia (19.6%) and cognitive function decline (25.9%) were more common for those who wore dentures than for those who did not wear dentures (p<0.001). Compared to those who did not wear dentures, those who wore dentures were linked to a 1.665 times higher suspicion of dementia (p<0.001). In comparison, cognitive decline was 0.964 times lower when the number of natural teeth increased by 1, and it was 0.941 times lower when the oral health evaluation index for the elderly increased by 1 point (p<0.001). Conclusions: As a result of this study, it was confirmed that cognitive function and oral health status are related in the elderly. Therefore, systematic measures for oral health management and oral health promotion should be prepared in tandem with awareness of possible cognitive decline in the elderly.

• Journal of Preventive Medicine and Public Health
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• 제54권6호
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• pp.395-403
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• 2021

Objectives: Previous studies have shown that participation in social activities (SA) can prevent cognitive decline (CD) and that living arrangements (LA) can affect cognitive function. This study aimed to evaluate the effects of SA and LA on CD, as well as their interactions, using longitudinal data. Methods: Data were used from the 2006-2018 Korean Longitudinal Study for Aging, which followed 10 254 adults older than 45 years over a 12-year period. CD was defined as a ≥4-point score decrease in the Mini-Mental Status Exam over 2 years. We developed an extended Cox proportional hazards model for time-dependent covariates to estimate the hazard ratio (HR) of CD in 4 groups: (1) socially active and living with others, (2) socially active and living alone, (3) socially inactive and living with others (SILO), and (4) socially inactive and living alone (SILA). The model was stratified by gender and adjusted for important confounders. Results: The HR of CD was significantly higher in the SILO group in men (HR,1.36; 95% confidence interval [CI], 1.08 to 1.78) and in the SILA group in women (HR, 1.72; 95% CI, 1.08 to 2.75). However, the interaction term for gender was not significant. Conclusions: Among socially inactive elderly adults, the HR of CD was elevated in men who lived with others and in women who lived alone, although the interaction term for gender was not significant. Socially inactive men who live with others and socially inactive women who live alone are particularly encouraged to participate in SA to prevent CD.

• 근관절건강학회지
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• 제8권2호
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• pp.278-286
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• 2001

With the aging of society a great deal of interest is being placed on the value of longitudinal data in evaluating physiological losses. We present data on test-one/test-two reliability and reproducibility for measures of training, bone density from a longitudinal study of master athletes. Fifty-two males (mean age at test $1=58.2{\pm}9.8\;years$) and thirty-two females ($54.4{\pm}8.8\;years$) were selected from the study population. Bone mineral density was determined using DEXA (Hologic 1500). The characteristics of the subjects are presented below as $means\;{\pm}\;S.D$. The data was imported into the Statistical Package for the Social Science (SPSS 9.0, Chicago, IL). Paired t-tests were performed between visit 1 and visit 2 in subjects. Pearson correlations were performed. The results of this study indicate the measures of training history, body mass and bone density are reasonably stable and reproducible. We conclude that body composition and bone density parameters are stable and reproducible over time in active older subjects. Physiologic measures in master athletes are fairly stable, and reproducible over time Longitudinal studies investigating age-related changes in master athletes need to be conducted on a time schedule of greater than two years.

• 보건행정학회지
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• 제32권3호
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• pp.282-292
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• 2022

Background: Aging societies face social problems of increased medical expenses for older adults due to increased geriatric diseases. This study aims to analyze the relationship between the state change of multiple chronic conditions (MCC) and out-of-pocket medical expenses in the elderly aged 60 or older. Methods: The 2014-2018 Korean Longitudinal Study of Aging data were used for 2,202 elderly people. Four status change groups were established according to the change in the number of chronic diseases. The association between the change of MCC and the out-of-pocket medical cost was analyzed using the generalized estimating equation model analysis. Results: The average out-of-pocket total medical costs were 1,384,900 won for participants with MCC and 542,700 won for those without MCC, which was a statistically significant difference (p<0.0001). Compared to the reference group (simple chronic disease, SCD→SCD), the change in multiple chronic conditions significantly increased the total out-of-pocket medical expenses in MCC→MCC and SCD→MCC groups (MCC→MCC: 𝛽=0.8260, p<0.0001; SCD→MCC: 𝛽=0.6607, p<0.0001). Conclusion: In this study, it was confirmed that the prevalence of MCC increased with age, and the out-of-pocket medical cost increased in the case of MCC. Continuity of treatment can be achieved for patients with MCC, and the system and management of treatment for MCC are required to receive appropriate treatment.

• 한국노년학
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• 제41권1호
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• pp.49-68
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• 2021

본 연구는 활동적 노화의 관점을 바탕으로 노년기 생산적 활동과 미래시간조망에 간의 관계에서 삶의 만족감의 매개효과를 검증한 연구이다. 연구방법은 제 7차 고령화연구패널(The Korean Longitudinal Study of Aging 2018) 조사자료를 활용하여, 55세 이상 고령자 6,756명의 생산적 활동, 삶의 만족감과 기대수명 기대감 및 일자리 기대감의 두 차원으로 측정한 미래시간조망의 관계를 복합표본 일반선형모형을 적용하여 분석하였다. 연구결과, 생산적 활동은 삶의 만족감 및 미래시간조망과 유의한 관계가 있는 것으로 나타났다. 구체적으로 비경제 활동자에 비해 무급 가족종사자를 포함한 취업자일수록 삶의 만족감, 기대수명 기대감, 일자리 기대감이 높은 것으로 나타났다. 이러한 생산적 활동과 미래시간조망 간의 관계는 삶의 만족감이 부분 매개하고 있는 것으로 나타났다. 즉, 비경제 활동자에 비해 무급 가족종사자를 포함한 취업자일수록 기대수명 기대감 및 일자리 기대감이 높아지는데, 이는 높아진 삶의 만족감의 영향에 의한 결과일 수 있음을 의미한다. 본 연구의 결과는 노년기 생산적 활동이 활동적 노화의 목적인 노년기 삶의 질을 향상시키고 미래를 긍정적으로 확장하여 조망하기 위한 중요한 요인임을 강조하였다. 이상의 연구 결과를 토대로 노년기 생산적 활동을 제고하기 위한 정책적 함의 및 시사점을 제시하였다.