• The Journal of Asian Finance, Economics and Business
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• v.7 no.1
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• pp.91-100
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• 2020

This study aims to find out the legalization status of a central Shariah regulatory authority for the Islamic banks in Bangladesh. In this regard, the central bank can legalize the existing Centralized Shariah Board for Islamic Banks of Bangladesh (CSBIB) or form a new Centralized Shariah Supervisory Board (CSBB) under the management of the central bank in Bangladesh. Based on the data obtained by the semi-structured interviews, this research finds diversified opinions regarding the legalization of CSBIB or the formation of a new CSBB. Initially, without the law, it would be difficult to form CSSB under the central bank as the Islamic banks and banking environment are still not ready. In addition, it is difficult to legalize the existing CSBIB because the format of its structure is different from the CSSB structure in Malaysia and Bahrain. The existing banking company act authorizes the central bank to provide circulars regarding banking issues and it will be considered as an act. The central bank can legalize the existing CSBIB or form a new CSSB through a circular which will be helpful to monitor the overall Shariah issues. The presence of a CSSB will fulfill the expectations of all Islamic banks, and the concerned stakeholders.

• Journal of Korean Clinical Health Science
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• v.12 no.1
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• pp.1654-1659
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• 2024

Purpose: The aim of this study was to determine Correlation analysis of central corneal thickness, anterior chamber volume, and anterior chamber depth in Koreans aged 20 to 24 years using the Pentacam tool. Methods: The subjects of this study were 53 Korean adults with healthy eyes. The central corneal thickness(CCT), anterior chamber volume(ACV), and anterior chamber depth(ACD) was measured with Pentacam device. Data was analyzed by means of the Pearson's correlation cofficient. P-values<0.001 were considered statistically significant. Results: Mean age of subjects was 22.0±2.01 years. The mean +/- central corneal thickness of the right eye and left eye were 546.66±32.221mmg and 545.70±32.759mm, respectively. Also The mean central cornea thickness was 546.19 um in the whole sample. The mean anterior chamber volume the right eye and left eye was 181.66±33.738 mm³ and 180.12±30.84 mm³, respectively. The mean anterior chamber depth was 3.158±0.257 mm and 3.122±0.233 mm in right eye and left eye, respectively. There was a statistically significant difference between anterior camber volume and anterior chamber depth(p<0.001, Pearson's correlation). However there was no statistically significant difference between central cornea thickness and anterior chamber volume. Also there was no statistically significant difference between central cornea thickness and anterior chamber depth. Conclusion: The results of this study could be used as a clinical reference data for diagnosis and treatment of cornea in Korean adolescents.

• Toxicological Research
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• v.17
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• pp.293-297
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• 2001

The international pharmaceutical and regulatory communities had been recognizing the limited utility of conventional rodent carcinogenicity study particularly on the second species, mouse, after intense investigation of carcinogenicity data base worldwide, and a new scheme for carcinogenicity testing for pharmaceuticals was proposed at the Expert Working Group on Safety in the International Conference on Harmonization (ICH) in 1996. CB6F 1-Tg rasH2 mouse carrying human prototype c-Ha-ras gene with its own promoter/enhancer is one oj the new carcinogenicity assay model for human cancer risk assessment. Studies have been conducted since 1992 to validate the transgenic (Tg) mice for rapid carcinogenicity test-ing, short term (26 weeks) studies with genotoxic (by Salmonella), non-genotoxic carcinogens, genotoxic non-carcinogens, non-genotoxic non-carcinogens revealed relatively high concordance oj the response of the Tg mouse with classical bioassay across classes of carcinogenic agents. Mechanistic basis for carcinogensis in the model are being elucidated in terms of the role of overexpression and/or point mutation of the transgene. This report review the initial studies of validation of the model and preliminary results of on-going ILSI HESI ACT project will be presented.

• Journal of Korean Neurosurgical Society
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• v.37 no.4
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• pp.296-299
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• 2005

We report a case of primary central nervous system(CNS) lymphoma in an organ recipient. A 33-years-old man who underwent a renal transplantation 3years previously presented with headache and vomiting. In Brain computed tomography scans and magnetic resonance images showed multiple periventricular cystic rim enhancing masses. Pathologic diagnosis by stereotactic biopsy revealed malignant non-Hodgkins B-cell lymphoma. After pathologic confirmation, methotrexate chemotherapy and whole brain radiation therapy were done. Having experienced such a case, the authors strongly recommend to add primary CNS lymphoma as one of the differential diagnoses to brain abscess, metastatic brain tumor and glioblastoma multiforme in cases of multiple ring enhancing periventricular lesions of immunocompromised patient or organ recipient.

• Annals of Clinical Neurophysiology
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• v.10 no.2
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• pp.98-100
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• 2008

Restless legs syndrome (RLS) is a sensorimotor neurological disorder in which the primary symptom is a compelling urge to move the legs, accompanied by unpleasant and disturbing sensations in the legs. Although pathophysiologic mechanism of RLS is still unclear, several evidences suggest that RLS is related to dysfunction in central nervous system involving brain and spinal cord. L-DOPA, as the precursor of dopamine, as well as dopamine agonists, plays an essential role in the treatment of RLS leading to the assumption of a key role of dopamine function in the pathophysiology of RLS. Patients with RLS have lower levels of dopamine in the substantia nigra and respond to iron administration. Iron, as a cofactor in dopamine production, plays a central role in the etiology of RLS. Functional neuroimaging studies using PET and SPECT support a central striatal D2 receptor abnormality in the pathophysiology of RLS. Functional MRI suggested a central generator of periodic limb movements during sleep (PLMs) in RLS. However, to date, we have no direct evidence of pathogenic mechanisms of RLS.

• Health Policy and Management
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• v.30 no.2
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• pp.142-150
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• 2020

The purpose of this study is to analyze the long-term plans of the central and local governments in order to plan policy and implementing programs. Through this, the governments is find out to reduce administrative burden. Based on the national health plan, evidence and related laws were collected and analyzed. As a quantitative methodology analyzed the contents of related laws in the overall plan. The qualitative methodologies analyzed and categorized the planning status of cities and provinces in the plan and were collated. There are a total of 39 plans for long-term plans by laws. The role of the central and local governments in the public health sector, there are a total of four plans (10.3%) that need to establish long-term and annual plans for the central and local (cities, provinces) government. A total of seven plans (17.9%) were required to establish a plan by the only local government. In terms of the public health sector on the local governments, 20 plans (51.3%) by cities and 12 plans (30.8%) by provinces were established by law. And in the health sector should be established 9 plans (40.9%) by cities and 7 plans (31.8%) by provinces. The plan needs to be reformed and merged between plans so that governments can focus on the program through planning central government policies, reducing local government administration.

• Nuclear Engineering and Technology
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• v.49 no.7
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• pp.1431-1441
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• 2017

The Fukushima accident reveals the vulnerability of existing active nuclear power plant (NPP) design against prolonged loss of external electricity events. The passive safety system is considered an attractive alternative to cope with this kind of disaster. Also, the passive safety system enhances both the safety and the economics of NPPs. The adoption of a passive safety system reduces the number of active components and can minimize the construction cost of NPPs. In this paper, reflecting on the experience during the development of the APR+ design in Korea, we propose the concept of an innovative Power Reactor (iPower), which is a kind of passive NPP, to enhance safety in a revolutionary manner. The ultimate goal of iPower is to confirm the feasibility of practically eliminating radioactive material release to the environment in all accident conditions. The representative safety grade passive system includes a passive emergency core cooling system, a passive containment cooling system, and a passive auxiliary feedwater system. Preliminary analysis results show that these concepts are feasible with respect to preventing and/or mitigating the consequences of design base accidents and severe accidents.

• Archives of Pharmacal Research
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• v.22 no.2
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• pp.189-193
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• 1999

Reversed-phase high-performance liquid chromatography/mass spectrometry (HPLC/MS) with an eletcrospray ionization (ESI) interface was applied to the identification of metabolites of IY81149 in the rat plasma. Fragments obtained using collision-induced dissociation (CID) in both positive and negative modes were utilized to elucidate the structure of metabolites. The eluent from the conventional HPLC column was split and directly introduced into an ESI-mass spectrometer for the identification of the structures. the CID technique allowed the sensitive identification of sulfonyl-IY81149 and hydroxy-IY81149 from the rat plasma.

• Archives of Pharmacal Research
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• v.27 no.4
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• pp.436-441
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• 2004

SJ compounds (SJ8002 and related compounds) are a group of novel anticancer agents (Cho, Chung, Lee, Kwon, Kang, Joo, and Oh. PCT/KR02/00392). To explore the anticancer mechanism of these compounds, we examined the effect of SJ8002 on microtubules of six human cell lines. At a high concentration ($2\;{\mu}g/mL$), SJ8002 effectively disrupted microtubules of the six cell lines within 1 h. At lower concentrations ($0.05\~1.0\;{\mu}g/mL$), the antimicrotubule activity of SJ8002 varied defending on cell lines. The inhibition of in vitro polymerization of pure tubulin by SJ8002 suggested that SJ8002 acts on free tubulin, inhibits the polymerization of tubulin dimer into microtubules, and hence induces the depolymerization of microtubules.

• YAKHAK HOEJI
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• v.42 no.3
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• pp.238-242
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• 1998

For the investigation of bioactive natural products with analgesic activity, we have evaluated various extracts of Saururi Herba (Saururaceae), which has been used in traditiona l medicine for edema, beriberi, jaundice, turbid urine, carbuncle and furuncle. The diethylether extract of this plant was found to show a significant analgesic effect on writhing syndrome in mice. Using bioactivity-guided separation of the diethylether extract, analgesic constituent, (8S, 8`R, 7R, 6`R)-2'-oxo-4,5: 4',5'-bis(methylenedioxy)-${\Delta}^{1,3,5,3'}$-8.8', 7.6', 2.O.5'-neolignan(sauchinone) was isolated and structurally identified by physico-chemical properties and spectroscopic evidences. This compound has good analgesic activity with lower toxicity, as compared to other antipyretic-analgesic drug(acetaminophen).